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Depression pp 133-136 | Cite as

Further Notes on Drug Therapy

  • Jonathan O. Cole

Abstract

I agree with most of Dr. Kline’s statements about the drug treatment of depression. For the benefit of the clinicians reading this section, I am providing a table (Table I) of the antidepressants available on a prescription basis in the United States at this time and their approximate effective dosages, as well as the dosage forms in which each is available. The reader who is also a careful student of package inserts will note that some of my dosage ranges slightly exceed the upper dosage recommended by the FDA and the company. Higher dosages should only be tried in patients who failed to respond at lower levels and showed no undesirable side effects at those dosages. In older patients who have had prior cardiovascular disease, consultation with an internist should be held and an electrocardiogram should be obtained before exceeding the upper “recommended” dosage. Where feasible, drug blood levels or platelet monoamine oxidase activity levels should be checked (see below).

Keywords

Undesirable Side Effect Careful Student Barbiturate Anesthesia Antidepressant DRUGs Tricyclic Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Everett HC: The use of bethanecholchloride with tricyclic antidepressants. Am. J. Psychiatry 132: 1202–1204, 1975.PubMedGoogle Scholar
  2. 2.
    Snyder SH, Yamamura HI: Antidepressants and the nuscarinic acetylcholine receptor. Arch. Gen. Psychiatry 34: 236–239, 1977.PubMedCrossRefGoogle Scholar
  3. 3.
    Cole JO, Schatzberg A: Memory difficulty and tricyclic antidepressants. McLean Hosp. J. 1: 102–107, 1976.Google Scholar
  4. 4.
    Granacher RP, Baldaressarini RJ: Physostigmine. Arch. Gen. Psychiatry 32: 375–380, 1975.PubMedCrossRefGoogle Scholar
  5. 5.
    Goldberg HL, Finnerty RJ, Cole JO: The effect of doxepin in the aged: An interim report on memory changes and electrocardiographic findings. In: Mendels J (ed) Sinequan (Doxepin Hydrochloride): A Monograph of Recent Clinical Studies. Excerptâ Medica, 1975.Google Scholar
  6. 6.
    Glassman AH, Perel JM, Shostak M, Kantor SJ, Fleiss JL: Clinical implications of imipramine plasma levels for depressive illness. Arch. Gen. Psychiatry 34: 197–204, 1977.PubMedCrossRefGoogle Scholar
  7. 7.
    Kane J, Rifkin A, Quitkin F, Klein DF: Antidepressant drug blood levels, pharmacokinetics and clinical outcome. In: Klein DF, Gittelman-Klein R (eds) Progress in Psychiatric Drug Treatment. Vol. 2. New York, Brunner/Mazel, 1976.Google Scholar
  8. 8.
    Fink M: Electroconvulsive therapy—a reevaluation. Arch. Gen. Psychiatry,1977 (in press).Google Scholar
  9. 9.
    Glassman A, Kantor S, Shostak M: Depression, delusions and drug response. Am. J. Psychiatry 132: 716–719, 1975.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Jonathan O. Cole
    • 1
  1. 1.McLean HospitalBelmontUSA

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