Development of Model Colorectal Cancer Systems for Pharmacological Research

  • John A. Double
  • Edward H. Cooper
Part of the Sloan-Kettering Institute Cancer Series book series (SKICS)


The success or failure of surgery to eliminate colorectal cancer depends on many factors. Essentially, they are hinged on whether the local lesion can be excised completely or whether the tumor is complicated by either overt metastases or occult micrometastases that are outside the confines of the portion of bowel that is resected. At present, the only hope of prolonged survival for patients with metastastic large bowel cancer is the use of other modalities of therapy in combination with surgery. Chemotherapy is the lynchpin of this strategy; preoperative radiotherapy may have an adjuvant role in carcinoma of the rectum and occasionally is a helpful palliative treatment of metastases in certain sites. As yet, the long-term benefits of immunotherapy are unknown, although there are enthusiasts for this novel approach. However, the immunostimulants available today are still a very crude way of effecting a biological cure of cancer.


Human Colorectal Cancer Human Solid Tumor Hamster Cheek Pouch Human Colorectal Tumor Intestinal Carcinoma 
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  1. Ball, C. R., and Double, J. A., 1975, Transplantable colon tumors as chemotherapy screening models, Cancer 36: 2437–2440.PubMedCrossRefGoogle Scholar
  2. Carter, S. K., 1976, Large bowel cancer The current status of treatment, J. Natl. Cancer Inst. 56 (1): 3–10.PubMedGoogle Scholar
  3. Carter, S. K., and Soper, W. T., 1974, Integration of chemotherapy into combined modality treatment of solid tumors. 1. The overall strategy, Cancer Treat. Rev. 2: 1–13.CrossRefGoogle Scholar
  4. Corbett, T. H., Griswold, D. P., Jr., Roberts, B. J., Peckham, J. C., and Schabel, F. J., Jr.,,1975a, Tumor induction relationships in the development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure, Cancer Res. 35: 2434–2439.Google Scholar
  5. Corbett, T. H., Griswold, D. P., Jr., Roberts, B. J., Peckham, J., and Schabel, F. M. J, 1975b, A mouse colon-tumor model for experimental therapy, Cancer Chemother. Rep. Part 2 5 (1): 169–186.Google Scholar
  6. Detre, S. I., Davies, A. J. S., and Connors, T. A., 1975, New models for cancer chemotherapy, Cancer Chemother. Rep. Part 2 5 (1): 133–143.Google Scholar
  7. Dixon, M. F., Cowen, D. M., and Cooper, E. H., 1975, Chronic hepatotoxicity and intestinal bleeding in 1, 2-dimethylhydrazine carcinogens in rats and mice, Biomedicine 23: 247–252.PubMedGoogle Scholar
  8. Double, J. A., 1975, Human tumor xenografts, Biomedicine 22: 461–465.PubMedGoogle Scholar
  9. Double, J. A., and BAIL, C. R., 1975a, Chemotherapy of transplantable colon tumors in mice, in: Chemotherapy, Vol. 7: Cancer Chemotherapy I, Plenum, New York.Google Scholar
  10. Double, J. A., and Ball, C. R., 1975b, Chemotherapy of transplantable adenocarcinomas of the colon in mice, Cancer Chemother. Rep. 59 (6): 1083–1089.PubMedGoogle Scholar
  11. Double, J. A., Ball, C. R., and Cowen, P. N., 1975, Transplantation of adenocarcinomas of the colon in mice, J. Natl. Cancer Inst. 54 (1): 271–275.PubMedGoogle Scholar
  12. Druckrey, H., 1972, Organospecific carcinogenesis in the digestive tract, in: Topics in Chemical Carcinogenesis (W. Wakahara, S. Takayama, T. Sugimara, and S. Odushima, eds.), pp. 73–120, Tokyo University Press, Tokyo.Google Scholar
  13. Filipe, M. I., 1975, Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine: A morphological and histochemical study, Br. J. Cancer 32: 60–77.PubMedCrossRefGoogle Scholar
  14. Geran, R. I., Greenberg, N. H., MacDonald, M. M., Schumacher, A. M., and Abbot, B. J., 1972, Protocols for screening chemical agents and natural products against animal tumor and other biological systems (third edition), Cancer Chemother. Rep. Part 3 3(2).Google Scholar
  15. Giovanella, B. C., 1974, Testing of chemotherapeutic agents on individual human solid tumors transplanted in “nude” mice, in: UICC Workshop on New Animal Models for Chemotherapy of Human Solid Tumors(E. Mihich, D. J. R. Laurence, D. M. Laurence, and S. Eckhardt, eds.), p. 29, UICC Technical Report Series, Vol. 15.Google Scholar
  16. Giovanella, B. C., Stelhein, J. S. and Williams, L. J., Jr., 1974, Hetero transplantation of human malignant tumors in “nude” thymusless mice. II. Malignant tumors induced by injection of cell cultures derived from human solid tumors, J. Natl. Cancer Inst. 52: 921–927.PubMedGoogle Scholar
  17. Goldenberg, D. M., 1974, Human tumors in the hamster cheek pouch, in: UICC Workshop of New Animal Models for Chemotheraphy of Human Solid Tumors (E. Mihich, D. J. R. Laurence, D. M. Laurence, and S. Eckhardt, eds.), p. 18, UICC Technical Report Series, Vol. 15.Google Scholar
  18. Goldenberg, D. M., and Hansen, H. J., 1972, Carcinoembryonic antigen present in human colonic neoplasms serially propagated in hamsters, Science 175: 1117–118.CrossRefGoogle Scholar
  19. Goldenberg, D. M., Bhan, R. D., and Pavia, R. A., 1970, Retention of human properties by a xenografted human colonic tumor, G. W. 77, propagated in unconditioned hamsters, Proc. Soc. Exp. Biol. Med. 135: 657–659.PubMedCrossRefGoogle Scholar
  20. Goldenberg, D. M., Preston, D. F., Primus, F. J., and Hansen, H. J., 1974, Photoscan localisation of G. W.-39 tumors in hamsters using radio labelled anticarcinoembryonic antigen immunoglobulin G, Cancer Res. 34: 1–9.PubMedGoogle Scholar
  21. Goto, K., Kurokawa, Y., Hayashi, J., and Sato, H., 1975, Transplantable adenocarcinomas from colo-rectal tumors induced by infusion of N-methyl N-nitro N-nitrosoguanidine in AC 1/N rats, Gann 66: 84–93.Google Scholar
  22. Griswold, D. P., and Corbett, T. H., 1975, A colon tumor model for anticancer agent evaluation, Cancer 36: 2441–2444.PubMedCrossRefGoogle Scholar
  23. Haase, P., Cowen, D. M., and Knowles, J. C., 1973, Evaluation of dimethyl hydrazine induced tumors in mice as a model system for colorectal cancer, Br. J. Cancer 28: 530.PubMedCrossRefGoogle Scholar
  24. Kirkman, H., and Chesterman, F. C., 1972, Additional data on transplanted tumors of the golden hamster, Progr. Exp. Tumor Res. 16: 580–62.PubMedGoogle Scholar
  25. Laqueur, G. L., 1964, Carcinogenic effects of cycad meal and cycasin, methylazoxymethanolglycoside in rats and effects of cycasin in germ free rats, Fed. Proc. 23: 1386.PubMedGoogle Scholar
  26. Laqueur, G. L., 1970, Contribution of intestinal macroflora and microflora to carcinogenesis, in: Carcinoma of the Colon and Antecedent Epithelium (W. J. Burdette, ed.), pp. 305–313, Thomas, Springfield, Ill.Google Scholar
  27. Laqueur, G. L., Michelsen, O., Whiting, M. G., and Kunland, L. T., 1963 Carcinogenic properties of nuts from cycas circinals, J. Natl. Cancer Inst. 31: 919–933.PubMedGoogle Scholar
  28. Martin, M. S., Martin, F., Michiels, R., Bastien, H., Justarbo, E., Bordes, M., and Virg. B., 1973a, An experimental model for cancer of the colon and rectum, Digestion 8: 22–34.PubMedCrossRefGoogle Scholar
  29. Martin, M. S., Bastien, H., Martin, F., Michiels, R., Martin, M. R., and Justarbo, E., 1973b, Transplantation of intestinal carcinoma in inbred rats, Biomedicine 19: 555–558.Google Scholar
  30. Martin, F., Martin, M. S., Bordes, M., and Knobel, S., 1975a, Antigens associated with chemically induced intestinal carcinomas of rats, Int.). Cancer 15: 144–151.CrossRefGoogle Scholar
  31. Martin, F., Knobel, S., Martin, M., and Bordes, M., 1975b, A carcino-fetal antigen located on the membrane of cells from rat intestinal carcinoma in culture, Cancer Res. 35: 333–336.PubMedGoogle Scholar
  32. McCall, D. C., and Cole, J. W., 1974, Transplantation of chemically induced adenocarcinomas of the colon in an inbred strain of rats, Cancer 4: 1021–1026.CrossRefGoogle Scholar
  33. Povlsen, C. O., and Rygaard, J., 1971, Heterotransplantation of human adenocarcinomas of the colon and rectum to the mouse mutant nude: A study of nine consecutive transplantations, Acta Pathol. Microbiol. Scand. 79: 159.Google Scholar
  34. Rygaard, J., and Povlsen, C. 0., 1969, Heterotransplantation of human malignant tumors to “nude” mice, Acta Pathol. Microbiol. Scand. 77: 758.PubMedCrossRefGoogle Scholar
  35. Sjögren, H. O., and Steele, G., 1975, The immunology of large bowel carcinoma in a rat model, Cancer 36: 2469–2471.PubMedCrossRefGoogle Scholar
  36. Steele, G., Jr., and Sjögren, H. 0., 1974, Cross-reacting tumor-associated antigen(s) among chemically induced rat colon carcinomas, Cancer Res. 34: 1801–1907.PubMedGoogle Scholar
  37. Steele, G., Jr., Sjögren, H. O., and Rosengren, J. E., 1975, Sequential studies of serum blocking activities in rats bearing chemically induced primary bowel tumors, J. Natl. Cancer Inst. 54 (4): 959–967.PubMedGoogle Scholar
  38. Tubiana, M., and Malaise, E. P., 1976, Growth rate and cell kinetics in human tumors: Some prognostic and therapeutic implications, in: Scientific Foundations of Oncology ( T. Symington and R. L. Carter, eds.), pp. 126–135, Heinemann Medical Books, London.Google Scholar
  39. Walpole, A. L., Williams, M. H. C., and Roberts, D. C., 1952, The carcinogenic action of 4-aminodiphenyl, Br. J . Ind. Med. 9: 255–263.PubMedGoogle Scholar
  40. Ward, J. M., 1974, Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats, Lab. Invest. 30 (4): 505–513.PubMedGoogle Scholar
  41. Ward, J. M., Yamamoto, R. S., and Brown, C. A., 1973, Pathology of intestinal neoplasms and other lesions in rats exposed to azoxymethane, J. Natl. Cancer Inst. 51: 1029–1039.PubMedGoogle Scholar
  42. Weisburger, J. H., 1971, Colon carcinogens: Their metabolism and mode of action, Cancer 28: 60–70.PubMedCrossRefGoogle Scholar
  43. Weisburger, J. H., 1973, Chemical carcinogenesis in the gastrointestinal tract, in: Seventh National Cancer Conference Proceedings, pp. 465–473.Google Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • John A. Double
    • 1
  • Edward H. Cooper
    • 1
  1. 1.Department of Experimental Pathology and Cancer Research, School of MedicineThe University of LeedsLeedsEngland

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