Treatment of Acute Intoxication

  • George Schreiner


My interest in detoxification began after my high school prom. Seriously, it began as a medical student when Dr. Theodore Koppanyi, who was then Professor of Pharmacology at Georgetown, carried out a very interesting but rather basic experiment, and that is, he took a group of dogs, poisoned them with barbital and phenobarbital in an amount that killed all of them and then took another group of dogs and gave then the same doses, and infused very, very rapidly a huge amount of saline into the dogs to dilute their circulating plasma concentration, and some of these dogs lived and did not go into congestive heart failure, but more importantly, they woke up. Immediately, this suggested to many of us that there was, at least in the case of these particular drugs, a relationship which we have subsequently defined, and which I think is a very important concept: i.e. — there are a group of drugs and substances which have a time-dose cycotoxic relationship, that is, there is a relationship between the exposure of the cells to a critical concentration of the molecule, and to a period of time, and that removal or lowering of the dose by any technique, whether it be drug removal, dilution, or what have you, can lessen the clinical toxicity of that particular compound.


Acute Intoxication Clinical Toxicity High Blood Level Drug Removal Artificial Liver 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • George Schreiner
    • 1
  1. 1.Nephrology DivisionGeorgetown University HospitalUSA

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