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Epidemiology of Colorectal Cancer

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Gastrointestinal Tract Cancer

Part of the book series: Sloan-Kettering Institute Cancer Series ((SKICS))

Abstract

In the following discussion the terms “colorectal cancer,” “cancer of the large intestine,” and “cancer of the large bowel” will be used to indicate that tumors classified according to the Eighth Revision of the International Classification of Disease (Public Health Service, 1968) as ICD 153 (cancer of the colon, excluding rectum) and ICD 154 (cancer of the rectum and rectosigmoid junction) are being considered in the aggregate. Where there are references to “cancer of the colon,” it will be understood that this is colon (ICD 153), excluding the rectum and rectosigmoid, and “cancer of the rectum” (ICD 154) will be understood to include the rectosigmoid junction. Some authors (Logan, 1976) use the term “cancer of the intestine” to include cancers of the small intestine (ICD 152) as well as cancer of the colon (ICD 153). While generally cancers of the small intestine contribute such a small proportion of the total that this makes little difference, in some countries this is not the case. In Belgium, with high rates at both sites, small intestinal neoplasms make up 10% of cancer of the intestine defined in this way. In Japan, where mortality from colon cancer is low and mortality from small intestine cancer is rather high, the latter constitutes 30% of all cancers of the two sites combined. Unless otherwise specified, small intestine cancers will not be included in this review.

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References

  • Acheson, E. D., 1959, On the mortality ascribed to ulcerative colitis, J. Chron. Dis. 10: 469 – 487.

    Article  PubMed  CAS  Google Scholar 

  • Alcantara, E. N., and Speckmann, E. W., 1976, Diet, nutrition, and cancer, Am. J. Clin. Nutr. 29: 1035 – 1047.

    PubMed  CAS  Google Scholar 

  • American Cancer Society, 1977, Cancer Statistics. Ca 27: 26 – 41.

    Google Scholar 

  • American Occupational Medical Association, 1977, NIOSH Advises Handling Acrylonitrile as Though a Human Carcinogen, AOMA Report, July/August.

    Google Scholar 

  • Armstrong, B., and Doll, R., 1975, Environmental factors and cancer incidence and mortality in different countries with special reference to dietary practices, Int. J. Cancer 15: 617 – 631.

    Article  PubMed  CAS  Google Scholar 

  • Axtell, L. M., and Chiazze, L., Jr., 1966, Changing relative frequency of cancers of the colon and rectum in the United States, Cancer 19: 750 – 754.

    Article  PubMed  CAS  Google Scholar 

  • Belleau, R., and Braasch, J. W., 1966, Genetics and polyposis, Med. Clin. N. Am. 50: 379 – 392.

    PubMed  CAS  Google Scholar 

  • Berezkin, D. P., and Neishtadt, E. L., 1969, Clinicomorphologic differences in two forms of colloid cancers in the rectum and sigmoid, vop. Onkol. 15:25–29. Cited by Berg and Godwin(1974).

    Google Scholar 

  • Berg, J. W., and Godwin, J. D., II, 1974, The epidemiologic pathology of carcinomas of the large bowel, J. Surg. Oncol. 6: 381 – 400.

    Article  PubMed  CAS  Google Scholar 

  • Berg, J. W., and Howell, M. A., 1974, The geographic pathology of bowel cancer, Cancer 34: 807 – 814.

    Article  PubMed  Google Scholar 

  • Berg, J. W., and Howell, M. A., 1975, Occupation and bowel cancer, J. Toxicol. Environ. Health 1: 75 – 89.

    Article  PubMed  CAS  Google Scholar 

  • Berg, J. W., Schottenfeld, D., Hutter, R. V. P., and Foot, F. W., 1969, Histology, Epidemiology, and End Results: The Memorial Hospital Cancer Registry, Memorial Hospital for Cancer and Allied Diseases, New York.

    Google Scholar 

  • Berg, J. W., Downing, A., and Lukes, R. J., 1970, Prevalence of undiagnosed cancer of the large bowel found at autopsy in different races, Cancer 25: 1076 – 1080.

    Article  PubMed  CAS  Google Scholar 

  • Blot, W. J., Fraumeni, J. F., Jr., Stone, B. J., and McKay, F. W., 1976, Geographic patterns of large bowel cancer in the United States, J. Natl. Cancer Inst. 57: 1225 – 1231.

    PubMed  CAS  Google Scholar 

  • Brodribb, A. J. M., and Humphreys, D. M., 1976, Diverticular disease: Three studies (Parts I, II, and III), Br. Med. J. 1: 424–430.

    Article  PubMed  CAS  Google Scholar 

  • Burbank, F., 1971, Patterns in cancer mortality in the United States: 1950–1967,Natl. Cancer Inst. Monogr., No. 33.

    Google Scholar 

  • Burkitt, D. P., Walker, A. R. P., and Painter, N. W., 1974, Dietary fiber and disease, J. Am. Med. Assoc. 229: 1068 – 1074.

    Article  CAS  Google Scholar 

  • Cain, A. S., and Longino, L. A., 1970, Carcinoma of the colon in children, J. Pediatr. Surg. 5: 527 – 532.

    Article  PubMed  CAS  Google Scholar 

  • Chabalko, J. J., and Fraumeni, J. F., Jr., 1975, Colorectal cancer in children: Epidemiologic aspects, Dis. Colon Rectum 18: 1 – 3.

    Article  PubMed  CAS  Google Scholar 

  • Chomchai, C. C., Bhadrachari, N., and Nigro, N. D., 1974, The effects of bile on the induction of experimental intestinal tumors in rats, Dis. Colon Rectum 17: 310 – 312.

    Article  PubMed  CAS  Google Scholar 

  • Correa, P., and Haenszel, W., 1975, Colon and rectum cancer—Comparative international incidence and mortality, in: Cancer Epidemiology and Prevention: Current Concepts ( D. Schottenfeld, ed.), pp. 386 – 403, Charles C. Thomas, Springfield.

    Google Scholar 

  • Cutler, S. J., and Young, J. L., Jr., 1975, Third National Cancer Survey: Incidence data, Natl. Cancer Inst. Monogr., No. 41.

    Google Scholar 

  • Danes, B. S., and Krush, A. J., 1977, The Gardner syndrome: A family study in cell culture, J. Natl. Cancer Inst. 58: 771 – 775.

    PubMed  CAS  Google Scholar 

  • DeCosse, J. J., Adams, M. B., and Condon, R. E., 1977, Familial polyposis, Cancer 39: 267 – 273.

    Article  PubMed  CAS  Google Scholar 

  • deDombal, F. T., 1971, Ulcerative colitis: Epidemiology and aetiology, course and prognosis, Br. Med. J. 1: 649 – 650.

    Article  CAS  Google Scholar 

  • deDombal, F. T., Watts, J. McK., Watkinson, G., and Goligher, J. C., 1966, Local complications of ulcerative colitis: Stricture, pseudopolyposis, and carcinoma of colon and rectum, Br. Med. J. 1: 1442 – 1447.

    Article  CAS  Google Scholar 

  • Devroede, G. J., Taylor, W. F., Sauer, W. G., Jackman, R. J., and Stickler, G. B., 1971, Cancer risk and life expectancy of children with ulcerative colitis, N. Engl. J. Med. 285: 17 – 21.

    Article  PubMed  CAS  Google Scholar 

  • Doll, R., and Cook, P., 1967, Summarizing indices for comparison of cancer incidence data, Int. J.Cancer 2: 269 – 279.

    Article  PubMed  CAS  Google Scholar 

  • Doll, R., Payne, P., and Waterhouse, J. A. H. (eds.), 1966, Cancer Incidence in Five Continents, I, Springer-Verlag, Berlin.

    Google Scholar 

  • Doll, R., Muir, C. S., and Waterhouse, J. A. H., 1970, Cancer Incidence in Five Continents, II, U.I.C.C., Geneva.

    Book  Google Scholar 

  • Editorial, 1973, Does Crohn’s disease predispose to intestinal cancer? Br. Med. J. 2: 3.

    Google Scholar 

  • Eisenberg, H., and Shambaugh, E., 1968, Cancers of the gastrointestinal tract: Trends in incidence and mortality rates, in: Sixth Annual Cancer Conference Proceedings, Lippincott, New York.

    Google Scholar 

  • Erbe, R. W., 1976, Inherited Gastrointestinal polyposis syndromes, N. Engl. J. Med. 294: 1101 – 1104.

    Article  PubMed  CAS  Google Scholar 

  • Glober, G. A., Klein, K. L., Moore, J. O., and Abba, B. C., 1974, Bowel transit-times in two populations experiencing similar colon-cancer risks, Lancet 2: 80 – 81.

    Article  PubMed  CAS  Google Scholar 

  • Farmer, R. G., and Brown, C. H., 1964, Colonic carcinoma and ulcerative colitis, Arch. Intern. Med. 113: 153 – 157.

    Article  PubMed  CAS  Google Scholar 

  • Farmer, R. G., Hawk, W, A., and Turnbull, R. B., 1971, Carcinomas associated with mucosal ulcerative colitis, and with transmural colitis and enteritis (Crohn’s disease), Cancer 28: 289 – 292.

    PubMed  CAS  Google Scholar 

  • Goldman, L. I., Bralow, S. P., Cox, W., and Peale, A., 1970, Adenocarcinoma of the small bowel complicating Crohn’s disease, Cancer 26: 1119 – 1125.

    Article  PubMed  CAS  Google Scholar 

  • Haenszel, W., and Dawson, E., 1965, A note on mortality from cancer of the colon and rectum in the United States, Cancer 18: 265 – 272.

    Article  PubMed  CAS  Google Scholar 

  • Haenszel, W., Correa, P., and Cuello, C., 1975, Social class differences among patients with large-bowel cancer in Cali, Colombia, J. Natl. Cancer Inst. 54: 1031 – 1035.

    PubMed  CAS  Google Scholar 

  • Henning, N., 1967, Carcinoma of the colon in ulcerative colitis: What is the risk? Ger. Med. Mon. 12: 402 – 403.

    Google Scholar 

  • Hill, M. J., Crowther, J. S., Drasar, B. S., et al., 1971, Bacteria and etiology of cancer of the large bowel, Lancet 1: 95 – 100.

    Article  PubMed  CAS  Google Scholar 

  • Hill, M. J., Drasar, B. S., Williams, R. E. O., et al., 1975, Fecal bile acids and clostridia in patients with cancer of the large bowel, Lancet 1: 535 – 538.

    Article  PubMed  CAS  Google Scholar 

  • IARC, 1977, Dietary fibre, transit-time, faecal bacteria, steroids, and colon cancer in two Scandinavian populations: Report from the International Agency for Research on Cancer Intestinal Microecology Group, Lancet 2: 207 – 212.

    Google Scholar 

  • Jensen, O. M., Mosbech, J., Salaspuro, M., and Jhamaki, T., 1974, A comparative study of the diagnostic basis for cancer of the colon and cancer of the rectum in Denmark and Finland, Int. J. Epidemiol. 3: 183 – 186.

    Article  PubMed  CAS  Google Scholar 

  • Laqueur, G. L., 1964, Carcinogenic effects of cycad meal and cycasin, methylazoxymethanolglycoside in rats and effects of cycasin in germfree rats, Fed. Proc. 23: 1386–1387.

    PubMed  CAS  Google Scholar 

  • Laqueur, G. L., 1965, The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone, Virchows Arch. Pathol. Anat. 340: 151 – 163.

    Article  CAS  Google Scholar 

  • Law, I. P., Herberman, R. B., Oldham, R. K., Bouzoukis, J., et al., 1977, Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies, dinical description, Cancer 39: 1224 – 1228.

    Article  PubMed  CAS  Google Scholar 

  • Lightdale, C. J., Sternberg, S. S., Posner, G. and Sherlock, P., 1975, Carcinoma complicating Crohn’s disease: Report of seven cases and review of the literature, Am. J. Med. 592: 262 – 268.

    Article  Google Scholar 

  • Logan, W. P. D., 1976, Cancers of the alimentary tract: International mortality trends, WHO Chronicle 30: 413 – 419.

    PubMed  CAS  Google Scholar 

  • Lynch, H. T., and Krush, A. J., 1967, Heredity and adenocarcinoma of the colon, Gastroenterology 53: 517 – 527.

    PubMed  CAS  Google Scholar 

  • Lynch, H. T., Guirgis, H., Lynch, J., Brodkey, F. D., and Magee, H., 1975, Cancer of the colon: Socioeconomic variables in a community, Am. J. Epidemiol. 102: 119 – 127.

    PubMed  CAS  Google Scholar 

  • Macklin, M. T., 1960, Inheritance of cancer of the stomach and large intestine in Man, J. Natl. Cancer Inst. 24: 551 – 571.

    PubMed  CAS  Google Scholar 

  • Mason, T. J., McKay, F. W., Hoover, R., Blot, W. J., and Fraumeni, F. J., Jr., 1975, Atlas of Cancer Mortality for U. S. Counties: 1950–1969, DHEW Publ. No. ( NIH ) 75 – 780.

    Google Scholar 

  • Mason, T. J., McKay, F. W., Hoover, R., Blot, W.J., and Fraumeni, J. F., Jr., 1976, Atlas of Cancer Mortality Among U.S. Nonwhites: 1950–1969, DHEW Publ. No. ( NIH ) 76 – 1204.

    Google Scholar 

  • Mass, N., and Modan, B., 1969, Epidemiological aspects of neoplastic disorders in Israeli migrant population. IV. Cancer of the colon and rectum, J. Natl. Cancer Inst. 42: 529 – 536.

    PubMed  CAS  Google Scholar 

  • McKusick, V. A., 1974, Genetics and large-bowel cancer, Digest. Dis. 19: 954 – 958.

    Article  CAS  Google Scholar 

  • Mendeloff, A. I., Monk, M., Siegel, C. I., and Lilienfeld, A., 1970, Illness experience and life stresses in patients with irritable colon with ulcerative colitis: An epidemiologic study of ulcerative colitis and regional enteritis in Baltimore, 1960–1964, N. Eng. J. Med. 282: 14 – 17.

    Article  CAS  Google Scholar 

  • Modan, B., 1977, Dietary role in cancer etiology, Cancer 40: 1887 – 1891.

    Article  PubMed  CAS  Google Scholar 

  • Modan, B., Barell, V., Lubin, F., Modan, M., Greenberg, R. A., and Graham, S., 1975, Low-fiber intake as an etiologic factor in cancer of the colon, J. Natl. Cancer Inst. 55: 15 – 18.

    PubMed  CAS  Google Scholar 

  • Monk, M., and Warshauer, M. W., 1975, Stomach and colon cancer mortality among Puerto Ricans in New York City and Puerto Rico, J. Chronic Dis. 28: 349–358.

    Article  PubMed  CAS  Google Scholar 

  • Newill, V. A., 1961, Distribution of cancer mortality among ethnic subgroups of the white population of New York City, 1953–58, J. Natl. Cancer Inst. 26: 405 – 417.

    PubMed  CAS  Google Scholar 

  • Nigro, N. D., Bhadrachari, N., and Chomchai, C., 1973, A rat model for studying colonic cancer: Effect of cholestyramine on induced tumors, Dis. Colon Rectum 16: 438 – 443.

    Article  PubMed  CAS  Google Scholar 

  • Painter, N. S., and Burkitt, D. P., 1971, Diverticular disease of the colon: A deficiency disease of Western civilization, Br. Med. J. 2: 450 – 454.

    Article  PubMed  CAS  Google Scholar 

  • Public Health Service, 1968, Eighth Revision International Classification of Diseases, Adapted for Use in the United States, DHEW Public Health Service Publ. No. 1693.

    Google Scholar 

  • Puffer, R. R., and Griffith, G. W., 1967, Patterns of Urban Mortality: Report of the Inter-American Investigation of Mortality, PAHO Scientific Publ. No. 151.

    Google Scholar 

  • Reddy, B. S., and Wynder, E. L., 1973, Large bowel carcinogenesis: Fecal constituents of populations with diverse incidence rates of colon cancer, J. Natl. Cancer Inst. 50: 1437 – 1442.

    PubMed  CAS  Google Scholar 

  • Reddy, B. S., Mastromarino, A., and Wynder, E., 1977, Diet and metabolism: Large-bowel cancer, Cancer 29:1815–1819, April Suppl.

    Article  Google Scholar 

  • Reid, J. D., 1974, Intestinal Carcinoma in the Peutz Jeghers syndrome, J. Am. Med. Assoc. 229: 833 – 834.

    Article  CAS  Google Scholar 

  • Schnur, P. L., David E., Brown, P. W., Beahrs, O. H., ReMine, W. H., and Harrison, E. G., Jr., 1973, Adenocarcinoma of the duodenum and the Gardner syndrome, J. Am. Med. Assoc. 223: 1229 – 1232.

    Article  CAS  Google Scholar 

  • Seidman, H., Silverberg, E., and Holleb, A. I., 1976, Cancer statistics 1976: A comparison of white and black populations, Ca 26: 2 – 29.

    PubMed  CAS  Google Scholar 

  • Shamberger, R. J., Rukovena, E., Longfield, A. K., Tytko, S. A., et al., 1973, Antioxidants and cancer. I. Selenium in the blood of normals and cancer patients, J. Natl. Cancer Inst. 50: 863 – 870.

    PubMed  CAS  Google Scholar 

  • Sherlock, P., 1967, Genetics and gastrointestinal disease. Gastroenterology 53: 575 – 677.

    Google Scholar 

  • Silverberg, E., 1970, Statistical Data on Cancer of the Colon and Rectum, American Cancer Society, New York.

    Google Scholar 

  • Snyder, D. N., Heston, J. F., Meigs, J. W., Flannery, J. T., 1977, Changes in site distribution of colorectal carcinoma in Connecticut, 1940–73, Am. J. Digest Dis. 22: 791 – 797.

    Article  PubMed  CAS  Google Scholar 

  • Staszewski, J., 1972, Migrant studies in alimentary tract cancer, in: Current Problems in the Epidemiology of Cancer and Lymphomas ( E. Grandmann and H. Tulinius, eds.), Spring-Verlag, New York.

    Google Scholar 

  • Staszewski, J., McCall, M. G., and Stenhouse, N. S., 1971, Cancer mortality in 1962–1966 among Polish migrants to Australia, Br. J. Cancer 25: 599 – 610.

    Article  PubMed  CAS  Google Scholar 

  • Stemmermann, G. N., 1966, Cancer of the colon and rectum discovered at autopsy in Hawaiian Japanese, Cancer 19: 1567 – 1572.

    Article  PubMed  CAS  Google Scholar 

  • Symonds, D. A., and Vickery, A. L., Jr., 1976, Mucinous carcinoma of the colon and rectum, Cancer 37: 1891 – 1900.

    Article  PubMed  CAS  Google Scholar 

  • Valdes-Dapena, A., Rudolph, I., Hidayat, A., Roth, J. L. A., and Laucks, R. B., 1976, Adenocarcinoma of the small bowel in association with regional enteritis—Four new cases, Cancer 37: 2938 – 2947.

    Article  PubMed  CAS  Google Scholar 

  • Waterhouse, J., Muir, C., Correa, P., and Powell, J. (eds.), 1976, Cancer Incidence in Five Continents, III, IARC Scientific Publications, Lyon.

    Google Scholar 

  • Wattenberg, L. W., 1974, Potential inhibitors of colon carcinogenesis, Digest Dis. 19: 947 – 953.

    Article  CAS  Google Scholar 

  • Weedon, D. D., Shorter, R. G., Ilstrup, D. M., Huizenga, K. A., and Taylor, W. F., 1973, Crohn’s disease and cancer, N. Eng. J. Med. 289: 1099 – 1103.

    Article  CAS  Google Scholar 

  • Welch, C. E., and Hedberg, S. E., 1965, Colonic cancer in ulcerative colitis and idiopathic colonic cancer, J. Am. Med. Assoc. 191: 815 – 818.

    Article  CAS  Google Scholar 

  • Winawer, S.J., Sherlock P., Schottenfeld, D., and Miller, D. G., 1976, Screening for colon cancer, Gastroenterology 70: 783 – 789.

    PubMed  CAS  Google Scholar 

  • Woolf, C. M., 1958, A genetic study of carcinoma of the large intestine, Am. J. Hum. Genet. 10: 42 – 47.

    PubMed  CAS  Google Scholar 

  • Wynder, E. L., and Reddy, B., 1973, Studies of large-bowel cancer: Human leads to experimental application, J. Natl. Cancer Inst. 50: 1099 – 1106.

    PubMed  CAS  Google Scholar 

  • Wynder, E. L., and Shigematsu, T., 1967, Environmental factors of cancer of the rectum and colon, Cancer, 20: 1520 – 1561.

    Article  PubMed  CAS  Google Scholar 

  • Wynder, E. L., Hyams, L., and Shigmatsu, T., 1967, Correlations of international cancer death rates, Cancer 20: 113 – 126.

    Article  PubMed  CAS  Google Scholar 

  • Wynder, E. L., Kajitani, T., Ishikawa, S., Dodo, H., and Takano, A., 1969, Environmental factors of cancer of the colon and rectum. II. Japanese epidemiological data, Cancer 23: 1210 – 1220.

    Article  PubMed  CAS  Google Scholar 

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Schottenfeld, D., Haas, J.F. (1978). Epidemiology of Colorectal Cancer. In: Lipkin, M., Good, R.A. (eds) Gastrointestinal Tract Cancer. Sloan-Kettering Institute Cancer Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2442-3_9

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