Metabolic Aspects of Renal Stone Disease
The problems of diagnosis and treatment of renal stone disease remain much the same as they have for the past several years. The most important of these is the question of basic pathogenetic mechanisms in stone formation and growth, particularly in the so-called “idiopathic stone-formers.” Solutions to this problem are slowly emerging and are essential for the development of rational and effective treatment programs. The causes of the common idiopathic hypercalciuria syndrome continue to be debated throughout the world, and some consensus is beginning to develop. The importance of urate in the nucleation of calcium oxalate stones and the role of relatively minor changes in urinary oxalate excretion in the development of these stones also remain as key issues in our understanding of recurrent nephrolithiasis.
KeywordsStone Formation Calcium Oxalate Stone Disease Calcium Oxalate Stone Uric Acid Stone
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