Charcoal Hemoperfusion: Georgetown University Hospital Experience
At Georgetown University Hospital, interest in charcoal hemoperfusion as a means of facilitating toxin removal from blood has shown a doubled peaked history. After the pioneering work of Yatzidis, et al (1) in 1965 in the treatment of barbiturate poisoning, DeMyttenaere, Maher, and Schreiner in 1967 demonstrated the effectiveness of charcoal hemoperfusion in the treatment of glutethimide overdosage in dogs (2). Unfortunately, because of the significant and potentially life threatening dangers of thrombocytopenia and charcoal embolization, charcoal hemoperfusion was not pursued as an attractive therapeutic modality for toxin removal in clinical practice.
KeywordsDrug Overdosage Fulminant Hepatic Failure Hepatic Coma Blood Ammonia Level Chronic Aggressive Hepatitis
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