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Theoretical Mechanisms of in Vitro Senescence

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Book cover Senescence

Part of the book series: Cellular Senescence and Somatic Cell Genetics ((CSSCG,volume 2))

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Abstract

In this chapter we will discuss how somatic mutations might be involved in the senescence of cells in culture and in the intact organism. We will also discuss the possible role that stable phenotypic variations may play in senescence.

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References

  • Alexander, P., and Connell, D.I., 1960. Shortening of the life span of mice by irradiation with x-rays and treatment with radiomimetic chemicals. Radiation Res. 12:38–48.

    Article  PubMed  CAS  Google Scholar 

  • Burnet, Sir MacF., 1974. INTRINSIC MUTAGENESIS: A GENETIC APPROACH TO AGING, Wiley, New York-Toronto.

    Book  Google Scholar 

  • Casarett, G.W., 1964. Similarities and contrasts between radiation and time pathology. In: Advances in Gerontological Research I, B.L. Strehler, ed., pp. 109-163, Academic Press.

    Google Scholar 

  • Chasin, L.A. and Urlaub, G., 1975. Chromosorne-wide event accompanies the expression of recessive mutations in tetraploid cells. Science 187:1091–1093.

    Article  PubMed  CAS  Google Scholar 

  • Christiansen, G., and Griffith, J., 1977. Salt and divalent cations affect the flexible nature of the natural beaded chromatin structure. Nucleic Acids Res. 4:1837.

    Article  PubMed  CAS  Google Scholar 

  • Clark, A.M., and Rubin, M.A., 1961. The modification by x-irradiation of the lifespan of haploid and diploids of the wasp, Habrobracon sp. Radiation Res. 15:244.

    Article  PubMed  CAS  Google Scholar 

  • Curtis, Jr., H., 1966. BIOLOGICAL MECHANISMS OF AGING, Thomas, Springfield.

    Google Scholar 

  • Curtis, J.M., and Miller, K., 1971. Chromosomal aberrations of liver cells of guinea pigs. J. Gerontol. 26:292–293.

    PubMed  CAS  Google Scholar 

  • DeMars, R., 1974. Resistance of cultured human fibroblasts and other cells to purine and pyrimidine analogues in relation to mutagenesis detection. Mutation Res. 24:335–364.

    Article  PubMed  CAS  Google Scholar 

  • Gurdon, J.B., 1973–74. Gene expression in early animal development: The study of its control by the microinjection of amphibian eggs. Harvey Lectures 69:49–69.

    PubMed  CAS  Google Scholar 

  • Harris, M., 1971. Mutation rates in cells at different ploidy levels. J. Cell. Physiol. 78:177–184.

    Article  PubMed  CAS  Google Scholar 

  • Hart, R.W. and Setlow, R.B., 1974. Correlation between deoxyribonucleic acid excision repair and life-span in a number of mammalian species. Proc. Nat. Acad. Sci. USA 71:2169–2173.

    Article  PubMed  CAS  Google Scholar 

  • Hart, R.W. and Setlow, R.B., 1977. DNA repair in late passage human cells. Mechan. Aging and Devel. 5:67–77.

    Article  Google Scholar 

  • Heneen, W.K. and Nichols, W.W., 1972. Nonrandom arrangement of metaphase chromosomes in cultured cells of the Indian deer Muntiacus muntjac. Cytogenetics II:153–164.

    Article  Google Scholar 

  • Herrmann, R.L., Bach, M.D., Dowling, L. and Russell, A.P., 1975. Age-related changes in a spontaneous reassociating fraction of mouse DNA. Mech. Age. and Devel. 4:181–189.

    Article  CAS  Google Scholar 

  • Jacobs, P.A., Brunton, M., Court Brown, W.M., Doll, R. and Goldstein, H., 1963. Change of human chromosome count distributions with age: evidence for a sex difference. Nature, Lond., 197:1080.

    Article  CAS  Google Scholar 

  • Jacobs, P.A., Court Brown, W.M., and Doll, R., 1961. Distribution of human chromosome counts in relation to age. Nature, Lond., 191:1178.

    Article  CAS  Google Scholar 

  • Jarvik, L.F., Yen, F., and Moralishvili, E., 1974. Chromosome examinations in aging institutionalized women. Jrl. Gerontol. 29:269–2761

    CAS  Google Scholar 

  • Kihlman, B.A., 1966. ACTIONS OF CHEMICALS ON DIVIDING CELLS, Prentice Hall, Englewood-Cliffs, N.J. 260 pp.

    Google Scholar 

  • Kurtz, D.I., Russell, A.P., and Sinex, F.M., 1974. Multiple peaks in the derivative melting curve of chromatin from animals of varying age. Mech. Aging and Devel. 3:37–49.

    Article  CAS  Google Scholar 

  • Lamb, M.J. and Maynard Smith, J., 1964. Radiation and aging in insects. Exper. Gerontol. 1:11–20.

    Article  Google Scholar 

  • Martin, G.M., and Sprague, C.A., 1969. Parasexual cycle in cultivated human somatic cells. Science 166:761–763.

    Article  PubMed  CAS  Google Scholar 

  • Masters, P.M., Bada, J.L. and Sigler, J.S., 1977. Aspartic acid racemization in the human lens during aging and in cataract formation. Nature 268:71–73.

    Article  PubMed  CAS  Google Scholar 

  • Mattern, M.R. and Cerutti, P.A., 1975. Age-dependent excision repair of damaged thymine from γ-irradiated DNA by isolated nuclei from human fibroblasts. Nature 254:450–452.

    Article  PubMed  CAS  Google Scholar 

  • Mayne, R., Vail, M., Mayne, P. and Metler, E.J., 1976. Changes in type of collagen synthesized in clones of chick chondrocytes grow and eventually lose division capacity. Proc. Nat. Acad. Sci. 73:1674–78.

    Article  PubMed  CAS  Google Scholar 

  • Mays, L., 1977. Abstracts of 7th Annual Meeting American Aging Association.

    Google Scholar 

  • Mezger-Freed, L., 1972. Effect of ploidy and mutagens on bromodeoxyuridine resistance in haploid and diploid frog cells. Nature New Biol. 235:245–246.

    Article  PubMed  CAS  Google Scholar 

  • O’Meara, A., and Herrman, R., 1927. A modified chromatin preparation displaying age related differences in salt dissociation and template ability. Biochem. Biophys. Acta., 269:419–429.

    Google Scholar 

  • Palmer, W.G. and Papaconstantinou, J., 1969. Aging of α-crystallins during development of the lens. Proc. Nat. Acad. Sci. 64:404–10.

    Article  PubMed  CAS  Google Scholar 

  • Robinson, A.B., 1974. Evaluation and the distribution of glutaminyl and asparaginyl residues in proteins. Proc. Nat. Acad. Sci. 71:885–888.

    Article  PubMed  CAS  Google Scholar 

  • Sinex, F.M., 1976. Molecular genetics of aging. In: HANDBOOK ON THE BIOLOGY OF AGING, C. Finch and L. Hayflick, eds. Van Nostrand Reinhold, New York, pp. 37–62.

    Google Scholar 

  • Sinex, F.M., 1974. The mutation theory of aging. In: THEORETICAL ASPECTS OF AGING, M. Rockstein, ed., pp. 23–31, Academic Press, New York.

    Google Scholar 

  • Sinex, F.M., 1960. Aging and the liability of irreplaceable molecules. II amide groups of collagen. Jr1. Gerontol. 15:15–18.

    CAS  Google Scholar 

  • Strauss, B.S., 1974. Repair of DNA in mammalian cells. Life Sciences 15:1685.

    Article  PubMed  CAS  Google Scholar 

  • Strehler, B.L., 1959. Origin and comparison of the effects of time and high-energy radiations on living systems. The Quarterly Rev. of Biol. 34:117–142.

    Article  CAS  Google Scholar 

  • Szilard, L., 1959. On the nature of the aging process. Proc. Nat. Acad. Sci. 45:30–45.

    Article  PubMed  CAS  Google Scholar 

  • Tas, S., 1976. Disulfide bonding in chromatin proteins with age and a suggested mechanism for aging and neoplasia. Exp. Gerontol. 11:17–24.

    Article  PubMed  CAS  Google Scholar 

  • Upton, A.C., 1957. Ionizing radiation and the aging process, a review. Jr1. Gerontol. 12:306–313.

    CAS  Google Scholar 

  • Upton, A.C., 1977. Pathobiology. In: HANDBOOK OF THE BIOLOGY OF AGING, C. Finch and L. Hayflick, eds. Van Nostrand Reinhold, New York, pp. 513–535.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Boston University School of Medicine, 80 East Concord St., Boston, Mass., 02118, USA

    F. Marott Sinex

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  1. F. Marott Sinex
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Editor information

Editors and Affiliations

  1. Institute for Medical Research, Camden, New Jersey, USA

    Warren W. Nichols

  2. National Institute on Aging, Bethesda, Maryland, USA

    Donald G. Murphy

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© 1977 Plenum Press, New York

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Sinex, F.M. (1977). Theoretical Mechanisms of in Vitro Senescence. In: Nichols, W.W., Murphy, D.G. (eds) Senescence. Cellular Senescence and Somatic Cell Genetics, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2508-6_1

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  • DOI: https://doi.org/10.1007/978-1-4684-2508-6_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2510-9

  • Online ISBN: 978-1-4684-2508-6

  • eBook Packages: Springer Book Archive

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