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The B-D Hemodetoxifier: Particulate Release and its Significance

  • John B. Hill
  • C. Russell Horres

Abstract

When a clinician considers the use of an extracorporeal blood circuit in treating a patient, in addition to the therapeutic value of the procedure, he should know what exogenous material the circuit adds to the blood flowing through it and what is the significance of this addition to the patient. The data presented in this communication represent preliminary attempts to address these questions in regard to the Becton, Dickinson HEMODETOXIFIER, an adsorption device containing activated charcoal immobilized to produce a minimum of particulate release with a maximum of adsorp-tive surface in direct contact with the bloodstream (1). Of primary interest was quantification of particulate release from the device under simulated use conditions and the evaluation of possible untoward biological effects of intravenous administration of such particulate material. A gravimetric technique was developed using Nuclepore®filters to trap and weigh microgram amounts of material released during perfusion of the devices. To monitor biological effects of intravenous charcoal particulates, single injections of pulverized charcoal in a saline-DEXTRAN vehicle were given to Sprague-Dawley rats.

Keywords

Activate Charcoal Stainless Steel Wire Particulate Release Test Filter Filter Holder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hill, J. B.; F. L. Palaia; J. L. McAdams; P. J. Palmer; J. T. Skinner; and S. M. Maret, The Rationale for Fixed-Bed Charcoal in Hemoperfusion, Kidney International 10 (1976), S-328.Google Scholar
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    Temple, A. R.; J. Walker; and G. A. Done, A Comparative Evaluation of Activated Charcoal Hemoperfusion Devices/1 presented at a joint meeting of the American Academy of Clinical Toxicology, The American Association of Poison Control Centers and the Canadian Academy of Clinical Toxicology, Seattle, Washington, 5 August 1976.Google Scholar
  3. 3.
    Van Wagenen, R.; D. L. Coleman; and J. D. Andrade, Adsorbent Hemoperfusion: Nonbiological Particulate Matter, Kidney International 7 (1975), S-397.CrossRefGoogle Scholar
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    Hagstarn, К. E.; L. E. Larsson; and H. Thysell, Experimental Studies on Charcoal Haemoperfusion in Pheobarbital Intoxication and Uraemia, Including Histopathologic Findings, Acta Medica Scandinavica 180 (1966), p. 593.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • John B. Hill
    • 1
  • C. Russell Horres
    • 1
  1. 1.Becton, Dickinson and Company Research CenterResearch Triangle ParkUSA

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