Hormone Dependent Differentiation, Maturation and Function of the Brain and Sexual Behavior

  • Günter Dörner
Part of the Perspectives in Sexuality book series (Persp. Sex.)


The first outstanding experiment in sexual endocrinology was done by Berthold (1849). Castration of roosters resulted in atrophy of the genital organs and decrease of sexual activity, which could be prevented by reimplantation of the testes. It was therefore suggested that a substance was produced by the testes responsible for the development and function of the sex organs and also for the appearance and maintenance of sexual behavior.


Sexual Behavior Luteinizing Hormone Feedback Control System Gonadotropin Secretion Gonadal Dysgenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Aschheim, S. and Zondek, B. (1927). Hypophysenvorderlappenhormon und Schwangerenhormon im Harn von Schwangeren, Klin. Wschr. 6: 1322.CrossRefGoogle Scholar
  2. Aschner, B. (1912). Uber die Beziehungen zwischen Hypophysis und Genitale. Arch. Gynak. 97: 200–228.CrossRefGoogle Scholar
  3. Barraelough, C.A. and Gorski, R.A. (1961). Evidence that the hypothalamus is responsible for androgen-induced sterility in the female rat. Endocrinology 68: 68–70.CrossRefGoogle Scholar
  4. Berthold, A.A. (1849). Transplantation der Hoden. Arch. Anat. Physiol. 42–46.Google Scholar
  5. Brookhart, J.M. and Dey, F.L. (1941). Reduction of sexual behavior in male guinea pigs by hypothalamic lesions. Amer. J. Physiol. 133: 551–554.Google Scholar
  6. Carrer, H., Asch, G. and Aron, C. (1973, 1974). New facts concerning the role played by the ventromedial nucleus in the control of estrous cycle duration and sexual receptivity in the rat. Neuroendocrinology, 13: 129–138.CrossRefGoogle Scholar
  7. Carter, C.S., Clemens, L.G. and Hoekema, D.J. (1972). Neonatal androgen and adult sexual behavior in the golden hamster. Physiol. and Behav. 9: 89–95.CrossRefGoogle Scholar
  8. Crowley, W.R., Feder, H.H. and Morin, L.P. (1976). Role of monoamines in sexual behavior of the female guinea pig. Pharmacol. Biochem. Behav. 4: 67–71.CrossRefGoogle Scholar
  9. Dantchakoff, V. (1938). Role des hormones dans la manifestation des instincts sexuels. Acad. Sci. 206: 945–947.Google Scholar
  10. Denenberg, V.H. (1964). Critical periods, stimulus input, and emotional reactivity: a theory of infantile stimulation. Psychological Review, 71: 335–351.CrossRefGoogle Scholar
  11. Dieckmann, G. and Hassler, R. (1975). Unilateral hypothalamotomy in sexual delinquents. Report on six cases. Confinia Neurologica, 37: 177–186.CrossRefGoogle Scholar
  12. Döcke, F. and Dörner, G. (1966). Tierexperimentelle Untersuchungen zur Ovulationsauslösung mit Gonadotropinen and Östrogenen. 4. Mittl., Zur neurohormonalen Regulation der Ovulation. Zbl. Gynäk. 88: 273–282.Google Scholar
  13. Döcke, F., Smollich, A., Rohde, W., Okrasa, R. and Dörner, G. (1975). Studies on extrahypophyseal sites of estrogen action in the induction of ovulation in rats. Endokrinologie, 65: 274–287.Google Scholar
  14. Dörner, G. (1967). Tierexperimentelle Untersuchungen zur Frage einer hormonalen Pathogenese der Homosexualität. Acta Biol. Med. Germ. 19: 569:584.Google Scholar
  15. Dörner, G. (1969). Zur Frage einer neuroendokrinen Pathogenese, Prophylaxe und Therapie angeborener Sexualdeviationen. Dtsch. Med. Wschr. 94: 390–396.CrossRefGoogle Scholar
  16. Dörner, G. (1970). The influence of sex hormones during the hypothalamic differentiation and maturation phases on gonadal function and sexual behavior during the hypothalamic functional phase. Endokrinologie, 56: 280–291.Google Scholar
  17. Dörner, G. (1972). Sexualhormonabhängige Gehirndifferenzierung und Sexualität, Jena, Gustav Fischer und Springer, Wien.Google Scholar
  18. Dörner, G. (1974). Environment-dependent brain differentiation and fundamental processes of life. Acta Biol. Med. Germ. 33: 129–148.Google Scholar
  19. Dörner, G. (1976). Hormones and Brain Differentiation, Elsevier, Amsterdam.Google Scholar
  20. Dörner, G. (1976). Further evidence of permanent behavioral changes in rats treated neonatally with neurodrugs. Endokrinologie, in press.Google Scholar
  21. Dörner, G. and Döcke, F. (1964). Sex-specific reaction of the hypothalamo-hypophysial system of rats. J. Endocr. 30: 265–266.CrossRefGoogle Scholar
  22. Dörner, G. Döcke, F. and Hinz, G. (1968). Entwicklung und Rückbildung neuroendokrin bedingter männlicher Homosexualität. Acta Biol. Med. Germ. 21: 577–580.Google Scholar
  23. Dörner, G., Döcke, F. and Hinz, G. (1969). Homo- and hypersexuality in rats with hypothalamic lesions. Neuroendocrinology, 4: 20–24.CrossRefGoogle Scholar
  24. Dörner, G., Döcke, F. and Hinz, G. (1971). Paradoxical effects of estrogen on brain differentiation. Neuroendocrinology, 7: 146–155.CrossRefGoogle Scholar
  25. Dörner, G., Döcke, F. and Moustafa, S. (1968). Differential localization of a male and a female hypothalamic mating centre. J. Reprod. Fert. 17: 583–586.CrossRefGoogle Scholar
  26. Dörner, G., Götz, F. and Rohde, W. (1975). On the evocability of a positive oestrogen feedback action on LH secretion in male and female rats. Endokrinologie, 66: 369–372.Google Scholar
  27. Dörner, G. and Hinz, G. (1971). Männlicher Hypogonadismus mit sekundärer Hyposexualität nach hochdosierten Gaben von Östrogenen während der hypothalamischen Differenzierungsphase. Endokrinologie, 58: 227–233.Google Scholar
  28. Dörner, G. and Hinz, G. (1972). Neuroeridokrin bedingte Prädisposition für weibliche Homosexualität bei erhaltener zyklischer Ovarialfunktion. Endokrinologie, 59: 48–52.Google Scholar
  29. Dörner, G., Rohde, W., Baumgarten, G., Herter, U., Halle, H., Gruber, G., Rössner, P., Bergmann, K.H., Götz, F. and Zillman, R. (1973). Zur pränatalen Geschlechtsbestimmung im Fruchtwasser und peripheren mütterlichen Blut durch fluoreszenzmikroskopischen Nachweis des Y-Chromosoms. Zbl. Gynäk. 95: 625–634.Google Scholar
  30. Dörner, G., Rohde, W. and Krell, L. (1972). Auslösung eines positiven Östrogenfeedback-Effekt bei homosexuellen Männern. Endokrinologie, 60: 297–301.Google Scholar
  31. Dörner, G., Rohde, W., Stahl, F., Krell, L. and Masius, W. (1975). Neuroendocrine conditioned predisposition for homosexuality in men. Arch. Sex. Behav. 4: 1–8.CrossRefGoogle Scholar
  32. Dörner, G., Stahl, F., Rohde, W., Halle, H., Rössner, P., Gruber, D. and Herter, U. (1973). Radioimmunologische Bestimmung des Testosterongehalts in fruchtwasser männlicher und weiblicher Feten. Endokrinologie, 61: 317–320.Google Scholar
  33. Dörner, G. and Staudt, J. (1968). Structural changes in the preoptic anterior hypothalamic area of the male rat, following neonatal castration and androgen substitution. Neuroendocrinology, 3: 136–140.CrossRefGoogle Scholar
  34. Dörner, G. and Staudt, J. (1969). Structural changes in the hypothalamic ventromedial nucleus of the male rat, following neonatal castration and androgen treatment. Neuroendocrinology, 4: 278–281.CrossRefGoogle Scholar
  35. Dörner, G. and Staudt, J. (1972). Vergleichende morphologische Untersuchungen der Hypothalamusdifferenzierung bei Ratte und Mensch. Endokrinologie, 59: 151–155.Google Scholar
  36. Eaton, G.G., Goy, R.W. and Phoenix, C.H. (1973). Effects of testosterone treatment in adulthood on sexual behavior of female pseudohermaphrodite Rhesus monkeys. Nature, 242: 119–120.CrossRefGoogle Scholar
  37. Everitt, B.J., Fuxe, K., Hökfelt, T. and Jonsson, G. (1975). Roleof monoamines in the control by hormones of sexual receptivity in the female rat. J. Comp. Physiol. Psychol. 89: 556–572.CrossRefGoogle Scholar
  38. Gessa, G.L. and Tagliamonte, A. (1975). Role of brain serotonin and dopamine in male sexual behavior. In Sandler, M. and Gesse, G.L. (eds.), Sexual Behavior: Pharmacology and Biochemistry, Raven Press, New York.Google Scholar
  39. Giles, H.R., Lox, Ch.D., Heine, M.W. and Christian, C.D. (1974). Intrauterine fetal sex determination by radioimmunoassay of amniotic fluid testosterone. Gynaec. Investigation 5: 317–323.CrossRefGoogle Scholar
  40. Götz, F. and Dömer, G. (1976). Sex hormone-dependent brain maturation and sexual behavior in rats. Endokrinologie, in press.Google Scholar
  41. Grady, K.L. and Phoenix, C.H. (1963). Hormonal determinants of mating behavior; the display of feminine behavior by adult male rats castrated neonatally. Amer. Zool. 3: 482–483.Google Scholar
  42. Griffith, P.D., Merry, J., Browning, M.C.K., Eisinger, A.H., Huntsman, R.G., Lord, E., Polani, P.E., Tanner, J.M. and Whitehouse, R.H. (1974). Homosexual women: an endocrine and psychological study. J. Endocr. 63: 549–556.CrossRefGoogle Scholar
  43. Harris, G.W. (1964). Sex hormones, brain development and brain function. Endocrinology, 75: 627–648.CrossRefGoogle Scholar
  44. Hohlweg, W. and Junkmann, K. (1932). Die hormonal-nervöse Regulierung der Funktion des Hypophysenvorderlappens. Klin. Wschr. 11: 321–323.CrossRefGoogle Scholar
  45. Kamberi, I. (1974). Catecholaminergic, indolaminergic and cholinergic pathways and the hypothalamic hypophysiotropic neurohormones involved in control of gonadotropin secretion. In Dörner, G. (ed.), Endocrinology of Sex, Leipzig, Barth.Google Scholar
  46. Kawakami, M. and Terasawa, E. (1974). Role of limbic forebrain structures on reproductive cycles. In Kawakami, M. (ed.), Biological Rhythms in Neuroendocrine Activity, Igaku Shoin Ltd, Tokyo.Google Scholar
  47. Müller, D., Orthner, H., Roeder, F., König, A., Bosse, K. and Kloos, G. (1974). The effect of hypothalamic lesions on sex behavior and gonadotropic functions in the human. In Dorner, G. (ed.), Endocrinology of Sex, Barth, Leipzig.Google Scholar
  48. Nadler, R.D. (1972). Intrahypothalamic exploration of androgen-sensitive brain loci in neonatal female rats. Transactions New York Academy of Sciences Series II, 34: 572–581.Google Scholar
  49. Napoli, A., Powers, J.B. and Valenstein, E.S. (1972). Hormonal induction of behavioral estrus modified by electrical stimulation of hypothalamus. Physiol. Behav. 9: 115–117.CrossRefGoogle Scholar
  50. Neumann, F., Elger, W. and von Berswordt-Wallrabe, R. (1967). Intersexualität männlicher Feten und Hemmung androgenab-hängiger Funktionen bei erwachsenen Tieren durch Testos-teronblocker. Dtsch. Med. Wschr. 92: 360–366.CrossRefGoogle Scholar
  51. Pfeiffer, C.A. (1936). Sexual differences of the hypophyses and their determination by the gonads. Amer. J. Anat. 58: 195–225.CrossRefGoogle Scholar
  52. Phoenix, C.H., Goy, R.W., Gerall, A.A. and Young, W.C. (1959). Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology, 65: 369–382.CrossRefGoogle Scholar
  53. Powers, J.B. (1972). Facilitation of lordosis in ovariectomized rats by intracerebral progesterone implants. Brain Res. 48: 311–325.CrossRefGoogle Scholar
  54. Powers, J.B. and Valenstein, E.S. (1972). Sexual receptivity facilitation by medial preoptic lesions in female rats. Science, 175: 1003–1005.CrossRefGoogle Scholar
  55. Roeder, F. and Müller, D. (1969). Zur stereotaktischen Heilung der pädophilen Homosexualität. Dtsch. Med. Wschr. 94:Google Scholar
  56. Rosenzweig, M.R. (1971). Effects of environment on development of brain and behavior. In Tobach, E., Aronson, L. and Shaw, E. (eds.), The Biopsychology of Development, Academic Press, New York.Google Scholar
  57. Schally, A.V., Kastin, A.J. and Arimura, A. (1971). Hypothalamic follicle stimulating hormone (FSH) and luteinizing hormone (LH)-regulating hormone: structure, physiology and clinical studies. Fertil. and Steril. 22: 703–721.Google Scholar
  58. Soulairac, M.L. and Soulairac, A. (1975). A Monoaminergic and cholinergic control of sexual behavior in the male rat. In Sandler, M., and Gessa, G.L. (eds.), Sexual Behavior: Pharmacology and Biochemistry, Raven Press, New York.Google Scholar
  59. Stahl, F., Dörner, G., Ahrens, L. and Graudenz, W. (1976). Significantly decreased apparently free testosterone levels in plasma of male homosexuals. Endokrinologie, in press.Google Scholar
  60. Staudt, J. and Dörner, G. (1976). Structural changes in the medial and central amygdala of the male rat, following neonatal castration and androgen treatment. Endokrinologie, 67: 296–300.Google Scholar
  61. Swanson, H., Brayshow, J.S. and Payne, A.P. (1974). Effects of neonatal androgenization on sexual and aggressive behavior in the golden hamster. In Dörner, G. (ed.), Endocrinology of Sex, Barth, Leipzig.Google Scholar
  62. Ward, I.L. (1969). Differential effect of pre- and postnatal androgen on the sexual behavior of intact and spayed female rats. Hormones and Behav. 1: 25–36.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Günter Dörner
    • 1
  1. 1.German Democratic Republic

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