Assembly of the Sarcoplasmic Reticulum

  • David H. Maclennan
  • Elzbieta Zubrzycka
  • Annelise O. Jorgensen
  • Vitauts I. Kalnins


The study of membrane biogenesis is greatly facilitated if systems are chosen which possess any of a set of unique features. First, the individual characteristics, localization, and orientation of each protein within the membrane should be known. For purposes of microanalysis, antibodies against single proteins should be available. Second, the synthesis of the membrane should be initiated, preferably de novo, under experimental conditions. Finally, genetic manipulation of the system should be possi­ble. It is apparent from other papers in this volume that these features have been the major determinants of our extensive knowledge of the biogenesis of mitochondria in fungi (see Chapters 13, 16, and 17, this volume). In this chapter we review our work, showing that these same features are helping to advance understanding of the biogenesis of the sarcoplasmic reticulum in cultured muscle cells.


Sarcoplasmic Reticulum Rough Endoplasmic Reticulum Extrinsic Protein Major Intrinsic Protein Sarcoplasmic Reticulum Membrane 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • David H. Maclennan
    • 1
  • Elzbieta Zubrzycka
    • 1
  • Annelise O. Jorgensen
    • 2
  • Vitauts I. Kalnins
    • 2
  1. 1.Banting and Best Department of Medical Research, Charles H. Best InstituteUniversity of TorontoTorontoCanada
  2. 2.Department of AnatomyUniversity of TorontoTorontoCanada

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