Cytogenetics of Aging

  • Edward L. Schneider


An analysis of the effects of aging on the genetic endowment of organisms would not be complete without an examination of cytogenetics. Early cytogenetic studies were focused on the chromosomal constitution of lower organisms such as Drosophila, since chromosomal preparations in these species were technically simple and chromosomal number was small. It was not until 1956 that the technology was finally developed to examine the human chromosome complement accurately. Until that date, the human chromosomal number was thought to be 48. The studies of Tijo and Levan (1956) demonstrated clearly, however, that human cells possess 22 pairs of autosomal chromosomes plus either an X and Y chromosome in the male or two X chromosomes in the female.


Down Syndrome Human Chromosome Specific Chromosome Chromosome Loss Chromosomal Alteration 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Edward L. Schneider
    • 1
    • 2
  1. 1.Laboratory of Cellular and Comparative PhysiologyGerontology Research CenterBaltimoreUSA
  2. 2.National Institute on Aging, National Institutes of Health, Public Health ServiceU.S. Department of Health, Education and WelfareBaltimoreUSA

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