Divalent Ion Metabolism

  • Jack W. Coburn
  • David L. Hartenbower
  • Charles R. Kleeman


The regulation of Ca homeostasis involves the precise control of Ca ion level in blood and extracellular fluid (ECF) and maintenance of the structural integrity of the skeleton. Under certain pathological conditions, the homeostatic mechanisms that regulate the Ca level in ECF may do so at the expense of skeletal integrity (e.g., renal osteodystrophy). The principal regulators of Ca include the serum level of inorganic phosphate and several hormones, including parathyroid hormone (PTH), calcitonin (CT), and vitamin D, or its active form, 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3]. The discussion of PTH will be limited to divalent ion control of its secretion, its actions on bone and kidney, and the immunoassay of PTH. A more detailed description of recent developments in PTH research can be found in The Year In Endocrinology 1977, Chapter 4.


Parathyroid Hormone Adenylate Cyclase Parathyroid Gland Renal Osteodystrophy Serum iPTH 
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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Jack W. Coburn
    • 1
  • David L. Hartenbower
    • 1
  • Charles R. Kleeman
    • 2
  1. 1.Medical and Research Services, Veterans Administration Wadsworth Hospital Center and Department of MedicineUniversity of California Los Angeles School of MedicineLos AngelesUSA
  2. 2.Department of MedicineUniversity of California Los Angeles School of MedicineLos AngelesUSA

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