Nutrition, Growth, and Development

  • Myron Winick


During 1976, there was considerable progress in investigating a number of areas concerned with nutrition and health. Three of these areas will be reviewed in detail:
  1. 1.

    Malnutrition and the mechanisms of cellular growth

  2. 2.

    Genetic obesity

  3. 3.

    Nutrition and pregnancy



Growth Hormone Zinc Deficiency Amino Acid Pool Serum Zinc Concentration Genetic Obesity 


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  1. Antinmo, T., Baldijão, C., Pond, W. G., and Barnes, R. H., 1976a, Decreased dietary protein or energy intake and plasma growth hormone levels of the pregnant pig, its fetuses and developing progeny, J. Nutr. 106:940.Google Scholar
  2. Antinmo, T., Baldijão, C., Pond, W. G. and Barnes, R. H., 1976b, Maternal protein malnutrition during gestation alone and its effects on plasma insulin levels of the pregnant pig, its fetuses and the developing offspring, J. Nutr. 106:1647.Google Scholar
  3. Bell, G. E., and Stern, J. S., 1976, Development of obesity and hyperinsulinemia in the Zucker obese rat (fa/fa), Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:657 (abstract).Google Scholar
  4. Björntorp, P., and Sjöström, L., 1971, Number and size of adipose tissue fat cells in relation to metabolism in human obesity, Metabolism 20:703.PubMedCrossRefGoogle Scholar
  5. Blackwell, R. Q., Chow, B. F., Chin, K. S., Blackwell, B., and Hsu, S. C., 1973, Prospective maternal nutrition study in Taiwan: Rationale, study design, feasibility, and preliminary findings, Nutr. Rep. Int. 7:517.Google Scholar
  6. Börjeson, M., 1976, The aetiology of obesity in children, Acta Paediatr. Scand. 65:279.PubMedCrossRefGoogle Scholar
  7. Brasel, J. A., 1972, Age dependent differences in DNA polymerase activity following uninephrectomy in rats, Growth 36:45.PubMedGoogle Scholar
  8. Brasel, J. A., Coffey, D. S., and Williams-Ashman, H. G., 1968, Androgen induced changes in DNA polymerase activity of coagulating glands of castrated rats, Med. Exp. 18:321.PubMedGoogle Scholar
  9. Brasel, J. A., Ehrenkranz, R. A., and Winick, M., 1973, Patterns of DNA polymerase activity in normal rat forebrain and cerebellum in the suckling period, Growth 37:301.PubMedGoogle Scholar
  10. Bray, G. A., and York, D. A., 1972, Studies on food intake of genetically obese rats, Amer. J. Physiol. 223:176.PubMedGoogle Scholar
  11. Brook, C. G. D., Lloyd, J. K., and Wolff, O. H., 1972, Relation between age of onset of obesity and size and number of adipose cells, Br. Med. J. 2:25.PubMedCrossRefGoogle Scholar
  12. Calloway, D. H., 1972, Nitrogen balance during pregnancy, in: Current Concepts in Nutrition, Vol. 2, Nutrition and Fetal Development (M. Winick, ed.), pp. 79–94, John Wiley & Sons, New York.Google Scholar
  13. Charney, E., Goodman, H. C., McBride, M., Lyon, B., and Pratt, R., 1976, Childhood antecedents of adult obesity: Do chubby infants become obese adults?, N. Engl. J. Med. 295:6.PubMedCrossRefGoogle Scholar
  14. Cleary, M. P., 1976, Postnatal growth and thymidine kinase activity in adipose tissue of normal, genetically obese, and overfed rats, Doctoral dissertation, Columbia University, New York.Google Scholar
  15. Cleary, M. P., Greenwood, M. R. C., and Brasel, J. A., 1975, Thymidine kinase as a measure of adipocyte proliferation in normal and obese rats, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 34:908 (abstract).Google Scholar
  16. Cleary, M. P., Klein, B. E., Greenwood, M. R. C., and Brasel, J. A., 1976, Proliferative enzymes in adipose tissue of normal and obese rats, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:502 (abstract).Google Scholar
  17. Cruce, J. A., Thoa, N. B., and Jacobowitz, D. M., 1976, Catecholamines in the brains of genetically obese rats, Brain Res. 101: 165.PubMedCrossRefGoogle Scholar
  18. Dallman, P. R., 1971, Malnutrition: Incorporation ofthymidine-3H into nuclear and mitochondrial DNA, J. Cell Biol. 51:549.PubMedCrossRefGoogle Scholar
  19. Dallman, P. R., and Maimes, E. C., 1973, Protein deficiency: Contrasting effects on DNA and RNA metabolism in rat liver, J. Nutr. 103:1311.PubMedGoogle Scholar
  20. Daniel, R. R., Metzger, B. E., Freinkel, N., Faloona, G., Unger, R. H., and Nitzan, M., 1974, Carbohydrate metabolism in pregnancy. XI. Response of plasma glucagon to overnight fast and oral glucose during normal pregnancy and in gestational diabetes, Diabetes 23:771.PubMedGoogle Scholar
  21. Deb, S., Martin, R. J., and Hirschberger, T. V., 1976, Maintenance requirement and energetic efficiency of lean and obese Zucker rats, J. Nutr. 106:191.PubMedGoogle Scholar
  22. Doran, T. A., Malone, R. M., Benzie, R. J., Jones O. V., Thompson, D. W., and New, M. L., 1976, Amniotic fluid tests for fetal maturity in normal and abnormal pregnancies, Amer. J. Obstet. Gynecol. 125:586.Google Scholar
  23. Dörner, G., Hagen, N., and Witthuhn, W., 1976, Die früh postnatale Überernährung als ätiopathogene tischer Faktor der Erwachsenen fettsucht, Acta Biol. Med. Ger. 35:799.PubMedGoogle Scholar
  24. Faust, I. M., Johnson, P. R., and Hirsch, J., 1976, Noncompensation of adipose mass in partially lipectomized mice and rats, Amer. J. Physiol. 231:538.Google Scholar
  25. Freinkel, N., 1965, Effects of the conceptus on maternal metabolism during pregnancy, in: On the Nature and Treatment of Diabetes (B. S. Leibel and G. A. Wrenshall, eds.), pp. 679–691, Excerpta Medica, Amsterdam.Google Scholar
  26. Freinkel, N., and Metzger, B. E., 1975, Some considerations of fuel economy in the fed state during late human pregnancy, in: Early Diabetes in Early Life (R. Camerini and H. Cole, eds.), pp. 289–301, Academic Press, New York.Google Scholar
  27. Freinkel, N., Metzger, B. E., Nitzan, H., Daniel, R., Surmaczynska, B., and Nagel, T., 1974, Facilitated anabolism in late pregnancy: Some novel maternal compensations for accelerated starvation, in: Proceedings of the VIIIth Congress of the International Diabetes Federation, Int. Cong. Ser. 312 (N.J. Malaise and J. Pirant, eds.), pp. 474–488, Excerpta Medica, Amsterdam.Google Scholar
  28. Garn, S. M., 1976, The origins of obesity, Amer. J. Dis. Child. 130:465.PubMedGoogle Scholar
  29. Garn, S. M., and Clark, D. C., 1976, Trends in fatness and the origins of obesity, Pediatrics 57:443.PubMedGoogle Scholar
  30. Goldberg, A. L., and Goldspink, D. P., 1975, Influence of food deprivation and adrenal steroids on DNA synthesis in various mammalian tissues, Amer. J. Physiol. 228:310.Google Scholar
  31. Greenwood, M. R. C., and Hirsch, J., 1974, Postnatal development of adipocyte cellularity in the normal rat, J. Lipid Res. 15:474.PubMedGoogle Scholar
  32. Greenwood, M. R. C., Hirsch, J., Quartermain, D., Johnson, P., and Cruce, J. A. F., 1974, Food motivated behavior in the genetically obese and hypothalamic-hyperphagic rats and mice, Physiol. Behav. 13:687.PubMedCrossRefGoogle Scholar
  33. Harbhajan, S. P., and Siamak, A. A., 1976, Assessment of effect of starvation, glucose, fatty acids and hormones on α-decarboxylation of leucine in skeletal muscle of rat, J. Nutr. 106:1079.Google Scholar
  34. Harding, H. R., Rosen, F., and Nichol, C. A., 1961, Influence of age, adrenolectomy and corticosteroids on hepatic transaminase activity, Amer. J. Physiol. 201:271.PubMedGoogle Scholar
  35. Herrera, E., and Freinkel, N., 1975, Metabolites in the liver, brain and placenta of fed or fasted mothers and fetal rats, Horm. Metab. Res. 7:247.CrossRefGoogle Scholar
  36. Herrera, E., Knopp, R. H., and Freinkel, N., 1969, Carbohydrate metabolism in pregnancy. VI. Plasma fuels, insulin, liver composition, gluconeogenesis and nitrogen metabolism during late gestation in the fed and fasted rat, J. Clin. Invest. 48:2260.PubMedCrossRefGoogle Scholar
  37. Hietanen, E., and Greenwood, M. R. C., 1976, lipoprotein lipase activity in epididymal fat pads of growing rats, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:502 (abstract).Google Scholar
  38. Hirsch, J., and Han, P. W., 1969, Cellularity of rat adipose tissue: Effects of growth, starvation, and obesity, J. Lipid Res. 10:77.PubMedGoogle Scholar
  39. Hirsch, J., and Knittle, J. L., 1970, Cellularity of obese and nonobese human adipose tissue, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 29:1516.Google Scholar
  40. Hurley, L. S., 1976, Trace elements and teratogenesis, Med. Clin. North Amer. 60:771.Google Scholar
  41. Hytten, F. E., and Thomson, A. M., 1970, Maternal physiological adjustments, in: Maternal Nutrition and the Course of Pregnancy, pp. 41–73, National Academy of Sciences, Washington, D.C.Google Scholar
  42. Jameson, S., 1976, Effects of zinc deficiency in human reproduction, Acta Medica Scand., Suppl. 593, p. 1.Google Scholar
  43. Jasper, H. G., and Brasel, J. A., 1973, The effects of growth hormone on DNA polymerase activity in the liver of normal and hypophysectomized rats, Endocrinology 92:194.PubMedCrossRefGoogle Scholar
  44. Jasper, H. G., and Brasel, J. A., 1974, Rat liver DNA synthesis in the “catch-up” growth of nutritional rehabilitation, J. Nutr. 104:405.PubMedGoogle Scholar
  45. Johnson, P. R., Stern, J. S., Greenwood, M. R. C., Zucker, L. M., and Hirsch, J., 1973, Effect of early nutrition on adipose cellularity and pancreatic insulin release in the Zucker rat, J. Nutr. 103:738.PubMedGoogle Scholar
  46. Kohrs, M. B., Harber, A. E., and Kerr, G. R., 1976, Effects of a low-protein diet during pregnancy of the rhesus monkey. 1. Reproductive efficiency, Amer. J. Clin.Nutr. 29:136.PubMedGoogle Scholar
  47. Kraft, N., and Shortman, K. A., 1970, A suggested control function for the animal tissue ribonuclease-ribonuclease inhibitor system, based on studies of isolated cells and phytohaemagglutinin-transformed lymphocytes, Biochim. Biophys. Acta 217:164.PubMedGoogle Scholar
  48. Kral, J. G., 1976, Surgical reduction of adipose tissue in male Sprague-Dawley rat, Amer. J. Physiol. 231:1090.PubMedGoogle Scholar
  49. Lechtig, A., Habicht, J.-P., Yarbrough, C., Delgado, H., Guzman, G., and Klein, R. E., 1975, Influence of food supplementation during pregnancy on birth weight in rural populations of Guatemala, in: Nutrition, Proceedings of the IXth International Congress of Nutrition, Prognosis for the Undernourished Surviving Child, Mexico, 1972, Vol. 2, (A. Chavez, H. Bourges, and S. Basta eds.), pp. 44–59, Karger, Basel.Google Scholar
  50. Leventhal, H., Biale, Y., and Ben-Adert, N., 1976, Leukocyte alkaline phosphate determinations and urinary estriol excretion in normal and pathologic pregnancies, J. Reprod. Med. 16:44.PubMedGoogle Scholar
  51. Lewis, C. B., and Winick, M., 1977, Regulation of in vivo ribosomal RNA synthesis and ribosome formation in livers of protein-deficient rats, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 36:1155 (abstract).Google Scholar
  52. Lewis, C. G., Rosso, P., and Winick, M., 1976, Demonstration of the existence of two “developmental” species of RNA in liver and brain cytoplasm, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:855 (abstract).Google Scholar
  53. Li, J. B., and Goldberg, A. L., 1976, Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles, Amer. J. Physiol. 231:441.PubMedGoogle Scholar
  54. McKenzie, J. M., Fosmire, G. J., and Sandstead, H. H., 1975, Zinc deficiency during the latter third of pregnancy: Effects on fetal rat brain, liver and placenta, J. Nutr. 105:1466.PubMedGoogle Scholar
  55. Meteoff, J., 1972, Biochemical markers of intrauterine malnutrition, in: Current Concepts in Nutrition, Vol. 2, Nutrition and Fetal Development (M. Winick, ed.), pp. 27–44, John Wiley & Sons, New York.Google Scholar
  56. Metzger, B. E., Unger, R. H., and Freinkel, N., 1977, Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a “mixed meal” in late pregnancy, Metabolism 26:151.PubMedCrossRefGoogle Scholar
  57. Miller, S. A., 1969, Protein metabolism during growth and development, in: Mammalian Protein Metabolism, Vol. 3 (H. N. Munro, ed.) pp. 183–233, Academic Press, New York.Google Scholar
  58. Millward, D. J., Garlick, P. J., Stewart, R.J. C., Nnanyelugo, D. O., and Waterlow, J. C., 1975, Skeletal-muscle growth and protein turnover, Biochem. J. 150:235.PubMedGoogle Scholar
  59. Monckeberg, F., Donoso, G., Oxman, S., Pak, N., and Meneghello, J., 1963, Human growth hormone in infant malnutrition, Pediatrics 31:58.Google Scholar
  60. Munro, H. N., 1970, Free amino acid pools and their role in regulation, in: Mammalian Protein Metabolism, Vol. 4 (H. N. Munro, ed.), pp. 299–386, Academic Press, New York.Google Scholar
  61. Muzzo, S., and Brasel, J. A., 1973, Neonatal hypothyroidism and DNA synthesis in rat cerebellum, presented at the 55th Annual Meeting of the Endocrine Society, June, 1973.Google Scholar
  62. Muzzo, S., Gregory, T., and Gardner, L. I., 1973, Oxygen consumption by brain mitochondria of rats malnourished in utero in the metabolism, J. Nutr. 103:314.PubMedGoogle Scholar
  63. Naismith, D. J., and Fears, R. B., 1971, Adaptations of protein during pregnancy in the rat, Proc. Nutr. Soc. 31:8A.Google Scholar
  64. Naismith, D. J., and Morgan, B. L. G., 1975, The regulation of protein metabolism during pregnancy in the rat, Proc. Nutr. Soc. 34:27A.PubMedGoogle Scholar
  65. Naismith, D. J., and Morgan, B. L. G., 1976, The biphasic nature of protein metabolism during pregnancy in the rat, Br. J. Nutr. 36:563.PubMedCrossRefGoogle Scholar
  66. Nitzan, M., Freinkel, N., Metzger, B. E., Unger, R. H., Faloona, G. R., and Daniel, R. R., 1975, The interrelations of glucose, insulin and glucagon after overnight fast and in response to oral glucose during late pregnancy, Isr. J. Med. Sci. 11:617.PubMedGoogle Scholar
  67. Nnanyelugo, D. O., 1976, Changes in RNA content during chronic protein deprivation in the hind limb muscles of rats, Nutr. Rep. Int. 14:209.Google Scholar
  68. Ogata, E. S., and Holliday, M. A., 1976, The effects of starvation glucose infusion and normal feeding on muscle protein synthesis and catabolism in the newborn guinea pig, Biol. Neonate 29:247.PubMedCrossRefGoogle Scholar
  69. Penney, D., Anderson, D., and Dongas, J., 1976, Effects of early severe malnutrition on heart and skeletal muscle lactate dehydrogenase, J. Nutr. 106:1235.PubMedGoogle Scholar
  70. Pimstone, B. L., Beck, D. J., and Hansen, J. D. L., 1973, Human growth hormone and sulphation factor in protein-calorie malnutrition, in: Endocrine Aspects of Malnutrition, Kroc Found. Symp., No. 1 (L. I. Gardner and P. Amacher, eds.), pp. 73–90, Kroc Foundation, Santa Ynez, California.Google Scholar
  71. Powley, T. L., and Morton, S. A., 1976, Hypophysectomy and regulation of body weight in the genetically obese Zucker rat, Amer. J. Physiol. 230:982.PubMedGoogle Scholar
  72. Quirin-Stricker, C., and Mandel, P., 1968, Etude du renouvellement du RNA des polysomes, du RNA de transfert et du RNA “messager” dans le foie de rat soumis a un jeune proteique, Bull. Soc. Chim. Biol. 50:31.PubMedGoogle Scholar
  73. Riopelle, A. J., Hale, P. A., and Watts, E. S., 1976, Protein deprivation in primates. VII. Determinants of size and skeletal maturity at birth in Rhesus monkeys, Hum. Biol. 48:203.PubMedGoogle Scholar
  74. Rosso, P., and Raguso, L., 1972, RNase activity: Rate of RNA degradation and cellular RNA content, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 31:697.Google Scholar
  75. Rosso, P., and Winick, M., 1975, Effects of early undernutrition and subsequent refeeding on alkaline ribonuclease activity of rat cerebrum and liver, J. Nutr. 105:1104.PubMedGoogle Scholar
  76. Rosso, P., Nelson, M., and Winick, M., 1973, Changes in cellular RNA content and alkaline ribonuclease activity in rat liver during development, Growth 37:143.PubMedGoogle Scholar
  77. Rozovski, J., Winick, M., and Rosso, P., 1976, Adaptive changes in polyamine metabolism during malnutrition and refeeding, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:341 (abstract).Google Scholar
  78. Salans, L. B., Cushman, S. W., and Weismann, R. E., 1973, Studies of human adipose tissue—adipose cell size and number in nonobese and obese patients, J. Clin. Invest. 52:929.PubMedCrossRefGoogle Scholar
  79. Shrader, R. E., Hastings-Roberts, M. M., Ferlatte, M. L., and Zeman, F. J., 1977a, Effect of prenatal protein deprivation on fetal and neonatal thyroid morphology in the rat, J. Nutr. 107;213.PubMedGoogle Scholar
  80. Shrader, R. E., Ferlatte, M. I., Hastings-Roberts, M. M., Schoenborne, B. M., Hoernicke, C. A., and, Zeman, F. J., 1977b, Thyroid funcion in prenatally protein-deprived rats, J. Nutr. 107:221.PubMedGoogle Scholar
  81. Stein, T. P., Oram-Smith, J. C., Leskiw, M. J., Wallace, H. W., Long, L. C., and Leonard, J. M., 1976, Effect of nitrogen and calorie restriction on protein synthesis in the rat, Amer. J. Physiol. 230:1321.PubMedGoogle Scholar
  82. Tagliamonte, B., Benedetti, C., and Spadoni, M. A., 1972, Effect of refeeding on liver thymidine-kinase activity of food restricted suckling rats, Nutr. Rep. Int. 5:305.Google Scholar
  83. Winick, M., 1968, Cellular response with increased feeding in pituitary dwarf mice, J. Nutr. 94:121.PubMedGoogle Scholar
  84. Winick, M., and Grant, P., 1968, Cellular growth in the organs of the hypopituitary dwarf mouse, Endocrinology 83:544.CrossRefGoogle Scholar
  85. Zamenhof, S., Van Marthens, E., and Grauel, L., 1971, Prenatal cerebral development: Effect of restricted diet, reversal by growth hormone, Science 174:954.CrossRefGoogle Scholar
  86. Zucker, L. M., and Antoniades, H. N., 1972, Insulin and obesity in the Zucker genetically obese rat “fatty,” Endocrinology 90:1320.PubMedCrossRefGoogle Scholar
  87. Zucker, L. M., and Zucker T. F., 1961, Fatty, a new mutation in the rat, J. Hered. 52:275.Google Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Myron Winick
    • 1
  1. 1.Institute of Human Nutrition, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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