Clinical Manifestations of Disorders of the Inflammatory Response
The inflammatory response has been recognized since antiquity and all of us as students of medicine have learned the cardinal signs of this host response to injury, i.e., tumor (swelling), rubor (redness), calor (heat), dolor (pain), functio laesa (loss of function). It seems hard to believe with our present understanding of the mechanisms of inflammation, that for centuries these signs and the inflammatory response in general were considered harmful pathologic responses to injury. The turning point in this concept occurred as recently as the late 1800s when Elie Metchnikoff described the process of inflammation in higher mammals as a process which is necessary for defense from injury and, indeed, necessary for existence (1). This concept, that the inflammatory response is essential for survival when the equilibrium between microbes and toxins on the host’s surface is disturbed, has stimulated tremendous interest in the inflammatory and immune response ever since. For example, “antibacterial power” of serum was shown several decades ago to be an interaction of antibody and complement when the relationship of serum opsonin and the phagocytic system was beginning to be unraveled. More recently an understanding of cell-mediated immunity or lymphocyte-macrophage-mediated immunity has evolved.
KeywordsSinglet Oxygen Chronic Granulomatous Disease Neutrophil Chemotaxis Chronic Granulomatous Disease Patient Chemotactic Responsiveness
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