Aldosterone and the Renin-Angiotensin System

  • Edward G. Biglieri


Measurement of the components of the mineralocorticoid hormone pathway to aldosterone and of the renin-angiotensin system (RAS) has now been coupled with the ability to measure an effective competitive antagonist of angiotensin II, a converting enzyme inhibitor, and smaller but active fragments of angiotensin II. This combination has permitted further in-depth probes of the system. The aldosterone-renin-angiotensin system (A-RAS) not only is a major effector of pathological disorders, but also can be the marker of events or substances that are more proximate causes of a specific disorder. The effectiveness of inquiries into the A-RAS as a regulator of blood pressure, electrolyte metabolism, and regulation of aldosterone secretion is examined herein.


Cortisol Angiotensin Prostaglandin Propranolol Indomethacin 
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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Edward G. Biglieri
    • 1
    • 2
  1. 1.Endocrinology Division of the Medical Service and the Clinical Study CenterSan Francisco General HospitalSan FranciscoUSA
  2. 2.Department of MedicineUniversity of CaliforniaSan FranciscoUSA

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