The Sympathoadrenal System

  • Lewis Landsberg


In considering the role of catecholamines in the regulation of physiological processes, it is important to remember that the sympathetic nerve endings and the adrenal medulla are extensions of the CNS. The sympathetic nerves function as neurochemical transducers, converting electrical impulses in the nervous system to a chemical messenger that is decoded locally in the innervated tissue by specialized receptors that mediate the physiological response characteristic of the innervated tissue. The chemical messenger of the sympathetic nerves is, of course, norepinephrine (NE), the prototypie neurotransmitter. The adrenal medulla is entirely analogous; it converts neural impulses into a circulating messenger or hormone, epinephrine (E), the message of which is decoded in tissues throughout the body. The diverse physiological manifestations that result depend on the characteristics of the particular tissue that is stimulated by E. As an extension of the nervous system, the physiological effects of the sympathoadrenal system are induced rapidly and dissipated quickly, in distinction to the slower, more prolonged effects of other hormones. In common with that of the other major divisions of the nervous system, sympathoadrenal outflow represents the integrated response of central neurons to a vast array of afferent neural inputs as well as the intrinsic activity of many central nervous structures.


Angiotensin Histamine Metoprolol Doyle Thyroxine 
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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Lewis Landsberg
    • 1
    • 2
  1. 1.Harvard Medical SchoolBeth Israel HospitalBostonUSA
  2. 2.Department of MedicineBeth Israel HospitalBostonUSA

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