Somatic Mutations and Aging

  • G. P. Hirsch


Somatic mutations have been a major focus of aging research for many years. Initial support for the view that aging in mammals was due to the accumulation of somatic mutations was the effect of radiation on life span (Prasad, 1974). This mutagenic effect of radiation has been established in several systems, including mammalian cells (Awa, 1975). A single dose of radiation in a young animal did not produce effects associated with aging such as graying until long after the administration of the radiation. That it did not led to the idea that aging had been accelerated by radiation (Finch, S. C., and Beebe, 1975).


Amino Acid Substitution Somatic Mutation Chromosome Aberration Human Hemoglobin Cancer Induction 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • G. P. Hirsch
    • 1
  1. 1.Division of BiologyOak Ridge National LaboratoryOak RidgeUSA

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