The Filtration of Plasma from Whole Blood: A Novel Approach to Clinical Detoxification

  • Franco Castino
  • Leonard I. Friedman
  • Barry A. Solomon
  • Clark K. Colton
  • Michael J. Lysaght


A variety of techniques have been examined for the removal of toxins from the bloodstream. The most common of these, hemodialysis, has been available as a clinical detoxification procedure, and its utilization for the treatment of renal diseases is now widespread. In recent years, the limitations of hemodialysis have become apparent, particularly for the removal of high molecular weight toxins(1). Consequently, alternative approaches have been investigated. For example, polymeric membranes highly permeable to molecules with molecular weight up to 5,000 have been incorporated into devices that rely primarily upon convection, rather than diffusion, for the removal of toxins (2). These devices may offer some advantages over hemodialysis (3) and are currently under clinical study. However, both of these techniques are inadequate if the toxins are proteins or are protein bound.


Shear Rate Mean Platelet Volume Mean Corpuscular Volume Microporous Membrane Transmembrane Pressure 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Franco Castino
    • 1
  • Leonard I. Friedman
    • 1
  • Barry A. Solomon
    • 2
  • Clark K. Colton
    • 3
  • Michael J. Lysaght
    • 2
  1. 1.Blood Research LaboratoryThe American National Red CrossBethesdaUSA
  2. 2.Amicon CorporationLexingtonUSA
  3. 3.Department of Chemical EngineeringMassachusetts Institute of TechnologyCambridgeUSA

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