Experimental Colon Carcinogenesis

  • Morris S. Zedeck
Part of the Sloan-Kettering Institute Cancer Series book series (SKICS)


Probably the most significant contribution in recent years toward the understanding of colon carcinogenesis has been the introduction of several compounds having marked propensity for induction of colon tumors in laboratory animals. Single or relatively few doses of MAM,* DMH, AOM, MNNG, or MNU result in the induction of large numbers of colon tumors in most, if not all, of the treated animals within a relatively short time. The intestinal distribution and the histological characteristics of the tumors are remarkably similar to what is found in humans. Animal model systems have been developed with the use of these agents and are invaluable for studying the mechanism(s) of initiation of tumor development as well as, in the case of those agents effective after a single treatment, the sequential changes from the moment of initiation until the formation of a tumor. In addition, epidemiological studies of various populations of the world have led to the suggestion that dietary fat, intestinal flora, and bile acids may influence the induction of colon tumors. The modifying effects of these factors in the formation of colon tumors can now also be evaluated in reliable animal model systems. The basic aims of this chapter are to present data of studies directed at understanding why colonic epithelium is especially sensitive to induction of tumors by these compounds and to present and consider the evidence obtained thus far of the role of dietary factors, intestinal flora, and bile acids in the induction of colon cancer. Other experimental systems that may prove useful in understanding colon carcinogenesis are also discussed.


Bile Acid Colon Tumor Intestinal Flora Colonic Epithelium Colon Carcinogenesis 
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© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Morris S. Zedeck
    • 1
  1. 1.Laboratory of PharmacologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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