Monoamines and Aversively Motivated Behaviors

  • David A. V. Peters
  • Hymie Anisman
  • Bruce A. Pappas


The role of the monoamines, norepinephrine (NE), dopamine (DA), and serotoin (5-HT), has been evaluated across numerous behavioral situations, ranging from apparently simple response patterns, e.g., locomotor activity, to complex ones involving associations between stimulus events and response consequences. Not surprisingly, theorizing concerning the relations between monoamines and behavior has extended beyond models involving infrahuman animals, and has been employed to account for a variety of aberrant human behaviors.


Tyrosine Hydroxylase Passive Avoidance Tryptophan Hydroxylase Avoidance Performance Aversive Behavior 


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  1. Aghajanian, G. K., 1972, Chemical feedback regulation of serotonin-containing neurons in brain, Ann. N.Y. Acad. Sci. 193: 86–94.Google Scholar
  2. Aghajanian, G. K., and Gallager, D. W., 1975, Raphe origin of serotonergic neurons terminating in the cerebral ventricles, Brain Res. 88: 221–231.Google Scholar
  3. Aghajanian, G. K., and Haigler, H. J., 1975, Hallucinogenic indoleamines: Preferential action upon presynaptic serotonin receptors, Psychopharmacology 1: 619–629Google Scholar
  4. Aghajanian, G. K., Bloom, F. E., and Sheard, M. H., 1969, Electron microscopy of degeneration within the serotonin pathway of rat brain, Brain Res. 13: 266–273.Google Scholar
  5. Aghajanian, G. K., Haigler, H. J., and Bloom, F. E., 1972, Lysergic acid diethylamide and serotonin: Direct actions on serotonin-containing neurons in rat brain, Life Sci. 11: 615–622.Google Scholar
  6. Ahlenius, S., 1973, Inhibition of catecholamine synthesis and conditioned avoidance acquisition, Pharmacol. Biochem. Behay. 1: 347–350.Google Scholar
  7. Ahlenius, S., 1974, Effects of L-dopa on conditioned avoidance responding after behavioral suppression by a-methyltyrosine or reserpine in mice, Neuropharmacology 13: 729–739.Google Scholar
  8. Ahlenius, S., and Engel, J., 1971, Behavioural and biochemical effects of L-DOPA after inhibition of dopamine-ß-hydroxylase in reserpine pretreated rats, Naunyn Schmiedelherg’s Arch. Pharmacol. 270: 349–360.Google Scholar
  9. Ahlenius, S., and Engel, J., 1974, Antagonism by DL-threo-DOPS of the suppression of a conditioned avoidance response induced by a dopamine-ß-hydrosylase inhibitor, J. Neural Transm. 34: 267–277.Google Scholar
  10. Ahlenius, S., and Engel, J., 1975, Antagonism by haloperidol of the L-dopa-induced disruption of a successive discrimination in the rat. J. Neural. Transm. 36: 43–49.Google Scholar
  11. Ahlenius, S., Carlsson, A., and Engel, J., 1975, Antagonism by baclophen of the d-amphetamine-induced disruption of a successive discrimination in the rat, J. Neural. Trans. 36: 327–333.Google Scholar
  12. Alexander, G. J., Kopeloff, L. M., and Alexander, R. B., 1971, Anticonvulsive effect of pchlorophenylalanine in audiosensitive mice, Life Sci. 10 (1): 877–882.Google Scholar
  13. Allen, C., Allen, B. S., and Rake, A. V., 1974, Pharmacological distinctions between “active” and “passive” avoidance memory formation shown by manipulation of biogenic amine active compounds, Psychopharmacologia 34: 1–10.Google Scholar
  14. Alpers, H. S., and Shore, P. A., 1969, Specific binding of reserpine —association with norepinephrine depletion, Biochem. Pharmacol. 18: 1363–1372.Google Scholar
  15. Amaral, D. G., and Foss, J. A., 1975, Locus coeruleus lesions and learning, Science 188: 377–378.Google Scholar
  16. Anden, N. E., Dahlstrom, A., Fuxe, K., Larsson, K., and Ungerstedt, U., 1966, Ascending monoamine neurons to the telecephalon and diencephalon, Acta Physiol. Scantl. 67: 313326.Google Scholar
  17. Anden, N. E., Corrodi, H., Fuxe, K., and Hökfelt, T., 1968, Evidence for a central 5hydroxytryptamine receptor stimulation by lysergic acid diethylamide, Br. J. Pharmacol. Chemother. 34: 1–7.Google Scholar
  18. Anden, N. E., Butcher, S. G., Corrodi, H., Fuxe, K., and Ungerstedt, U., 1970, Receptor activity and turnover of dopamine and noradrenaline after neuroleptics, Eur.J. Pharmacol. 11: 303–314.Google Scholar
  19. Anden, N., Strombom, U., and Svensson, T. H., 1973, Dopamine and noradrenaline receptor stimulation: Reversal of reserpine-induced suppression of motor activity, Psychopharmacologia 29: 289–298.Google Scholar
  20. Angeletti, P. V., 1971, Chemical sympathectomy in newborn animals, Neuropharmacology 10: 55–59.Google Scholar
  21. Anisman, H., 1975a, Time dependent variations in aversively motivated behaviors: Nonassociative effects of cholinergic and catecholaminergic activity, Psychol. Rev. 82: 359–385.Google Scholar
  22. Anisman, H., 1975b, Differential effects of scopolamine and d-amphetamine on avoidance: Strain interactions, Pharmacol. Biochem. Behay. 3: 809–817.Google Scholar
  23. Anisman, H., 1975c, Effects of scopolamine and d-amphetamine on one-way shuttle and inhibitory avoidance: A diallel analysis in mice, Pharmacol. Biochem. Behay. 3: 1037–1042.Google Scholar
  24. Anisman, H., 1975d, Acquisition and reversal learning of an active avoidance response in three strains of mice, Behay. Biol. 14: 51–58.Google Scholar
  25. Anisman, H., 1976, Effects of scopolamine and d-amphetamine on locomotor activity before and after shock: A diallel analysis in mice, Psychopharmacology 48: 165–173.Google Scholar
  26. Anisman, H., and Cygan, D., 1975, Central effects of scopolamine and d-amphetamine on locomotor activity: Interaction with strain and stress variables, Neuropharmacology 14: 835–840.Google Scholar
  27. Anisman, H., and Kokkinidis, L., 1974, Effects of central and peripheral adrenergic and cholinergic modification on time dependent processes in avoidance performance, Behay. Biol. 10: 161–171.Google Scholar
  28. Anisman, H., and Kokkinidis, L., 1975, Effects of scopolamine, d-amphetamine and other drugs affecting catecholamines on spontaneous alternation and locomotor activity in mice, Psychopharmacologia 45: 55–64.Google Scholar
  29. Anisman, H., and Waller, T. G., 1971, Effects of methamphetamine and shock duration during inescapable shock exposure on subsequent active and passive avoidance,,. Comp. Physiol. Psychol. 77: 143–151.Google Scholar
  30. Anisman, H., Wahlsten, D., and Kokkinidis, L., 1975, Effects of d-amphetamine and scopolamine on activity before and after shock in three mouse strains, Pharmacol. Biochem. Behay. 3: 819–824.Google Scholar
  31. Anisman, H., Kokkinidis, L., Glazier, S., and Remington, G., 1976, Differentiation of response biases elicited by scopolamine and d-amphetamine: Effects on habituation, Behay. Biol. 18: 401–417.Google Scholar
  32. Anlezark, G. H., Crow, T. J., and Greenway, A. P., 1973, Impaired learning and decreased cortical norepinephrine after bilateral locus coeruleus lesion, Science 181: 682–684.Google Scholar
  33. Aprison, M. H., and Hingtgen, J. N., 1966, Neurochemical correlates of behavior. V. Differential effects of drugs on approach and avoidance behavior in rats with related changes in brain serotonin and norepinephrine, Recent Adv. Biol. Psychiatry 8: 87–100.Google Scholar
  34. Aprison, M. H., and Hingtgen, J. N., 1969, Brain acetylcholine and excitation in avoidance behavior, Biol. Psychiat. 1: 87–89.Google Scholar
  35. Aprison, M. H., and Hingtgen, J. N., 1970, Evidence of a central cholinergic mechanism functioning during drug-induced excitation in avoidance behavior, in “Drugs and Cholinergic Mechanisms in the CNS” (E. Heilbronn and A. Winter, eds.), pp. 543–560, Forsvarets Forskning-Sansalt, Stockholm.Google Scholar
  36. Aprison, M. H., Hingtgen, J. N., and McBride, W. J., 1975, Serotonergic and cholinergic mechanisms during disruption of approach and avoidance behavior, Fed. Proc. Fed. Am. Soc. Exp. Biol. 34: 1813–1822.Google Scholar
  37. Asher, I. M., and Aghajanian, G. K., 1974, 6-hydroxydopamine lesions of olfactory tubercles and caudate nuclei: Effect on amphetamine-induced stereotyped behaviour in rats, Brain Res. 82: 1–12.Google Scholar
  38. Aunis, D., Miras-Portugal, M. T., and Mandel, P., 1973, Inhibition of adrenal dopamine-ßhydroxylase by 6-hydroxydopamine, Biochem. Pharmacol. 22: 2581–2589.Google Scholar
  39. Axelrod, J., and Tomchick, R., 1958, Enzymatic O-methylation of epinephrine and other catechols, J. Biol. Chem. 233: 702–705.Google Scholar
  40. Azzaro, A. J., and Rutledge, C. O., 1973, Selectivity of release of norepinephrine, dopamine and 5-hydroxytryptamine by amphetamine in various regions of rat brain, Biochem. Pharmacol. 22: 2801–2813.Google Scholar
  41. Baldessarini, R. J., and Kopin, I. J., 1967, The effect of drugs on the release of norepinephrine-H3 from central nervous system tissues by electrical stimulation in vitro, J. Pharmacol. Exp. Ther. 156: 31–38.Google Scholar
  42. Baldessarini, R. J., and Griffith, F. F., 1976, Acute increases by p-chlorophenylalanine of apomorphine-induced stereotyped behavior in the rat, Psychopharmacology 48: 91–95.Google Scholar
  43. Banerjee, U., and Lin, G. S., 1973, On the mechanism of central action of amphetamine: The role of catecholamines, Neuropharmacology 12: 917–931.Google Scholar
  44. Barrett, R. J., and Steranka, L. R., 1974, Analysis of d-amphetamine produced facilitation of avoidance acquisition in rats and performance changes subsequent to drug termination, Life Sci. 14: 163–180.Google Scholar
  45. Barrett, R. J., Leith, N. J., and Ray, O. S., 1973, A behavioral and pharmacological analysis of the variables mediating active avoidance behavior in rats, J. Comp. Physiol. Psychol. 82: 489–500.Google Scholar
  46. Barrett, R. J., Leith, N. J., and Ray, O. S., 1974, An analysis of the facilitation of avoidance acquisition produced by d-amphetamine and scopolamine, Behay. Biol. 11: 189–205.Google Scholar
  47. Barry, III, H., Steenberg, M. L., Manian, A. A., and Buckley, J. P., 1974, Effects of chlorpromazine and three metabolites on behavioral responses in rats, Psychopharmacologia 34: 351–360.Google Scholar
  48. Bartholini, G., and Pletscher, A., 1968, Cerebral accumulation and metabolism of C“-DOPA after selective inhibition of peripheral decarboxylase, J. Pharmacol. Exp. Ther. 161: 1420.Google Scholar
  49. Baumgarten, H. G., Björklund, A., Lachenmayer, L., Nobin, A., and Stenevi, U., 1971, Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine, Acta Physiol. Scand. Suppl. 373: 1–15.Google Scholar
  50. Baumgarten, H. G., Evetts, K. D., Holman, R. B., Iversen, L. L., Vogt, M., and Wilson, G., 1972, Effects of 5,6-dihydroxytryptamine on monoaminergic neurons in the central nervous system of the rat, J. Neurochem. 19: 1587–1597.Google Scholar
  51. Baumgarten, H. G., Björklund, A., Lachenmayer, L., and Nobin, A., 1973, Evaluation of the effects of 5,7-dyhydroxytryptamine on serotonin and catecholamine neurons in the rat CNS, Acta Physiol. Scand. Suppl. 391: 1–22.Google Scholar
  52. Beaton, J. M., LeBlanc, A. E., and Webster, C. D., 1974, The effects of d-amphetamine on the interresponse times of rats and guinea pigs on a modified Sidman discriminated avoidance schedule, Psychopharmacologia 37: 199–203.Google Scholar
  53. Beer, B., and Lenard, L. G., 1975, Differential effects of intraventricular administration of 6hydroxydopamine on behavior of rats in approach and avoidance procedures: Reversal of avoidance decrements by diazepam, Pharmacol. Biochem. Behay. 3: 879–886.Google Scholar
  54. Bennett, J. L., and Aghajanian, G. K., 1975, D-LSD binding to brain homogenates: Possible relationship to serotonin receptors, Life Sci. 15: 1935–1944.Google Scholar
  55. Bennett, J. L., and Aghajanian, G. K., 1976, Response of single raphe neurons to (+)-LSD: Correlation with (+)-LSD binding in brain, J. Pharm. Pharmacol. 28: 516–518.Google Scholar
  56. Bertler, A., Hillarp, N. A., and Rosengren, E., 1960, “Bound” and “free” catecholamines in the brain, Acta Physiol. Scand. 50:113–118.Google Scholar
  57. Besson, M. J., Cheramy, A., Feltz, P., and Glowinski, J., 1969, Release of newly synthesized dopamine from dopamine-containing terminals in the striatum of the rat, Proc. Nat. Arad. Sci. C.S.A. 62: 741–748.Google Scholar
  58. Björklund, A., Nobin, A., and Stenevi, U., 1973a, The use of neurotoxic dihydroxytryptamines as tools for morphological studies and localized lesioning on central indoleamine neurons, Z. Zellforsch. 145: 479–501.Google Scholar
  59. Björklund, A., Nobin, A., and Stenevi, U., 1973b, Regeneration of central serotonin neurons after axonal degeneration induced by 5,6-dihydroxytryptamine, Brain Res. 50: 214–220.Google Scholar
  60. Björklund, A., Baumgarten, H. G., and Rensch, A., 1975, 5,7-Dihydroxytryptamine: Improvement of its selectivity for serotonin neurons in the CNS by pre-treatment with desipramine, J. Neurochem. 24: 833–835.Google Scholar
  61. Bonnay, M. M., Guirinol, F., and Bohuon, C. J., 1974, Evidence for a peripheral effect of fusaric acid, a dopamine-ß-hydroxylase inhibitor on serotonin metabolism, Biochem. Pharmacol. 23: 2770–2773.Google Scholar
  62. Borbely, A. A., Huston, J. P., and Waser, P. G., 1973, Physiological and behavioral effects of parachlorophenylalanine in the rat, Psychopharmacologia 31: 131–142.Google Scholar
  63. Bolles, R. C., 1970, Species-specific defense reactions and avoidance learning, Psychol. Rev. 77: 32–48.Google Scholar
  64. Bovet, D., Robustelli, F., and Bignami, G., 1965, Étude du conditionnement inhibiteur chez le rat. Action de l’amphétamine, de la chlorpromazine et des agents cholinergiques, C. R. Acad. Sci. 260: 4641.Google Scholar
  65. Braestrup, C., and Nielsen, M., 1975, Intra-and extraneuronal formation of the two major noradrenaline metabolities in the CNS of rats, J. Pharm. Pharmacol. 27: 413–419.Google Scholar
  66. Bradley, P. B., and Briggs, I., 1974, Further studies on the mode of action of psychotomimetic drugs: Antagonism of the excitatory actions of 5-hydroxytryptamine by methylated derivatives of tryptamine, Br. J. Pharmacol. 50: 345–354.Google Scholar
  67. Brawley, P., and Duffield, J. C., 1972, The pharmacology of hallucinogens, Pharmacol. Rev. 24: 31–66.Google Scholar
  68. Breese, G. R., 1975, Chemical and immuno chemical lesions by specific neurotoxic substances and antisera, in “Handbook of Psychopharmacology” (L. L. Iverson, S. D. Iverson, and S. H. Snyder, eds.), Vol. I, pp. 137–189, Plenum Press, New York.Google Scholar
  69. Breese, G. R., and Cooper, B. R., 1975, Behavioral and biochemical interactions of 5,7dihydroxytryptamine with various drugs when administered intracisternally to adult and developing rats, Brain Res. 98: 517–527.Google Scholar
  70. Breese, G. R., and Howard, J. L., 1971, Effect of central catecholamine alterations on the hypothermic response to 6-hydroxydopamine in desipramine treated rats, Br. J. Pharmacol. 43: 671–674.Google Scholar
  71. Breese, G. R., Howard, J. L., and Leahy, J. P., 1971, Effect of 6-hydroxydopamine on electrical self-stimulation of the brain, Br. J. Pharmacol. 43: 255–257.Google Scholar
  72. Breese, G. R., Cooper, B. R., Grant, L. D., and Smith, R. D., 1974a, Biochemical and behavioral alterations following 5,6-dihydroxytryptamine administration into brain, Neuropharmacology 13: 177–187.Google Scholar
  73. Breese, G. R., Cooper, B. R., and Mueller, R. A., 1974b, Evidence for involvement of 5-hydroxytryptamine in the actions of amphetamine, Br. J. Pharmacol. 52: 307–314Google Scholar
  74. Broch, O. J., and Fonnum, F., 1972, The regional and subcellular distribution of catechol-O-methyl transferase in the rat brain, J. Neurochem. 19: 2049–2055.Google Scholar
  75. Brodie, B. B., Tomich, E. G., Kuntzman, R., and Shore, P. A., 1957, The mechanism of action of reserpine: Effect of reserpine on capacity of tissue to bind serotonin, J. Pharmacol. Exp. Ther. 119: 461–467.Google Scholar
  76. Brody, J. F., 1970, Behavioral effects of serotonin depletion and of p-chlorophenylalanine (a serotonin depletor) in rats, Psychopharmacologia 17: 14–33.Google Scholar
  77. Brownstein, M., Saavedra, J. M., and Palkovits, M., 1974, Norepinephrine and dopamine in the limbic system of the rat, Brain Res. 79: 431–436.Google Scholar
  78. Brownstein, M. J., Palkovits, M., Saavedra, J. M., and Kizer, J. S., 1975, Tryptophan hydroxylase in the rat brain, Brain Res. 97: 163–166.Google Scholar
  79. Butcher, L. L., and Engel, J., 1969, Behavioral and biochemical effects of L-DOPA after peripheral decarboxylase inhibition, Brain Res. 15: 233–242.Google Scholar
  80. Butcher, L. L., Engel, J., and Fuxe, K., 1972, Behavioral, biochemical and histochemical analysis of the central effects of monoamine precursors after peripheral decarboxylase inhibition, Brain Res. 41: 387–411.Google Scholar
  81. Buus-Lassen, J., 1974, The effect of p-chloroamphetamine on motility in rats after inhibition of monoamine synthesis, storage, uptake and receptor interaction, Psychopharmacologia 34: 243–254.Google Scholar
  82. Carew, T. J., 1970, Do passive avoidance tasks permit assessment of retrograde amnesia in rats?, J. Comp. Physiol. Psychol. 72: 267–271.Google Scholar
  83. Campbell, J. C., and Seiden, L. S., 1973, Performance influence on the development of tolerance to amphetamine, Pharmacol. Biochem. Behay. 1: 703–708.Google Scholar
  84. Carlsson, A., 1970, Amphetamine and brain catecholamines, in “Amphetamines and Related Compounds” (E. Costa and S. Garattini, eds.), pp. 289–300, Raven Press, New York.Google Scholar
  85. Carlsson, A., and Waldeck, B., 1964, A method for fluorimetric determination of 3-methoxytyramine in tissues and the occurrance of this amine in brain, Scand. J. Clin. Lab. Invest. 16: 133–138.Google Scholar
  86. Carlsson, A., Rosengren, E., Bertler, A., and Nilsson, J., 1957, Effect of reserpine on the metabolism of catecholamines, in “Psychotropic Drugs” (S. Garattini and V. Ghetti, eds.), pp. 363–372, Elsevier. Amsterdam.Google Scholar
  87. Carlsson, A., Corrodi, H., Fuxe, K., and Hökfelt, T., 1969a, Effect of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4, adimethyl-meta-tyramine, Eur. J. Pharmacol. 5: 367–373.Google Scholar
  88. Carlsson, A., Corrodi, H., Fuxe, K., and Hökfelt, T., 1969b, Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyla-ethyl-meta-tyramine, Eur. J. Pharmacol. 5: 357–366.Google Scholar
  89. Carey, R. J., and Kritkansky, R. P., 1972, Absence of a response-rate-dependent effect of d-amphetamine on a DRL schedule when reinforcement is signalled, Psychon. Sci. 26: 285–286.Google Scholar
  90. Carlton, P. L., and Advokat, C., 1973, Attenuated habituation due to parachlorophenylalanine, Pharmacol. Biochem. Behay. 1: 657–663.Google Scholar
  91. Carlton, P. L., and Wolgin, D. L., 1971, Contingent tolerance to the anorexigenic effects of amphetamine, Physiol. Behay. 7: 221–223.Google Scholar
  92. Castellano, C., Sansone, M., Renzi, P., and Annecker, L., 1973, Central stimulant drugs on avoidance behaviour in hamsters, Pharmacol. Res. Commun. 5: 287–293.Google Scholar
  93. Cerletti, A., and Rothlin, E., 1955, Role of 5-hydroxytryptamine in mental diseases and its antagonism to lysergic acid derivatives, Nature (London) 176: 785–786.Google Scholar
  94. Chalmers, J. P., Baldessarini, R. J., and Wurtman, R. J., 1971, Effects of 1-dopa on norepinephrine metabolism in the brain, Proc. Nat. Acad. Sci. U.S.A. 68: 662–666.Google Scholar
  95. Chase, T. N., Breese, G. R., and Kopin, I. J., 1967, Serotonin release from brain slices by electrical stimulation: Regional differences and effect of LSD, Science 157: 1461–1463.Google Scholar
  96. Ciaranello, R. D., Barchas, R. E., Byers, G. S., Stemmle, D. W., and Barchas, J. D., 1969, Enzymatic synthesis of adrenaline in mammalian brain, Nature (London) 221: 368–369Google Scholar
  97. Cicero, T. J., Sharpe, L. G., Robins, E., and Grote, S. S., 1972, Regional distribution of tyrosine hydroxylase in rat brain, J. Neurochem. 19: 2241–2243.Google Scholar
  98. Clineschmidt, B. V., and Lotti, V. J., 1974, Indoleamine antagonists: Relative potencies as inhibitors of tryptamine and 5-hydroxytryptamine-evoked responses, Br. J. Pharmacol. 50: 311–313.Google Scholar
  99. Colburn, R. W., Goodwin, F. K., Murphy, D. L., Bunney, W. E., and Davis, J. M., 1968, Quantitative studies of norepinephrine uptake by synaptosomes, Biochem. Pharmacol. 17: 957–964.Google Scholar
  100. Conner, R. L., Stolk, J. M., Barchas, J. D., and Levine, S., 1970, Parachlorophenylalanine and habituation to repetitive auditory startle stimuli in rats, Physiol. Behay. 5: 1215–1219.Google Scholar
  101. Cooper, B. R., Breese, G. R., Howard, J. L., and Grant, L. D., 1972a, Effect of central catecholamine alterations by 6-hydroxydopamine on shuttle box avoidance acquisition, Physiol. Behay. 9: 727–731.Google Scholar
  102. Cooper, B. R., Breese, G. R., Howard, J. L., and Grant, L. D., 1972b, Enhanced behavioral depressant effects of reserpine and a-methyl-tyrosine after 6-hydroxydopamine treatment, Psychopharmacologia 27: 99–110.Google Scholar
  103. Cooper, B. R., Breese, G. R., Grant, L., and Howard, J. L., 1973, Effects of 6-hydroxydopamine treatments on active avoidance responding: Evidence for involvement of brain dopamine, J. Pharmacol. Exp. Ther. 185: 358–370.Google Scholar
  104. Cooper, B. R., Cott, J. M., and Breese, G. R., 1974a, Effects of catecholamine-depleting drugs and amphetamine on self-stimulation of brain following various 6-hydroxydopamine treatments, Psychopharmacologia 377: 235–248.Google Scholar
  105. Cooper, B. R., Howard, J. L., Grant, L. D., Smith, R. D., and Breese, G. R., 1974b, Alteration of avoidance and ingestive behavior after destruction of central catecholamine pathways with 6-hydroxydopamine, Pharmacol. Biochem. Behay. 2: 639–649.Google Scholar
  106. Corrodi, H., and Hanson, L. C. F., 1966, Central effects of an inhibitor of tyrosine hydroxylation, Psychopharmacologia 10: 116–125.Google Scholar
  107. Corrodi, H., Fuxe, K., Hamberger, B., and Ljungdahl, A., 1970, Studies on central and peripheral noradrenaline neurons using a new dopamine-ß-hydroxylase inhibitor, Eur. J. Pharmacol. 12: 145–155.Google Scholar
  108. Coscina, D. V., Goodman, J., Godse, D., and Stancer, H. C., 1975, Effects of handling before central 6-hydroxydopamine treatment on subsequent emotionality and neurochemical changes in rats, Physiol. Psychol. 3: 225–228.Google Scholar
  109. Costa, E., Lefevre, H., Meek, J., Revuelta, A., Spano, F., Strada, S., and Daly, J., 1972, Serotonin and catecholamine concentrations in brain of rats injected intracerebrally with 5,6-dihydroxytryptamine, Brain Res. 44: 304–308.Google Scholar
  110. Costal!, B., and Naylor, R. J., 1974, The involvement of dopaminergic systems with the stereotyped behavior patterns induced by methylphenidate, J. Pharm. Pharmacol. 26: 3033.Google Scholar
  111. Coyle, J. T., and Axelrod, J., 1972, Dopamine-ß-hydroxylase in the rat brain: Developmental characteristics, J. Neurochem. 19: 449–459.Google Scholar
  112. Crabbe, J. C., and Alpern, H. P., 1973, Facilitation and disruption of the long-term store of memory with neural excitants, Pharmacol. Biochem. Behay. 1: 197–202.Google Scholar
  113. Crabbe, J. C., and Alpern, H. P., 1975, d-Amphetamine: Disruptive effects on the long-term store of memory and proactive facilitatory effects on learning in inbred mice, Pharmacol. Biochem. Behay. 3: 647–652.Google Scholar
  114. Creese, I., and Iversen, S. D., 1972, Amphetamine response in rat after dopamine neurone destruction, Nature (London), New Biol. 238: 247–248.Google Scholar
  115. Creese, I., and Iversen, S. D., 1973, Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine, Brain Res. 55: 369–382.Google Scholar
  116. Creese, I., and Iversen, S. D., 1974, The role of forebrain dopamine systems in amphetamine induced stereotyped behaviour in the rat, Psychopharmacologia 39: 345–357.Google Scholar
  117. Creese, I., and Iversen, S. D., 1975a, The pharmacological and anatomical substrates of the amphetamine response in the rat, Brain Res. 83: 419–436.Google Scholar
  118. Creese, I., and Iversen, S. D., 1975b, Behavioral sequelae of dopaminergic degeneration: Postsynaptic supersensitivity?, in “Pre-and Post-Synaptic Receptors” (E. Usdin and W. E. Bunney, eds.), pp. 171–190, Marcel Dekker, New York.Google Scholar
  119. Creese, I., Burt, D. R., and Snyder, S. H., 1976, The dopamine receptor: Differential binding of d-LSD and related agents to agonist and antagonist states, Life Sci. 17: 1715–1720.Google Scholar
  120. Creveling, C. R., Daly, J. W., Witkop, B., and Udenfriend, S., 1962, Substrates and inhibitors of dopamine-ß-oxidase, Biochim. Biophys. Acta 64: 125–134.Google Scholar
  121. Crow, T. J., and Arbuthnott, G. W., 1972, Function of catecholamine-containing neurones in mammalian central nervous system, Nature (London), New Biol. 238: 245–246.Google Scholar
  122. Crow, T. J., and Wendlandt, S., 1976, Impaired acquisition of a passive avoidance response after lesion induced in the locus coeruleus by 6-OH-dopamine, Nature (London) 259: 4244.Google Scholar
  123. Curzon, G., and Marsden, C. A., 1975, The effect of L-tryptophan on changes in motor activity caused by parachlorophenylalanine, Br. J. Pharmacol. 54: 232.Google Scholar
  124. Dahlstrom, A., and Fuxe, K., 1965, Evidence for the existence of monoamine containing neurons in the central nervous system. 1. Demonstration of the monoamines in the cell bodies of brain stem neurons, Acta Physiol. Scand. Suppl. 62, 232: 1–55.Google Scholar
  125. Daly, J., Fuxe, K., and Jonsson, G., 1974, 5,7-Dihydroxytryptamine as a tool for the morphological and functional analysis of central 5-hydroxytryptamine neurons, Res. Commun. Chem. Pathol. Pharmacol. 7: 175–187.Google Scholar
  126. Davidson, A. B., and Weidley, E., 1976, Differential effects of neuroleptic and other psychotropic agents on acquisition of avoidance in rats, Life Sci. 18: 1279–1284.Google Scholar
  127. Davies, J. A., and Redfern, P. H., 1974, The interaction of dopamine-antagonists and amantadine hydrochloride on the acquisition of the conditioned avoidance response in rats, Neuropharmacology 13: 941–948.Google Scholar
  128. Davis, M., 1974, Sensitization of the rat startle response by noise, J. Comp. Physiol. Psychol. 87: 571–581.Google Scholar
  129. Davis, M., and Sheard, M.H., 1974a, Habituation and sensitization of the rat startle response: Effects of raphe lesions, Physiol. Behay. 12: 425–431.Google Scholar
  130. Davis, M., and Sheard, M. H., 1974b, Effects of lysergc acid diethylamide (LSD) on habituation and sensitization of the startle response in the rat, Pharmacol. Biochem. Behay. 2: 675–683.Google Scholar
  131. Davis, M., and Sheard, M. H., 1974c, Biphasic dose—response effects of N,N-dimethyltryptamine on the rat startle reflex, Pharmacol. Biochem. Behay. 2: 827–829.Google Scholar
  132. Davis, M., and Sheard, M. H., 1976, p-Chloroamphetamine (PCA): Acute and chronic effects on habituation and sensitization of the acoustic startle response in rats, Ear. J. Pharmacol. 35: 261–273.Google Scholar
  133. Davis, M., Svensson, T. H., and Aghajanian, G. K., 1975, Effects of d-and I-amphetamine on habituation and sensitization of the acoustic startle response in rats, Psychopharmacology 43: 1–12.Google Scholar
  134. Dawson, R. G., and McGaugh, J. L., 1973, Drug facilitation of learning and memory, in “The Physiological Basis of Memory” U. A. Deutsch, ed.), Academic, New York.Google Scholar
  135. Deguchi, T., and Barchas, J., 1972, Regional distribution and developmental change of tryptophan hydroxylase activity in rat brain, J. Neurochem. 19: 927–929.Google Scholar
  136. Dengler, H. J., Spiegel, H. E., and Titus, E. O., 1961, Uptake of tritium-labeled norepinephrine in brain and other tissues of cat in vitro, Science 133: 1072–1073.Google Scholar
  137. Descarries, L., Beaudet, A., and Watkins, K. C., 1975, Serotonin nerve terminals in adult rat neocortex, Brain Res. 100: 563–588.Google Scholar
  138. Dews, P. B., 1958, Studies on behavior. IV. Stimulant actions of methamphetamine, J. Pharmacol. Exp. Thar. 122: 137–147.Google Scholar
  139. Dismukes, R. K., and Rake, A. V., 1972, Involvement of biogenic amines in memory formation, Psychopharmacologia 23: 17–25.Google Scholar
  140. Doepfner, W. and Cerletti, A., 1958, Comparison of lysergic acid derivatives and antihistamines as inhibitors of the edema provoked in the rat’s paw by serotonin, Int. Arch. Allergy (Basel) 12: 89–97.Google Scholar
  141. Doty, B., and Doty, L., 1966, Facilitation effects of amphetamine on avoidance conditioning in relation to age and problem difficulty, Psychopharmacologia 9: 239–241.Google Scholar
  142. Dowson, J. H., 1973, Quantitative histochemical studies of striatal dopamine depletion following m.-a-methyl-p-tyrosine administration, Neuropharmacology 12: 949–953.Google Scholar
  143. Duch, D. S., Viveros, O. H., and Kirshner, N., 1968, Endogenous inhibitor(s) in adrenal medulla of dopamine-ß-hydroxylase, Biochem. Pharmacol. 17: 255–264.Google Scholar
  144. Duncan, R. J. S., and Sourkes, T. L., 1974, Some enzymic aspects of the production of oxidized or reduced metabolites of catecholamines and 5-hydroxytryptamine by brain tissues, J. Neurochem. 22: 663–669.Google Scholar
  145. Edwards, D. J., and Blau, K., 1972, The in vivo formation of p-chloro-ß-phenylethylamine in young rats injected with p-chlorophenylalanine, J. Neurochem. 19: 1829–1832.Google Scholar
  146. Eichelman, B. S., Jr., Thoa, N. B., and Nq, K.Y., 1972, Facilitated aggression in the rat following 6-hydroxydopamine administration, Physiol. Behay. 8: 1–3.Google Scholar
  147. Engel, J., 1971, Metatyrosine-induced reversal of the suppression of the conditioned avoidance response in reserpine-treated rats, Acta Pharmacol. Toxicol. 30: 1–10.Google Scholar
  148. Engel, J., and Carlsson, A., 1976, Catecholamines and behavior, Curr. Develop. Psychopharmacol. 4: 3–31.Google Scholar
  149. Engel, J., and Modigh, K., 1974, Trvptophan-induced suppression of conditioned avoidance behavior in rats, in “Advances in Biochemical Pharmacology” (E. Costa, G. L. Gessa, and M. Sandler, eds.), Vol. II, pp. 405–409, Raven, New York.Google Scholar
  150. Erwin, V. G., and Deitrich, R. A., 1966, Brain aldehyde dehydrogenase. Localization, purification and properties, J. Biol. Chem. 241: 3533.Google Scholar
  151. Essman, W. B., 1971, Role of biogenic amines in memory consolidation, in “Biology of Memory” (G. Adams, ed.), pp. 213–238, Plenum, New York.Google Scholar
  152. Essman, W. B., 1973, Age dependent effects of 5-hydroxytryptamine upon memory consolidation and cerebral protein synthesis, Pharmacol. Biochem. Behay. 1: 7–14.Google Scholar
  153. Essman, W. B., 1974, Brain 5-hydroxytryptamine and memory consolidation, in “Serotonin, New vistas—Biochemistry and Behavioral and Clinical Studies” (E. Costa, G. L., Gessa, and M. Sandler, eds.), pp. 265–274, Raven, New York.Google Scholar
  154. Evangelista, A. M., and Izquierdo, I., 1971, The effect of pre-and post-trial amphetamine injections on avoidance responses of rats, Psychopharmacologia 20: 42–47.Google Scholar
  155. Everett, G. M., and Borcherding, J. W., 1970, L-Dopa: Effect on concentrations of dopamine, norepinephrine and serotonin in brains of mice, Science 168: 849–850.Google Scholar
  156. Evetts, K. D., and Iversen, L. L., 1970, Effects of protriptyline on the depletion of catecholamines induced by 6-hydroxydopamine in the brain of the rat, J. Pharm. Pharmacol. 22: 540–543.Google Scholar
  157. Evetts, K. D., Uretsky, N. J., Iversen, L. L., and Iversen, S. D., 1970, Effects of 6-hydroxydopamine on CNS catecholamines, spontaneous motor activity and amphetamine-induced hyperactivity in the rat, Nature (London) 225: 961–962.Google Scholar
  158. Fahn, S., Rodman, J. S., and Cote, L. J., 1969, Association of tyrosine hydroxylase with synaptic vesicles in bovine caudate nucleus, J. Neurochem. 16: 1293–1300.Google Scholar
  159. Farnebo, L. O., Fuxe, K., Goldstein, M., Hamberger, B., and Ungerstedt, U., 1971, Dopamine and noradrenaline releasing action of amantadine in the central and peripheral nervous system: A possible mode of action in Parkinson’s disease, Eur. J. Pharmacol. 16: 27–38.Google Scholar
  160. Farrow, J. T., and Van Vunakis, H., 1973, Characteristics of n-lysergic acid diethylamide binding to subcellular fractions derived from rat brain, Biochem. Pharmacol. 22: 1103–1113.Google Scholar
  161. Fernstrom, J. D., and Wurtman, R. J., 1971, Brain serotonin content: Physiological dependence on plasma tryptophan levels, Science 173: 149–152.Google Scholar
  162. Fernstrom, J. D., and Wurtman, R. J., 1972, Brain serotonin content: Physiological regulation by plasma neutral amino acids, Science 178: 414–416.Google Scholar
  163. Fernstrom, J. D., Faller, D. V., and Shabshelowitz, H., 1975, Acute reduction of brain serotonin and 5-HIAA following food consumption: Correlation with the ratio of serum tryptophan to the sum of competing neutral amino acids, J. Neural Transmission 36: 113–121.Google Scholar
  164. Fibiger, H. C., and Campbell, B. A., 1971, The effect of para-chlorophenylalanine on spontaneous locomotor activity in the rat, Neuropharmacology 10: 25–32.Google Scholar
  165. Fibiger, H. C., and Grewaal, D. S., 1974, Neurochemical evidence for denervation supersensitivity: The effect of unilateral substantia nigra lesions on apomorphine-induced increases in neostriatal acetylcholine levels, Life Sci. 15: 57–63.Google Scholar
  166. Fibiger, H. C., Fibiger, H. P., and Zis, A. P., 1973, Attenuation of amphetamine-induced motor stimulation and stereotypy by 6-hydroxydopamine in the rat, Br. J. Pharmacol. 47: 683–692.Google Scholar
  167. Fibiger, H. C., Phillips, A. G., and Zis, A. P., 1974, Deficits in instrumental responding after 6-hydroxydopamine lesions of the nigro-neostriatal dopaminergic projection, Pharmacol. Biochem. Behay. 2: 87–96.Google Scholar
  168. Fibiger, H. C., Zis, A. P., and Phillips, G., 1975, Haloperidol-induced disruption of conditioned avoidance responding: Attenuation by prior training or by anticholinergic drugs, Eur. J. Pharmacol. 30: 309–314.Google Scholar
  169. Fog, R., 1969, Stereotyped and non-stereotyped behaviour in rats induced by various stimulant drugs, Psychopharmacologia 14: 299–304.Google Scholar
  170. Foldes, A., and Costa, E., 1975, Relationship of brain monoamine and locomotor activity in rats, Biochem. Pharmacol. 24: 1617–1621.Google Scholar
  171. Foree, D. D., Moretz, F. H., and McMillan, D. E., 1973, Drugs and punished responding. II. d-Amphetamine-induced increases in punished responding, J. Exp. Anal. Behay. 20: 291–300.Google Scholar
  172. Friedman, S., and Kaufman, S., 1965, 3,4-Dihydroxyphenylethylene-ß-hydroxylase: A copper protein, J. Biol. Chem. 240: 552–554.Google Scholar
  173. Friedman, S., Kappelman, A. H., and Kaufman, S., 1972, Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain, J. Biol. Chem. 247: 4165–4173.Google Scholar
  174. Frontali, M., Amorico, L., DeAcetis, L., and Bignami, G., 1976, A pharmacological analysis of processes underlying differential responding: A review and further experiments with scopolamine, amphetamine, lysergic acid diethylamide (LSD-25), chlordiazepoxide, physostigmine, and chlorpromazine, Behay. Biol. 18: 1–74.Google Scholar
  175. Fuentes, J. A., and Neff, N. H., 1975, Selective monoamine oxidase inhibitor drugs as aids in evaluating the role of type A and B enzymes, Neuropharmacology 14: 819–825.Google Scholar
  176. Fuller, R. W., and Perry, K. W., 1974, Long-lasting depletion of brain serotonin by 4-chloramphetamine in guinea pigs, Brain Res. 82: 383–385.Google Scholar
  177. Fuller, R. W., Baker, J. C., Perry, K. W., and Molloy, B. B., 1975, Comparison of 4-chloro-, 4-bromo-and 4-fluoroamphetamine in rats: Drug levels in brain and effects on brain serotonin metabolism, Neuropharmacology 14: 739–746.Google Scholar
  178. Fuxe, K., and Jonsson, G., 1973, The histochemical fluorescence method for the demonstration of catecholamines: Theory, practice and application, J. Histochem. Cytochem. 21: 293–311.Google Scholar
  179. Fuxe, K., Hökfelt, T., and Ungerstedt, U., 1968, Localization of indolealkylamines in CNS, in “Advances in Pharmacology” (S. Garattini and P. A. Shore, eds.), Vol. 6A pp. 235–251, Academic, New York.Google Scholar
  180. Gal, E. M., Poczik, M., and Marshall, F. D., 1963, Hydroxylation of tryptophan to 5- hydroxytryptophan by brain tissue in vivo, Biochem. Biophys. Res. Commun. 12: 39–43.Google Scholar
  181. Gal, E. M., Heater, R. D., and Millard, S. A., 1968, Studies on the metabolisms of 5hydroxytryptamine (serotonin). VI. Hydroxylation and amines in cold-stressed reserpinised rats, Proc. Soc. Exp. Biol. Med. (N.Y.) 128: 412–415.Google Scholar
  182. Gal, E. M., Roggeveen, A. E., and Millard, S. A., 1970, nL[s-’4C]p-chlorophenylalanine as an inhibitor of tryptophan 5-hydroxylase, J. Neurochem. 17: 1221–1235.Google Scholar
  183. Geller, I., and Blum, K., 1970, The effects of 5-HT on para-chlorophenylalanine (p-CPA) attenuation of “conflict” behavior, Eur. J. Pharmacol. 9: 319.Google Scholar
  184. Geller, I., and Seifter, J., 1960, The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat, Psychopharmacologia 1: 482–492.Google Scholar
  185. Gerson, S., and Baldessarini, R. J., 1975, Selective destruction of serotonin terminals in rat forebrain by high doses of 5,7-dihydroxytryptamine, Brain Res. 85: 140–145.Google Scholar
  186. Gerson, S., Baldessarini, R. J., and Wheeler, S. C., 1974, Biochemical effects of dihydroxy- lated tryptamines on central indoleamine neurons, Neuropharmacology 13: 987–1004.Google Scholar
  187. Geyer, M. A., 1976, Functional heterogeneity within neurotransmitter systems, Psychopharmacol. Commun. 1: 675–685.Google Scholar
  188. Geyer, M. A., and Segal, D. S., 1973, Differential effects of reserpine and alpha-methyl-ptyrosine on norepinephrine and dopamine induced behavioral activity, Psychopharmacologia 29: 131–140.Google Scholar
  189. Glowinski, J., and Iversen, L. L., 1966, Regional studies of catecholamines in the rat brain. I. The disposition of [3H1-norepinephrine, [3H]-dopamine and [3H1-dopa in various regions of the brain, J. Neurochem. 13: 655–669.Google Scholar
  190. Goldstein, M., 1966, Inhibition of norepinephrine biosynthesis at the dopamine-ß-hydroxylation stage, Pharmacol. Rev. 18: 77–82.Google Scholar
  191. Goldstein, M., Lauber, E., and McKereghan, M. R., 1965, Studies on the purification and characterization of 3,4-dihydroxyphenylethylamine-/3-hydroxylase, J. Biol. Chem. 240: 2066–2072.Google Scholar
  192. Gorelick, D. A., Bozewicz, T. R., and Bridger, W. H., 1975, The role of catecholamines in animal learning and memory, in “Catecholamines and Behavior. 2” (A. J. Friedhoff ed.), pp. 1–30, Plenum, New York.Google Scholar
  193. Gozzani, J. C., and Izquierdo, I., 1976, Possible peripheral adrenergic and central dopaminergic influences in memory consolidation, Psychopharmacology 49: 109–111.Google Scholar
  194. Graeff, F. G., and Schoenfeld, R. I., 1970, Tryptaminergic mechanisms in punished and nonpunished behavior, J. Pharmacol. Exp. Ther. 173: 277–283.Google Scholar
  195. Grahame-Smith, D. G., 1964, Tryptophan hydroxylation in brain, Biochem. Biophys. Res. Commun. 16: 586–592.Google Scholar
  196. Grahame-Smith, D. G., 1967, The biosynthesis of 5-hydroxytryptamine in brain, Biochem. J. 105: 351–360.Google Scholar
  197. Grahame-Smith, D. G., 197la, Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with monoamine oxidase inhibitor and L-tryptophan, J. Neurochem. 18: 1053–1066.Google Scholar
  198. Grahame-Smith, D. G., 1971b, Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N, N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor, Br. J. Pharmacol. 43: 856–864.Google Scholar
  199. Grahame-Smith, D. G., 1973, Does the total turnover of brain 5-HT reflect the functional activity of 5-HT in brain?, in “Serotonin and Behavior” (J. Barchas, and E. Usdin, eds.), pp. 5–7, Academic, New York.Google Scholar
  200. Green, H., Greenberg, S. M., Erickson, R. W., Sawyer, J. L., and Ellison, T., 1962, Effect of dietary phenylalanine and tryptophan upon rat brain amine levels, J. Pharmacol. Exp. Ther. 136: 174–178.Google Scholar
  201. Grelak, R. P., Clark, R., Stump, J. M., and Vernier, V. G., 1970, Amantadine—dopamine interaction. Possible mode of action in Parkinsonism, Science 169: 203–204.Google Scholar
  202. Griffiths, D., and Wahlsten, D., 1974, Interacting effects of handling and d-amphetamine on avoidance learning, Pharm. Biochem. Behay. 2: 439–441.Google Scholar
  203. Grossman, S. P., 1968, Behavioral and electroencephalographic effects of microinjections of neurohumors into the midbrain reticular formation, Physiol. Behay. 3: 777–786.Google Scholar
  204. Grossman, S. P., and Sclafani, A., 1971, Sympathomimetic amines, in “Pharmacological and Biophysical Agents and Behavior” (E. Furchtgott, ed.), Academic, New York.Google Scholar
  205. Groves, P. M., and Thompson, R., 1970, Habituation: A dual process theory, Psychol. Rev. 77: 419–450.Google Scholar
  206. Guroff, G., Kondo, K., and Daly, J., 1966, The production of metachlorotyrosine from parachlorophenylalanine by phenylalanine hydroxylase, Biochem. Biophys. Res. Commun. 25: 622–628.Google Scholar
  207. Häggendal, J., and Dalström, A., 1972, The recovery of the capacity for uptake—retention of [3H]-noradrenaline in rat adrenergic nerves after reserpine, J. Pharm. Pharmacol. 24: 565–574.Google Scholar
  208. Halaris, A. E., and Freedman, D. X., 1975, Psychotropic drugs and dopamine uptake inhibition, in “Biology of the Major Psychoses” (D. X. Freedman, ed.), Vol. 54, Raven, New York.Google Scholar
  209. Halaris, A. E., Belendiuk, K. T., and Freedman, D. X., 1975, Antidepressant drugs affect dopamine uptake, Biochem. Pharmacol. 24: 1896–1898.Google Scholar
  210. Hall, M. E., 1976, The effects of norepinephrine biosynthesis inhibition on the consolidation of two discriminated escape responses, Behay. Biol. 16: 145–153.Google Scholar
  211. Hall, M. E., and Mayer, M. A., 1975, Effects of alpha methyl-para-tyrosine on the recall of a passive avoidance response, Pharmacol. Biochem. Behay. 3: 579–582.Google Scholar
  212. Hanson, L.C.F., 1967a, Evidence that the central action of (+) amphetamine is mediated via catecholamines, Psvchopharmacologia 10: 289–297.Google Scholar
  213. Hanson, L.C.F., 1967b, Biochemical and behavioral effects of tyrosine—hydroxylase inhibition, Psychopharmacologia 11: 8–17.Google Scholar
  214. Hanson, L.C.F., 1965, The disruption of conditioned avoidance response following selective depletion of brain catecholamines, Psychopharmacologia 8: 100–110.Google Scholar
  215. Hartmann, R. J., and Geller, I., 1971, p-Chlorophenylalanine effects on a conditioned emotional response in rats, Life Sci.10(1):927–933.Google Scholar
  216. Harvey, J. A., McMaster, S. E., and Yunger, L. M., 1975, p-Chloroamphetamine: Selective neurotoxic action in brain, Science 187: 841–843.Google Scholar
  217. Hedreen, J. C., and Chalmers, J. P., 1972, Neuronal degeneration in rat brain induced by 6-hydroxydopamine; A histological and biochemical study, Brain Res. 47: 1–36.Google Scholar
  218. Heikkila, R., and Cohen, G., 1973, 6-Hydroxydopamine: Evidence for superoxide radical as an oxidative intermediate, Science 181: 456–458.Google Scholar
  219. Heise, G. A., and Boff, E., 1971, Stimulant action of d-amphetamine in relation to test compartment dimensions and behavioral measure, Neuropharmacology 10: 259–266.Google Scholar
  220. Heise, G. A., and Lilie, N. L., 1970, Effects of scopolamine atropine and d-amphetamine on internal and external control of responding on non-reinforced trials, Psychopharmacologia 18: 38–39.Google Scholar
  221. Heise, G. A., Laughlin, N., and Keller, C., 1970, A behavioral and pharmacological analysis of reinforcement withdrawal, Psychopharmacologia 16: 345–368.Google Scholar
  222. Herman, Z. S., 1970, The effects of noradrenaline on rats’ behaviour, Psychopharmacologia 16: 369.Google Scholar
  223. Hidaka, H., 1973, Picolinic acid derivatives as inhibitors of dopamine-ß-hydroxylase in vivo; their effects on blood pressure and stress ulcer, in “Frontiers in Catecholamine Research” (E. Usdin and S. Snyder, eds.), pp. 87–90, Pergamon, Oxford.Google Scholar
  224. Hillarp, N. A., Fuxe, K., and Dahlstrom, A., 1966, Demonstration and mapping of central neurons containing dopamine, noradrenaline and 5-hydroxytryptamine and their reactions to psychopharmaca, Pharmacol. Rev. 18: 727–741.Google Scholar
  225. Hingtgen, J. N., Smith, J. E., Shea, P. A., Aprison, M. H., and Gaff, T. M., 1976, Cholinergic changes during conditioned suppression in rats, Science 193: 193–195.Google Scholar
  226. Hökfelt, T., 1973, Neuronal catecholamine storage vesicles, in “Frontiers in Catecholamine Research” (E. Usdin and S. H. Snyder, eds.), pp. 439–446, Pergamon, New York.Google Scholar
  227. Hökfelt, T., Fuxe, K., Goldstein, M., and Johansson, O., 1974, lmmunohistochemical evidence for the existence of adrenaline neurons in the rat brain, Brain Res. 66: 235–251.Google Scholar
  228. Hole, K., and Lorens, S. A., 1975, Response to electric shock in rats: Effects of selective midbrain raphé lesions, Pharmacol. Biochem. Behay. 3 (1): 95–102.Google Scholar
  229. Hole, K., Fuxe, K., and Jonsson, G., 1976, Behavioral effects of 5,7-dihydroxytryptamine lesions of ascending 5-hydroxytryptamine pathways, Brain Res. 107: 385–399.Google Scholar
  230. Hollister, A. S., Breese, G. R., and Cooper, B. R., 1974, Comparison of tyrosine hydroxylase and dopamine-ß-hydroxylase inhibition with the effects of various 6-hydroxydopamine treatments on d-amphetamine induced motor activity, Psychopharmacologia 36: 1–16.Google Scholar
  231. Holzbauer, M., and Sharman, D. F., 1972, The distribution of catecholamines in vertebrates, in “Catecholamines” (H. Blashko and E. Muscholl, eds.), pp. 110–185, Springer, Berlin.Google Scholar
  232. Hornykiewicz, O., 1966, Dopamine (3-hydroxytyramine) and brain function, Pharmacol. Rev. 18: 925–964.Google Scholar
  233. Howard, J. L., Grant, L. D., and Breese, G. R., 1974, Effects of intracisternal 6-hydroxydopamine treatment on acquisition and performance of rats in a double T-maze, J. Comp. Physiol. Psychol. 86: 995–1007.Google Scholar
  234. Ichiyama, A., Nakamura, S., Nishizuka, Y., and Hayaishi, O., 1968, Tryptophan 5-hydroxylase in mammalian brain, in “Advances in Pharmacology” (S. Garattini and P. A. Shore, eds.), Vol. 6a, pp. 5–17, Academic, New York.Google Scholar
  235. Iversen, S. D., and Iversen, L. L., 1975, “Behavioral Pharmacology” Oxford University Press.Google Scholar
  236. Izquierdo, I., 1974, Effect on pseudoconditioning of drugs with known central nervous activity, Psychopharmacologie 38: 259–266.Google Scholar
  237. lzquierdo, I., 1975, Relations between orienting pseudoconditioned and conditioned responses in the shuttle-box—A pharmacological analysis by means of LSD and dibenamine, Behay. Biol. 15: 193–206.Google Scholar
  238. Izquierdo, I., 1976, A pharmacological separation of buzzer-shock pairing and of the shuttle-shock contingency as factors in the elicitation of shuttle responses to a buzzer in rats, Behay. Biol. 18: 75–88.Google Scholar
  239. Izquierdo, I., and Cavalheiro, E. A., 1976, Three main factors in rat shuttle behavior: Their pharmacology and sequential entry in operation during a two-way avoidance session, Psychopharmacolorl 49: 145–158.Google Scholar
  240. Izquierdo, J. A., 1974, Animal behavior: Influence of drugs affecting monoaminergic and cholinergie neuro-transmission, Acta Physiol. Lat. Am. 24: 644–655.Google Scholar
  241. Izquierdo, J. A., Jofré, I. J., and Acevedo, C., 1972, Effect of disulfiram and ascorbic acid on catecholamine content in rat brain, J. Pharm. Pharmacol. 24: 330–332.Google Scholar
  242. Jacobowitz, D., and Kostrzewa, R., 1971, Selective action of 6-hydroxydopa on noradrenergic terminals: Mapping of preterminal axons of the brain, Life Sci. 10 (1): 1329–1342.Google Scholar
  243. Jacobs, B. L., 1974, Evidence for the functional interaction of two central neurotransmitters, Psychopharmacologia 39: 81–86.Google Scholar
  244. Jacobs, B. L., and Cohen, A., 1976, Differential behavioral effects of lesions of the median or dorsal raphé nuclei in rats: Open field and pain-elicited agression, J. Comp. Physiol. Psychol. 90: 102–108.Google Scholar
  245. Jacobs, B. L., Eubanks, E. E., and Wise, W. D., 1974a, Effect of indole-alkylamine manipulations on locomotor activity in rats, Neuropharmacology 13: 575–583.Google Scholar
  246. Jacobs, B. L., Wise, W. D., and Taylor, K. M., 1974b, Differential behavioral and neurochemical effects following lesions of the dorsal or median raphé nuclei in rats, Brain Res. 79: 353–361.Google Scholar
  247. Jacobs, B. L., Wise, W. D., and Taylor, K. M., 1975a, Is there a catecholamine-serotonin interaction in the control of locomotor activity?, Neuropharmacology 14: 501–506.Google Scholar
  248. Jacobs, B. L., Trimback, C., Eubanks, E. E., and Trulson, M., 1975b, Hippocampal mediation of raphé lesion-and PCPA-induced hyperactivity in the rat, Brain Res. 94: 253–261Google Scholar
  249. Jacobs, B. L., Mosko, S. S., and Trulson, M. E., 1976, in “Neurobiology of Sleep and Memory” (R. R. Drucker and J. L. McGaugh, eds.), Academic, New York.Google Scholar
  250. Jacoby, J. H., Shabshelowitz, H., Fernstrom, J. D., and Wurtman, R. J., 1975, The mechanisris by which methiothepin, a putative serotonin receptor antagonist, increases brain 5-hydroxyindole levels, J. Pharmacol. Exp. Ther. 195: 257–264.Google Scholar
  251. Jalfre, M., Ruch-Monachon, M. A., and Haefely, W., 1974, Methods for assessing the interaction of agents with 5-hydroxytryptamine neurons and receptors in the brain, in “Advances in Biochemical Psychopharmacology” (E. Costa, G. L. Gessa and M. Sandler, eds.), Vol. 10, pp. 121–134, Raven, New York.Google Scholar
  252. James, D.T.D., 1975, Postrial d-amphetamine sulfate and one-trial learning in mice, J. Comp. Physiol. Psychol. 89: 626–635.Google Scholar
  253. Jéquier, E., Lovenberg, W., and Sjoerdsma, A., 1967, Tryptophan hydroxylase inhibition: The mechanism by which p-chlorophenylalanine depletes rat brain serotonin, Mol. Pharmacol. 3: 274–278.Google Scholar
  254. Johnson, G. A., Kim. E. G., and Boukma, S. J., 1972, 5-Hydroxyindole levels in rat brain after inhibition of dopamine-f3-hydroxylase, J. Pharmacol. Exp. Ther. 180: 539–546.Google Scholar
  255. Johnston, J. P., 1968, Some observations upon a new inhibitor of monoamine oxidase in brain tissue, Biochem. Pharmacol. 17: 1285–1297.Google Scholar
  256. Jonsson, G., and Sachs, C., 1971, Uptake and accumulation of 3H-6-hydroxydopamine in adrenergic nerves, Eur. J. Pharmacol. 16: 55–62.Google Scholar
  257. Jonsson, G., Pycock, C. L., Fuxe, K., and Sachs, C., 1974, Changes in the development of central noradrenaline neurones following neonatal administration of 6-hydroxydopamine, J. Neurochem. 22: 419–426.Google Scholar
  258. Karoum, F., Gillin, J. C., Wyatt, R. J., and Costa, E., 1975, Mass-fragmentography of nanogram quantities of biogenic amine metabolites in human cerebrospinal fluid and whole rat brain, Biomed. Mass Spectrum. 2: 183–189.Google Scholar
  259. Katzman, R., Björklund, A., Owman, C., Stenevi, U., and West, K. A., 1971, Evidence for regenerative axon sprouting of central catecholamine neurons in the mesencephalon following electrolytic lesions, Brain Res. 25: 579–596.Google Scholar
  260. Kaufman, S., 1963, The structure of the phenylalanine-hydroxylation cofactor, Proc. Natl. Acad. Sci. U.S.A. 50: 1085–1093.Google Scholar
  261. Kehr, W., Carlsson, A., and Lindqvist, M., 1972, A method for the determination of 3,4-dihydroxyphenylalanine (DOPA) in brain, Arch. Pharmacol. 274: 273–280.Google Scholar
  262. Kelleher, R. T., and Morse, W. H., 1968, Determinants of the specificity of behavioral effects of drugs, Ergeb. Physiol. Biol. Chem. Exp. Pathol. 60: 1–56.Google Scholar
  263. Keller, H. H., Bartholini, G., and Pletscher, A., 1974, Enhancement of noradrenaline turnover in rat brain by l-dopa, J. Pharm. Pharmacol. 26: 649–651.Google Scholar
  264. Kelly, P. H., and Iversen, L. L., 1975, LSD as a agonist at mesolimbic dopamine receptors, Psychopharmacologia 45: 221–224.Google Scholar
  265. Kety, S. S., 1970, The biogenic amines in the central nervous system: Their possible roles in arousal, emotion and learning, in “The Neurosciences, Second Study Program” (G.C., Quenton, T. Melnechuk, and G. Adelman, eds.), The Rockefeller University Press, New York.Google Scholar
  266. Kirshner, N., and Goodall, M. C., 1957, The formation of adrenaline from noradrenaline, Biochem. Biophys, Acta 24: 658–659.Google Scholar
  267. Knapp. S., and Mandell, A. J., 1972, Parachlorophenylalanine—Its three phase sequence of interactions with the two forms of brain tryptophan hydroxylase, Life Sci. 11 (I): 761–771.Google Scholar
  268. Koe, B. K., and Corkey, R. F., 1976, Inhibition of rat brain tryptophan hydroxylation with pchloroamphetamine, Biochem. Pharmacol. 25: 31–35.Google Scholar
  269. Koe, B. K., and Weissman, A., 1966, p-Chlorophenylalanine: A specific depletor of brain serotonin, J. Pharmacol. Exp. Ther. 154: 499–516.Google Scholar
  270. Koe, B. K., and Weissman, A., 1968, The pharmacology of Para-chlorophenylalanine, a selective depletor of serotonin stores, Adv. Pharmacol. 6B: 29–47.Google Scholar
  271. Kokkinidis, L., and Anisman, H., 1976a, Interaction between cholinergic and catecholaminergic agents in a spontaneous alternation task, Psychopharmacology 48: 261–270.Google Scholar
  272. Kokkinidis, L., and Anisman, H., 1976b, Dissociation of the effects of scopolamine and damphetamine on spontaneous alternation: Genuine perseveration or dishabituation, Pharm. Biochem. Behay. 5: 293–297.Google Scholar
  273. Kokkinidis, L., and Anisman, H., 1977, Perseveration and rotational behavior elicited by d-amphetamine in a Y-maze exploratory task: Differential effects of intraperitoneal and unilateral intraventricular administration, Psychopharmacology 52: 123–128.Google Scholar
  274. Kopin, I. J., Breese, G. R., Krauss, K. R., and Weise, V. K., 1968, Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation, J. Pharmacol. Exp. Ther. 161: 271–278.Google Scholar
  275. Korf, J., and Van Praag, H. M., 1972, Action of p-chloroamphetamine on cerebral serotonin metabolism: An hypothesis, Neuropharmacology 11: 141–144.Google Scholar
  276. Kostowski, W., Giacolone, E., Garattini, S., and Valzelli, L., 1968, Studies on behavioural and biochemical changes in rats after lesion of midbrain raphé, Eur. J. Pharmacol. 4: 371–376.Google Scholar
  277. Kostrzewa, R. M., 1975, Effects of neonatal 6-hydroxydopa treatment on monoamine content of rat brain and peripheral tissues, Res. Commun. Chem. Path. Pharmacol. 11: 567–579.Google Scholar
  278. Kostrzewa, R. M., and Garey, R. E., 1976, Effects of 6-hydroxydopa on noradrenergic neurons in developing rat brain, J. Pharmacol. Exp. Ther. 197: 105–118.Google Scholar
  279. Krieckhaus, E. E., Miller, N. E., and Zimmerman, P., 1965, Reduction of freezing behavior and improvement of shock avoidance by d-amphetamine, J. Comp. Physiol. Psychol. 60: 36–40.Google Scholar
  280. Kuczenski, R. T., and Mandell, A. J., 1972, Regulatory properties of soluble and particulate rat brain tyrosine hydroxylase, J. Biol. Chem. 247: 3114–3122.Google Scholar
  281. Kuczenski, R. T., and Segal, D. S., 1975, Differential effects of o-and L-amphetamine and methylphenidate on rat striatal dopamine biosynthesis, Ear. J. Pharmacol. 30: 244–251.Google Scholar
  282. Kuhar, M. J., Aghajanian, G. K., and Roth, R. H., 1972, Trypotophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphé lesions: Correlations with serotonin levels and histochemical fluorescence, Brain Res. 44: 165–176.Google Scholar
  283. Kulkarni, A. S., 1968, Facilitation of instrumental avoidance learning by amphetamine: An analysis, Psychopharmacologia 13: 418–425.Google Scholar
  284. Kulkarni, A. S., 1972, Selective increase in avoidance responding by methamphetamine in naive rats, Psychopharmacologia 24: 449–455.Google Scholar
  285. Kumar, R., 1971, Extinction of Fear. I: Effects of amylobarbitone and dexamphetamine given separately and in combination on fear and exploratory behaviour in rats, Psychopharmacologia 19: 163–187.Google Scholar
  286. Laduron, P., and Belpaire, F., 1968, Transport of noradrenaline and dopamine-ß-hydroxylase in sympathetic nerves, Life Sci. 7 (1): 1–7.Google Scholar
  287. Lagercrantz, H., and Stjärne, L., 1974, Evidence that most noradrenaline in sympathetic large dense core nerve vesicles is stored without ATP, Nature (London) 249: 843–845.Google Scholar
  288. Lassen, J. B., 1973, The effect of amantadine and (+)amphetamine on motility in rats after inhibition of monoamine synthesis and storage, Psychopharmacology 29: 55–64.Google Scholar
  289. Laties, V. G., 1972, The modification of drug effects on behavior by external discriminative stimuli, J. Pharmacol. Exp. Ther. 183: 1–13.Google Scholar
  290. Laties, V. G., and Weiss, B., 1966, Influence of drugs on behavior controlled by internal and external stimuli, J. Pharmacol. Exp. Ther. 152: 388–396.Google Scholar
  291. Latz, A., Bain, G. T., Kornetsky, C., 1969, Attenuated effect of chlorpromazine on conditioned avoidance as a function of rapid acquisition, Psychopharmacologia 14: 23–32Google Scholar
  292. Laverty, R., and Taylor, K. M., 1970, Effects of intraventricular 2,4,5-trihydroxyphenylethylamine (6-hydroxydopamine) on rat behavior and brain catecholamine metabolism, Br. J. Pharmacol. 40: 836–846.Google Scholar
  293. Leith, N. J., and Barrett, R. J., 1975, Effects of hippocampal microinjections of d-amphetamine and scopolamine on active avoidance behaviour in rats, J. Comp. Physiol. Psychol. 88: 285–299.Google Scholar
  294. LeMoal, M., Galey, D., and Cardo, B., 1975, Behavioral effects of local injection of 6hydroxydopamine in the medial ventral tegmentum in the rat. Possible role of the mesolimbic dopaminergic system, Brain Res. 88: 190–194.Google Scholar
  295. Lenard, L. G., and Beer, B., 1975a, 6-Hydroxydopamine and avoidance: Possible role of response suppression, Pharmacol. Biochem. Behay. 3: 873–878.Google Scholar
  296. Lenard, L. G., and Beer, B., 1975b, Modification of avoidance behavior in 6-hydroxydopamine-treated rats by stimulation of central noradrenergic and dopaminergic receptors, Pharmacol. Biochem. Behay. 3: 887–893.Google Scholar
  297. Lenard, L. G., and Beer, B., 1975c, Relationship of brain levels of norepinephrine and dopamine to avoidance behavior in rats after intraventricular administration of 6hydroxydopamine, Pharmacol. Biochem. Behay. 3: 895–899.Google Scholar
  298. Levison, P. K., and Freedman, D. X., 1967, Recovery of discriminated lever press avoidance performance from the effects of reserpine, chlorpromazine and tetrabenazine, Arch. Int. Pharmacodvn. Ther. 170: 31–38.Google Scholar
  299. Levitt, M., Spector, S., Sjoerdsma, A., and Udenfriend, S., 1965, Elucidation of the ratelimiting step in norepinephrine biosynthesis in the perfused guinea-pig heart. J. Pharrnacol. Exp. Ther. 148: 1–8.Google Scholar
  300. Lindvall, O., and Björklund, A., 1974, The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method, Acta Physiol. Scand. Suppl. 412: 1–48.Google Scholar
  301. Lindvall, O., Björklund, A., Nobin, A., and Stenevi, U., 1974a, The adrenergic innervation of the rat thalamus as revealed by the glyoxylic acid fluorescence method, J. Comp. Neurol. 154: 317–348.Google Scholar
  302. Lindvall, O., Björklund, A., Moore, R. Y., and Stenevi, U., 1974b, Mesencephalic dopamine neurons projecting to neocortex, Brain Res. 81: 325–331.Google Scholar
  303. Lord, B. J., King, M. G., and Pfister, H. P., 1976, Chemical sympathectomy and two-way escape and avoidance learning in the rat, J. Comp. Physiol. Psychol. 90: 303–316.Google Scholar
  304. Lorens, S. A., 1973, Raphé lesions in cats: Forebrain serotonin avoidance behavior, Pharmacol. Biochem. Behay. 1: 487–490.Google Scholar
  305. Lorens, S. A., and Yunger, L. M., 1974, Morphine analgesia, two-way avoidance, and consummatory behavior following lesions in the midbrain raphé muclei of the rat, Pharmacol. Biochem. Behar. 2: 215–221.Google Scholar
  306. Lorens, S. A., Gulberg, H. C., Hole, K. Kolater, C., and Srebro, B., 1976, Activity, avoidance learning and regional 5-hydroxytryptamine following intra-brain stem 5,7-dihydroxytryptamine and electrolytic midbrain raphé lesions in rats, Brain Res. 108: 97–114.Google Scholar
  307. Lorez, H. P., Pieri, L., and Richards, J. G., 1975, Diappearance of supraependymal 5-HT axons in the rat forebrain after electrolytic and 5,6-DHT-induced lesions of the medial forebrain bundle, Brain Res. 100: 1–12.Google Scholar
  308. Lovenberg, W., and Victor, S. J., 1974, Regulation of tryptophan and tyrosine hydroxylase, Life Sci. 14: 2337–2353.Google Scholar
  309. Lovenberg, W., Weissbach, H., and Udenfriend, S., 1962, Aromatic L-amino acid decarboxylase, J. Biol. Chem. 237: 89–93.Google Scholar
  310. Lyon, M., 1971, The effect of no-shock or continuous shock upon avoidance behavior in rats under d-amphetamine, Act. Nerv. Super. 13: 78–81.Google Scholar
  311. Lyon, M., and Randrup, A., 1972, The dose—response effect of amphetamine upon avoidance behaviour in the rat seen as a function of increasing stereotypy, Psychopharmacologia 23: 334–347.Google Scholar
  312. Lytle, L. D., Jacoby, J. H., Nelson, M. F., and Baumgarten, H. G., 1975, Long-term effects of 5,7-dihydroxytryptamine administered at birth on the development of brain monoamines, Life Sci. 15: 1203–1217.Google Scholar
  313. Mabry, P. D., and Campbell, B. A., 1973, Serotonergic inhibition of catecholamine-induced behavioural arousal, Brain Res. 49: 381–391.Google Scholar
  314. Maj, J., and Pawlowski, L., 1975, 1 he effect of r,-5-hydroxytryptophan (5-HIP) on locomotor activity in mice, Pol. J. Pharmacol. Pharm. Suppl. 27: 145–149.Google Scholar
  315. Margules, D. L., 1971, Localization of anti-punishment actions of norepinephrine and atropine in amygdala and endopeduncular nucleus of rats, Brain Res. 35: 177–184.Google Scholar
  316. Marsden, C. A., and Curzon, G., 1976, Studies on the behavioral effects of tryptophan and p-chlorophenylalanine, Neuropharmacology 15: 165–171.Google Scholar
  317. Mason, S. T., and Iversen, S. D., 1975, Learning in the absence of forebrain noradrenaline, Nature (London) 258: 422–424.Google Scholar
  318. Massari, V. J., and Sanders-Bush, E., 1975, Synaptosomal uptake and levels of serotonin in rat brain areas after p-chloroamphetamine or B-9 lesions, Eur. J. Pharmacol. 33: 419–422.Google Scholar
  319. McBride, W. J., Hyde, T. P., Smith, J. E., Lane, J. D., and Aprison, M. H., 1976, Effects of tryptophan on serotonin in nerve endings, J. Neurochem. 26: 175–178.Google Scholar
  320. McGaugh, J. L., 1966, Time-dependent processes in memory storage, Science 153: 1351–1358.Google Scholar
  321. McGaugh, J. L., and Petrinovich, L. F., 1965, Effects of drugs on learning and memory, Inter. Rev. Neurobiol. 8: 139–191.Google Scholar
  322. McGeer, E. G., and McGeer, P. L., 1967, In vitro screen of inhibitors of rat brain tyrosine hydroxylase, Can. J. Biochem. 45: 115–131.Google Scholar
  323. McGeer, E. G., and Peters, D. A. V., 1969, In vitro screen of inhibitors of rat brain serotonin synthesis, Can. J. Biochem. 47: 501–506.Google Scholar
  324. McGeer, E. G., Gibson, S., and McGeer, P. L., 1967a, Some characteristics of brain tyrosine hydroxylase, Can. J. Biochem. 45: 1557–1563.Google Scholar
  325. McGeer, E. G., Gibson, S., Wada, J. A., and McGeer, P. L., 1967b, Distribution of tyrosine hydroxylase activity in adult and developing brain, Can. J. Biochem. 45: 1943–1952.Google Scholar
  326. McGeer, E. G., McGeer, P. L., and Peters, D. A., 1967c, Inhibition of brain tyrosine hydroxylase by 5-halotryptophan, Life Sci. 6: 2221–2232.Google Scholar
  327. McGeer, E. G., McGeer, P. L., and Wada, J. A., 1971, Distribution of tyrosine hydroxylase in human and animal brain, J. Neurochem. 18: 1647–1658.Google Scholar
  328. McGeer, P. L., Bagchi, S. P., and McGeer, E. G., 1965, Subcellular localization of tyrosine hvdroxylase in beef caudate nucleus, Life Sci. 4: 1859–1867.Google Scholar
  329. McKearney, J. W., 1972, Schedule-dependent effects: Effects of drugs, and maintenance of responding with response-produced electric shocks, in “Schedule Effects: Drugs, Drinking and Aggression” (R. M. Gilbert and J. D. Keehn, eds.), Toronto Press, CanadaGoogle Scholar
  330. McKearney, J. W., 1973, Methamphetamine effects on responding under a multiple schedule of shock presentation, Pharmacol. Biochem. Behay. 1: 547–550.Google Scholar
  331. McKearney, J. W., 1974, Effects of d-amphetamine, morphine and chlorpromazine on responding under fixed interval schedules of food presentation or electric shock presentation, J. Pharmacol. Exp. Ther. 190: 141–153.Google Scholar
  332. McKearney, J. W., and Barrett, J. E., 1975, Punished behavior: Increases in responding after d-amphetamine, Psychopharmacologia 41: 23–26.Google Scholar
  333. McLean, J. H., Kostrzewa, R. M., and May, J. G., 1976, Behavioral and biochemical effects of neonatal treatment of rats with 6-hydroxydopa, Pharmacol. Biochem. Behay. 4: 601–607.Google Scholar
  334. McMillan, D. E., 1968, The effects of sympathomimetic amines on schedule-controlled behavior in the pigeon, J. Pharmacol. Exp. Ther. 160: 315–325.Google Scholar
  335. McMillan, D. E., 1973, Drugs and punished responding. I: Rate-dependent effects under multiple schedules, J. Exp. Anal. Behay. 19: 133–145.Google Scholar
  336. Meek, J. L., and Bertilsson, L., 1975, Comparison of the effects of lesion in the “B-9” cell body group and p-chloroamphetamine on tryptophan hydroxylase and 5-hydroxytryptamine in rat brain nuclei, Brain Res. 100: 140–144.Google Scholar
  337. Messing, R. B., Phebus, L., Fisher, L. A., and Lytle L. D., 1976, Effects of p-chloroamphetam- ine on locomotor activity and brain 5-hydroxyindoles, Neuropharmacology 15: 157–164.Google Scholar
  338. Michaelson, I. A., Whittaker, V. P., Laverty, R., and Sharman, D. F., 1963, Localization of acetylcholine, 5-hydroxytryptamine and noradrenaline within subcellular particles derived from guinea-pig subcortical tissue, Biochem. Pharmacol. 12: 1450–1453.Google Scholar
  339. Miczek, K. A., 1973a, Effects of scopolamine, amphetamine and chlordiazepoxide on punishment, Psychopharmacologia 28: 373–389.Google Scholar
  340. Miczek, K. A., I973b, Effects of scopolamine, amphetamine and benzodiazepines on conditioned suppression, Pharmacol. Biochem. Behay. 1: 401–411.Google Scholar
  341. Millard, S. A., Costa, E., and Gal, E. M., 1972, On the control of brain serotonin turnover rate by end product inhibition, Brain Res. 40: 545–551.Google Scholar
  342. Miller, K. W., Sanders-Bush, E., and Dingell, J. V., 1971, p-Chloroamphetamine-species differences in the rate of diappearance and lowering of cerebral serotonin, Biochem. Pharmacol. 20: 500–503.Google Scholar
  343. Milner, V. S., 1974, Effects of d-amphetamine on acquisition of lever press Sidman avoidance in rats, Physiol. Psychol. 2: 392–396.Google Scholar
  344. Modigh, K., 1972, Central and peripheral effects of 5-hydroxytryptophan on motor activity in mice, Psychopharmacologia 23: 48–54.Google Scholar
  345. Modigh, K., 1974, Studies on DL-5-hydroxytryptophan induced hyperactivity in mice, in “Serotonin: New Vistas. Histochemistry and Pharmacology” (E. Costa, G. L. Gessa, and M. Sandler, eds.), Raven, New York.Google Scholar
  346. Mogilnicka, E., and Przewlocka, B., 1975, The influence of dopamine-beta-hydroxylase inhibitors on avoidance reaction in rat, Pol. J. Pharmacol. Pharm. 27: 513–519.Google Scholar
  347. Mogilnicka, E., and Braestrup, C., 1976, Noradrenergic influence on the stereotyped behavior induced by amphetamine, phenethylamine and apomorphine, J. Pharm. Pharmacol. 28: 253–255.Google Scholar
  348. Molander, L., and Randrup, A., 1974, Investigation of the mechanisms by which 1-DOPA induces gnawing in mice, Acta Pharmacol. Toxicol. 34: 312–324.Google Scholar
  349. Molinoff, P. B., and Axelrod, J., 1971, Biochemistry of catecholamines, Ann. Rev. Biochem. 40: 465–500.Google Scholar
  350. Monti, J. M., and Ruiz, M., 1973, Potentiation of the haloperidol induced blockade of a conditioned avoidance response by a-methyl-tyrosine, Eur. J. Pharmacol. 24: 25–28.Google Scholar
  351. Monti, J. M., and Ruiz, M., 1975, Increased disrupting effects of haloperidol on a conditioned avoidance response after 6-hydroxydopamine treatment, Pharmacol. Biochem. Behay. 3: 943–945.Google Scholar
  352. Moore, K. E., 1966, Toxicological studies with a-methyl tyrosine (a-MT), Fed. Proc. Fed. Am. Soc. Exp. Biol. 25: 688.Google Scholar
  353. Moore, K. E., and Dominic, J. A., 1971, 1 yrosine hydroxylase inhibitors, Fed. Proc. Fed. Am. Soc. Exp. Biol. 30: 859–870.Google Scholar
  354. Moore, K. E., and Rech, R. H., 1967a, Reversal of a-methyltyrosine-induced behavioural depression with dihydroxyphenylalanine and amphetamine, J. Pharm. Pharmacol. 19: 405–407.Google Scholar
  355. Moore, K. E., and Rech, R. H., 1967b, Antagonism by monoamine oxidase inhibitors of amethyltyrosine induced catecholamine depletion and behavioral depression, J. Pharmacol. Exp. Ther. 156: 70–75.Google Scholar
  356. Mueller, R. A., Thoenen, H., and Axelrod, J., 1969a, Inhibition of trans-synaptically increased tyrosine hydroxylase activity by cycloheximide and actinomycin D, Mol. Pharmacol. 5: 463–469.Google Scholar
  357. Mueller, R. A., Thoenen, H., and Axelrod, J., 1969b, Increase in tyrosine hydroxylase activity after reserpine administration, J. Pharmacol. Exp. Ther. 169: 74–79.Google Scholar
  358. Musacchio, J., Goldstein, M., Anagnoste, B., Poch, G., and Kopin, I. J., 1966, Inhibition of dopamine-/3-hydroxylase by disulfiram in vivo, J. Pharmacol. Exp. Ther. 152: 56–61.Google Scholar
  359. Nagatsu, T., Levitt, M., and Udenfriend, S., 1964, Tyrosine hydrosylase. The initial step in norepinephrine biosynthesis, J. Biol. Chem. 239: 2910–2917.Google Scholar
  360. Nagatsu, T., Kuzuya, H., and Hidaka, H., 1967, Inhibition of dopamine-ß-hydroxylase by sulfhydryl compounds and the nature of the natural inhibitors, Biochim. Biophys. Acta 139: 319–327.Google Scholar
  361. Nagatsu, T., Sudo, Y., and Nagatsu, I., 1971, Tyrosine hydroxylase in bovine caudate nucleus, J. Neurochem. 18: 2179–2189.Google Scholar
  362. Nagatsu, T., Kako, T., Kuzuya, H., Umezawa, H., and Takeuchi, T., 1973, New inhibitors of microbial origin for dopamine-ß-hydroxylase, in “Frontiers in Catecholamine Research” (E. Usdin and S. Snyder, eds.), pp. 83–86, Pergamon, Oxford.Google Scholar
  363. Nakamura, K., and Thoenen, H., 1972, Increased irritability: A permanent behavior change induced in the rat by intraventricular administration of 6-hydroxydopamine, Psychopharmacologia 24: 359–372.Google Scholar
  364. Nakamura, K., and Nakamura, K., 1976, Behavioral and neurochemical changes following administration of 6-hydroxydopamine into the ventral tegmental area of the midbrain, Japan. J. Pharmacol. 26: 269–273.Google Scholar
  365. Naylor, R. J., and Olley, J. E., 1972, Modification of the behavioural changes induced by haloperidol in the rat by lesions in the caudate nucleus, the caudate-putamen and globus pallidus, Neuropharmacology 11: 81–89.Google Scholar
  366. Neill, D. B., Boggan, W. O., and Grossman, S. P., 1974, Impairment of avoidance performance by intrastriatal administration of 6-hydroxydopamine, Pharmacol. Biochem. Behay. 2: 97–103.Google Scholar
  367. Niemegeers, C.J.E., Verbruggen, F. J., and Janssen, P.A.J., 1969, The influence of various neuroleptic drugs on shock avoidance responding in rats. I. Nondiscriminated Sidman avoidance procedure, Psychopharmacologia 16: 161–174.Google Scholar
  368. Niemegeers, C.J.E., Verbruggen, F. J., and Janssen, P. A., 1970, The influence of various neuroleptic drugs on shock avoidance responding in rats. 3. Amphetamine antagonism in the discriminated Sidman avoidance procedure, Psychopharmacologia 17: 151–159.Google Scholar
  369. Niemegeers, C.J.E., Verbruggen, F. J., Wauquier, A., and Janssen, P.A.J., 1972, The influence of haloperidol and amphetamine on two different noise-escape situations in rats, Psychopharmacologia 25: 22–31.Google Scholar
  370. Nikodidevic, B., Creveling, C. R., and Udenfriend, S., 1963, Inhibition of dopamine-[3hydroxylase in vivo by benzyloxyamine and benzylhydrazine analogs, J. Pharmacol. Exp. Ther. 140: 224–228.Google Scholar
  371. Nygren, L. G., Olson, L., and Seiger, A., 1971, Regeneration of monoamine-containing axons in the developing and adult spinal cord of the rat following intraspinal 6-OHdopamine injections or transections, Histochemie 28: 1–15.Google Scholar
  372. Nygren, L. G., Fuxe, K., Jonsson, G., and Olson, L., 1974, Functional regeneration of 5hydroxytryptamine nerve terminals in the rat spinal cord following 5,6-dihydroxytryptamine induced degeneration, Brain Res. 78: 377–394.Google Scholar
  373. Olton, D. S., 1973, Shock-motivated avoidance and the analysis of behavior, Psyclwl. Bull. 79: 243–251.Google Scholar
  374. Osborne, R. H., and Kerkut, G. A., 1972, Inhibition of noradrenaline biosynthesis and its effects on learning in rats, Comp. Gen. Pharmacol. 3: 359–362.Google Scholar
  375. Otten, U., Paravicini, U., Oesch, F., and Thoenen, H., 1973, Time requirement for the single steps of trans-synaptic induction of tyrosine hydroxylase in the peripheral sympathetic nervous system, Naumn-Schrniedelherg’s Arch. Pharmacol. 280: 117–127.Google Scholar
  376. Pappas, B. A., 1974, Immunological and chemical sympathectomy in the neonatal rodent: Effects on emotional behavior, in “Limbic and Autonomic Nervous Systems Research” (L. V. Dilara, ed.), Plenum, New York.Google Scholar
  377. Pappas, B. A., and Sobrian, S. K., 1972, Neonatal sympathectomy by 6-hydroxydopamine in the rat: No effects on behavior but changes in endogenous brain norepinephrine, Life Sci. 11: 653–659.Google Scholar
  378. Pappas, B. A., Peters, D.A.V., Saari, M., Sobrian, S. K., and Minch, E., 1974, Neonatal 6hydroxydopamine sympathectomy in normotensive and spontaneously hypertensive rat, Pharmacol. Biochem. Behay. 2: 381–386.Google Scholar
  379. Pappas, B. A., Peters, D.A.V., Sobrian, S. K., Blouin, A., and Drew, B., 1975, Early behavioral and catecholaminergic effects of 6-hydroxydopamine and guanethidine in the neonatal rat, Pharm. Biochem. Behay. 3: 681–685.Google Scholar
  380. Pappas, B. A., Saari, M., and Peters, D.A.V., 1976, Regional brain catecholamine levels after intraventricular 6-hydroxydopamine in the neonatal rat, Res. Commun. Chem. Pathol. Pharmacol. 14: 751–754.Google Scholar
  381. Pérez-Cruet, J., Chase, T. N., and Murphy, D. L., 1974, Dietary regulation of brain tryptophan metabolism by plasma ratio of free tryptophan and neutral amino acids in humans, Nature (London) 248: 693–695.Google Scholar
  382. Persip, G. L., and Hamilton, L. W., 1973, Behavioral effects of serotonin or a blocking agent applied to the septum of the rat. Pharmarol. Biochem. Behay. 1: 139–147.Google Scholar
  383. Peters, D.A.V., 1971, Inhibition of serotonin biosynthesis of 6-halotryptophans in vivo, Biochem. Pharmacol. 20: 1413–1420.Google Scholar
  384. Peters, D.A.V., McGeer, P. L., and McGeer, E. G., 1968, The distribution of tryptophan hydroxylase in cat brain, J. Neurochem. 15: 1431–1435.Google Scholar
  385. Peters, D.A.V., Filczewski, M., and Mazurkiewicz-Kwilecki, M., 1972, Effect of parachlorophenylalanine on catecholamine synthesis in rat brain, heart and adrenals, Biochem. Pharmacol. 21: 2282–2284.Google Scholar
  386. Peters, D.A.V., Mazurkiewicz-Kwilecki, I. M., and Pappas, B. A., 1974, 6-Hydroxydopamine sympathectomy in the neonatal rat—effects on brain serotonin and histamine, Biochem. Pharmacol. 23: 2395–2401.Google Scholar
  387. Peterson, D. W., and Sparker, S. B., 1973, Increased fixed ratio response rates following norepinephrine depletion by 6-hydroxydopamine (6-HDA), Fed. Proc. 32: 753.Google Scholar
  388. Pieri, L., Pieri, M., and Haefely, W., 1974, LSD as an agonist of dopamine receptors in the striatum. Nature (London) 252: 586–588.Google Scholar
  389. Pijnenburg, A.J.J., Honig, W.M.M., Van Rossum, J. M., 1975, Effects of antagonists upon locomotor stimulation induced by injection of dopamine and noradrenaline into the nucleus accumbens of nialamide-pretreated rats, Psychopharmacologia 41: 175–180.Google Scholar
  390. Plech, A., Herman, Z. S., Wierzbicki, A., 1975a, Role of the noradrenergic and the dopaminergic receptors in the mechanism of the avoidance reflex in rats, Acta Med. Pol. 16: 225–230.Google Scholar
  391. Plech, A., Herman, Z. S., Brus, R., and Drybanski, A., 1975b, The impairment of learning of conditioned avoidance response in rats after 6-hydroxydopamine, Acta Nerv. Super. 17: 176–178.Google Scholar
  392. Pletscher, A., 1966, Monoamine oxidase inhibitors, Pharmacol. Rev. 18: 121–129.Google Scholar
  393. Pletscher, A., and Bartholini, G., 1971, Selective rise in brain dopamine by inhibition of extracerebral levodopa decarboxylation, Clin. Pharmacol. Therap. 12: 344–352.Google Scholar
  394. Pohorecky, L. A., Zigmond, M., Karten, H., and Wurtman, R. J., 1969, Enzymatic conversion of norepinephrine to epinephrine by the brain, J. Pharmacol. Exp. Tiler. 165: 190–195.Google Scholar
  395. Poirier, L. J., 1975, Histopathological changes associated with the intracerebral injection of 6-hydroxydopamine (6-OHDA) and peroxide (F1202) in the cat and rat, J. Neural Transmission 37: 209–218.Google Scholar
  396. Poirier, L. J., Singh, P., Sourkes, T. L., and Boucher, R., 1967, Effect of amine precursors on the concentration of striatal dopamine and serotonin in cats with and without unilateral brain stem lesions, Brain Res. 6: 654–666.Google Scholar
  397. Poirier, L. J., Langelier, P., Roberge, A. G., Boucher, R., and Kitsikis, A., 1972, Non-specific histophathological changes induced by the intracerebral injection of 6-hydroxydopamine (6-OHDA), J. Neurol. Sci. 16: 401–416.Google Scholar
  398. Porter, C. C., Watson, L. S., Titus, D. C., Totaro, J. A., and Byer, S. S., 1962, Inhibition of dopa decarboxylase by the hydrozino analog of a-methyl dopa, Biochem. Pharmacol. 11: 1067–1077.Google Scholar
  399. Posluns, D., 1962, An analysis of chlorpromazine-induced suppression of the avoidance response, Psychopharmacologia 3: 361–373.Google Scholar
  400. Powell, B. J., 1970, The role of d-amphetamine-amobarbital in suppressing freezing behavior during avoidance acquisition and extinction, Psychol. Rec. 20: 101–105.Google Scholar
  401. Price, M.T.C., and Fibiger, H. C., 1974, Apomorphine and amphetamine stereotypy after 6- hydroxydopamine lesions of the substantia nigra, Eur. J. Pharmmcol. 29: 249–252.Google Scholar
  402. Price, M. T., and Fibiger, H. C., 1975, Discriminated escape learning and response to electric shock after 6-hydroxydopamine lesions of the nigro-neostriatal dopaminergic projection, Pharmacol. Biochem. Behay. 3: 285–290.Google Scholar
  403. Prichard, J. W., and Guroff, G., 1971, Increased cerebral excitability caused by p-chlorophenylalanine in young rats, J. Neurochem. 18: 153–160.Google Scholar
  404. Rainbow, T. C., Adler, J. E., and Flexner, L. B., 1976, Comparison in mice of the amnesic effects of cycloheximide and 6-hydroxydopamine in a one-trial passive avoidance task, Pharmacol. Biochem. Behave. 4: 347–349.Google Scholar
  405. Rake, A., 1973, Involvement of biogenic amines in memory formation: The central nervous system indole amine involvement, Psychopharmacologia 29: 91–100.Google Scholar
  406. Randrup, A., and Munkvad, I., 1967, Stereotyped activities produced by amphetamine in several animal species and man, Pychopharmacologia 11: 300–310.Google Scholar
  407. Randrup, A., and Munkvad, I., 1970, Biochemical, anatomical and psychological investigations of stereotyped behavior induced by amphetamines, in “Amphetamines and Related Compounds” (E. Costa and S. Garattini, eds.), Raven, New York.Google Scholar
  408. Randt, C. T., Quartermain, D., Goldstein, M., and Anagnoste, G., 1971, Norepinephrine biosynthesis inhibition: Effects on memory in mice, Science 172: 498–499.Google Scholar
  409. Ray, O. S., and Barrett, R. J., 1975, Behavioral, pharmacological and biochemical analysis of genetic differences in rats, Behay. Biol. 15: 391–417.Google Scholar
  410. Rech, R. H., 1964, Antagonism of reserpine behavioural depression by d-amphetamine, J. Pharmacol. Exp. Ther. 146: 369–376.Google Scholar
  411. Rech, R. H., 1966, Amphetamine effects on poor performance of rats in a shuttlebox, Psychopharmacologia 9: 110–117.Google Scholar
  412. Rech, R. H., and Moore, K. E., 1968, Interactions between d-amphetamine and a-methyltyrosine in rat shuttle-box behaviour, Brain Res. 8: 398–400.Google Scholar
  413. Rech, R. H., and Stolk, J. M., 1970, Amphetamine-drug interactions that relate brain catecholamines to behavior, in “Amphetamines and Related Compounds” (E. Costa and S. Garattini, eds.), Raven, New York.Google Scholar
  414. Rech, R. H., Borys, H. K., and Moore, K. E., 1966, Alterations in behavior and brain catecholamine levels in rats treated with a-methyltyrosine, J. Ph armacol. Exp. Ther. 153: 412–419.Google Scholar
  415. Rech, R. H., Tilson, H. A., and Marquis, W. J., 1975, Adaptive changes in behavior after repeated administration of various psychoactive drugs, in “Neurobiological Mechanisms of Adaptation and Behavior” (A. J. Mandell, ed.), Raven, New York; Adv. Biochem. Psychopharmacol. 13:263–286.Google Scholar
  416. Reis, D. J., Joh, T. H., and Ross, R. A., 1975, Effects of reserpine on activities and amounts of tyrosine hydroxylase and dopamine-3-hydroxylase in catecholamine neuronal systems in rat brain, J. Pharmacol. Exp. Ther. 193: 775–784.Google Scholar
  417. Remington, G., and Anisman, H., 1974, Disruptive effects of epinephrine on active avoidance behavior: Alteration by scopolamine and d-amphetamine, Pharmacol. Biochem. Behay. 2: 427–430.Google Scholar
  418. Renson, J., 1973, Assays and properties of tryptophan 5-hydroxylase, in “Serotonin and Behavior” (J. Barchas and E. Usdin, eds.), pp. 19–32, Academic, New York.Google Scholar
  419. Richardson, J. S., and Jacobowitz, D. M., 1973, Depletion of brain norepinephrine by intraventricular injection of 6-hydroxydopa: A biochemical histochemical and behavioral study in rats, Brain Res. 58: 117–133.Google Scholar
  420. Robbins, T. W., and Iverson, S. D., 1973, Amphetamine-induced disruption of temporal discrimination by response disinhibition, Nature (London) New Biol. 245: 191–192.Google Scholar
  421. Roberts, D.C.S., Zis, A. P., and Fibiger, H. C., 1975, Ascending catecholamine pathways and amphetamine-induced locomotor activity: Importance of dopamine and apparent noninvolvement of norepinephrine, Brain Res. 93: 441–454.Google Scholar
  422. Roberts, D.C.S., Price, M.T.C., and Fibiger, H. C., 1976, The dorsal tegmental noradrenergic projection: An analysis of its role in maze learning,,. Comp. Physiol. Psychol. 90: 363–372.Google Scholar
  423. Robichaud, R., and Sledge, K., 1969, The effects of p-chlorophenylalanine on experimentally induced conflict in the rat, Life Sci. 8: 965–969.Google Scholar
  424. Rolinski, Z., and Scheel-Druger, J., 1973, The effect of dopamine and noradrenaline antagonists on amphetamine induced locomotor activity in mice and rats, Acta Pharmacol. Toxicol. 33: 385–399.Google Scholar
  425. Rosen, A. J., and LaFlore, J. E., and 1973, Effects of intraperitoneal and intraventricular d-amphetamine administration on active avoidance performance in the rat, Life Sci. 13: 1573–1580.Google Scholar
  426. Rosengren, E., 1960, On the role of monoamine oxidase for the inactivation of dopamine,in brain. Acta Physiol. Scand. 49: 370–375.Google Scholar
  427. Roth, R. H., Salzman, P. M., and Morgenroth, V. H., 1974, Noradrenergic neurons: Allosteric activation of hippocampal tyrosine hydroxylase by stimulation of the locus coeruleus, Biochem. Pharmacol. 23: 2779–2784.Google Scholar
  428. Rubin, B., Piala, J. J., Burke, J. C., and Craver, B. N., 1964, A new potent and specific serotonin inhibitor (SQ 10643) 2’-(3-dimethylaminopropylthio) cinnamanilide hydrochloride: Antiserotonin activity on uterus and on gastrointestinal, vascular and respiratory systems of animals, Arch. Int. Pharmacodyn. 152: 132–143.Google Scholar
  429. Ruiz, M., and Monti, J. M., 1972, Prevention of the haloperidol-induced blockade of a conditioned avoidance response by 1-dopa, Eur. J. Pharmacol. 20: 93–96.Google Scholar
  430. Saari, M., and Pappas, B. A., 1973, Neonatal 6-hydroxydopamine sympathectomy reduces footshock induced suppression of water-licking in normotensive and hypertensive rats, Nature (London), New Biol. 244: 181–183.Google Scholar
  431. Sachs, C., 1973, Development of the blood-brain barrier for 6-hydroxydopamine, J. Neurochem. 20: 1753–1760.Google Scholar
  432. Sachs, C., and Jonsson, G., 1972, Degeneration of central noradrenaline neurons after 6hydroxydopamine in newborn animals, Res. Commun. Chem. Pathol. Pharmacol. 4: 203–220.Google Scholar
  433. Sachs, C., and Jonsson, G., 1975a, Mechanisms of action of 6-hydroxydopamine, Biochem. Pharmacol. 24: 1–8.Google Scholar
  434. Sachs, C., and Jonsson, G., 1975b, Effects of 6-hydroxydopamine on central noradrenaline neurons during ontogeny, Brain Res. 99: 277–291.Google Scholar
  435. Sanders-Bush, E., Bushing, J. A., and Sulser, F., 1972a, Long-term effects of p-chloroamphetamine on tryptophan hydroxylase activity and on the levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in brain, Eur. J. Pharmacol. 20: 385–388.Google Scholar
  436. Sanders-Bush, E., Bushing, J. A., and Sulser, F., 1972b, p-Chloroamphetamine-inhibition of cerebral tryptophan hydroxylase, Biochem. PharmacoL 21: 1501–1510.Google Scholar
  437. Sanders-Bush, E., Gallager, D. A., and Sulser, F., 1974, On the mechanism of brain 5Hydroxytryptamine depletion of p-chloroamphetamine and related drugs and the specificity of their actions, in “Advances in Biochemical Psychopharmacology” (E. Costa, G. L. Gessa, and M. Sandler, eds.), Vol. 10, pp. 185–194, Raven, New York.Google Scholar
  438. Sansone, M., and Bovet, D., 1969, Effects of amphetamine on the decrement of performance in avoidance conditioning of guinea pigs, Psychopharmacologia 16: 234–239.Google Scholar
  439. Satinder, K. P., 1970, Effects of electric shock, d-amphetamine sulphate and chlorpromzaine on factors of emotionality in inbred mice, J. Comp. Physiol. Psychol. 71: 448–452.Google Scholar
  440. Satinder, K. P., 1971, Genotype-dependent effects of d-amphetamine sulphate and caffeine on escape-avoidance behavior of rats, J. Comp. Physiol. Psychol. 76: 359–364.Google Scholar
  441. Schanberg, S. M., Breese, G. R., Schildkraut, J. J., Gordon, E. K., and Kopin, I. J., 1968, 3-Methoxy-4-hydroxyphenylglycol sulphate in brain and cerebrospinal fluid, Biochem. Pharmacol. 17: 2006–2008.Google Scholar
  442. Scheel-Kruger, J., 1971, Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain, Eur. J. Pharmacol. 14: 47–59.Google Scholar
  443. Scheuer, C., and Moore, N. J., 1974, Breakdown of stimulus control by d-amphetamine, Physiol. Psychol. 2: 427–430.Google Scholar
  444. Schnaitman, C., Erwin, V. G., and Greenawalt, J. W., 1967, The submitochondrial localization of monoamine oxidase. An enzymatic marker for the outer membrane of rat liver mitochondria, J. Cell. Biol. 32: 719–735.Google Scholar
  445. Schoenfeld, R. I., and Seiden, L. S., 1969, Effect of a-methyltyrosine on operant behavior and brain catecholamine levels, J. Pharmacol. Exp. Ther. 167: 319–326.Google Scholar
  446. Schuster, C. R., and Zimmerman, J., 1961, Timing behavior during prolonged treatment with dl-amphetamine, J. Exp. Anal. Behay. 4: 327–330.Google Scholar
  447. Schuster, C. R., Dockens, W. S., and Woods, J. H., 1966, Behavioral variables affecting the development of amphetamine tolerance, Psychopharmacologia 9: 170–182.Google Scholar
  448. Scotti De Carolis, A., Ziegler, H., Del Basso, P., and Longo, V. G., 1971, Central effects of 6-hydroxydopamine, Physiol. Behay. 7: 705–708.Google Scholar
  449. Seeman, P., and Lee, T., 1975, Antipsychotic drugs: Direct correlation between clinical potency and presynaptic action on dopamine neurons, Science 188: 1217–1219.Google Scholar
  450. Segal, D. S., 1975, Behavioral and neurochemical correlates of repeated d-amphetamine administration, in “Neurobiological Mechanisms of Adaptation and Behavior” (A. J. Mandell, ed.), Raven, New York.Google Scholar
  451. Segal, D. S., and Mandell, A.J., 1974, Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy, Pharm. Biochem. Behay. 2: 249–255.Google Scholar
  452. Segal, D. S., Sullivan, J. L., Kuczenski, R. T., and Mandell, A. J., 1971, Effects of long-term reserpine treatment on brain tyrosine hydroxylase and behavioral activity, Science 173: 847–849.Google Scholar
  453. Seiden, L. S., 1976, The role of catecholamines in the action of drugs affecting behavior, Pharmacol. Ther. 2: 155–165.Google Scholar
  454. Seiden, L. S., and Carlsson, A., 1963, Temporary and partial antagonism by L-DOPA of reserpine-induced suppression of conditioned avoidance response, Psychopharmacologia 4: 418–423.Google Scholar
  455. Seiden, L. S., and Carlsson, A., 1964, Brain and heart catecholamine levels after L-DOPA administration in reserpine treated mice: Correlations with a conditioned avoidance response, Psychopharmacologia 5: 178–181.Google Scholar
  456. Seiden, L. S., and Hanson, L.C.F., 1964, Reversal of the reserpine-induced suppression of the conditioned avoidance response in the cat by L-DOPA, Psychopharmacologia 6: 239–244.Google Scholar
  457. Seiden, L. S., and Peterson, D. D., 1968, Reversal of the reserpine-induced suppression of the conditioned avoidance response by L-DOPA: Correlation of behavioral and biochemical differences in two strains of mice, J. Pharmacol. Exp. Ther. 159: 422–428.Google Scholar
  458. Seliger, D. L., 1975, Dose response effects of d-amphetamine on passive avoidance learning in the rat, Psychopharmacologia 44: 191–193.Google Scholar
  459. Senoh, S., Daly, J., Axelrod, J., and Witkop, B., 1959, Enzymatic p-O-methylation by catechol 0-methyl transferase, J. Am. Chem. Soc. 81: 6240–6245.Google Scholar
  460. Seller, P., Saran, H., and McKenzie, G., 1976, Differential attenuation of some effects of haloperidol in rats given scopolamine, Eur. J. Pharmacol. 39: 117–126.Google Scholar
  461. Sharman, D. F., 1963, A fluorimetric method for the estimation of 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid) and its identification in brain tissue, Br. J. Pharmacol. Chemother. 20: 204–213.Google Scholar
  462. Sharman, D. F., 1969, Glycol metabolites of noradrenaline in brain tissue, Br. J. Pharmacol. 36: 523–534.Google Scholar
  463. Sharman, D. F., 1973, The catabolism of the catecholamines. Recent studies, Br. Med. Bull. 29: 110–115.Google Scholar
  464. Shaywitz, B. A., Yager, R. D., and Klopper, J. H., 1976, Selective main dopamine depletion in developing rats: An experimental model of minimal brain dysfunction, Science 191: 305–307.Google Scholar
  465. Sheard, M. H., 1974, The effect of p-chloroamphetamine on single raphé neurons, Adv. Biochem. Psychopharmacol. 10: 179–184.Google Scholar
  466. Sheard, M. H., Zolovick, A., and Aghajanian, G. K., 1972, Raphé neurons: Effect of tricyclic antidepressant drugs, Brain Res. 43: 690–694.Google Scholar
  467. Shettleworth, S. J., 1972, Constraints on learning, in “Advances in the Study of Behavior” (D. S. Lehrman, R. A. Hinde and E. Shaw, Eds.), Vol. 4, Academic, New York.Google Scholar
  468. Shields, P. J., and Eccleston, D., 1972, Effects of electrical stimulation of rat midbrain on 5hydroxytryptamine synthesis as determined by a sensitive radioisotope method, J. Neurochem. 19: 265–272.Google Scholar
  469. Shields, P. J., and Eccleston, D., 1973, Evidence for the synthesis and storage of 5-hydroxytryptamine in two separate pools in the brain, J. Neurochem. 20: 881–888.Google Scholar
  470. Sims, K. L., and Bloom, F. E., 1973, Rat brain L-3, 4-dihydroxyphenylalanine and 5hydroxytryptophan decarboxylase activities: Differential effect of 6-hydroxydopamine, Brain Rec. 49: 165–175.Google Scholar
  471. Sims, K. L., Davis, G. A., and Bloom, F. E., 1973, Activities of 3,4-dihydroxy-c-phenylalanine and 5-hydroxy-L-tryptophan decarboxylases in rat brain: Assay characteristics and distribution, J. Neurochem. 20: 449–464.Google Scholar
  472. Singh, B., and De Champlain, J., 1972, Altered ontogenesis of central noradrenergic neurons following neonatal treatment with 6-hydroxydopamine, Brain Res. 48: 432–437.Google Scholar
  473. Smith, A. D., 1972, Subcellular localization of noradrenaline in sympathetic neurons, Pharmacol. Rev. 24: 435–457.Google Scholar
  474. Smith, R. D., Cooper, B. R., and Breese, G. R., 19.73, Growth and behavioral changes in developing rats treated intracisternally with 6-hydroxydopamine: Evidence for involvement of brain dopamine, J. Pharrnacol. Exp. Ther. 185: 609–619.Google Scholar
  475. Smith, G. P., Levin, B. E., and Ervin, G. N., 1975, Loss of active avoidance responding after lateral hypothalamic injections of 6-hydroxydopamine, Brain Res. 88: 483–498.Google Scholar
  476. Sorenson, C. A., and Ellison, G. D., 1973, Nonlinear changes in activity and emotional reactivity scores following central noradrenergic lesions in rats, Psychopharmacologia 32: 313–325.Google Scholar
  477. Sorimachi, M., 1975, Increase of tyrosine hydroxylase activity after reserpine: Evidence for the selective response of noradrenergic neurons, Brain Res. 99: 400–404.Google Scholar
  478. Spector, S., Sjoerdsma, A., and Udenfriend, S., 1965, Blockade of endogenous norepinephrine synthesis by a-methyl-tyrosine, an inhibitor of tyrosine hydroxylase, J. Pharmacol. Exp. Ther. 147: 86–95.Google Scholar
  479. Srebro, B., and Lorens, S. A., 1975, Behavioral effects of selective midbrain raphé lesions in the rat, Brain Res. 89: 303–325.Google Scholar
  480. Stark, P., and Fuller, R. W., 1972, Behavioral and biochemical effects of p-chlorophenylalanine, 3-chlorotyrosine and 3-chlorotyramine. A proposed mechanism for inhibition of self-stimulation, Neuropharmacology 11: 261–272.Google Scholar
  481. Stark, P., Fuller, R. W., Hartley, L. W., Schaffer, R. J., and Turk, J. A., 1970, Dissociation of the effects of p-chlorophenylalanine on self-stimulation and on brain serotonin, Life Sci. 9 (1): 41–48.Google Scholar
  482. Stein, L., Wise, C. D., and Berger, B. D., 1973, Antianxiety action of benzodiazepines: Decrease in activity of serotonin neurons in the punishment system, in “The Benzodiazepines” (S. Garattini, E. Mussini and L. O. Randall, eds.), pp. 299–326, Raven, New York.Google Scholar
  483. Stein, L., Belluzzi, J. D., and Wise, C. D., 1975, Memory enhancement by central administration of norepinephrine, Brain Res. 84: 329–335.Google Scholar
  484. Steranka, L. R., and Barrett, R.J., 1974, Facilitation of avoidance acquisition by lesion of the median raphé nucleus: Evidence for serotonin as a mediator of shock-induced suppression, Behay. Biol. 11: 205–213.Google Scholar
  485. Stern, W. C., and Morgane, P. J., 1973, Effects of a-methyl tyrosine on REM sleep and brain amine levels in the cat, Biol. Psychiat. 6: 301–306.Google Scholar
  486. Stern, W. C., Hartmann, E. L., Draskoczy, P. R., and Schildkraut, J. L., 1972, Behavioral effects of centrally administered 6-hydroxydopamine, Psvchol Rep. 30: 815–820.Google Scholar
  487. Stevens, D. A., and Fechter, L. D., 1969, The effects of p-chlorophenylalanine, a depletor of brain serotonin, on behavior: II. Retardation of passive avoidance learning, Life Sci. 8: 379–385.Google Scholar
  488. Stjarne, L., and Lishajko, F., 1967, Localization of different steps in noradrenaline synthesis to different fractions of bovine splenic nerve homogenate, Biochem. Pharmacol. 16: 1719–1728.Google Scholar
  489. Stolk, J. M., and Rech, R. H., 1970, Antagonism of d-amphetamine by alpha-methyl-Ltyrosine: Behavioral evidence for the participation of catecholamine stores and synthesis in the amphetamine stimulant response, Neuropharmacology 9: 249–263.Google Scholar
  490. Stone, C. A., Wenger, H. C., Ludden, C. T., Stavorski, J. M., and Ross, C. A., 1961, Antiserotonin-antihistaminic properties of cyproheptadine, J. Pharmacol. Exp. Ther. 131: 73–84.Google Scholar
  491. Strömberg, U., and Svensson, T. H., 1971, L-DOPA induced effects on motor activity in mice after inhibition of dopamine-ß-hydroxylase, Psychopharmacologia 19: 53–60.Google Scholar
  492. Strömberg, U., Svensson, T. H., and Waldeck, B., 1970, On the mode of action of amantadine, J. Pharm. Pharmacol. 22: 959–962.Google Scholar
  493. Strömbom, U., 1975, Effects of low doses of catecholamine receptor agonists on exploration in mice, J. Neural Transmission 37: 229–235.Google Scholar
  494. Strömbom, U., 1976, Catecholamine receptor agonists (effects on motor activity and rate of tyrosine hydroxylation in mouse brain), Naunyn. Schiedelberg’s Arch. Pharmacol. 292: 167–176.Google Scholar
  495. Svensson, T. H., 1973, Increased dopamine concentration in the striatum in the mouse by FLA-63, a dopamine-ß-hydroxylase inhibitor, J. Pharm. Pharmacol. 25: 73–75.Google Scholar
  496. Svensson, T., and Waldeck, B., 1969, On the significance of central noradrenaline for motor activity: Experiments with a new dopamine-ß-hydroxylase inhibitor, Eur. J. Pharmacol. 7: 278–282.Google Scholar
  497. Svensson, T. H., and Waldeck, B., 1970, On the role of brain catecholamines in motor activity experiments with inhibitors of synthesis and monoamine oxidase, Psychopharmacologia 18: 357–365.Google Scholar
  498. Swanson, L. W., and Hartman, B. K., 1975, The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-ß-hydroxylase as a marker, J. Comp. Neurol. 163: 467–506.Google Scholar
  499. Sweig, R., McLean, J. H., Kostrzewa, R. M., and May, J. G., 1975, Behavioral and Biochemical Effects of Neonatal 6-Hydroxydopa Injections, paper presented at Society for Neuroscience 5th Annual Meeting, New York.Google Scholar
  500. Swonger, A. K., and Rech, R. H., 1972, Serotonergic and cholinergic involvement in habituation of activity and spontaneous alternation of rats in a Y-maze, J. Comp. Physiol. Psychol. 81:509.-522.Google Scholar
  501. Swonger, A. K., Chambers, W. F., and Rech, R. H., 1970, The effects of alterations in brain 5-HT on habituation of the cortical evoked response and the startel response in rats, The Pharmacologist 12: 207.Google Scholar
  502. Symchowicz, S., Korduba, C. A., and Veals, J., 1973, The effect of amantadine on radiolabelled biogenic amines in the rat brain, Eur. J. Pharmacol. 21: 155–160.Google Scholar
  503. Tabakoff, B., and Erwin, V. G., 1970, Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain, J. Biol. Chem. 245: 3263–3268.Google Scholar
  504. Tagliamonte, A., Biggio, G., Vargiu, L., and Gessa, G. L., 1973, Free tryptophan in serum controls brain tryptophan level and serotonin synthesis, Life Sci. 12 (II): 227–287.Google Scholar
  505. Tanaka, C., Yuh, Y., and Takaori, S., 1972, Relationship between brain monoamine levels and Sidman avoidance behavior in rats treated with tyrosine and tryptophan hydroxylase inhibitors, Brain Res. 45: 186–194.Google Scholar
  506. Tanaka, C., Inagaki, C., and Fujiwara, H., 1976, Labelled noradrenaline release from rat cerebral cortex following electrical stimulation of locus coeruleus, Brain Res. 106: 384–389.Google Scholar
  507. Taylor, K. M., and Laverty, R., 1972, The effects of drugs on the behavioral and biochemical actions of intraventricular 6-hydroxydopamine, Eur. J. Pharmacol. 17: 16–24.Google Scholar
  508. Taylor, K. M., Clark, D. W. J., Laverty, R., and Phelan, E. L., 1972, Specific noradrenergic neurons destroyed by 6-hydroxydopamine injection into newborn rats, Nature (London), New Biol. 239: 247–248.Google Scholar
  509. Tenen, S., 1967, The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat, Psychopharmacologia 10: 204–219.Google Scholar
  510. Thierry, A. M., Blanc, G., Sobel, A., Stinus, L., and Glowinski, J., 1973, Dopamine terminals in the rat cortex, Science 182: 499–501.Google Scholar
  511. Thoa, N. B., Eichelman, B., Richardson, J. S., and Jacobowitz, D., 1972, 6-hydroxydopa depletion of brain norepinephrine and the facilitation of aggressive behavior, Science 178: 75–77.Google Scholar
  512. Thoenen, H., Kettler, R., Burkard, W., and Saner, A., 1971, Neurally mediated control of enzymes involved in the synthesis of norepinephrine: Are they regulated as an operational unit?, Naunyn Schmicdclberg’s Arch. Pharmacol. 270: 146–160.Google Scholar
  513. Thornburg, J. E., and Moore, K. E., 1971, Stress-related effects of various inhibitors of catecholamine synthesis in the mouse, Arch. Int. Pharmacodvn. 194: 158–167.Google Scholar
  514. Thornburg, J. E., and Moore, K. E., 1973, The relative importance of dopaminergic and noradrenergic neuronal systems for the stimulation of locomotor activity induced by amphetamine and other drugs, Neuropharmacolov 12: 853–866.Google Scholar
  515. Thornburg, J. E., and Moore, K. E., 1975, Supersensitivity to dopamine agonists following unilateral, 6-hydroxydopamine-induced striatal lesions in mice, J. Pharmacol. Exp. Ther. 192: 42–49.Google Scholar
  516. Thornton, E. W., Goudie, A. J., and Bithell, V., 1975, The effects of neonatal 6-hydroxydopamine induced sympathectomy on response inhibition in extinction, Life Sci. 17: 363–368.Google Scholar
  517. Thut, P. D., 1974, Effect of L-dopa and L-dopa analogues on Sidman avoidance performance in mice, The Pharmacologist 16: 307.Google Scholar
  518. Tilson, H. A., and Rech, R. H., 1973a, Prior drug experience and effects of amphetamine on schedule controlled behavior, Pharmacol. Biochem. Behan. 1: 129–132.Google Scholar
  519. Tilson, H. A., and Rech, R. H., 1973b, Conditioned drug effects and absence of tolerance to d-amphetamine induced motor activity, Pharmacol. Biochem. Behay. 1: 149–153.Google Scholar
  520. Tilson, H. A., Maisel, A. S., Jourdan, M. G., and Rech, R. H., 1976, Comparison of the effects of d-amphetamine and lysergic acid diethylamide in two strains of rats having different behavioral baselines, Behay. Biol. 17: 463–471.Google Scholar
  521. Tozer, T. N., Neff, N. H., and Brodie, B. B., 1966, Application of steady state kinetics to the synthesis rate and turnover time of serotonin in the brain of normal and reserpinetreated rats, J. Pharmacol. Exp. Ther. 153: 177–182.Google Scholar
  522. Trulson, M. E., and Jacobs, B. L., 1976, Dose—response relationships between systemically administered L-tryptophan or L-5-hydroxytryptophan and raphé unit activity in the rat, Neuropharmacology 15: 339–344.Google Scholar
  523. Turner, A. J., and Tipton, K. F., 1972, The purification and properties of an NADPHlinked aldehyde reductase from pig brain, Eur. J. Biochem. 30: 361–368.Google Scholar
  524. Udenfriend, S., Witkop, B., Redfield, B. G., and Weissbach, H., 1958, Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds, Biochem. Pharmacol. 1: 160–165.Google Scholar
  525. Udenfriend, S., Zaltzman-Nirenberg, P., and Nagatsu, T., 1965, Inhibitors of purified beef adrenal tyrosine hydroxylase, Biochem. Pharmacol. 14: 837–845.Google Scholar
  526. Ungerstedt, U., 1971, Stereotaxic mapping of the monoamine pathways in the rat brain, Acta Physiol, Scand. Suppl. 367: 1–48.Google Scholar
  527. Uretsky, N. J., and Iversen, L. L., 1970, Effects of 6-hydroxydopamine on catecholamine containing neurons in the rat brain, J. Neurochem. 17: 269–278.Google Scholar
  528. Van Zwieten-Boot, B. J., and Noach, E. L., 1975, The effect of blocking dopamine release on synthesis rate of dopamine in the striatum of the rat, Eur. J. Pharmacol. 33: 247–254.Google Scholar
  529. Verhave, T., 1958, The effect of methamphetamine on operant level and avoidance behavior, J. Exp. Anal. Behay. 1: 207–219.Google Scholar
  530. von Hungen, K., Roberts, S., and Hill, D. F., 1974, LSD as an agonist and antagonist at central dopamine receptors, Nature (London) 252: 588–589.Google Scholar
  531. VonVoigtlander, P. F., Losey, E. G., Triezenberg, H. J., 1975, Increased sensitivity to dopaminergic agents after chronic neuroleptic treatment, J. Pharmacol Exp. Ther. 193: 88–94.Google Scholar
  532. Wallach, M. B., 1974, Drug-induced stereotyped behavior: Similarities and differences, in “Neuropsychopharmacology of Monoamines and their Regulatory Enzymes” (E. Usdin, ed.), Raven, New York.Google Scholar
  533. Weiner, W. J., Goetz, C., Westheimer, R., and Klawans, H. L., Jr., 1973, Serotonergic and antiserotonergic influences on amphetamine-induced stereotyped behavior, J. Neurol. Sci. 20: 373–379.Google Scholar
  534. Weiner, W. J., Goetz, C., and Klawans, H. L., 1975, Serotonergic and antiserotonergic influences on apomorphine-induced stereotyped behaviour, Acta Pharmacol. Toxicol. 36: 155–160.Google Scholar
  535. Weissman, A., 1967, Drugs and retrograde amnesia, Int. Rev. Neurobiol. 10: 167–198.Google Scholar
  536. Weissman, A., 1973, Behavioral pharmacology of p-chlorophenylalanine (PCPA), in “Serotonin and Behavior” (I. Barchas and E. Usdin, eds.), pp. 235–248, Academic, New York.Google Scholar
  537. Weissman, A., Koe, B. K., and Tenen, S. S., 1966, Antiamphetamine effects following inhibition of tyrosine hydroxylase, J. Pharmacol. Exp. Ther. 151: 339–352.Google Scholar
  538. Welch, A. S., and Welch, B. L., 1968, Effects of stress and parahlorophenylanine upon brain serotonin, 5-hydroxyindoleacetic acid and catecholamines in grouped and isolated mice, Biochem. Pharmacol. 17: 699–708.Google Scholar
  539. White, T. D., 1976, Evidence that the rapid binding of newly accumulated noradrenaline within synaptosomes involves synaptic vesicles, Brain Res. 108: 87–96.Google Scholar
  540. White, T. D., and Keen, P., 1970, The role of internal and external Na+ and K+ on the uptake of [3H]-noradrenaline by synaptosomes prepared from rat brain, Biochem. Biophys. Acta 196: 285–295.Google Scholar
  541. Whittaker, V. P., 1966, Catecholamine storage particles in the central nervous system, Pharmacol. Rev. 18: 401–412.Google Scholar
  542. Williams, J. M., Hamilton, L. W., and Carlton, P. L., 1974, Pharmacological and anatomical dissociation of two types of habituation, J. Comp. Physiol. Psychol. 87: 724–732.Google Scholar
  543. Williams, J. M., Hamilton,L. W., and Carlton, P. L., 1975, Ontogenetic dissociation of two classes of habituation, J. Comp. Physiol. Psychol. 89: 733–737.Google Scholar
  544. Winokur, G., and Bagchi, S. P., 1974, Effects of bufotenine and p-chlorophenylalanine on reactivity to footshock, Physiol. Psychol. 2: 75–79.Google Scholar
  545. Winokur, G., Bagchi, S. P., and Hubbard, P., 1971, Effects of bufotenine and p-chlorophenylalanine on stress induced behaviour, Psychopharmacologia 22: 100–110.Google Scholar
  546. Wise, C. D., Berger, B. D., and Stein, L., 1970, Brain serotonin and conditioned fear, Proc. 78th Ann. Meet. Am. Psychol. Assoc. 5: 821–822.Google Scholar
  547. Wong, D. T., Horng, J. S., and Fuller, R. W., 1973, Kinetics of serotonin accumulation into synaptosomes of rat brain—effects of amphetamine and chloroamphetamines, Biochem. Pharmacol. 22: 311–322.Google Scholar
  548. Wright, D. C., 1974, Differentiating stimulus and storage hypotheses of state dependent learning, Fed. Proc. Fed. Am. Soc. Exp. Biol. 33: 1797–1799.Google Scholar
  549. Yang, H.Y.T., and Neff, N. H., 1974, The monoamine oxidases of brain: Selective inhibition with drugs and the consequences for the metabolism of the biogenic amines, J. Pharmacol. Exp. Ther. 189: 733–740.Google Scholar
  550. Yarbrough, G. G., 1975, Supersensitivity of caudate neurons after repeated administration of haloperidol, Eur. J. Pharmacol. 31: 367–369.Google Scholar
  551. Zhelyaskov, D. K., Levitt, M., and Udenfriend, S., 1968, Tryptophan derivatives as inhibitors of tyrosine hydroxylase in vivo and in vitro, Mol. Pharmacol. 4: 445–451.Google Scholar
  552. Ziance, R. J., Azzaro, A. J., and Rutledge, C.O., 1972, Characteristics of amphetamine-induced release of norepinephrine from rat cerebral cortex in vitro, J. Pharmacol. Exp. Ther. 182: 284–294.Google Scholar
  553. Zieher, L. M., and Jaim-Etcheverry, G., 1975, 6-hydroxydopa during development of central adrenergic neurons produces different long-term changes in rat brain noradrenaline, Brain Res. 86: 271–281.Google Scholar
  554. Zigmond, M. J., and Sticker, E. M., 1972, Deficits in feeding behavior after intraventricular injection of 6-hydroxydopamine in rats, Science, 177: 1211–1214.Google Scholar
  555. Zis, A. P., Fibiger, H. C., and Phillips, A. G., 1974, Reversal by 1-DOPA of impaired learning due to destruction of the dopaminergic nigro-neostriatal projection, Science 185: 960–962.Google Scholar
  556. Zivkovic, B., Guidotti, A., and Costa, E., 1973, Increase of tryptophan hydroxylase activity elicited by reserpine, Brain Res. 57: 522–526.Google Scholar
  557. Zornetzer, S. F., Gold, M. S., and Hendrickson, J., 1974, Alpha-methyl-p-tyrosine and memory: State-dependency and memory failure, Behay. Biol. 12: 135–141.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • David A. V. Peters
    • 1
  • Hymie Anisman
    • 2
  • Bruce A. Pappas
    • 2
  1. 1.Department of PharmacologyUniversity of OttawaOttawaCanada
  2. 2.Department of PsychologyCarleton UniversityOttawaCanada

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