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Recognitive Immunity in Colon Cancer

  • Chapter
Gastrointestinal Tract Cancer

Part of the book series: Sloan-Kettering Institute Cancer Series ((SKICS))

  • 51 Accesses

Abstract

The possibility of controlling cancer by immunological means continues to provoke the interest and excitement of many workers. Such a possibility, however, is entirely dependent on the fact that tumors express antigens which are associated with those tumors. Efforts have been made to demonstrate tumor antigenicity by serological methods. As early as 1930, Witebsky produced in guinea pigs a putative antiserum to a human stomach cancer. After adsorption of this antiserum with extracts of normal human stomach, he found that it was still capable of producing a precipitation reaction with the cancer extract. This work suggested that an antigen was present in a cancerous stomach which was not present in a normal stomach. Other serological evidence followed. Graham and Graham (1955) claimed the ability to demonstrate positive complement fixation reactions for some patients using extracts of autologous tumors. Other claims were made (Finney et al., 1960) for the demonstration of precipitating antibody in the sera of cancer patients against extracts of their own tumors.

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Authors and Affiliations

  1. Research Associate, Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    Norman T. Berlinger

  2. Fellow, Clinical Immunology Service, Memorial Hospital for Cancer and Allied Diseases, New York, New York, 10021, USA

    Norman T. Berlinger

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  1. Norman T. Berlinger
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  1. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Martin Lipkin M.D.  & Robert A. Good Ph.D., M.D.  & 

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Berlinger, N.T. (1978). Recognitive Immunity in Colon Cancer. In: Lipkin, M., Good, R.A. (eds) Gastrointestinal Tract Cancer. Sloan-Kettering Institute Cancer Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2442-3_4

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