Heredity and Gastrointestinal Tract Cancer

  • Henry T. Lynch
  • Patrick M. Lynch
Part of the Sloan-Kettering Institute Cancer Series book series (SKICS)


The study of cancer genetics in man has been steeped in controversy. Undoubtedly most of these problems center around the complexity of man himself as a subject for cancer genetic investigations; man’s matings cannot be controlled, he has relatively few progeny, and his generation span is longer than that of most other animal species. In addition, it is difficult to obtain reliable information about his medical history, particularly histological verification of cancer one or more decades after treatment. In the study of gastrointestinal tract cancer, such verification is exceedingly important since the assessment of cancer of interal organs may be hampered significantly in the absence of such information. The pervasive fear of cancer among the populace compounds these difficulties; in some circumstances the investigations of a cancer-prone family may have to be curtailed or even abandoned when overpowering fear and denial cause certain patients to refuse further cooperation. Perhaps the most difficult obstacle in elucidating genetic patterns of cancer susceptibility is the omnipresence of environmental and dietary factors, the differential clustering of which may doggedly mimic a genetic model.


Gastric Cancer Pancreatic Cancer Esophageal Cancer Celiac Disease Gastric Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Henry T. Lynch
    • 1
  • Patrick M. Lynch
    • 1
  1. 1.Department of Preventive Medicine/Public HealthCreighton University School of MedicineOmahaUSA

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