Recognitive Immunity in Colon Cancer
The possibility of controlling cancer by immunological means continues to provoke the interest and excitement of many workers. Such a possibility, however, is entirely dependent on the fact that tumors express antigens which are associated with those tumors. Efforts have been made to demonstrate tumor antigenicity by serological methods. As early as 1930, Witebsky produced in guinea pigs a putative antiserum to a human stomach cancer. After adsorption of this antiserum with extracts of normal human stomach, he found that it was still capable of producing a precipitation reaction with the cancer extract. This work suggested that an antigen was present in a cancerous stomach which was not present in a normal stomach. Other serological evidence followed. Graham and Graham (1955) claimed the ability to demonstrate positive complement fixation reactions for some patients using extracts of autologous tumors. Other claims were made (Finney et al., 1960) for the demonstration of precipitating antibody in the sera of cancer patients against extracts of their own tumors.
KeywordsMigration Inhibitory Factor Tumor Antigen Leukocyte Migration Delay Hypersensitivity Reaction Sinus Histiocytosis
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