Cancer in Inflammatory Bowel Disease: Risk Factors and Prospects for Early Detection

  • Paul Sherlock
  • Sidney J. Winawer
Part of the Sloan-Kettering Institute Cancer Series book series (SKICS)


Chronic inflammation or irritation has been considered responsible for the development of various cancers in man, although the etiology and mechanisms associated with the development of the neoplastic state have never been clarified. Examples include achalasia and lye strictures with carcinoma of the esophagus, atrophic gastritis with carcinoma of the stomach, cholelithiasis with cancer of the gallbladder, tobacco and alcohol with cancers of the oral cavity, Clonorchis sinesis infestation with cholangiocarcinoma, Schistosoma haematobium infestation with cancer of the urinary bladder, mucosal ulcerative colitis with carcinoma of the colon, and Crohn’s disease with both carcinoma of the ileum and colon.


Inflammatory Bowel Disease Ulcerative Colitis Carcinoembryonic Antigen Atrophic Gastritis Rectal Mucosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Berk, J. E., 1967, Fluorescence techniques in the diagnosis of malignant lesions of the gastrointestinal tract, Gastrointest. Endoscopy 14: 102–105.Google Scholar
  2. Binder, V., Bonnevic, O., Gertz, T., Krasilnikoff, P., Vestermock, S., Rus, P., 1972, Ulcerative colitis in children: Treatment, cause and prognosis, Scand. J. Gastroenterol. 8: 161–167.Google Scholar
  3. Bleiberg, H., Mainguet, P., Galand, P., Chretian, J., and Dupont-Mairesse, N., 1970, Cell renewal in the human rectum: In vitro autoradiographic study on ulcerative colitis, Gastroenterology 58: 851–855.PubMedGoogle Scholar
  4. Booth, S. N., King, J. P. G., Leonard, J. C., and Dykes, P. W., 1972, Serum carcinoembryonic antigen in clinical disorders, Gut 14: 794–799.CrossRefGoogle Scholar
  5. Brown, N., Weinstein, V. A., and Janowitz, H. D., 1970, Carcinoma of the ileum twenty-five years after by-pass for regional enteritis: A case report, Mt. Sinai J . Med. 37: 675–677.PubMedGoogle Scholar
  6. Cornes, J. S., Smith, J. L., and Southwood, F. W., 1961, Lymphosarcoma in chronic ulcerative colitis, Br. J . Surg. 49: 50–53.PubMedCrossRefGoogle Scholar
  7. Danovitch, S. M., Galucci, A., and Shora, W., 1972, Colonic mucosal lysosomal enzyme activities in ulcerative colitis, Am. J . Digest. Dis. 17: 977–992.PubMedCrossRefGoogle Scholar
  8. Deschner, E. E., Lewis, C. M., and Lipkin, M., 1963, In vitro study of human rectal epithelial cells. I. Atypical zone of H3 thymidine incorporation in mucosa of multiple polyposis, J. Clin. Invest. 42: 1922–1928.Google Scholar
  9. Deschner, E. E., Long, F. C., and Katz, S., 1973, Autoradiographic method for an expanded assessment of colonic cytology, Acta Cytol. 17: 435–438.PubMedGoogle Scholar
  10. Diaz, R. J., Farmer, R. G., and Brown, C. H., 1965, Carcinoma of the colon and ulcerative colitis, Am. J. Digest. Dis. 10: 643–656.PubMedCrossRefGoogle Scholar
  11. Dykes, P. W., and King, J., 1972, Progress report: Carcinoembryonic antigen, Gut 13:1000–1013.Google Scholar
  12. Eastwood, G. L., and Trier, S., 1973, Epithelial cell renewal in cultured rectal biopsies in ulcerative colitis, Gastroenterology 64: 383–390.PubMedGoogle Scholar
  13. Edwards, F. C., and Truelove, S. C., 1964, Course and prognosis of ulcerative colitis. IV. Carcinoma of the colon, Gut 5: 15–22.CrossRefGoogle Scholar
  14. Enterline, H. T., and Aryan, D. A., 1967, Chromosome constitution of adenoma and adenocarcinoma of the colon, Cancer 20: 1746–1759.PubMedCrossRefGoogle Scholar
  15. Freed, D. L. G., and Taylor, G., 1972, Carcinoembryonic antigen in faeces, Br. Med. J. 1: 85–87.PubMedCrossRefGoogle Scholar
  16. Go, V. L. W., Ammon, H. V., Holtermuller, K. H., Krag, E., and Phillips, S. F., 1975, Quantifica- tion of carcinoembryonic antigen-like activities in normal human gastrointestinal secretions, Cancer 36: 2346–2350.PubMedCrossRefGoogle Scholar
  17. Goldenberg, D. M., Preston, D. F., Primus, F. J., et al.,1974, Photoscan localization of GW-39 tumors in hamsters using radiolabeled anticarcinoembryonic antigen immunoglobulin G, Cancer Res. 34:1–9.PubMedGoogle Scholar
  18. Goldgraber, M. B., and Kirsner, J. B., 1964, Carcinoma of the colon in ulcerative colitis, Cancer 17: 657–665.PubMedCrossRefGoogle Scholar
  19. Hall, R. A., Lawrence, D. J. R., Darey, D., Stevens, U., James, R., Roberts, S., and Munro, N. A., 1972, Carcinoembryonic antigen in the urine of patients with urothelial carcinoma, Br. Med. J. 3: 604–611.CrossRefGoogle Scholar
  20. Hinton, J. M., 1966, Risk of malignant change in ulcerative colitis, Gut 7: 427–432.PubMedCrossRefGoogle Scholar
  21. Katz, S., Sherlock, P., and Winawer, S. J., 1972, Rectocolonic exfoliative cytology: A new approach, Am. J. Digest. Dis. 17:1109–1116.Google Scholar
  22. Kim, Y. S., and Plant, A. G., 1965, ß-Glucuronidase activity of gastric secretion from patients with gastric cancer, Gastroenterology 49: 50–57.Google Scholar
  23. Lesher, T., Dilwari, J. B., and Hawley, P. R., 1973, Comparison between collagenase activity in rectal biopsies and plasma carcinoembryonic antigen (CEA) levels in patients with carcinoma of the colon and rectum (abstr.), Gut 14: 819.PubMedGoogle Scholar
  24. Lewis, B., Morson, B. C., February, A. W., Jones, H. J., and Misiewicz, J. J., 1971, Abnormal lactic dehydrogenase isoenzyme patterns in ulcerative colitis with precancerous change, Gut 12: 16–19.PubMedCrossRefGoogle Scholar
  25. Lightdale, C. J., Sternberg, S. S., Posner, G., and Sherlock, P., 1975, Carcinoma complicating Crohn’s disease: Report of seven cases and review of the literature, Am. J. Med. 59: 262–268.PubMedCrossRefGoogle Scholar
  26. Lipkin, M., 1973, Proliferation and differentiation of gastrointestinal cells, Physiol. Rev. 53: 891–915.PubMedGoogle Scholar
  27. MacDougall, I. P. M., 1964, The cancer risk in ulcerative colitis, Lancet 2: 655–658.PubMedCrossRefGoogle Scholar
  28. Michener, W. M., Gage, R. P., Sauer, W. G., and Stickler, G. B., 1961, Prognosis of chronic ulcerative colitis in children, N. Eng. J. Med. 265: 1075–1079.CrossRefGoogle Scholar
  29. Molnar, I. G., Vandevoorde, J. P., and Gitnick, G. L., 1976, CEA levels in fluids bathing gastrointestinal tumors, Gastroenterology 70: 513–515.PubMedGoogle Scholar
  30. Morson, B. C., 1966, Cancer in ulcerative colitis, Gut 7: 425–426.PubMedCrossRefGoogle Scholar
  31. Morson, B. C., and Pang, L. S. C., 1967, Rectal biopsy as an aid to cancer control in ulcerative colitis, Gut 8: 423–434.PubMedCrossRefGoogle Scholar
  32. Muir, G. G., and Valeris, G., 1969, Vaginal fluid enzyme pattern in benign and malignant lesions of the female genital tract, J. Clin. Pathol. 22: 593–597.PubMedCrossRefGoogle Scholar
  33. Nash, A. G., Dance, D. K., Macready, V. R., and Griffiths, J. D., 1972, Uptake of gallium-67 in colonic and rectal tumors, Br. Med. J. 3: 508–510.PubMedCrossRefGoogle Scholar
  34. Nelson, R. S., 1968, The detection of malignant neoplasms of the gastrointestinal tract by the use of radioactive phosphorus (32P) and a miniature Geiger tube, Gastrointest. Endoscopy 15: 18–23.Google Scholar
  35. Perrett, A. D., Truelove, S. C., and Massarella, G. R., 1968, Crohn’s disease and carcinoma of the colon, Br. Med. J. 2: 466–468.PubMedCrossRefGoogle Scholar
  36. Rule, A. H., Goleski-Reilly, C., Sachar, D. B., Vandevoorde, J., and Janowitz, H. D., 1972, Circulating carcinoembryonic antigen (CEA): Relationship to clinical status of patients with inflammatory bowel disease, Gut 14: 880–884.CrossRefGoogle Scholar
  37. Sherlock, P., 1967, Genetics and gastrointestinal disease, Gastroenterology 53: 675–677.PubMedGoogle Scholar
  38. Shorter, R. G., Spencer, R. J., and Hallenbeck, G. A., 1966, Kinetic studies of the epithelial cells of the rectal mucosa in normal subjects and in patients with ulcerative colitis, Gut 7: 593–596.PubMedCrossRefGoogle Scholar
  39. Streifler, C., Schnitzer, N., and Harell, A., 1972, A rare isoenzyme of alkaline phosphatase in 4 patients with ulcerative colitis, Clin. Chim. Acta 38: 244–246.PubMedCrossRefGoogle Scholar
  40. Wattenberg, L. W., 1959, A histochemical study of five oxidative enzymes in carcinoma of the large intestine in man, Am. J. Pathol. 35: 113–126.PubMedGoogle Scholar
  41. Weedon, D. D., Shorter, R. G., Ilstrup, D. M., Huizenga, K. A., and Taylor, W. F., 1973, Crohn’s disease and cancer, N. Eng. J . Med. 289: 1099–1103.CrossRefGoogle Scholar
  42. Winawer, S. J., Fleisher, M., Melamed, M., Sherlock, P., Deschner, E. E., and Schwartz, M. K., 1974, Cytological, immunological (CEA) and isotope labeling studies based on gastrointestinal endoscopie lavage (abstr.), Gastroenterology 66: 800.Google Scholar
  43. Xavier, R. G., Prolla, J. C., Bemvenuti, G. A., and Kirsner, J. B., 1973, Further tissue cytogenic studies in inflammatory bowel disease (abstr.), Gastroenterology 64: 875.Google Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Paul Sherlock
    • 1
    • 2
  • Sidney J. Winawer
    • 1
    • 2
  1. 1.Gastroenterology Service, Department of MedicineMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Department of MedicineCornell University Medical CollegeNew YorkUSA

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