It is worth remembering the simple syllogism which led to the amine hypothesis of depression. A number of workers, including myself, had shown in 1954 that reserpine would produce depression, even in non-depressed normal subjects. Subsequent pharmacologic studies of its mode of action showed that it impaired the storage in nerve endings of serotonin, of norepinephrine, and, ultimately, of dopamine. Thus, the conclusion was reached that depression was associated with a depletion of neurotransmission due to one or the other of these amines. In some parts of the world norepinephrine was favored, while in others it was serotonin; the role of dopamine is still unclear.
KeywordsSecondary Amine Tertiary Amine Antidepressant Drug Hydroxy Tryptophan Endogenous Depression
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