The B-D Hemodetoxifier: Particulate Release and its Significance
When a clinician considers the use of an extracorporeal blood circuit in treating a patient, in addition to the therapeutic value of the procedure, he should know what exogenous material the circuit adds to the blood flowing through it and what is the significance of this addition to the patient. The data presented in this communication represent preliminary attempts to address these questions in regard to the Becton, Dickinson HEMODETOXIFIER, an adsorption device containing activated charcoal immobilized to produce a minimum of particulate release with a maximum of adsorp-tive surface in direct contact with the bloodstream (1). Of primary interest was quantification of particulate release from the device under simulated use conditions and the evaluation of possible untoward biological effects of intravenous administration of such particulate material. A gravimetric technique was developed using Nuclepore®filters to trap and weigh microgram amounts of material released during perfusion of the devices. To monitor biological effects of intravenous charcoal particulates, single injections of pulverized charcoal in a saline-DEXTRAN vehicle were given to Sprague-Dawley rats.
KeywordsActivate Charcoal Stainless Steel Wire Particulate Release Test Filter Filter Holder
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- 1.Hill, J. B.; F. L. Palaia; J. L. McAdams; P. J. Palmer; J. T. Skinner; and S. M. Maret, The Rationale for Fixed-Bed Charcoal in Hemoperfusion, Kidney International 10 (1976), S-328.Google Scholar
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