Studies on Nicotinamide Nucleotide Dehydrogenation Transhydrogenation by Mitochondria

  • Youssef Hatefi
  • Yves M. Galante


Nicotinamide nucleotides constitute the major vehicle for the transfer of reducing equivalents to the mitochondrial electron transport system. The mitochondrial respiratory chain is capable of oxidizing NADH and NADPH as well as catalyzing transhydrogenation from NAD (P) H to NAD (P). In this chapter, we should like to describe the nicotinamide nucleotide dehydrogenase and transhydrogenase properties of mitochondria at three levels of structural complexity, i.e., submitochondrial particles, complex I, and the soluble NADH dehydrogenase isolated from complex I.


Submitochondrial Particle NADH Dehydrogenase Activity Nicotinamide Ring NADPH Dehydrogenase Arginyl Residue 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Youssef Hatefi
    • 1
  • Yves M. Galante
    • 1
  1. 1.Department of BiochemistryScripps Clinic and Research FoundationLa JollaUSA

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