Vasopressin and Water Metabolism

  • Gary L. Robertson


The antidiuretic hormone, arginine vasopressin, is known to play a major role in the complex homeostatic system by which man and other mammals regulate salt and water balance. Efforts to define its function in normal as well as abnormal states of water metabolism have long been hampered by the lack of a suitable assay method. Recently, several laboratories have succeeded in developing radioimmunoassay techniques that permit vasopressin to be measured easily and accurately at physiological concentrations in small volumes of plasma or other body fluids. These methodological advances have stimulated a new investigative interest in the hormone that is the source of an increasing volume of information about its physiology, pharmacology, and pathophysiology. These findings have clarified some long-standing controversies about vasopressin function and are beginning to provide a much more detailed and comprehensive picture of how the various parts of the system act and interact to regulate water balance in health and disease. There have also been a few surprises that reveal some previously unrecognized effects of vasopressin function and challenge conventional views about the importance of certain others.


Diabetes Insipidus Plasma Osmolality Arginine Vasopressin Nephrogenic Diabetes Insipidus Water Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Gary L. Robertson
    • 1
    • 2
  1. 1.Indiana University School of MedicineUSA
  2. 2.Endocrinology and Metabolism Section, Medical ServiceVeterans Administration HospitalUSA

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