The use of Membranes and Sorbents for Blood Detoxification: Cuprophan Sorbent Membranes
The use of membranes and sorbents for blood detoxification are well published topics in the field of artificial organs. The advantage of the membrane process is that it exhibits low trauma in contact with blood, no particulate is generated, and the removal of large molecular weight substances or cells can be prevented from passage due to the porosity or permeability of the membrane’s wall. Herein lies also a disadvantage in that transport is a function of solute size and discriminate solute removal patterns are thus not possible. The advantage of sorbents is that their physical and chemical characteristics can be matched with those of the solute to be removed. Thereby, specific solute removal patterns different than that of membrane separations and not really as dependent as molecular size can be achieved. Disadvantages in the use of sorbents, however, have been the blood trauma related to damage of blood components or the removal of the cellular elements and particular generation with carryover into the vascular system. As a practical consideration in the use of sorbents for blood detoxification in the treatment of most disease states in which the range of solutes to be removed is broad and generally no one sorbent is totally effective, multiple sorbents must be employed. Past studies have concentrated primarily on the use of a single sorbent.
KeywordsUric Acid Hollow Fiber Activate Charcoal Phosphorous Removal Plasma Filtration
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- 1.Nose, Y., Malchesky, P.S., Castino, F., Koshino, I., Scheucher, K. and Nokoff, R.: Improved hemoperfusion systems for renal-hepatic support. Kidney International, 10:S244, 1976.Google Scholar
- 2.Castino, F., Scheucher, K., Malchesky, P.S., Koshino, I. and Nose, Y.: Microemboli-free blood detoxification utilizing plasma filtration. Trans. Amer. Soc. Artif. Int. Organs, 22:637, 1976.Google Scholar
- 3.Maini, R. and Baillie, H.: Detoxification system utilizing microporous membranes and sorbents. Program, Conference on Fulminant Hepatic Failure, February 29, 1977, NIH, Bethesda, Maryland.Google Scholar
- 4.Yamazaki, Z., Fujimori, Y., Sanjo, K., Sugiura, M., Wada, T., Inoue, N., Oda, T., Kominami, N., Fujisaki, U. and Hayano, F.: New artificial liver support system (plasma perfusion detoxification) for hepatic coma. Abstracts Amer. Soc. Artif. Int. Organs, 6:99, 1977.Google Scholar
- 7.Gordon, A., Better, O.S., Greenbaum, M.A., Marantz, L.B., Gral, L., Maxwell, M.H.: Clinical maintenance hemodialysis with a sorbent based low volume dialysate regeneration system. Trans. Amer. Soc. Artif. Int. Organs, 17:253, 1971.Google Scholar
- 8.Enka Glanzstoff, Cuprophan Technical Information Bulletin No. 12, 1976, Wuppertal-Barmen, West Germany.Google Scholar
- 9.Malchesky, P.S., Varnes, W., Nokoff, R. and Nose, Y.: The charcoal capillary hemoperfusion system. Proc. EDTA, 13: 242, 1976.Google Scholar