Interrelation of Hemoperfusion, Plasma Clearance and Half Life
One goal of therapy of acute poisoning is to achieve a maximal rate of elimination. In the past two decades, forced diuresis and hemodialysis have been used for this purpose most successfully in the management of water soluble intoxicants (1). Lipid soluble poisons are removed only minimally, in part because of low clearances and large distribution spaces (2). Hemoperfusion, however, achieves higher clearances, even of lipid soluble toxins (3,4,5).
KeywordsPlasma Clearance Plasma Half Life Distribution Space High Clearance Artificial Kidney
Unable to display preview. Download preview PDF.
- 2.Maher JF, Schreiner GE: An evaluation of the effectiveness of dialysis for sedative and analgesic poisoning. Proc Eur Dial Transpl Assoc 5:246, 1968Google Scholar
- 3.DeMyttenaere MH, Maher JF, Schreiner GE: Hemoperfusion through a charcoal column for glutethimide poisoning. Trans Am Soc Artif Int Organs 13:190, 1967Google Scholar
- 5.Rosenbaum JL, Kramer MS, Raja R, Winsten S, Dalol F: Hemoperfusion for acute drug intoxication. Kidney Int 10:S341, 1976Google Scholar
- 6.Nolph KD, Bass OE, Maher JF: Acute effects of hemodialysis on removal of intracellular solutes. Trans Am Soc Artif Int Organs 20: 622, 1974Google Scholar
- 7.Brodie BB, Bernstein E, Mark LC: The role of body fat in limiting the duration of action of thiopental. J Pharm Exp Ther 105:421, 1952Google Scholar
- 8.Maher JF: Determinants of serum half life of glutethimide in intoxicated patients. J Pharm Exp Ther 174:450, 1970Google Scholar