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Coupling Factors in Oxidative Phosphorylation

  • D. Rao Sanadi
  • Saroj Joshi
  • Fariyal M. Shaikh

Abstract

A classical approach to the study of the mechanism of multienzyme systems involves resolution of the constituent parts and reconstitution of the system from the purified components. Application of this approach to the study of the mechanism of oxidative phosphorylation was first initiated in David Green’s laboratory. He devised the procedures for the large-scale isolation of mitochondria from bovine heart.(1) Even now this is the source for much of the fractionation studies. In 1958 the preparation of phosphorylating submitochondrial particles, ETPH, and the first coupling factor(2) was reported. General use of these pioneering techniques led to the isolation and characterization of four generally accepted coupling factors, shown in Table I.

Keywords

ATPase Activity Oxidative Phosphorylation Coupling Factor None None Inhibitor Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • D. Rao Sanadi
    • 1
    • 2
  • Saroj Joshi
    • 1
    • 2
  • Fariyal M. Shaikh
    • 1
    • 2
  1. 1.Department of Cell PhysiologyBoston Biomedical Research InstituteBostonUSA
  2. 2.Department of Biological ChemistryHarvard Medical SchoolBostonUSA

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