Oxystarch and other Polyaldehydes: The Present Status in the Treatment of Uremia

  • Carmelo Giordano
  • Renato Esposito


Polyaldehydes, such as oxidized starch and cellulose, are in theory very potent urea and ammonia binders. However, their clinical use in the last ten years has lit some hope; their efficacy in reducing body uremic waste nitrogen accumulation has suffered, admittedly, comparable enthusiasm. In this short presentation, we wish to give some reasons and focus the possible ways for improving the clinical efficacy of these sorbents.


Binding Capacity Nitrogen Removal Uremic Patient Residual Renal Function Urea Clearance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Giordano, C; Esposito, R; Demma, G. Possibilita di ridurre l’azotemia nell’uomo mediante somministrazione di una polialdeide. Boll, Soc. Ital. Biol. Sper. 44: 2232–2238, 1968Google Scholar
  2. 2.
    Man, NK; Drucke, T; Paris, J; Elizalde Monteverde, C; Rondon Nucete, M; Zingraff, J; Jungers, P. Increased nitrogen removal from intestinal tract of uremic patients. Proc. Eur. Dial. Transpl. Assoc. (Pitman Medical London) 10: 143–151, 1973Google Scholar
  3. 3.
    Friedman, EA; Fastook, J; Beyer, MM; Rattazzi, T; Josephson, AS. Potassium and nitrogen binding in the human gut by ingested oxidized starch. Trans. Am. Soc. Artif. Intern. Organs 20: 161–167, 1974Google Scholar
  4. 4.
    Giordano, C; Esposito, R; Pluvio, M. Oxycellulose and ammonia treated oxystarch as insoluble polyaldehydes in uremia. Kidney Internat. 7: S-380–S-382, 1975Google Scholar
  5. 5.
    Meriwether, LS; Kramer, HM. In vitro reactivity of oxystarch and oxycellulose. Kidney Internat. 10: S-259–S-265, 1976Google Scholar
  6. 6.
    Wrong, O. The metabolism of urea and ammonia in the alimentary tract. Proc. Workshop on Gastrointestinal Sorbents in Uremia. DHEW Publication no. (NIH) 72–78 p. 139–156, 1971Google Scholar
  7. 7.
    Giordano, G; Esposito, R; Pluvio, M. An improved oxystarch in the treatment of renal failure. Proc. Strathclyde Bioengineering Seminar Series, Glasgow, August, 1976.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Carmelo Giordano
    • 1
  • Renato Esposito
    • 1
  1. 1.I PolyclinicUniversity of NaplesNaplesItaly

Personalised recommendations