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Evaluation of an Experimental Anticholinergic Drug, Elantrine, in Treating the Tremor of Parkinsonism

  • Alvin Rix
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

An experimental anticholinergic drug, elantrine, had shown sig nificant improvement in tremor of parkinsonism in 89 patients not taking L-dopa. A double-blind study of 22 parkinsonian patients stabilized on L-dopa showed marked improvement in tremor and moderate improvement in rigidity and bradykinesia when elantrine was added to their treatment program. Nine of 15 patients taking L-dopa (or Sinemet®) and elantrine had cessation of all tremor and have continued free of tremor to date, over two years.

Keywords

Multiple Sclerosis Essential Tremor Methyl Dopa Parkinsonian Patient Placebo Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Rix, A., and Fisher, R.G. (1972) Comparison of trihexyphenidyl and dihydromorphanthridine derivative in control of tremor of parkinsonism. South. Med. Journal 65, 1385–1389.CrossRefGoogle Scholar
  2. Blonsky, E.R., Ericsson, A.D., McKinney, A.S., Rix, A., Wang, R.I.H., and Rimm, A.A. (1974) Phase II multiclinic study of elantrine in parkinsonism. Clinical Pharmacology and Therapeutics 15 ,46–50.PubMedGoogle Scholar
  3. Hoehn, M.M. and Yahr, M.D. (1967) Parkinsonism: onset, progression and mortality. Neurology 17, 427–442.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Alvin Rix
    • 1
  1. 1.Department of Neurological SurgeryUniversity of Oklahoma School of MedicineOklahoma CityUSA

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