Interrelation of Hemoperfusion, Plasma Clearance and Half Life

  • John F. Maher


One goal of therapy of acute poisoning is to achieve a maximal rate of elimination. In the past two decades, forced diuresis and hemodialysis have been used for this purpose most successfully in the management of water soluble intoxicants (1). Lipid soluble poisons are removed only minimally, in part because of low clearances and large distribution spaces (2). Hemoperfusion, however, achieves higher clearances, even of lipid soluble toxins (3,4,5).


Plasma Clearance Plasma Half Life Distribution Space High Clearance Artificial Kidney 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • John F. Maher
    • 1
  1. 1.Division of Nephrology, Department of MedicineUniversity of Connecticut Health CenterFarmingtonUSA

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