Dominance or Recessiveness of the Senescent Phenotype in Somatic Cell Fusions
I would like to raise a few points for discussion of Dr. Muggleton-Harris’ paper, after which I will describe some of our recent work that pertains to the central theme of this symposium. Dr. Muggleton-Harris’ data suggest that both the cytoplasm and the nucleus of an old cell have the ability to confer senescence on a reconstructed cell. On the other hand, when Wright and Hayflick (1975) looked at (whole cell)/(cytoplast) fusions they concluded that the cytoplasm of an old cell does not have the ability to confer senescence on young cells. Can these results be reconciled? Let us consider several possibilities that could account for the apparent disparity between the two sets of data.
KeywordsT98G Cell Young Cell Senescence Factor Modal Chromosome Number Senescent Phenotype
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