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Development of Model Colorectal Cancer Systems for Pharmacological Research

  • John A. Double
  • Edward H. Cooper
Part of the Sloan-Kettering Institute Cancer Series book series (SKICS)

Abstract

The success or failure of surgery to eliminate colorectal cancer depends on many factors. Essentially, they are hinged on whether the local lesion can be excised completely or whether the tumor is complicated by either overt metastases or occult micrometastases that are outside the confines of the portion of bowel that is resected. At present, the only hope of prolonged survival for patients with metastastic large bowel cancer is the use of other modalities of therapy in combination with surgery. Chemotherapy is the lynchpin of this strategy; preoperative radiotherapy may have an adjuvant role in carcinoma of the rectum and occasionally is a helpful palliative treatment of metastases in certain sites. As yet, the long-term benefits of immunotherapy are unknown, although there are enthusiasts for this novel approach. However, the immunostimulants available today are still a very crude way of effecting a biological cure of cancer.

Keywords

Human Colorectal Cancer Human Solid Tumor Hamster Cheek Pouch Human Colorectal Tumor Intestinal Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • John A. Double
    • 1
  • Edward H. Cooper
    • 1
  1. 1.Department of Experimental Pathology and Cancer Research, School of MedicineThe University of LeedsLeedsEngland

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