Combination of Hemodialysis and Hemoperfusion in a Single Hollow-Fiber Unit for Treatment of Uremia
In the past, various researchers have attempted to obtain improved permeability in the middle molecular range by the development of new dialysis membranes. As a consequence of this, it is clearly indicated that an improvement in this area can only be achieved at the expense of an increased hydrodynamic permeability. This additionally requires new techniques to regulate ultrafiltration. Therefore, it was intended to avoid this high ultrafiltration side-effect by combining diffusion and adsorption in a single membrane. The result was a new double-layer cuprophane-membrane of hollow-fiber type consisting on the inner (blood compartment) side of a thin layer of pure cuprophane-cellulose and on the outer (dialysate compartment) side of a second layer, containing about 40to 50% activated charcoal. The total thickness of the charcoal containing hollow-fiber therefore increased by three as compared to the conventional hollow-fiber (Figures 1 and 2).
KeywordsActivate Charcoal Test Substance Blood Compartment Single Membrane Ultrafiltration Rate
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