Depression pp 103-106 | Cite as

The Amine Hypothesis Revisited: A Clinician’s View

  • Leo E. Hollister


It is worth remembering the simple syllogism which led to the amine hypothesis of depression. A number of workers, including myself, had shown in 1954 that reserpine would produce depression, even in non-depressed normal subjects. Subsequent pharmacologic studies of its mode of action showed that it impaired the storage in nerve endings of serotonin, of norepinephrine, and, ultimately, of dopamine. Thus, the conclusion was reached that depression was associated with a depletion of neurotransmission due to one or the other of these amines. In some parts of the world norepinephrine was favored, while in others it was serotonin; the role of dopamine is still unclear.


Secondary Amine Tertiary Amine Antidepressant Drug Hydroxy Tryptophan Endogenous Depression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Leo E. Hollister
    • 1
  1. 1.Department of PsychiatryStanford University School of MedicinePalo AltoUSA

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