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Senescence pp 39-55 | Cite as

Comments about the Paper by Norwood et al. and an Idea Relating Somatic Cell Mutations to Cellular Senescence

  • Robert DeMars
Part of the Cellular Senescence and Somatic Cell Genetics book series (CSSCG, volume 2)

Abstract

Cells, nuclei and cytoplasms from young, senescent and permanent line populations of human cells can be usefully combined as pairs in 30 different ways. Dr. Norwood, with his collaborators at Seattle, and others, have been attempting to create these combinations in order to answer three main questions: (i) Is the senescence phenotype dominant?; (ii) Can the senescence phenotype be imposed and maintained by the cytoplasm of a senescent cell or must the nucleus be present, too?; (iii) Is the senescence phenotype determined by primary, stable nuclear changes? Some of the possible combinations of cells and parts of cells have not been studied yet and the interpretation of the observations made so far must be tentative. Therefore, my main comments about Dr. Norwood’s presentation are an expression of admiration for what has been accomplished and a hope that the good work will continue.

Keywords

Human Fibroblast Cellular Senescence Population Doubling Diploid Human Fibroblast Senescence Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Robert DeMars
    • 1
  1. 1.Laboratory of GeneticsUniversity of WisconsinMadisonUSA

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