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Effects of Neuroleptics, Ethanol, Hypnotic-Sedatives, Tranquilizers, Narcotics, and Minor Stimulants in Aversive Paradigms

  • Giorgio Bignami

Abstract

A broad survey of the organization of aversively motivated behaviors as well as the pharmacological evidence on the physiological-biochemical substrates that subserve these behaviors has been provided in the first six chapters of the present volume. The purpose of this chapter is to analyze a wide variety of behavioral effects of several agents that are not comfortably subsumed under the previously discussed headings. At the same time, the reader should be aware that the following discussion is in many ways complementary to the analyses carried out previously. This is illustrated, for example, by the fact that different types of neuroleptics, with variable profiles with respect to biochemical changes (e.g., greater or lesser antinoradrenergic properties given a particular antidopaminergic effect), are used routinely in the analyses of the neurochemical substrates that sub-serve simple behavioral responses (see, e.g., Chapter 5, and Schenker and Herbst, 1963; Bradley, 1963; Janssen, 1965; Gordon, 1967a; Crismon, 1967; Bobon et al., 1970; Forrest et al., 1974; Fielding and Lal, 1974; Gordon, 1974; Iversen, 1975; Iversen et al., 1975; Matthysse and Kety, 1975; Sedvall and Uvnäs, 1975; Usdin and Bunney, 1975; Wyatt, 1976). This notwithstanding, several effects obtained in more complex testing situations either with neuroleptics or with various other drugs not included in previous chapters (ethanol, hypnotic-sedatives, tranquilizers, narcotics, and several stimulants excepting amphetamine and related agents) need to be examined in behavioral terms. In fact, if an analysis cutting through several levels of organization is to take a substantial step forward (relative to the achievements that have been made so far), then behavioral models of drug effects are required which are more sophisticated than those that simply emphasize the analogies and differences of profiles obtained by conventional testing methods.

Keywords

Passive Avoidance Avoidance Response Active Avoidance Conditioned Avoidance Conditioned Emotional Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aged, A. M., Chin, L., Trafton, C. L., Jones, B. C., and Picchioni, A. L., 1976, Acute effects of morphine and chlorpromazine on the acquisition of shuttle box conditioned avoidance response, Psychopharmacologia 46: 311–315.Google Scholar
  2. Ahlenius, S., and Engel, J., 1971, Effects of small doses of haloperidol on timing behaviour, J. Pharm. Pharmacol. 23: 301–302.Google Scholar
  3. Andén, N. E., and Jackson, D. M., 1975, Locomotor activity stimulation in rats produced by dopamine in the nucleus accumbens: Potentiation by caffeine, J. Pharm. Pharmacol. 27: 666–670.Google Scholar
  4. Anichkov, S. V., 1965, Pavlov’s method of conditioned reflexes in pharmacology, Proc. Int. Pharmacol. Meet. 2nd 1963 1: 17–24.Google Scholar
  5. Anisman, H., 1972, Fear reduction and active avoidance learning after alcohol administration during prior CS-shock exposure, Q. J. Stud. Alcohol 33: 783–793.Google Scholar
  6. Anisman, H., and Waller, T. G., 1974, Effects of alcohol on discriminative active avoidance behavior in mice, Q. J. Stud. Alcohol 35: 439–444.Google Scholar
  7. Appel, J. B., 1963, Drugs, shock intensity and the CER, Psychopharmacologia 4: 148–153.Google Scholar
  8. Aron, C., Simon, P., Larousse, C., and Boissier, J. R., 1971, Evaluation of a rapid technique for detecting minor tranquilizers, Neuropharmacology 10: 459–469.Google Scholar
  9. Babbini, M., Gaiardi, M., and Bartoletti, M., 1973, Effects of morphine on a quickly learned conditioned suppression in rats, Psychopharmacologia 33: 329–332.Google Scholar
  10. Babbini, M., Gaiardi, M., and Bartoletti, M., 1976, Effects of combined treatment with nortriptiline and lorazepam on conflict behavior and motility of rats, Psychopharmacology 48: 251–254.Google Scholar
  11. Bainbridge, J. G., and Greenwood, D. T., 1971, Tranquillizing effects of propanolol demonstrated in rats, Neuropharmacology 10: 453–458.Google Scholar
  12. Banerjee, U., 1971, Acquisition of conditioned avoidance responses in rats under the influence of addicting drugs, Psychopharmacologia 22: 133–143.Google Scholar
  13. Banerjee, U., 1974, Programmed self-administration of potentially addictive drugs in young rats and its effects on learning, Psychopharmacologia 38: 111–124.Google Scholar
  14. Barrett, J. E., 1976, Effects of alcohol, chlordiazepoxide, cocaine and pentobarbital on responding maintained under fixed-interval schedules of food or shock presentation, J. Pharmacol. Exp. Ther. 196: 605–615.Google Scholar
  15. Barry, H., III, and Buckley, J. P., 1966, Drug effects on animal performance and the stress syndrome, J. Pharm. Sci. 55: 1159–1183.Google Scholar
  16. Barry, H., III, and Miller, N. E., 1962, Effects of drugs on approach-avoidance conflict tested repeatedly by means of a “telescope alley,” J. Comp. Physiol. Psychol. 55: 201–210.Google Scholar
  17. Barry, H., III, Miller, N. E., and Tidd, G. E., 1962, Control for stimulus change while testing effects of amobarbital on conflict, J. Comp. Physiol. Psychol. 55: 1071–1074.Google Scholar
  18. Barry, H., III, Wagner, S. A., and Miller, N. E., 1963, Effects of several drugs on performance in an approach-avoidance conflict, Psychol. Rep. 12: 215–221.Google Scholar
  19. Barry, H., III, Etheredge, E. F., and Miller, N. E., 1965, Counterconditioning and extinction of fear fail to transfer from amobarbital to nondrug state, Psychopharmacologia 8: 150–156.Google Scholar
  20. Baum, M., 1969, Paradoxical effect of alcohol on the resistance-to-xtinction of an avoidance response in rats, J. Comp. Physiol. Psychol. 69: 238–240.Google Scholar
  21. Baum, M., 1971a, Effect of alcohol on the resistance-to-extinction of an avoidance response: Replication in mice, Physiol. Behay. 6: 307–309.Google Scholar
  22. Baum, M., 1971b, Avoidance training in both alcohol and non-drug states increases the resistance-to-extinction of an avoidance response in rats, Psychopharmacologia 19: 87–90.Google Scholar
  23. Baum, M., 1973, Extinction of avoidance in rats: The effects of chlorpromazine and methylphenidate administered in conjunction with flooding (response prevention), Behay. Res. Ther. 11: 165–169.Google Scholar
  24. Beer, B., and Lenard, L. G., 1975, Differential effects of intraventricular administration of 6hydroxydopamine on behavior of rats in approach and avoidance procedures: Reversal of avoidance decrements by diazepam, Pharmacol. Biochem. Behay. 3: 879–886.Google Scholar
  25. Beer, B., and Migler, B., 1975, Effects of diazepam on galvanic skin response and conflict in monkeys and humans, in “Predictability in Psychopharmacology: Preclinical and Clinical Correlations” (A. Sudilovsky, S. Gershon, and B. Beer, eds.), pp. 143–157, Raven, New York.Google Scholar
  26. Beer, B., Chasin, M., Clody, D. E., Vogel, J. R., and Horovitz, Z. P., 1972, Cyclic adenosine monophosphate phosphodiesterase in brain: Effect on anxiety, Science 176: 428–430.Google Scholar
  27. Benson, H. J., Herd, J. A., Morse, W. H., and Kelleher, R. T., 1970, Hypotensive effects of chlordiazepoxide, amobarbital and chlorpromazine on behaviorally induced elevated arterial blood pressure in the squirrel monkey, J. Pharmacol. Exp. Ther. 173: 399–406.Google Scholar
  28. Bernstein, B. M., and Cancro, L. P., 1962, The effect of two temporal variables of avoidance conditioning on drug-behavior interaction, Psychopharmacologia 3: 105–113.Google Scholar
  29. Biel, J. H., and Bopp, B., 1974, Antidepressant drugs, in “Psychopharmacological Agents” (M. Gordon, ed.), Vol. III, pp. 283–341, Academic, New York.Google Scholar
  30. Biel, J. H., Horita, A., and Drukker, A. E., 1964, Monoamine oxidase inhibitors (hydrazines), in “Psychopharmacological Agents” (M. Gordon, ed.), Vol. I, pp. 359–443, Academic, New York.Google Scholar
  31. Bignami, G., 1976, Behavioral pharmacology and toxicology, Annu. Rev. Pharmacol. Toxicol. 16: 329–366.Google Scholar
  32. Bignami, G., and Carro, G., 1967, Variazioni di sensibilità alla cloropromazina della risposta strumentale di salvaguardia nel ratio: Condizionamento semplice e discriminazione, Ann. Ist. Super. Sanità 3: 35–44.Google Scholar
  33. Bignami, G., and De Acetis, L., 1973, An investigation on the nature of continuous avoidance deficits: Differential response to chlordiazepoxide treatment, Pharnacol. Biochem. Behay. 1: 277–283.Google Scholar
  34. Bignami, G., and Gatti, G. L., 1969, Analysis of drug effects on multiple fixed ratio 33-fixed interval 5 min in pigeons, Psychophaonacoiogia 15: 310–332.Google Scholar
  35. Bignami, G., De Acetis, L., and Gatti, G. L., 1971, Facilitation and impairment of avoidance responding by phenobarbital sodium, chlordiazepoxide and diazepam-The role of performance baselines, J. Pharmacol. Exp. Ther. 176: 725–732.Google Scholar
  36. Bignami, G., Pinto-Scognamiglio, W., and Gatti, G. L., 1974, The evaluation of the behavioural toxicity of psychotropic agents: The case of lithium, Proc. Eur. Soc. Study Drug Toxic. 15th 1973: 33–42.Google Scholar
  37. Blakely, T. A., and Parker, L. F., 1973, The effects of parachlorophenylalanine on experimentally induced conflict behavior, Pharmacol. Biochem. Behan. 1: 609–613.Google Scholar
  38. Bloch, S., Bakay Pragay, E., and Mirsky, A. F., 1973, Heart rate and respiratory rate changes during drug-induced impairment in a conditioned avoidance task in monkeys, Pharntacol. Biochem. Behay. 1: 29–34.Google Scholar
  39. Bloom, F. E. (ed.), 1975, “The Opiate Narcotics: Neurochemical Mechanisms in Analgesia and Dependence,” Pergamon, New York.Google Scholar
  40. Bobon, D. P., Janssen, P. A. J., and Bobon, J. (eds.). 1970, “The Neuroleptics”, Mod. Prob. Pharmacopsychiatry 5:1–190.Google Scholar
  41. Boldovici, J. A., and Cicala, G. A., 1968, Increased aversion thresholds in rats as a function of aspirin and meprobamate administration, Psychol. Rec. 18: 389–394.Google Scholar
  42. Bovet, D., and Gatti, G. L., 1965, Pharmacology of instrumental avoidance conditioning, Proc. 2nd Int. Pharmacol. Meet. 1963 1: 75–89.Google Scholar
  43. Bowman, R., 1966, Magnesium pemoline and behavior, Science 153:902.Google Scholar
  44. Bradley, P. B., 1963, Tranquilizers. 1. Phenothiazine derivatives, in “Physiological Pharmacology” (W. S. Root and F. G. Hofmann, eds.), Vol. I, Part A, pp. 417–472, Academic, New York.Google Scholar
  45. Brady, J. P., 1968, Drugs in behavior therapy, in “Psychopharmacology. A Review of Progress 1957–1967” (D. H. Efron, J. O. Cole, J. Levine, and J. R. Wittenborn, eds.), pp. 271–280, Superintendent of Documents, U.S. Government Printing Office (P.H.S. Publication No. 1836 ), Washington, D.C.Google Scholar
  46. Braude, M. C., Harris, L. S., May, E. L., Smith, J. P., and Villarreal, J. E. (eds.), 1974, “Narcotic Antagonists”, Adv. Biochem. Prychopharmacol. 8:1–592.Google Scholar
  47. Bremner, F. J., Cobb, H. W., and Hahn, W. C., 1970, The effect of chlordiazepoxide on the behavior of rats in a conflict situation, Psychopharmacologia 17: 275–282.Google Scholar
  48. Brick, J., Sun, J. Y., Davis, L., and Pohorecky, L. A., 1976, Ethanol and the response to electric shock in rats, Life Sci. 18: 1293–1298.Google Scholar
  49. Bryant, R. C., Petty, F., Warren, J. L., and Byrne, W. L., 1973, Facilitation by alcohol of active avoidance acquisition performance in the goldfish, Pharmacol. Biochem. Behay. 1: 523–529.Google Scholar
  50. Bucci, L., 1974, The biphasic effect of small doses of tranylcypromine on the spontaneous motor activity and learned conditioned behaviour in rats, Pharmacology 12: 354–361.Google Scholar
  51. Bucci, L., and Bovet, D., 1974, The effect of iproniazid and tranylcypromine studied with a dark-avoidance conditioned schedule, Psychopharmacologia 35: 179–188.Google Scholar
  52. Burov, Yu. V., and Speranskaya, N. P., 1973, The effect of psychotropic substances upon one among the interspecies relation forms (in Russian), Farmakol. Toksikol. (Moscow) 36: 266–268.Google Scholar
  53. Byrd, L. D., 1976, Effects of morphine alone and in combination with naloxone or d-amphetamine on shock-maintained behavior in the squirrel monkey, Psychopharmacology 49: 225–234.Google Scholar
  54. Calhoun, W. H., 1971, Central nervous system stimulants, in “Pharmacological and Biophysi- cal Agents and Behavior” (E. Furchtgott, ed.), pp. 181–268, Academic, New York.Google Scholar
  55. Cannizzaro, G., Nigito, S., Provenzano, P. M., and Vitikova, T., 1972, Modification of depressant and disinhibitory action of flurazepam during short term treatment in the rat, Psychopharmacologia 26: 173–184.Google Scholar
  56. Cappell, H., and LeBlanc, A. E., 1973, Punishment of saccharin drinking by amphetamine in rats and its reversal by chlordiazepoxide, J. Comp. Physiol. Psychol. 85: 97–104.Google Scholar
  57. Cappell, H., LeBlanc, A. E., and Endrenyi, L., 1972, Effects of chlordiazepoxide and ethanol on the extinction of a conditioned taste aversion, Physiol. Behay. 9: 167–169.Google Scholar
  58. Cappell, H., LeBlanc, A. E., and Endrenyi, L., 1973, Aversive conditioning by psychoactive drugs: Effects of morphine, alcohol and chlordiazepoxide, Psychopharmacologia 29: 239–246.Google Scholar
  59. Carlton, P. L., 1963, Cholinergic mechanisms in the control of behavior by the brain, Pssychol. Rev. 70: 19–39.Google Scholar
  60. Castellano, C., 1976, Effects of caffeine on discrimination learning, consolidation, and learned behavior in mice, Psychopharmacologp 48: 255–260.Google Scholar
  61. Castellano, C., Eleftheriou, B. E., Bailey, D. W., and Oliverio, A., 1974, Chlorpromazine and avoidance: A genetic analysis, Psychopharmacologia 34: 309–316.Google Scholar
  62. Chase, T. C., and Rescorla, R. A., 1968, The effect of magnesium pemoline on learning an active avoidance-passive avoidance discrimination, Psychon. Sei. 10: 87–88.Google Scholar
  63. Chen, C. S., 1968, A study of the alcohol-tolerance effect and an introduction of a new behavioural technique, Psychopharmacologia 12: 433–440.Google Scholar
  64. Chen, C. S., 1972, A further note on studies of acquired behavioural tolerance to alcohol, Psychopharmacologia 27: 265–274.Google Scholar
  65. Chesher, G. B., 1974, Facilitation of avoidance acquisition in the rat by ethanol and its abolition by a methyl p-tyrosine, Psychopharmacologia 39: 87–95.Google Scholar
  66. Chi, C. C., 1965, The effect of amobarbital sodium on conditioned fear as measured by the potentiated startle response in rats, Psychopharmacologia 7: 115–122.Google Scholar
  67. Chipman, H. L., 1966, The differential effects of conditioned stimulus intensity and chlorpromazine on avoidance, Psychon. Sci. 6: 413–414.Google Scholar
  68. Chisholm, D. C., and Moore, J. W., 1970, Effects of chlordiazepoxide on discriminative fear conditioning and shuttle avoidance performance in the rabbit, Psychopharmacologia 18: 162–171.Google Scholar
  69. Chisholm, D. C., Couch, J. V., and Moore, J. W., 1971, Chlordiazepoxide and aversive conditioning: Effects on acquisition and performance of the conditioned nictitating membrane response in the rabbit, Psychon. Sci. 23: 203–204.Google Scholar
  70. Chittal, S. M., and Sheth, U. K., 1963, Effect of drugs on conditioned avoidance response in rats, Arch. Int. Pharmacodyn. Ther. 44: 471–480.Google Scholar
  71. Christy, D., and Reid, L., 1975, Methods of deconditioning persisting avoidance: Amphetamine and amobarbital as adjuncts to response prevention, Bull. Psychon. Soc. 5: 175–177.Google Scholar
  72. Chute, D. L., and Wright, D. C., 1973, Retrograde state dependent learning, Science 180: 878–880.Google Scholar
  73. Cicala, G. A., and Hartley, D. L., 1967, Drugs and the learning and performance of fear, J. Comp. Physiol. Psychol. 64: 175–178.Google Scholar
  74. Clark, F. C., and Steele, B. J.,1964, Some observations on the interaction of chlorpromazine and free operant avoidance bursts, Psychopharmacologia 4:221–231.Google Scholar
  75. Clark, R., and Samuel, G. K., 1969, Drug effects on a discrete conditioned avoidance response in dogs, rhesus monkeys and rats, Psychopharmacologia 14: 106–114.Google Scholar
  76. Clody, D. E., and Beer, B., 1975, Conditioned avoidance: A predictor of efficacy and duration of action for long-acting neuroleptic agents, in “Predictability in Psychopharmacology: Preclinical and Clinical Correlations” (A. Sudilovsky, S. Gershon, and B. Beer, eds.), pp. 213–224, Raven, New York.Google Scholar
  77. Clody, D. E., Beer, B., and Lenard, L. G., 1972, Opposite behavioral effects of imidazole-4acetic acid and chlordiazepoxide on the conditioned emotional response in the rat, Proc. 80th Ann. Cony. Am. Psvchol. Assoc. 7: 825–826.Google Scholar
  78. Clouet, D. H. (ed.), 1971, “Narcotic Drugs-Biochemical Pharmacology,” Plenum, New York.Google Scholar
  79. Clouet, D. H., and Iwatsubo, K., 1975, Mechanisms of tolerance and dependence to narcotic analgesic drugs, Anon. Rev. Pharmacol. 15: 49–71.Google Scholar
  80. Cole, H. F., and Wolf, H. H., 1969, A pharmacological evaluation of a genetically predisposed conditioned avoidance response, Proc. Soc. Exp. Biol. Med. 132: 1067–1071.Google Scholar
  81. Collins, L. G., 1965, Effects of morphine sulfate on the extinction of conditioned escape behavior in the rat, Psychon. Sci. 3: 31–32.Google Scholar
  82. Conger, J. J., 1951, The effects of alcohol on conflict behavior in the albino rat, Q. J. Stud. Alcohol 12: 1–29.Google Scholar
  83. Cook, I., 1964, Effects of drugs on operant conditioning, in “Animal Behaviour and Drug Action” (H. Steinberg and A.V.S. de Reuck, eds.), pp. 23–40, Churchill, London.Google Scholar
  84. Cook, L., and Catania, A. C., 1964, Effects of drugs on avoidance and escape behavior, Fed. Proc. Fed. Am. Soc. Exp. Biol. 23: 818–835.Google Scholar
  85. Cook, L., and Davidson, A. B., 1973, Effects of behaviorally active drugs in a conflict–punishment procedure in rats, in “The Benzodiazepines” (S. Garattini, E. Mussini, and L. O. Randall, eds.), pp. 327–345, Raven, New York.Google Scholar
  86. Cook, L., and Kelleher, R. T., 1961, The interaction of drugs and behavior, Neuro-Psychopharmacol. Proc. Meet. Coll. Int. Neuro-Psychopharmacol. 2nd 1960: 77–92.Google Scholar
  87. Cook, L., and Kelleher, R. T., 1962, Drug effects on the behavior of animals, Ann. N.Y. Acad. Sci. 96: 315–335.Google Scholar
  88. Cook, L., and Sepinwall, J., 1975a, Reinforcement schedules and extrapolations to humans from animals in behavioral pharmacology, Fed. Proc. Fed. Am. Soc. Exp. Biol. 34: 1889–1897.Google Scholar
  89. Cook, L., and Sepinwall, J., 1975b, Psychopharmacological parameters of emotion, in “Emotions-Their Parameters and Measurement” (L. Levi, ed.), pp. 379–404, Raven, New York.Google Scholar
  90. Cook, L., and Sepinwall, J., 1975e, Behavioral analysis of the effects and mechanisms of action of benzodiazepines, Adv. Biochem. Psychopharmacol. 14: 1–28.Google Scholar
  91. Cook, L., and Weidley, E., 1957, Behavioral effects of some psychopharmacological agents, Ann. N.Y. Acad. Sci. 66: 740–752.Google Scholar
  92. Cooper, S., Coon, K., Mejta, C., and Reid, L., 1974, Methods of deconditioning persisting avoidance: Amphetamine, chlorpromazine, and chlordiazepoxide as adjuncts to response prevention, Physiol. Psychol. 2: 519–522.Google Scholar
  93. Corson, J. A., 1969, Magnesium pemoline: Different effects with different subject stocks, Psychon. Sci. 17: 45–46.Google Scholar
  94. Corson, S. A., and O’Leary Corson, E., 1967, Pavlovian conditioning as a method for studying the mechanism of action of minor tranquilizers, Neuro-Psycho-Pharmacol. Proc. Int. Congr. Coll. Int. Neuro-Psycho-Pharmacol. 5th 1966: 857–878.Google Scholar
  95. Costa, E., and Greengard, P. (eds.), 1975, “Mechanism of Action of Benzodiazepines”, Adv. Biochem. Psychopharmacol. 14:1–181.Google Scholar
  96. Costa, E., Guidotti, A., Mao, C. C., and Suria, A., 1975, New concepts on the mechanism of action of benzodiazepines, Life Sci. 17: 167–186.Google Scholar
  97. Cotten, M. deV. (ed.), 1975, “Symposium on Control of Drug-taking Behavior by Schedules of Reinforcement”, Pharmacol. Rev. 27:287–548.Google Scholar
  98. Courvoisier, S., Fournel, J., Ducrot, R., Kolsky, M., and Koetschet, P., 1953, Propriétés pharmacodynamiques du chlorhydrate de chloro-3 (diméthylamino-3’ propyl)-l0 phénothiazine (4560 R.P.). Etude expérimentale d’un nouveau corps utilisé dans l’anesthésie potentialisée et dans l’hibernation artificielle, Arch. Int. Pharmacodyn. Ther. 92: 305–361.Google Scholar
  99. Cox, T., 1970, The effects of caffeine, alcohol, and previous exposure to the test situation on spontaneous alternation, Psychopharmacologia 17: 83–88.Google Scholar
  100. Crismon, C., 1967, Chlorpromazine and imipramine: Parallel studies in animals, Psychopharmacol. Bull. 4(2): 1–151.Google Scholar
  101. Curtis, D. R., Game, C.J.A., and Lodge, D., 1976, Benzodiazepines and central glycine receptors, Br. J. Pharmacol. 56: 307–311.Google Scholar
  102. Cytawa, J., and Kutulas, G., 1972, Influence of chlorpromazine on emotional hyperreactivity resulting from septal forebrain injury, Psychopharmacologia 27: 389–392.Google Scholar
  103. Dallemagne, G., 1970, Action de la chlorpromazine, du méprobamate et de l’amphétamine sur trois comportements conditionnés sous contrôle aversif, Arch. Int. Pharmacodyn. Ther. 183: 46–59.Google Scholar
  104. Dallemagne, G., 1971, Traitement prolongé à la morphine chez le rat: Interaction drogue comportement dans des conditionnements sous contrôle aversif, Psychopharmacologia 20: 77–84.Google Scholar
  105. Dantzer, R., 1975a, Etude de l’activité des substances psychotropes sur le comportement de punition du porc, J. Pharmacol. 6: 323–340.Google Scholar
  106. Dantzer, R., 1975b, Absence d’effet désinhibiteur du propanolol sur le comportement de punition du porc, Thérapie 30: 585–589.Google Scholar
  107. Dantzer, R., and Baldwin, B. A., 1974, Effects of chlordiazepoxide on heart rate and behavioural suppression in pigs subjected to operant conditioning procedures, Psychopharmacologia 37: 169–177.Google Scholar
  108. Dantzer, R., and Mormede, P., 1976, Fear-dependent variations in continuous avoidance behavior of pigs. I. Lack of effect of diazepam on performance of discriminative fear conditioning, Psychopharmacology 49: 69–73.Google Scholar
  109. Dantzer, R., and Roca, M., 1974, Tranquilizing effects of diazepam in pigs subjected to a punishment procedure, Psychopharmacologia 40: 235–240.Google Scholar
  110. Dantzer, R., Mormede, P., and Favre, B., 1976, Fear-dependent variations in continuous avoidance behavior of pigs. II. Effects of diazepam on acquisition and performance of Pavlovian fear conditioning and plasma corticosteroid levels, Psychopharmacology 49: 75–78.Google Scholar
  111. Davidson, A. B., and Cook, L., 1969, Effects of combined treatment with trifluoperazine HC1 and amobarbital on punished behavior in rats, Psychopharmacologia 15: 159–168.Google Scholar
  112. Davidson, A. B., and Weidley, E., 1976, Differential effects of neuroleptic and other psychotropic agents on acquisition of avoidance in rats, Life Sci. 18: 1279–1284.Google Scholar
  113. Davies, J. A., Navaratnam, V., and Redfern, P. H., 1974, The effect of phase-shift on the passive avoidance response in rats and the modifying action of chlordiazepoxide, Br. J. Pharmacol. 51: 447–451.Google Scholar
  114. Davis, T. R. A., Kensler, C. J., and Dews, P. B., 1973, Comparison of behavioral effects of nicotine, d-amphetamine, caffeine and dimethylheptyl tetrahydrocannabinol in squirrel monkeys, Psechopharmacologia 32: 51–65.Google Scholar
  115. Davis, W. M., and Smith, T. P., 1975, Morphine enhancement of shuttle avoidance prevented by a-methyltyrosine, Psychopharmacologia 44: 95–97.Google Scholar
  116. Davis, W. M., Holbrook, J. M., and Babbini, M., 1973, Differential effects of morphine on active avoidance as a function of pre-drug performance, Pharmacol. Res. Commun. 5: 47–53.Google Scholar
  117. Delgado, J.M.R., 1973, Antiaggressive effects of chlordiazepoxide, in “The Benzodiazepines” (S. Garattini, E. Mussini, and L. O. Randall, eds.), pp. 419–432, Raven, New York.Google Scholar
  118. Delini-Stula, A., 1971, Drug-induced suppression of conditioned hyperthermic and conditioned avoidance behavior response in rats, Psychopharmacologia 20: 153–159.Google Scholar
  119. Delini-Stula, A., and Morpurgo, C., 1970, The influence of a fear evoking-situation on the rectal temperature of rats, Int. J. Psychobiol. 1: 71–75.Google Scholar
  120. Del Rio, J., 1971, Facilitating effects of some chlorpromazine-d-amphetamine mixtures on avoidance learning, Psychopharmacologia 21: 39–48.Google Scholar
  121. Di Giusto, E. L., and King, M. G., 1972, Magnesium pemoline: Enhancement of performance, Psychol. Rep. 20: 863–866.Google Scholar
  122. Dilts, S. L., and Berry, C. A., 1966, Modification of conditional behavior by prior experience: Effects of morphine and pentobarbital, Fed. Proc. Fed. Am. Soc. Exp. Biol. 25: 261 (Abstract No. 406).Google Scholar
  123. Dinsmoor, J. A., and Lyon, D. O., 1961, The selective action of chlorpromazine on behavior suppressed by punishment, Psychopharmacologia 2: 456–460.Google Scholar
  124. Dinsmoor, J. A., Bonbright, J. C., Jr., and Lilie, D. R., 1971, A controlled comparison of drug effects on escape from conditioned aversive stimulation (“anxiety”) and from continuous shock, Psychopharmacologia 22: 323–332.Google Scholar
  125. Dobrin, P. B., and Rhyne, R. L., 1969, Effects of chlorpromazine on two types of conditioned avoidance behavior, Arch. Int. Pharmacodyn. Ther. 178: 351–356.Google Scholar
  126. Doggett, N. S., and Spencer, P.S.J., 1973, Pharmacological properties of centrally-administered agents which interfere with neurotransmitter function: A comparison with the central depressant effects of ouabain, Br. J. Pharmacol. 47: 26–38.Google Scholar
  127. Domino, E. F., 1975, Role of central cholinergic mechanisms in the specific actions of narcotic agonists, in “Cholinergic Mechanisms” (P. G. Waser, ed.), pp. 433–453, Raven, New York.Google Scholar
  128. Domino, E. F., Vasko, M. R., and Wilson, A. E., 1976, Mixed depressant and stimulant actions of morphine and their relationship to brain acetylcholine, Life Sci. 18: 361–376.Google Scholar
  129. Doty, L. A., and Doty, B. A., 1963, Chlorpromazine-produced response decrements as a function of problem difficulty level, J. Comp. Physiol. Psychol. 56: 740–745.Google Scholar
  130. Editorial, 1976, Beta-blockers in anxiety and stress, Br. Med. J. 1: 415.Google Scholar
  131. Eliasson, M., and Kornetsky, C., 1972, Interaction effects of chlorpromazine and reticular stimulation on visual attention behavior in rats, Psychon. Sci. 26: 261–262.Google Scholar
  132. Eliasson, M., and Kornetsky, C., 1973, Effects of electrical stimulation of the reticular formation and chlorpromazine on performance of trace conditioned avoidance response in the rat, Pharmacol. Biochem. Behay. 1: 731–734.Google Scholar
  133. Feldman, R. S., 1968, The mechanism of fixation prevention and “dissocation” learning with chlordiazepoxide, Psychopharmacologia 12:384–399.Google Scholar
  134. Feldman, R. S., Kaada, B. R., and Langfeldt, T., 1973, Effects of septal lesions and chlordiazepoxide (Librium) on avoidance behavior in rats, Pharmacol. Biochem. Behay. 1: 379–387.Google Scholar
  135. Fibiger, H. C., Zis, A. P., and Phillips, A. G., 1975, Haloperidol-induced disruption of conditioned avoidance responding: Attenuation by prior training or by anticholinergic drugs, Eur. J. Pharmacol. 30: 309–314.Google Scholar
  136. Fielding, S., and Lal, H., 1974, “Neuroleptics,” Futura, Mount Kisco, New York.Google Scholar
  137. File, S. E., and Pope, J. H., 1974, The action of chlorpromazine on exploration in pairs of rats, Psychopharmacologia 37: 249–254.Google Scholar
  138. Fischman, M. W., Smith, R. C., and Schuster, C. R., 1976, Effects of chlorpromazine on avoidance and escape responding in humans, Pharmacol. Biochem. Behay. 4: 111–114.Google Scholar
  139. Fontaine, O., and Richelle, M., 1969, Etude comparative chez le rat des effets de la chlorpromazine et du chlordiazépoxide sur une série de programmes à renforcement positif et à renforcement négatif, Psychol. Belg. 9: 17–29.Google Scholar
  140. Fontaine, O., Libon, P., and Richelle, M., 1974, Action of a new psychotropic drug (sulpiride) on avoidance behavior in rats, Psychopharmacologia 39: 309–314.Google Scholar
  141. Foree, D. D., Moretz, F. H., and McMillan, D. E., 1973, Drugs and punished responding. II. d-Amphetamine-induced increases in punished responding, J. Exp. Anal. Behay. 20: 291–300.Google Scholar
  142. Forrest, I. S., Carr, C. J., and Usdin, E. (eds.), 1974, “Phenothiazines and Structurally Related Drugs”, Adv. Biochem. Psychopharmacol. 9:1–818.Google Scholar
  143. Fowler, H., Goldman, L., and Wischner, G. J., 1968, Sodium amytal and the shock-right intensity function for visual discrimination learning, J. Comp. Physiol. Psychol. 65: 155–159.Google Scholar
  144. Freed, E. X., 1968, Effect of alcohol on conflict behaviors, Psychol. Rep. 23: 151–159.Google Scholar
  145. Freed, E. X., 1972, Alcohol and conflict: The role of self-intoxication in a punishment discrimination by rats, Q. J. Stud. Alcohol 33: 756–768.Google Scholar
  146. Frontali, M., Amorico, L., De Acetis, L., and Bignami, G., 1976, A pharmacological analysis of processes underlying differential responding: A review and further experiments with scopolamine, amphetamine, lysergic acid diethylamide (LSD-25), chlordiazepoxide, physostigmine, and chlorpromazine, Behay. Biol. 18: 1–74.Google Scholar
  147. Fukuda, S., and Iwahara, S., 1976, State-dependent learning produced by chlordiazepoxide and its transfer at different dose levels, Psychopharinacology 48: 193–198.Google Scholar
  148. Fuller, J. L., 1966, Variation in effects of chlorpromazine in three strains of mice, Psychopharmacologia 8: 408–414.Google Scholar
  149. Fuller, J. L., 1970, Strain differences in the effects of chlorpromazine and chlordiazepoxide upon active and passive avoidance in mice, Psychopharmacologia 16: 261–271.Google Scholar
  150. Garattini, S., Mussini, E., and Randall, L. O. (eds.), 1973, “The Benzodiazepines,” Raven, New York.Google Scholar
  151. Gatti, G. L., 1957, Azione dei farmaci tranquillanti sui vari tipi di comportamento del ratto condizionato, in “Psychotropic Drugs” (S. Garattini and V. Ghetti, eds.), pp. 125–135, Elsevier, Amsterdam.Google Scholar
  152. Gatti, G. L., 1961, Caratteristiche psicofarmacologiche di alcuni farmaci recentemente introdotti nella terapia delle malattie mentali. Tecnica della “lever pressing avoidance” con contemporanea registrazione dell’efficienza e del numero delle risposte operative, del numero delle punizioni e del tipo di reazione, Riv. Sperim. Freniatria Med. Leg. Alien. Ment. 85: 496–503.Google Scholar
  153. Gatti, G. L., 1967, Comparative conditioning studies of drugs in laboratory animals, Neuro- Psycho-Pharmacol. Proc. Int. Congr. Coll. Int. Neuro-Psycho-Pharmacol. 5th 1966: 840–847.Google Scholar
  154. Gatti, G. L., and Bovet, D., 1963, Analysis of the action of the psychotropic drugs in a “lever pressing avoidance” conditioning, in “Psychopharmacological Methods” (Z. Votava, M. Horvath, and O. Vinar, eds.), pp. 50–57, Pergamon, Oxford.Google Scholar
  155. Geller, I., 1962, Use of approach avoidance behavior (conflict) for evaluating depressant drugs, in “Psychosomatic Medicine” (J. H. Nodine and J. H. Moyer, eds.), pp. 267–274, Lea and Febiger, Philadelphia.Google Scholar
  156. Geller, I., 1964, Relative potencies of benzodiazepines as measured by their effects on conflict behavior, Arch. Int. Pharmacodvn. Ther. 149: 243–247.Google Scholar
  157. Geller, I., 1966, Psychopharmacology of tybamate, J. Psychopharmacol. 1: 47–55.Google Scholar
  158. Geller, I., and Seifter, J., 1960, The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat, Psychopharmacologia 1: 482–492.Google Scholar
  159. Geller, I., and Seifter, J., 1962, The effects of mono-urethans, di-urethans and barbiturates on a punishment discrimination, J. Pharmacol. Exp. Ther. 136: 284–288.Google Scholar
  160. Geller, I., Kulak, J. T., Jr., and Seifter, J., 1962, The effects of chlordiazepoxide and chlorpromazine on a punishment discrimination, Psychopharmacologia 3: 374–385.Google Scholar
  161. Geller, I., Bachman, E., and Seifter, J., 1963, Effects of reserpine and morphine on behavior suppressed by punishment, Life Sci. 2: 226–231.Google Scholar
  162. Geller, I., Croy, D. J., and Ryback, R. S., 1974, Effects of ethanol and sodium Phenobarbital on conflict behavior of goldfish (Carassins auratus), Pharmacol. Biochem. Behay. 2: 545–548.Google Scholar
  163. Gibbins, R. J., Kalant, H., LeBlanc, A. E., and Clark, J. W., 1971, The effects of chronic administration of ethanol on startle thresholds in rats, Psychopharmacologia 19: 95–104.Google Scholar
  164. Gilbert, R. M., 1976, Caffeine as a drug of abuse, Res. Adv. Alcohol Drug Prob. 3:49–176. Glasky, A. J., and Simon, L. N., 1966, Magnesium pemoline: Enhancement of brain RNA polymerases, Science 151: 702–703.Google Scholar
  165. Gliedman, L. H., and Gantt, W. H., 1956, The effects of reserpine and chlorpromazine on orienting behavior and retention of conditioned reflexes, South. Med. J. 49: 880–888.Google Scholar
  166. Glowa, J. R., and Barrett, J. E., 1976, Effects of alcohol on punished and unpunished responding of squirrel monkeys, Pharmacol. Biochem. Behay. 4: 169–173.Google Scholar
  167. Goldwurm, G. F., 1961, Discussion second symposium, Neuro-Psychopharmacol. Proc. Meet. Coll. Int. Neuro-Psychopharmacol. 2nd 1960: 134–136.Google Scholar
  168. Göpfert, E., Haschke, W., and Sinz, R., 1968, Die Wirkung von Pentobarbital auf die Konsolidierungsphase bedingter Abwehrreflexe, Acta Biol. Med. Ger. 21: 345–351.Google Scholar
  169. Gordon, M. (ed.), 1967a, “Psychopharmacological Agents,” Vol II, Academic, New York. Gordon, M., 1967b, Appendix A. Phenothiazine bibliographies, in “Psychopharmacological Agents” (M. Gordon, ed.), Vol. II, pp. 305–474, Academic, New York.Google Scholar
  170. Gordon, M. (ed.), 1974, “Psychopharmacological Agents,” Vol. 1II, Academic, New York.Google Scholar
  171. Gray, J. A., 1977, Drug effects on fear and frustration: Possible limbic site of action of minor tranquilizers, in “Handbook of Psychopharmacology. Section Two. Behavioral Pharmacology in Animals” (L. L. Iversen, S. Iversen, and S. H. Snyder, eds.), pp. 433–527, Plenum, New York.Google Scholar
  172. Grossman, S. P., 1961, Effects of chlorpromazine and perphenazine on bar-pressing perfor-mance in an approach-avoidance conflict, J. Comp. Physiol. Psychol. 54: 517–521.Google Scholar
  173. Grossman, S. P., 1968, Behavioral and electrophysiological effects of intracranial microinjections of phenothiazines, Commun. Behay. Biol. 1: 9–17.Google Scholar
  174. Grossman, S. P., and Miller, N. E., 1961, Control for stimulus-change in the evaluation of alcohol and chlorpromazine as fear-reducing drugs, Psychopharmacologia 2: 342–351.Google Scholar
  175. Groves, P. M., Wilson, C. J., Young, S. J., and Rebec, G. V., 1975, Self-inhibition by dopaminergic neurons, Science 190: 522–529.Google Scholar
  176. Gurowitz, E. M., Lubar, J. F., Ain, B. R., and Gross, D. A., 1967, Disruption of passive avoidance learning by magnesium pemoline, Psychon. Sci. 8: 19–20.Google Scholar
  177. Häfliger, F., and Burckhardt, V., 1964, Iminodibenzyl and related compounds, in “Psycho- pharmacological Agents” (M. Gordon, ed.), Vol. I, pp. 35–101, Academic, New York.Google Scholar
  178. Hanson, H. M., Witoslaswki, J. J., and Campbell, E. H., 1967, Drug effects in squirrel monkeys trained on a multiple schedule with a punishment contingency, J. Exp. Anal. Behay. 10: 565–569.Google Scholar
  179. Hanson, H. M., Stone, C. A., and Witoslawski, J. J., 1970, Antagonism of the antiavoidance effects of various agents by anticholinergic drugs, J. Pharmacol. Exp. Ther. 173: 117–124.Google Scholar
  180. Harris, A. H., Oppel, W. C., Jr., and Brady, J. P., 1974, Narcotic and narcotic antagonist effects upon baboons responding under fixed ratio and variable interval schedules of reinforcement, Fed. Proc. Fed. Am. Soc. Exp. Biol. 33: 516 (Abstract No. 1722).Google Scholar
  181. Hearst, E., 1964, Drug effects on stimulus generalization gradients in the monkey, Psychopharmacologia 6: 57–70.Google Scholar
  182. Hecht, K., 1967, The importance of different conditioned-reflex experimental situations (light-dark; silence-noise; escape-feeding) for the effect of different centrally acting drugs (psychopharmaca), Neuro-Psycho-Pharmacol. Proc. Int. Congr. Coll. Int. NeuroPsycho-Pharmacol. 5th 1966: 848–856.Google Scholar
  183. Hecht, K., Treptow, K., Poppei, M., and Hecht, T., 1968, Zur Abhängigkeit pharmakologischer Effekte von der Umgebungshelligkeit, Acta. Biol. Med. Ger. 20: 757–772.Google Scholar
  184. Hecht, K., Treptow, K., and Hecht, T., 1969, Zur Abhängigkeit pharmakologischer Effekte vom Geräuschpegel, Acta Biol. Med. Ger. 23: 121–132.Google Scholar
  185. Heise, G. A., and Boff, E., 1962, Continuous avoidance as a base-line for measuring behavioral effects of drugs, Psychopharmacologia 3: 264–282.Google Scholar
  186. Heise, G. A., and McConnell, H., 1961, Differences between chlordiazepoxide-type and chlorpromazine-type action in “trace” avoidance, Proc. World Congr. Psychiatry 3rd: 917–921.Google Scholar
  187. Henriksson, B. G., and Järbe, T., 1971, Effects of diazepam on conditioned avoidance learning in rats and its transfer to normal state conditions, Psychopharmacologia 20: 186–190.Google Scholar
  188. Herman, S. J., Freeman, B. J., and Ray, O. S., 1972, The effects of multiple injections of morphine sulfate on shuttle-box behavior in the rat, Psychopharmacologia 26: 146–154.Google Scholar
  189. Herz, A., 1960, Drugs and the conditioned avoidance response, Int. Rev. Neurobiol. 2: 229–277.Google Scholar
  190. Hidalgo, J., Tarleton, W. A., DiLeo, R. J., and Thompson, C. R., 1968, Effects of drugs on the cardiac conditioned responses of dogs, Behay. Res. Thee. 6: 461–471.Google Scholar
  191. Hill, H. E., Pescor, F. T., Belleville, R. E., and Wikler, A., 1957, Use of differential bar-pressing rates of rats for screening analgesic drugs. I. Techniques and effects of morphine, J. Pharmacol. Exp. Thee. 120: 388–397.Google Scholar
  192. Hill, H. E., Belleville, R. E., Pescor, F. T., and Wikler, A., 1966, Comparative effects of methadone, meperidine and morphine on conditioned suppression, Arch. Int. PharmacodNn. Ther. 163: 341–352.Google Scholar
  193. Hill, H. E., Bell, E. C., and Wikler, A., 1967, Reduction of conditioned suppression: Actions of morphine compared with those of amphetamine, pentobarbital, nalorphine, cocaine, LSD-25 and chlorpromazine, Arch. Int. Pharmacodyn. Ther. 165: 212–226.Google Scholar
  194. Holloway, F. A., 1972, State-dependent effects of ethanol on active and passive avoidance learning, Psychopharmacologia 25: 238–261.Google Scholar
  195. Holmgren, H., 1964, Conditioned avoidance reflex under pentobarbital, Bol. Inst. Est. Med. Biol. 22: 21–38.Google Scholar
  196. Holtzman, S. G., 1974a, Tolerance to the stimulant effects of morphine and pentazocine on avoidance responding in the rat, Psychopharmacologia 39: 23–37.Google Scholar
  197. Holtzman, S. G., 1974b, Behavioral effects of profadol in the rat, Psychopharmacologia 34: 135–142.Google Scholar
  198. Holtzman, S. G., 1974e, Effects of nalorphine on avoidance behavior and locomotor activity in the rat, Arch. Int. Pharmacodyn. Ther. 212: 199–204.Google Scholar
  199. Holtzman, S. G., 1976, Effects of morphine and narcotic antagonists on avoidance behavior of the squirrel monkey, J. Pharmacol. Exp. Thee. 196: 145–155.Google Scholar
  200. Holtzman, S. G., and Jewett, R. E., 1971, Interactions of morphine and nalorphine with physostigmine on operant behavior in the rat, Psychopharmacologia, 22: 384–395.Google Scholar
  201. Holtzman, S. G., and Jewett, R. E., 1972a, Shock intensity as a determinant of the behavioral effects of morphine in the rat, Life Sci. 11(1): 1085–1091.Google Scholar
  202. Holtzman, S. G., and Jewett, R. E., 1972b, Some actions of pentazocine on behavior and brain monoamines in the rat, J. Pharmacol. Exp. Ther. 181: 346–356.Google Scholar
  203. Holtzman, S. G., and Jewett, R. E., 1973, Stimulation of behavior in the rat by cyclazocine: effects of naloxone, J. Pharmacol. Exp. Ther. 87: 380–390.Google Scholar
  204. Holtzman, S. G., and Villarreal, J. E., 1969, The effects of morphine on conditioned suppression in rhesus monkeys, Psychon. Sci. 17: 161–162.Google Scholar
  205. Holtzman, S. G., and Villarreal, J. E., 1973, Operant behavior in the morphine-dependent rhesus monkey, J. Pharmacol. Exp. Ther. 184: 528–541.Google Scholar
  206. Houser, V. P., 1975a, The alteration of aversive thresholds after chronic administration of two tranquilizing agents, Behay. Biol. 12: 383–392.Google Scholar
  207. Houser, V. P., 1975b, The effects of meprobamate upon the aversive threshold of rats, Bull. Psychon. Soc. 6: 325–326.Google Scholar
  208. Houser, V. P., 1976, The effects of chlorpromazine upon fear-motivated behavior in the squirrel monkey, Physiol. Psyclul. 4: 189–194.Google Scholar
  209. Houser, V. P., and Cash, R. J., 1975, The effects of chronic morphine administration upon a modified Sidman avoidance schedule that utilizes response-independent shock, Psychopharmacologia 41: 255–262.Google Scholar
  210. Houser, V. P., and Paré, W. P., 1973, Analgesic potency of sodium salicylate, indomethacin, and chlordiazepoxide as measured by the spatial preference technique in the rat, Psychopharmacologia 32: 121–131.Google Scholar
  211. Houser, V. P., and Van Hart, D. A., 1974, The effect of chlorpromazine and imipramine on the aversive threshold of rats, Physiol. Psychol. 2: 333–336.Google Scholar
  212. Houser, V. P., Rothfeld, B., and Varady, A., Jr., 1975, Effects of chlordiazepoxide upon fear-motivated behavior in dogs, Psychol. Rep. 36: 987–998.Google Scholar
  213. Houser, V. P., Rothfelcl, B., and Varady, A., Jr., 1976, Effects of chlorpromazine on fear-motivated behavior, urinary cortisol, urinary volume and heart rate in the dog, Psychol. Rep. 38: 299–308.Google Scholar
  214. Hunt, H. F., 1956, Some effects of drug on classical (Type S) conditioning, Ann. N.Y. Acad. Sci. 65: 258–267.Google Scholar
  215. Ruppert, F. A., and Iversen, S. D., 1975, Response suppression in rats: A comparison of response-contingent and noncontingent punishment and the effect of the minor tranquilizer, chlordiazepoxide, Psychopharmacologia 44: 67–75.Google Scholar
  216. Irwin, S., 1960, Factors influencing sensitivity to stimulant and depressant drugs affecting (A) locomotor and (B) conditioned avoidance behavior in animals, in “The Dynamics of Psychiatric Drug Therapy” (G. J. Sarwer-Foner, ed.), pp. 5–22, Thomas, Springfield, Illinois.Google Scholar
  217. Irwin, S., 1961, Correlation in rats between the locomotor and avoidance suppressant potencies of eight phenothiazine tranquilizers, Arch. Int. Pharmacodyn. Ther. 132: 279–286.Google Scholar
  218. Irwin, S., 1966, Considerations for the pre-clinical evaluation of new psychiatric drugs: A case study with phenothiazine-like tranquilizers, Psychopharmacologia 9: 259–287.Google Scholar
  219. Iversen, L. L., 1975, Dopamine receptors in the brain, Science 188: 1084–1089.Google Scholar
  220. Iversen, L. L., Iversen, S. D., and Snyder, S. H., (eds.), 1975, “Handbook of Psychopharmacology. Section One. Basic Neuropharmacology,” Vols. 1–6, Plenum, New York.Google Scholar
  221. Iwahara, S., 1971, Effects of drug-state changes upon two-way shuttle avoidance responses in rats, treated with chlordiazepoxide or placebo, Japan. Psychol. Res. 13: 207–218.Google Scholar
  222. Iwahara, S., and Matsushita, K., 1971, Effects of drug-state changes upon black white discrimination learning in rats, Psychopharmacologia 19: 347–358.Google Scholar
  223. Iwahara, S., and Noguchi, S., 1972, Drug-state dependency as a function of overtraining in rats, japan. Psychol. Res. 14: 141–144.Google Scholar
  224. Iwahara, S., Iwasaki, T., and Hasegawa, Y., 1968, Effects of chlorpromazine and homofena- zinc upon a passive avoidance response in rats, Psychopharmacologia 13: 320–331.Google Scholar
  225. Iwasaki, T., Iwahara, S., and Nomura, S. I., 1966, Effect of chlorpromazine and pentobarbital upon shock-and fear-motivated behavior in mice, Psychol. Rep. 19: 63–70.Google Scholar
  226. Iwasaki, T., Katayama, M., and Iwahara, S., 1968, Differential effects of chlorpromazine upon passive avoidance response in rats under two types of shock treatment. Japan. Psychol. Res. 10: 191–198.Google Scholar
  227. Iwasaki, T., Ezawa, K., and Iwahara, S., 1976, Differential effects of chlordiazepoxide on simultaneous and successive brightness discrimination learning in rats, Psychopharmacol-ogy 48: 75–78.Google Scholar
  228. Izquierdo, I., 1974, Effect on pseudoconditioning of drugs with known central nervous system activity, Psychopharmacologia 38: 259–266.Google Scholar
  229. Izquierdo, J. A., Merlo, A. B., Chemerinski, E., and Billiet, M., 1974, Effects of ethanol and sherry on the performance of a conditioned response in the rat, Pharmacol. Biochem. Behan. 2: 317–323.Google Scholar
  230. Jackson, J., Pylkko, O., Butler, W., and Easterday, O., 1964, Comparison of four centrally acting drugs in two avoidance tasks, Fed. Proc. Fed. Am. Soc. Exp. Biol. 23: 103 (Abstract No. 16).Google Scholar
  231. Jacob, J., Lafille, C., Loiseau, G., Echinard-Garin, P., and Barthelemy, C., 1964, Drogues hallucinogènes et onirogènes. Recherches concernant la caractérization et la différenciation pharmacologique des drogues hallucinogènes (dérivés indoliques et mescaline, nalorphine, anticholinergiques centraux, phencyclidine), Encéphale 53: 520–535.Google Scholar
  232. Jacobsen, E., 1965, Experimental neurosis as a method for screening of psychotropic drugs, Proc. 2nd Int. Pharmacol. Meet. 1963 1: 181–192.Google Scholar
  233. Jankú, I., 1964, The influence of delayed and immediate exposure to trials upon the effect of chlorpromazine on conditioned avoidance behaviour, Psychopharmacologia 6: 280–285.Google Scholar
  234. Janssen, P.A.J., 1965, The evolution of butyrophenones, haloperidol and trifluperidol, from meperidine-like 4-phenylpiperidines, Int. Rev. Neurobiol. 8: 221–263.Google Scholar
  235. Janssen, P.A.J., Niemegeers, C.J.E., and Schellekens, K.H.L., 1966, Is it possible to predict the clinical effects of neuroleptic drugs (major tranquilizers) from animal data? Part III: The subcutaneous and oral activity in rats and dogs of 56 neuroleptic drugs in the jumping box test, Arzneim. Forsch. 16: 339–346.Google Scholar
  236. Jarosch, E., and Nitsch, F. M., 1968, Experimente über “paradoxe” Wirkungen von Tranquilizern im Tierversuch. Einfluss von Diazepam (Valium Roche) auf Konflikt-verhalten bei Totenkopfäffchen (Saimiri sciureus), Int. Pharmacopsychiatry 1: 168–183.Google Scholar
  237. Johnson, F. N., 1969, The effects of chlorpromazine on the decay and consolidation of short-term memory traces in mice, Psychopharmacologia 16: 105–114.Google Scholar
  238. Johnson, F. N., 1970a, The effects of chlorpromazine on one-trial passive avoidance learning in mice: further examination of pre-and post-learning administration, Psychopharmacologia 18: 11–18.Google Scholar
  239. Johnson, F. N., 1970b, The effects of chlorpromazine on the expression of an acquired passive avoidance response in mice, Psychopharmacologia 18: 333–345.Google Scholar
  240. Johnson, F. N., 197la, Stimulus significance and chlorpromazine-induced impairment of avoidance learning in mice, Neuropharmacology 10: 9–14.Google Scholar
  241. Johnson, F. N., 1971 b, Stimulus significance and chlorpromazine effects on the expression of avoidance learning in mice, Neuropharmacology 10: 267–272.Google Scholar
  242. Johnson, F. N., 1975a, Behavioural and cognitive effects of lithium: Experiments and observations, in “Lithium Research and Therapy” (F. N. Johnson, ed.) pp. 315–337, Academic, New York.Google Scholar
  243. Johnson, F. N., 1975b, Behavioural and cognitive effects of lithium: Mechanisms, in “Lithium Research and Therapy” (F. N. Johnson, ed.), pp. 339–350, Academic, New York.Google Scholar
  244. Johnson, F. N., 1976, The effect of lithium chloride on one-trial passive avoidance learning in rats, Br. J. Pharmacol 56: 87–91.Google Scholar
  245. Julou, L., 1972, Etude expérimentale des neuroleptiques injectables à action prolongée, Actual. Pharmacol. 25: 22–59.Google Scholar
  246. Kähling, J., Ziegler, H., and Ballhause, H., 1975, Zentrale Wirkungen von WA 335-BS, einer Substanz mit peripherer Antiserotonin- und Antihistamin-Wirkung, Arzneim, Forsch. 25: 1737–1744.Google Scholar
  247. Kalant, H., LeBlanc, A. E., and Gibbins, R. J., 1971, Tolerance to, and dependence on, some non-opiate psychotropic drugs, Pharmacol. Rev. 23: 135–191.Google Scholar
  248. Kamano, D. K., 1972, Using drugs to modify the effect of response prevention on avoidance extinction, Behay. Res. Ther. 10: 367–370.Google Scholar
  249. Kamano, D. K., 1973a, Extinction of unsignaled shuttlebox avoidance and the effect exerted subsequently by a conditioned fear stimulus as a function of amobarbital, Psychopharmacologia 28: 45–50.Google Scholar
  250. Kamano, D. K., 1973b, Effects of stimulus associated with amobarbital administration on avoidance behavior, Physiol. Psychol. 1: 321–323.Google Scholar
  251. Kamano, D. K., and Arp, D. J., 1964, Effects of chlordiazepoxide (Librium) on the acquisition and extinction of avoidance responses, Psychopharmacologia 6: 112–119.Google Scholar
  252. Kamano, D. K., and Martin, L. K., 1967, Effects of amobarbital, chlordiazepoxide and chlorpromazine administered following shock trauma, Prychol. Rep. 21: 247–248.Google Scholar
  253. Kamano, D. K., Powell, B. J., Martin, L. K., and Ogle, M. E., 1967, Amobarbital effects on extinction and spontaneous recovery of active avoidance, Psychol. Rec. 17: 97–102.Google Scholar
  254. Karasawa, T., Furukawa, K., Yoshida, K., and Shimizu, M., 1976, Effect of theophylline on monoamine metabolism in the rat brain, Eur. J. Pharmacol. 37: 97–104.Google Scholar
  255. Karoly, A. J., Domino, E. F., and Walker, E. L., 1964, Differential effects of various drugs on the conditioned motor and heart rate responses in dogs resistant to extinction, Arch. Int. Pharmacodyn. Ther. 148: 40–52.Google Scholar
  256. Kelleher, R. T., and Morse, W. H., 1964, Escape behavior and punished behavior, Fed. Proc. Fed. Am. Soc. Exp. Biol. 23: 808–817.Google Scholar
  257. Kelleher, R. T., and Morse, W. H., 1968, Determinants of the specificity of behavioral effects of drugs, Ergeb. Physiol. Biol. Chem. Exp. Pharmakol. 60: 1–56.Google Scholar
  258. King, A. R., 1970, Drive related effects of amylobarbitone and chlorpromazine on appetitive and aversively controlled behavior in the rat, Physiol. Behay. 5: 1365–1371.Google Scholar
  259. Kornetsky, C., and Bain, G., 1965, The effects of chlorpromazine and pentobarbital on sustained attention in the rat, Psychopharmacologia 8: 277–284.Google Scholar
  260. Kornetsky, C., and Eliasson, M., 1969, Reticular stimulation and chlorpromazine: An animal model for schizophrenia overarousal, Science 165: 1273–1274.Google Scholar
  261. Kornetsky, C., and Eliasson, M., 1970, Reticular stimulation and chlorpromazine, Science 168: 1123.Google Scholar
  262. Kosterlitz, H. W., and Waterfield, A. A., 1975, In vitro models in the study of structure-activity relationships of narcotic analgesics, Annu. Rev. Pharmakol. 15: 29–47.Google Scholar
  263. Kulkarni, A. S., 1972, Avoidance acquisition and CNS stimulants, Naunyn-Schmiedeberg’s Arch. Pharmacol. 273: 394–400.Google Scholar
  264. Kumar, R., 1971a, Extinction of fear II: Effects of chlordiazepoxide and chlorpromazine on fear and exploratory behaviour in rats, Psychopharmacologia 19: 297–312.Google Scholar
  265. Kumar, R., 1971b, Extinction of fear I: Effects of amylobarbitone and dexamphetamine given separately and in combination on fear and exploratory behaviour in rats, Psychopharmacologia 19: 163–187.Google Scholar
  266. Kuschinsky, K., 1976, Actions of narcotics on brain dopamine metabolism and their relevance for “psychomotor” effects, Arzneim. Forsch. 26: 563–567.Google Scholar
  267. Lader, M., 1974, The peripheral and central role of the catecholamines in the mechanisms of anxiety, Int. Pharmacopsychiatry 9: 125–137.Google Scholar
  268. Lahti, R. A., and Barsuhn, C., 1974, The effect of minor tranquilizers on stress-induced increases in rat plasma corticosteroids, Psychopharmacologia 35: 215–220.Google Scholar
  269. Lahti, R. A., and Barsuhn, C., 1975, The effect of various doses of minor tranquilizers on plasma corticosteroids in stressed rats, Res. Commun. Chem. Pathol. Pharmacol. 11: 595–603.Google Scholar
  270. Lai, H., 1975, Narcotic dependence, narcotic action and dopamine receptors, Life Sci. 17: 483–496.Google Scholar
  271. Lal, S., Missala, K., and Sourkes, T. L., 1971, Effect of neuroleptics on brain amphetamine concentrations in the rat, J. Pharm. Pharmacol. 23: 967–969.Google Scholar
  272. Lashley, K. S., 1917, The effects of strychnine and caffeine upon the rate of learning, Psychobiology 1: 141–169.Google Scholar
  273. Latz, A., Kornetsky, C., and Bain, G., 1967, Changes in conditioned behavior under chlorpromazine and damphetamine as a function of the motivational characteristics and parametric values of the tests, Neuro-Psycho-Pharmacol. Proc. Int. Congr. Coll. Int. NeuroPsycho-Pharmacol 5th 1966: 1003–1007.Google Scholar
  274. Lauener, H., 1963, Conditioned suppression in rats and the effect of pharmacological agents thereon, Psychopharmacologia 4: 311–325.Google Scholar
  275. Leaf, R. C., and Muller, S. A., 1965, Effects of shock intensity, deprivation, and morphine in a simple approach-avoidance conflict situation, Psychol. Rep. 17: 819–823.Google Scholar
  276. Leander, J. D., 1976, Effects of d-amphetamine, pentobarbital, chlorpromazine and promazine on electric shock postponement responding by the pigeon, J. Pharmacol. Exp. Ther. 198: 4–11.Google Scholar
  277. Leander, J. D., McMillan, D. E., and Ellis, F. W., 1976, Ethanol and isopropanol effects on schedule-controlled responding, Psychopharmacology 47: 157–164.Google Scholar
  278. LeBlanc, A. E., Kalant, H., Gibbins, R. J., and Berman, N. D., 1969, Acquisition and loss of tolerance to ethanol by the rat, J. Pharmacol. Exp. Ther. 168: 244–250.Google Scholar
  279. LeBlanc, A. E., Gibbins, R. J., and Kalant, H., 1973, Behavioral augmentation of tolerance to ethanol in the rat, Psychopharmacologia 30: 117–122.Google Scholar
  280. Lepore, F., Ptito, M., Freibergs, V., and Guillemot, J-P., 1974, Effects of low doses of chlorpromazine on a conditioned emotional response in the rat, Psychol. Rep. 34: 231–237.Google Scholar
  281. Liberson, W. T., Feldman, R. S., and Ellen, P., 1959, The behavioral analysis of the effects of meprobamate as compared with other tranquilizers and electro-convulsive shock, NeuroPsychopharmacol. Proc. Int. Congr. 1st 1958: 351–357.Google Scholar
  282. Lipper, S., and Kornetsky, C., 1971, Effect of chlorpromazine on conditioned avoidance as a function of CS-US interval length, Psychopharmacologia 22: 144–150.Google Scholar
  283. Low, L. A., Eliasson, M., and Kornetsky, C., 1966, Effect of chlorpromazine on avoidance acquisition as a function of CS-US interval length, Psychopharmacologia 10: 148–154.Google Scholar
  284. Ludwig, B. J., and Potterfield, J. R., 1971, The pharmacology of propanediol carbamates, Adv. Pharmacol. Chemother. 9: 173–240.Google Scholar
  285. Lyubimov, B. I., 1972, Influence of neuroleptics of the phenothiazine series introduced into the hippocampus on the conditioned defense reflex (in Russian), Farmakol. Toksikol. (Moscow) 35: 653–657.Google Scholar
  286. Maclnnes, J. W., and Uphouse, L. P., 1973, Effects of alcohol on acquisition and retention of passive-avoidance conditioning in different mouse strains, J. Comp. Physiol. Psychol. 84: 398–402.Google Scholar
  287. Maffii, G., 1959a, The secondary conditioned response of rats and the effects of some psychopharmacological agents, J. Pharm. Pharmacol. 11: 129–139.Google Scholar
  288. Maffii, G., 1959b, Influenza dell’amfetamina, atropina e caffeina sull’apprendimento dei riflessi condizionati di salvaguardia (primario e secondario) nel ratto, Farmaco Ed. Sci 14: 425–439.Google Scholar
  289. Maickel, R. P., Cox, R. H., Jr., Miller, F. P., Segal, D. S., and Russell, R. W., 1969, Correlation of brain levels of drugs with behavioral effects, J. Pharmacol. Exp. Ther. 165: 216–224.Google Scholar
  290. Malhotra, C. L., and Costa, E. (eds.), 1975, “Studies of Narcotic Drugs”, Neuropharmacology 14:893–949.Google Scholar
  291. Marcy, R., and Quermonne, M. A., 1975, Benzodiazepines: A comparison of their effects in mice on the magnitude of the pal mar skin conductivity response and on pentylenetetrazole-induced seizures, Experientia 31: 954–955.Google Scholar
  292. Margules, D. L., and Stein, L., 1967, Neuroleptics vs. tranquilizers: Evidence from animal behavior studies of mode and site of action, Neuro-Psychopharmacol. Proc. Int. Congr. Coll. Int. Neuro-Psycho-Pharmacol. 5th 1966: 108–120.Google Scholar
  293. Margules, D. L., and Stein, L., 1968, Increase of “anti-anxiety” activity and tolerance of behavioral depression during chronic administration of oxazepam, Psychopharnzacologia 13: 74–80.Google Scholar
  294. Maser, J. D., and Hammond, L. J., 1972, Disruption of a temporal discrimination by the minor tranquilizer, oxazepam, Psychopharmacologia 25: 69–76.Google Scholar
  295. Masserman, J. H., 1957, Stress situations in animals and the nature of conflict, in “Neuro-pharmacology, Transactions of the Third Conference, 1956, Princeton” (H. A. Abramson, ed.), pp. 147–167, Josiah Macy Jr. Foundation, New York.Google Scholar
  296. Masserman, J. H., 1959, Behavioral pharmacology in animals, Neuro-Psychopharmacol. Proc. Int. Congr. 1st 1958: 97–107.Google Scholar
  297. Masserman, J. H., and Yum, K. S., 1946, An analysis of the influence of alcohol on experimental neuroses in cats, Psychosom. Med. 8: 36–52.Google Scholar
  298. Matthysse, S. W., and Kety, S. S. (eds.), 1975, “Catecholamines and Schizophrenia,” Perga-mon, Oxford.Google Scholar
  299. Maxwell, D. R., and Palmer, H. T., 1961, Demonstration of antidepressant or stimulant properties of imipramine in experimental animals, Nature (London) 191: 84–85.Google Scholar
  300. Maxwell, D. R., Palmer, H. T., and Ryall, R. W., 1961, A comparison of the analgesic and some other central properties of methotrimeprazine and morphine, Arch. Int. Pharmacodyn. Ther. 132: 60–73.Google Scholar
  301. McGaugh, J. L., 1973, Drug facilitation of learning and memory, Anew. Rev. Pharmacol. 13: 229–241.Google Scholar
  302. McGaugh, J. L., and Petrinovich, L. F., 1965, Effects of drugs on learning and memory, Int. Rev. Neurobiol. 8: 139–196.Google Scholar
  303. McKearney, J. W., 1974, Effects of d-amphetamine, morphine and chlorpromazine on responding under fixed-interval schedules of food presentation or electric shock presentation, J. Pharmacol. Exp. Ther. 190: 141–153.Google Scholar
  304. McMillan, D. E., 1973a, Drugs and punished responding. IV: Effects of propanolol, ethchlorvynol and chloral hydrate, Res. Commun. Chem. Pathol. Pharmacol. 6: 167–174.Google Scholar
  305. McMillan, D. E., 1973b, Drugs and punished responding. I: Rate-dependent effects under multiple schedules, J. Exp. Anal. Behay. 9: 133–145.Google Scholar
  306. McMillan, D. E., 1973e, Drugs and punished responding. III: Punishment intensity as a determinant of drug effect, Psychopharmacologia 30: 61–74.Google Scholar
  307. McMillan, D. E., 1975, Determinants of drug effects on punished responding, Fed. Proc. Fed. Am. Soc. Exp. Biol. 34: 1870–1879.Google Scholar
  308. McMillan, D. E., 1976, Drugs and punished responding. VI: Body weight as a determinant of drug effects, Res. Commun. Chem. Pathol. Pharmacol. 13: 1–7.Google Scholar
  309. McMillan, D. E., and Leander, J. D., 1975, Drugs and punished responding. V. Effects of drugs on responding suppressed by response-dependent and response-independent electric shock, Arch. Int. Pharmacodyn. Ther. 213: 22–27.Google Scholar
  310. Mehar, G. S., Parker, J. M., and Tubas, T., 1974, Interaction between alcohol, minor tranquilizers and morphine, Int. J. Clin. Pharmacol. Ther. Toxicol. 9: 70–74.Google Scholar
  311. Miczek, K. A., 1973a, Effects of scopolamine, amphetamine and chlordiazepoxide on punishment, Psychopharmacologia 28: 373–389.Google Scholar
  312. Miczek, K. A., 1973b, Effects of scopolamine, amphetamine and benzodiazepines on conditioned suppression, Pharmacol. Biochem. Behay. 1: 401–411.Google Scholar
  313. Miczek, K. A., and Lau, P., 1975, Effects of scopolamine, physostigmine and chlordiazepoxide on punished and extinguished water consumption in rats, Psychopharmacologia 42: 263–269.Google Scholar
  314. Millenson, J. R., and Leslie, J., 1974, The conditioned emotional response (CER) as a baseline for the study of anti-anxiety drugs, Neuropharmacology 13: 1–9.Google Scholar
  315. Miller, N. E., 1956, Effects of drugs on motivation: The value of using a variety of measures, Ann. N.Y. Acad. Sci. 65: 318–333.Google Scholar
  316. Miller, N. E., 1957, Objective techniques for studying motivational effects of drugs on animals, in “Psychotropic Drugs” (S. Garattini and V. Ghetti, eds.), pp. 83–103, Elsevier, Amsterdam.Google Scholar
  317. Miller, N. E., 1961, Some recent studies of conflict behavior and drugs, Am. Psychol. 16: 12–24.Google Scholar
  318. Miller, N. E., 1964, The analysis of motivational effects illustrated by experiments on amylobarbitone sodium, in “Animal Behaviour and Drug Action” (H. Steinberg and A.V.S. de Reuck, eds.), pp. 1–18, Churchill, London.Google Scholar
  319. Miller, N. E., 1966, Some animal experiments pertinent to the problem of combining psychotherapy with drug therapy, Compr. Psychiatry 7: 1–12.Google Scholar
  320. Miller, N. E., and Barry, H., III, 1960, Motivational effects of drugs: Methods which illustrate some general problems in psychopharmacology, Psychopharmacologia 1: 169–199.Google Scholar
  321. Miller, N. E., and Miles, W. R., 1936, Alcohol and removal of reward. An analytical study of rodent maze behavior. J. Comp. Psychol. 21: 179–204.Google Scholar
  322. Miller, R. E., Murphy, J. V., and Mirsky, I. A., 1957, The effect of chlorpromazine on fear-motivated behavior in rats, J. Pharmacol. Exp. Ther. 20: 379–387.Google Scholar
  323. Mirsky, A. F., Tecce, J. J., Harman, N., and Oshima, H., 1975, EEG correlates of impaired attention performance under secobarbital and chlorpromazine in the monkey, Psychopharmacologia 41: 35–41.Google Scholar
  324. Misslin, R., 1971, Actions de 1’imipramine sur une réaction conditionnée d’évitement chez le poisson rouge, C.R. Acad. Sci. D. 272: 2352–2355.Google Scholar
  325. Mitchell, C. L., 1966, The effect of drugs on the latency for an escape response elicited by electrical stimulation of the tooth pulp in cats, Arch. Int. Pharmacodyn. Ther. 164: 427–434.Google Scholar
  326. Moller-Nielsen, I., Fjalland, B., Pedersen, V., and Nymark, M., 1974, Pharmacology of neuroleptics upon repeated administration, Psychopharmacologia 34: 95–104.Google Scholar
  327. Monti, J. M., and Hance, A. J., 1967, Effects of haloperidol and trifluperidol on operant behavior in the rat, Psychopharmacologia 12: 34–43.Google Scholar
  328. Morpurgo, C., 1965, Drug-induced modifications of discriminated avoidance behavior in rats, Psychopharmacologia 8: 91–99.Google Scholar
  329. Morrison, C. F., 1969, The effects of nicotine on punished behaviour, Psychopharmacologia 14: 221–232.Google Scholar
  330. Morrison, C. F., and Stephenson, J. A., 1970, Drug effects on a measure of unconditioned avoidance in the rat, Psychopharmacologia 18: 133–143.Google Scholar
  331. Morrison, C. F., and Stephenson, J. A., 1972, Drug effects on unconditioned light-avoidance in the rat, Psychopharmoacologia 24: 456–461.Google Scholar
  332. Morse, W. H., 1964, Effect of amobarbital and chlorpromazine on punished behavior in the pigeon, Psychopharmacologia 6: 286–294.Google Scholar
  333. Niemegeers, C.J.E., 1962, A new technique for studying the inhibitory effects of drugs on discriminatory avoidance escape behaviour in rats, Int. J. Neuropharmacol. 1: 79–83.Google Scholar
  334. Niemegeers, C.J.E., Verbruggen, F. J., and Janssen, P.A.J., 1969a, The influence of various neuroleptic drugs on shock avoidance responding in rats. I. Nondiscriminated Sidman avoidance procedure, Psychopharmacologia 16: 161–174.Google Scholar
  335. Niemegeers, C.J.E., Verbruggen, F. J., and Janssen, P.A.J., 1969b, The influence of various neuroleptic drugs on shock avoidance responding in rats. II. Nondiscriminated Sidman avoidance procedure with alternate reinforcement and extinction periods and analysis of the interresponse times (IRT’s), Psychopharmacologia 16: 175–182.Google Scholar
  336. Nigro, M. R., 1967, Chlorpromazine-induced suppression in appetitive and avoidance responding as a function of shock intensity, Psychol. Rep. 21: 61–69.Google Scholar
  337. Noble, W., and Delini-Stula, A., 1976, Effect of oxprenolol on some fear-induced behavioral responses and hyperthermia in rats subjected to inescapable shocks, Psychopharmacology 49: 17–22.Google Scholar
  338. Oishi, H., Iwahara, S., Yang, K-M., and Yogi, A., 1972, Effects of chlordiazepoxide on passive avoidance responses in rats, Psychopharmacologia 23: 373–385.Google Scholar
  339. Olds, M. E., 1966, Facilitatory action of diazepam and chlordiazepoxide on hypothalamic reward behavior, J. Comp. Physiol. Psychol. 62: 136–140.Google Scholar
  340. Oliverio, A., Castellano, C., Renzi, P., and Sansone, M., 1973, Decreased sensitivity of septal mice to impairment of two-way avoidance by chlorpromazine, Psychopharmacologia 29: 13–20.Google Scholar
  341. Orzach, M. H., Taylor, C. L., and Kornetsky, C., 1968, A research report on the anti-fatigue effects of magnesium pemoline, Psychopharmacologia 13: 413–417.Google Scholar
  342. Owen, J. E., Jr., and Rathbun, R. C., 1967, Effects of long, intermittent schedules on phenothiazine-induced avoidance loss, Psychopharmacologia 12: 24–33.Google Scholar
  343. Pautler, E. L., and Clark, G., 1961, The effect of chlorpromazine on the discrimination between intermittent photic stimulation and a steady light in normal and brain-damaged cats, J. Comp. Physiol. Psychol. 54: 493–497.Google Scholar
  344. Pepeu, G., and Nistri, A., 1974, Interaction between morphine and neurotransmitters in the central nervous system, in “Recent Advances on Pain” U. J. Bonica, P. Procacci, and C. A. Pagni, eds.), pp. 64–81, Thomas, Springfield, Illinois.Google Scholar
  345. Petty, F., Bryant, R. C., and Byrne, W. L., 1973, Dose-related facilitation by alcohol of avoidance acquisition in the goldfish, Pharmacol. Biochem. Behan. 1: 173–176.Google Scholar
  346. Phillips, M. I., 1970, Drug effects on direct reticular activation, Proc. 78th Ann. Cony. Am. Psychol. Ass. 5: 815–816.Google Scholar
  347. Phillips, M. I., and Bradley, P. B., 1970, Reticular stimulation and chlorpromazine, Science 168: 1122–1123.Google Scholar
  348. Pirch, J. H., and Norton, S., 1966, “Rebound” increase in fixed-interval lever pressing following a single dose of chlorpromazine in septal rats, J. Psycho-Pharmacol. 1:16–26.Google Scholar
  349. Plotnikoff, N., 1966, Magnesium pemoline: Enhancement of learning and memory of a conditioned avoidance response, Science 151: 703–704.Google Scholar
  350. Plotnikoff, N. P., 1973, Pemoline: Enhancement of maze performance in young rats, Behan. Biol. 9: 177–121.Google Scholar
  351. Plotnikoff, N., Will, F., and Ditzler, W., 1969, Stimulant activity of pemoline and magnesium hydroxide, Arch. Int. Pharmacocl_yn. Ther. 181: 441–458.Google Scholar
  352. Pohorecky, L A., Cagan, M., Brick, J., and Jaffe, L. S., 1976, The startle response in rats: effect of ethanol, Pharmacol. Biochem. Behay. 4: 311–316.Google Scholar
  353. Polidora, V. J., and Urbanek, R. J., 1964, Drug effects upon visual signal-from-noise detection by monkeys, Psychon. Sci. 1: 237–238.Google Scholar
  354. Posluns, D., 1962, An analysis of chlorpromazine-induced suppression of the avoidance response, Psychopharmacologia 3: 361–373.Google Scholar
  355. Pringsheim, J., 1908, Chemische Untersuchungen über das Wesen der Alkoholtoleranz, Biochem. Z. 12: 143–192.Google Scholar
  356. Pusakulich, R. L., and Nielson, H. C., 1972, Neural thresholds and state-dependent learning, Exp. Neurol. 34: 33–44.Google Scholar
  357. Raitt, J. R., Nelson, J. W., and Tye, A., 1961, Effect of chlorpromazine on septal hyperactivity in the rat, Br. J. Pharmacol. 17: 473–478.Google Scholar
  358. Randall, L. O., Schallek, W., Sternbach, L. H., and Ning, R. Y., 1974, Chemistry and pharmacology of the 1,4-benzodiazepines, in “Psychopharmacological Agents” (M. Gordon, ed.), Vol. III, pp. 175–281, Academic, New York.Google Scholar
  359. Ray, O. S., 1963, The effects of tranquilizers on positively and negatively motivated behavior in rats, Psychopharmacologia 4: 326–342.Google Scholar
  360. Ray, O. S., and Bivens, L. W., 1967, Phenothiazine depression of approach and avoidance behavior, Psychopharmacologia 10: 196–203.Google Scholar
  361. Reitz, R. H., Bocknik, S. E., and Kulkarni, A. S., 1972, A comparison of Mg pemoline and (+)-amphetamine effects upon avoidance behaviour and the amine pump, J. Pharm. Pharmacol. 24: 830–832.Google Scholar
  362. Reynolds, G. S., and Van Sommers, P., 1960, Effects of ethyl alcohol on avoidance behavior, Science 132: 42–43.Google Scholar
  363. Robichaud, R. C., Sledge, K. L., Hefner, M. A., and Goldberg, M. E., 1973, Propanolol and chlordiazepoxide on experimentally induced conflict and shuttlebox performance in rodents, Psychopharmacologia 32: 157–160.Google Scholar
  364. Robinson, E., 1965, The effect of chlorpromazine on fear-motivated behavior of amygdalectomized rats, Psychol. Rec. 15: 211–216.Google Scholar
  365. Ross, N., and Monti, J. M., 1971, Effects of haloperidol, trifluperidol, nitrazepam and chlordiazepoxide upon conditioned midbrain behavioral responses, Psychopharmacologia 22: 31–44.Google Scholar
  366. Rudy, T. A., and Wolf, H. H., 1967, Relation of chlorpromazine-evoked hypothermia to disruption of conditioned avoidance-escape behavior, J. Pharmacol. Exp. Ther. 156: 397–406.Google Scholar
  367. Sachs, E., Weingarten, M., and Klein, N. W., Jr., 1966, Effects of chlordiazepoxide on the acquisition of avoidance learning and its transfer to the normal state and other drug conditions, Psychopharmacologia 9: 17–30.Google Scholar
  368. Sahgal, A., and Iversen, S. D., 1975, Colour preferences in the pigeon: A behavioural and psychopharmacological study, Psychopharmacologia 43: 175–179.Google Scholar
  369. Sanger, D. J., and Blackman, D. E., 1976, Effects of chlordiazepoxide, ripazepam, and d-amphetamine on conditioned acceleration of timing behaviour in rats, Psychopharmacology 48: 209–215.Google Scholar
  370. Sansone, M., 1975a, Facilitation of avoidance learning by chlordiazepoxide-amphetamine combinations in mice, Psychopharmacologia 41: 117–121.Google Scholar
  371. Sansone, M., 19756, Effects of chlordiazepoxide, CNS stimulants and their combinations on avoidance behaviour in mice, Arch. Int. Pharmacodyn. Ther. 215: 190–196.Google Scholar
  372. Sansone, M., 1975c, Benzodiazepines and amphetamine on avoidance behaviour in mice, Arch. Int. Pharmacodyn. Ther. 218: 125–132.Google Scholar
  373. Sansone, M., and Messeri, P., 1974, Strain differences on the effects of chlordiazepoxide and chlorpromazine in avoidance behaviour of mice, Pharmacol. Res. Commun. 6: 179–185.Google Scholar
  374. Sansone, M., Renzi, P., and Messeri, P., 1972, Effects of monoamino oxidase inhibitors on shuttle-box avoidance behaviour of hamsters, Pharmacol. Res. Commun. 4: 357–362.Google Scholar
  375. Santacana, M. P., Sanchez, E., and Munoz, M. C., 1976, Effects of the administration of two doses of sulpiride on the behaviour of the rat, Neuropharmacology 15: 415–420.Google Scholar
  376. Satinder, K. P., 1971, Genotype-dependent effects of d-amphetamine sulphate and caffeine on escape-avoidance behavior of rats, J. Comp. Physiol. Psychol. 76: 359–364.Google Scholar
  377. Satinder, K. P., 1976, Differential effects of morphine on two-way avoidance in selectively bred rat strains, Psychopharmacology 48: 235–237.Google Scholar
  378. Schenker, E., and Herbst, H., 1963, Phenothiazine and Azaphenothiazine als Heilmittel, Prog. Drug Res. 5: 269–627.Google Scholar
  379. Schoenfeld, R. I., 1971, Melatonin: Effect on punished and nonpunished operant behavior in the pigeon, Science 171: 1258–1260.Google Scholar
  380. Sedvall, G., and Uvnäs, B. (eds.), 1975, “Antipsychotic Drugs, Pharmacodynamies and Pharmacokinetics,” Pergamon, Oxford.Google Scholar
  381. Sepinwall, J., Grodsky, F. S., Sullivan, J. W., and Cook, L., 1973, Effects of propanolol and chlordiazepoxide on conflict behavior in rats, Psychopharmacologia 31: 375–382.Google Scholar
  382. Setier, P., Sarau, H., and McKenzie, G., 1976, Differential attenuation of some effects of haloperidol in rats given scopolamine, Eur. J. Pharmacol. 39: 117–126.Google Scholar
  383. Siegel, S., 1975, Evidence from rats that morphine tolerance is a learned response, J. Comp. Physiol. Psychol. 89: 498–506.Google Scholar
  384. Siegel, S., 1976, Morphine analgesic tolerance: its situation specificity supports a Pavlovian conditioning model, Science 193: 323–325.Google Scholar
  385. Skinner, B. F., and Heron, W. T., 1937, Effects of caffeine and benzedrine upon conditioning and extinction, Psychol. Rec. 1: 340–346.Google Scholar
  386. Snyder, S. H., 1975, The glycine synaptic receptor in the mammalian central nervous system. Br. J. Pharmacol. 53: 473–484.Google Scholar
  387. Snyder, S. H., and Bennett, J. P., Jr., 1976, Neurotransmitter receptors in the brain: Biochemical identification, Annu. Rev. Physiol. 38: 153–175.Google Scholar
  388. Solyom, L., Enesco, H. E., and Beaulieu, C., 1968, The effect of RNA, uric acid and caffeine on conditioning and activity in rats, J. Psychiatric Res. 6: 175–183.Google Scholar
  389. Soubrié, P., Schoonhoed, L., Simon, P., and Boissier, J. R., 1972, Conflict behavior in a heated-floor maze: Effects of oxazepam, Psychopharmacologia 26: 317–320.Google Scholar
  390. Stark, P., and Henderson, J. K., 1966, Differentiation of classes of neurosedatives using rats with septal lesions, Int. J. Neuropharmacol. 5: 385–389.Google Scholar
  391. Stein, L., and Berger, B. D., 1969, Paradoxical fear-increasing effects of tranquilizers: Evidence of repression of memory in the rat, Science 166: 253–256.Google Scholar
  392. Stein, L., and Wise, C. D., 1974, Serotonin and behavioral inhibition, Adv. Biochem. Psychopharmacol. 11: 281–291.Google Scholar
  393. Stein, L., Wise, C. D., and Berger, B. D., 1973, Anti-anxiety action of benzodiazepines: Decrease in activity of serotonin neurons in the punishment system, in “The Benzodiazepines” (S. Garattini, E. Mussini, and L. O. Randall, eds.), pp. 299–326, Raven, New York.Google Scholar
  394. Steiner, S. S., Fitzgerald, H. L., and Taber, R. I., 1967, Effects of chlordiazepoxide on acquisition and extinction of shuttle box and pole-climb avoidance, The Pharmacologist 9: 200 (Abstract No. 92).Google Scholar
  395. Steinert, H. R., Holtzman, S. G., and Jewett, R. E., 1973, Some agonistic actions of the morphine antagonist levallorphan on behavior and brain monoamines in the rat, Psychopharmacologia 31: 35–48.Google Scholar
  396. Sternbach, L. H., Randall, L. O., and Gustafson, S. R., 1964, 1,4-benzodiazepines (chlordiazepoxide and related compounds), in “Psychopharmacological Agents” (M. Gordon, ed.), Vol. I. pp. 137–224, Academic, New York.Google Scholar
  397. Stille, G., Ackermann, H., Eichenberger, E., and Lauener, H., 1965, The pharmacological properties of a potent neurotropic compound from the dibenzothiazepine group, Int. J. Neuropharmacol. 4: 375–391.Google Scholar
  398. Stitzer, M., 1974, Comparison of morphine and chlorpromazine effects on moderately and severely suppressed punished responding in the pigeon, J. Pharmacol. Exp. Ther. 191: 172–178.Google Scholar
  399. Stock, G., Heinemann, H., and Bergande, F., 1976, Changes in excitability of amygdaloid and septal nuclei induced by medazepam hydrochloride, Psychopharmacologia 46: 197–203.Google Scholar
  400. Stone, G. C., 1964a, Effects of drugs on nondiscriminated avoidance behavior. I. Individual differences in dose-response relationships, Psychopharmacologia 6: 245–255.Google Scholar
  401. Stone, G. C., 1964b, Dosing order and depression of avoidance behavior by chlorpromazine, Psychol. Rep. 15: 175–178.Google Scholar
  402. Stone, G. C., 1965, Effects of drugs on avoidance behavior. II. Individual differences in susceptibilities, Psychopharmacologia 7: 283–302.Google Scholar
  403. Stone, G. S., Leung, K. C., and Hine, C. H., 1966, Effects of alcohol, drugs, and lowered environmental temperatures on conditioned avoidance response in rats, Toxicol. App. Pharmacol. 8: 357 (Abstract No. 64).Google Scholar
  404. Taber, R. I., Latranyi, M. B., and Steiner, S. S., 1967, Prevention of extinction of an active avoidance response by “anti-anxiety” agents, Pharmacologist 9: 200 (Abstract No. 91).Google Scholar
  405. Taeschler, M., and Cerletti, A., 1961, Inhibition of emotional reactions by phenothiazine tranquilizers, Nature (London) 190: 1014–1015.Google Scholar
  406. Takaori, S., Yada, N., and Mori, G., 1969, Effects of psychotropic agents on Sidman avoidance response in good-and poor-performed rats, Japan. J. Pharmacol. 19: 587–596.Google Scholar
  407. Theobald, W., Büch, O., Delini-Stula, A., Eigenmann, R., and Levin, P., 1968, Pharmakologische Untersuchungen zur Wirkung von Neuroleptica am Tier nach einmaliger and wiederholter Applikation, Arzneim. Forsch. 18: 1491–1495.Google Scholar
  408. Thompson, T., and Pickens, R. (eds.), 1971, “Stimulus Properties of Drugs,” AppletonCentury-Crofts, New York.Google Scholar
  409. Torres, A., 1961, Anxiety versus escape conditioning and tranquilizing action, J. Comp. Physiol. Psychol. 54: 349–353.Google Scholar
  410. Trafton, C. L., 1973, Effects of injected or orally ingested opiate drugs on conditioned avoidance response learning in rats, Physiol. Psychol. 1: 364–368.Google Scholar
  411. Ts’o, T.O.T., and Chenoweth, M. B., 1976, Comparison between chronic chlordiazepoxide treatment and shock removal in a conflict situation in rats, Neuropharmacology 15: 99–101.Google Scholar
  412. Tye, N. C., Sahgal, A., and Iversen, S. D., 1977, Benzodiazepines and discrimination behaviour: Dissociation of response and sensory factors, Psychopharmacology 52: 191–194.Google Scholar
  413. Umemoto, M., and Olds, M. E., 1975, Effects of chlordiazepoxide, diazepam and chlorpromazine on conditioned emotional behaviour and conditioned neuronal activity in limbic, hypothalamic and geniculate regions, Neuropharmacology 14: 413–425.Google Scholar
  414. Uryvaev, Yu. V., and Gamaleya, A. A., 1973, Pharmacological analysis of disturbances of directed behaviour in intact and lobectomized dogs (in Russian), Byull. Eksp. Bui. Med. 75 (2): 14–16.Google Scholar
  415. Usdin, E., and Bunney, W. E. (eds.), 1975, “Pre-and Postsynaptic Receptors,” Dekker, New York.Google Scholar
  416. Vogel, J. R., 1975, Conditioning of taste aversion by drugs of abuse, unpublished review paper.Google Scholar
  417. Vogel, J. R., Beer, B., and Clody, D. E., 1971, A simple and reliable conflict procedure for testing anti-anxiety agents, Psychopharmacologia 21: 1–7.Google Scholar
  418. Waddington, J. L., and Olley, J. E., 1977, Dissociation of the antipunishment activities of chlordiazepoxide and atropine using two heterogeneous passive avoidance tasks, Psycho-pharmacology 52: 93–96.Google Scholar
  419. Waldeck, B., 1975, Effect of caffeine on locomotor activity and central catecholamine mechanisms: A study with special reference to drug interaction, Acta Pharmacol. Toxicol. Suppl. 36 (IV): 1–23.Google Scholar
  420. Waller, M. B., and Waller, P. F., 1962, Effects of chlorpromazine on appetitive and aversive components of a multiple schedule, J. Exp. Anal. Behay. 5: 259–264.Google Scholar
  421. Weissman, A., 1959, Differential drug effects upon a three-ply multiple schedule of reinforcement, J. Exp. Anal. Behay. 2: 271–287.Google Scholar
  422. Weissman, A., 1973, Behavioral pharmacology of phlorophenylalanine, in “Serotonin and Behavior” (J. Barchas and E. Usdin, eds.), pp. 235–248, Academic, New York.Google Scholar
  423. Weller, C. P., Ibrahim, I., and Sulman, F. G., 1968, Analgesic profile of tranquilizers in multiple screening tests in mice, Arch. Int. Pharmacodyn. Ther. 176: 176–192.Google Scholar
  424. Wikler, A., and Masserman, J. H., 1943, Effects of morphine on learned adaptive responses and experimental neuroses in cats, Arch. Neurol. Psychiatry 50: 401–404.Google Scholar
  425. Wiley, R. G., Dilts, S. L., and Berry, C. A., 1971, Modification of conflict behavior by prior experience: Effects of scheduling and pentobarbital, Arch. Int. Pharmacodyn. Ther. 192: 231–237.Google Scholar
  426. Winter, J. C., 1972, Comparison of chlordiazepoxide, methysergide, and cinanserin as modifiers of punished behavior and as antagonists of N,N-dimethyltryptamine, Arch. Int. Pharmacodyn. Ther. 197: 147–159.Google Scholar
  427. Wojtczak-Jaroszowa, J., 1964, Conditioning and tranquilizing action. I. The effect of tranquilizing drugs on conditioned reflex type II activity following transformation of an alimentary CS into a defense CS, Acta. Biol. Exp. (Warsaw) 24: 37–45.Google Scholar
  428. Wolf, H. H., Swinyard, E. A., and Clark, L. D., 1962, The differential effects of chlorpromazine and pentobarbital on two forms of conditioned avoidance behavior in Peromyscus maniculatus gracilis, Psychopharmacologia 3: 438–448.Google Scholar
  429. Wray, S. R., 1972, A correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats, Psychopharmacologia 26: 29–43.Google Scholar
  430. Wray, S. R., 1973a, Possible catecholamine mediation of levallorphan-induced behavioural disruption in rats, Psychopharmacologia 30: 251–262.Google Scholar
  431. Wray, S. R., 1973b, Interaction of stress and psychotomimetic drug-action: Possible implication for psychosis, Psychopharmacologia 30: 263–268.Google Scholar
  432. Wray, S. R., and Cowan, A., 1971a, The effects of naloxone, chlorpromazine, and haloperidol pretreatment on levallorphan-induced disruption of rat’s operant behaviour, Psychopharmacologia 22: 261–270.Google Scholar
  433. Wray, S. R., and Cowan, A., 197 lb, The behavioural effects of levallorphan, cyprenorphine (M285) and amphetamine on repeated Y-maze performance in rats, Psychopharmacologia 21: 257–267.Google Scholar
  434. Wright, D. C., and Chute, D. L., 1973, State dependent learning produced by post trial intrathoracic administration of sodium pentobarbital, Psychopharmacologia 31: 91–94.Google Scholar
  435. Wright, D. C., Chute, D. L., and McCollum, G. C., 1974, Reversible sodium pentobarbital amnesia in one trial discrimination learning, Pharmacol. Biochenz. Behay. 2: 603–606.Google Scholar
  436. Wuttke, W., and Kelleher, R. T., 1970, Effects of some benzodiazepines on punished and unpunished behavior in the pigeon, J. Pharnzacol. Exp. Ther. 172: 397–405.Google Scholar
  437. Wyatt, R. J., 1976, Biochemistry and schizophrenia (Part IV). The neuroleptics-their mechanism of action: A review of the biochemical literature, Psychopharmacol. Bull. 12 (3): 5–50.Google Scholar
  438. Yamaguchi, K., and Iwahara, S., 1974, Effects of chlordiazepoxide upon differential heart rate conditioning in rats, Psychopharmacologia 39: 71–79.Google Scholar
  439. Yen, H.C.Y., Krop, S., Mendez, H. C., and Katz, M. H., 1970, Effects of some psychoactive drugs on experimental “neurotic” (conflict induced) behavior in cats, Pharmacology 3: 32–40.Google Scholar
  440. Yeudall, L. T., Poley, W., and Royce, J. R., 1969, Effect of magnesium pemoline on avoidance conditioning and intertrial activity in two inbred strains of mice, Psychen. Sci. 17: 299–301.Google Scholar
  441. Zirkle, C. L., and Kaiser, C., 1964, Monoamine oxidase inhibitors (nonhydrazines), in “Psychopharmacological Agents” (M. Gordon, ed.) Vol. I. pp. 445–554, Academic, New York.Google Scholar
  442. Ziskind, D. Amit, Z., and Baum, M., 1974, Resistance to extinction of an avoidance response in rats following the administration of chlordiazepoxide (Librium) or diazepam (Valium), Psychopharmacologia 38: 231–238.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Giorgio Bignami
    • 1
  1. 1.Laboratorio di FarmacologiaIstituto Superiore di SanitàRomaItaly

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