Use of Experimental Models in the Study of Approaches to Treatment of Colorectal Cancer

  • Daniel P. GriswoldJr.
  • Thomas H. Corbett
Part of the Sloan-Kettering Institute Cancer Series book series (SKICS)


Animal tumors have been widely used as models in studies of the etiology, behavior, and treatment of cancer of man. It is the last consideration that is of concern here, i.e., the development of optimal approaches to therapy through the use of experimental models. Many questions of the clinical oncologist cannot be answered from therapeutic trials in man because of the limitations imposed by ethics that preclude the use of certain controls and assay procedures. If, then, a totally empirical approach is to be avoided, the answers to those questions must come through the use of likely relevant animal tumors. Yet relevancy can often be determined only in retrospect. Nevertheless, experimentalists as well as clinicians have already recognized the need for better tumor models. It is hoped that their use will lead to improved therapeutic results as well as a better understanding of the nature of cancer growth and spread.


Colon Tumor Animal Tumor Animal Tumor Model Human Colon Tumor Volume Doubling Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Daniel P. GriswoldJr.
    • 1
  • Thomas H. Corbett
    • 1
  1. 1.Southern Research InstituteBirminghamUSA

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