The Chemical and Immune Mediators of the Inflammatory Response

  • Allen P. Kaplan


In the allergic reaction the critical cells are the basophils, the circulating granulocytes that contains histamine, and the tissue mast cells as shown in Fig. 1. The antibody that we deal with is Immunoglobulin E(IgE) which is the least plentiful of the immunoglobulins in plasma (the normal level being between 25 and 600 ng per milliliter).


Immune Complex Platelet Activate Factor Chemotactic Factor Complement Pathway Immune Mediator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ishizaka, T., and K. Ishizaka. In: The Biological Role of the Immunoglobulin E System, K. Ishizaka and D. H. Dayton, Jr. (eds.), U. S. Department of Health, Education and Welfare, National Institute of Child Health and Development, U. S. Government Printing Office, Washington, D.C., p. 33, 1973.Google Scholar
  2. 2.
    Kay, A. B., D. J. Stechschulte and K. F. Austen, J. Exp. Med. 133:602, 1971.CrossRefGoogle Scholar
  3. 3.
    Kay, A. B., and K. F. Austen, J. Immunol. 107:894, 1971.Google Scholar
  4. 4.
    Goetzl, E. J., and K. F. Austen, Proc. Nat. Acad. Sci. 72:4123, 1975.CrossRefGoogle Scholar
  5. 5.
    Benveniste, J., P. M. Henson and C. G. Cochrane, J. Exp. Med. 136:1356, 1972.CrossRefGoogle Scholar
  6. 6.
    Schayer, R. W. In: Handbook of Experimental Pharmacology, Histamine and Antihistaminics, Part I, M. Rocha e Silva (ed.), Springer-Valeg, Inc., New York 18:688, 1966.Google Scholar
  7. 7.
    Orange, R. P., R. C. Murphy and K. F. Austen, J. Immunol. 113:316, 1974.Google Scholar
  8. 8.
    Benveniste, J., P. Karmoun and J. Polonsky, Fed. Proc. 34:985, 1975 (Abst.).Google Scholar
  9. 9.
    Clark, R. A. F., J. I. Gallin and A. P. Kaplan, J. Exp. Med. 142:1462, 1975.CrossRefGoogle Scholar
  10. 10.
    Clark, R. A. F., J. I. Gallin and A. P. Kaplan, J. Allergy and Clin. Immunol. 58:623, 1976.CrossRefGoogle Scholar
  11. 11.
    Lichtenstein, L. M., and S. Margolis, Science 161:902, 1968.CrossRefGoogle Scholar
  12. 12.
    Bourne, H. K., L. M. Lichtenstein and K. L. Melmon, J. Immunol. 108:695, 1972.Google Scholar
  13. 13.
    Orange, R. P., G. W. Austen and K. F. Austen, J. Exp. Med. Suppl. 134:1365, 1971.Google Scholar
  14. 14.
    Orange, R. P., M. A. Kaliner, P. J. La Raia and K. F. Austen, Fed. Proc. 30:1725, 1971.Google Scholar
  15. 15.
    Kaliner, M. A., R. P. Orange and K. F. Austen, J. Exp. Med. 136:556, 1972.CrossRefGoogle Scholar
  16. 16.
    Beaven, M. A., N. Eng. J. Med. 294:320, 1976.CrossRefGoogle Scholar
  17. 17.
    Clark, R. A. F., J. I. Gallin and A. P. Kaplan, J. Immunol., in press.Google Scholar
  18. 18.
    Fearon, D. T., and K. F. Austen, Immunochemistry of the classi cal and alternative pathways of complement. In: Immuno-chemistry, Glen and Stuart (eds.), in press.Google Scholar
  19. 19.
    Müller-Eberhard, H. J., Annual Review of Biochemistry 44:697, 1975.CrossRefGoogle Scholar
  20. 20.
    Donaldson, V. H., and R. R. Evans, Am. J. Med. 35:47, 1963.CrossRefGoogle Scholar
  21. 21.
    Donaldson, V. H., O. D. Ratnoff, W. D. DaSilva and F. S. Rosen, J. Clin. Invest. 48:642, 1969.CrossRefGoogle Scholar
  22. 22.
    Willms, K., F. S. Rosen and V. H. Donaldson, Clin. Immunol. and Immunopath. 4:174, 1975.CrossRefGoogle Scholar
  23. 23.
    Pillemer, L., L. Blum, I. H. Lepow, O. A. Ross, E. W. Todd and A. C. Wardlaw, Science 120:279, 1954.CrossRefGoogle Scholar
  24. 24.
    Götze, O., and H. J. Müller-Eberhard, J. Exp. Med. 134, 905, 1971.Google Scholar
  25. 25.
    Medicus, R. G., R. D. Schreiber, O. Götze and H. J. Müller-Eberhard, Proc. Nat. Acad. Sci. 73:612, 1976.CrossRefGoogle Scholar
  26. 26.
    Schreiber, R. D., O. Götze and H. J. Müller-Eberhard, J. Exp. Med. 144:1062, 1976.CrossRefGoogle Scholar
  27. 27.
    Michael, A. F., N. G. Westberg, A. J. Fish and R. L. Vernier, J. Exp. Med. 134:208s, 1971.Google Scholar
  28. 28.
    Fearon, D. T., K. F. Austen and S. Ruddy, J. Exp. Med. 139: 355, 1974.CrossRefGoogle Scholar
  29. 29.
    Medicus, R. G., O. Götze and H. J. Müller-Eberhard, J. Exp. Med. 144, 1076, 1976.CrossRefGoogle Scholar
  30. 30.
    Ruddy, S., and K. F. Austen, Surgical Clinics of North America 49:741, 1969.Google Scholar
  31. 31.
    Ruddy, S., D. T. Fearon and K. F. Austen, Arthritis and Rheumatism 18:289, 1975.CrossRefGoogle Scholar
  32. 32.
    Ruthfield, N., H. A. Ross, J. O. Minta and I. H. Lepow, N. Eng. J. Med. 287:681, 1972.CrossRefGoogle Scholar
  33. 33.
    Ratnoff, O. D., and J. E. Colopy, J. Clin. Invest. 34:602, 1955.CrossRefGoogle Scholar
  34. 34.
    Kaplan, A. P., and K. F. Austen, J. Immunol. 105:802, 1970.Google Scholar
  35. 35.
    Revak, S. D., and C. G. Cochrane, J. Clin. Invest. 57:852, 1976.CrossRefGoogle Scholar
  36. 36.
    Schreiber, R. D., A. P. Kaplan and K. F. Austen, J. Clin. Invest. 52:1402, 1973.CrossRefGoogle Scholar
  37. 37.
    Stead, N. W., A. P. Kaplan and R. D. Rosenberg, J. Biol. Chem. 251:6481, 1976.Google Scholar
  38. 38.
    Jacobsen, S., Brit. J. Pharmacol. 26:403, 1966.Google Scholar
  39. 39.
    Jacobsen, S., and M. Kriz, Brit. J. Pharmacol. 29:25, 1967.Google Scholar
  40. 40.
    Pierce, J. V., Fed. Proc. 27:52, 1968.Google Scholar
  41. 41.
    Ratnoff, O. D., E. W. Davie and D. L. Mallet, J. Clin. Invest. 40:803, 1961.CrossRefGoogle Scholar
  42. 42.
    Kaplan, A. P., and K. F. Austen, J. Exp. Med. 136:1378, 1972.CrossRefGoogle Scholar
  43. 43.
    Wuepper, K. D., D. R. Miller and M. J. La Combe, J. Clin. Invest. 56:1663, 1975.CrossRefGoogle Scholar
  44. 44.
    Colman, R. W., P. Bagdasarian, R. C. Galamo, C. F. Scott, M. Seavey, J. A. Guimaraes, J. V. Pierce and A. P. Kaplan, J. Clin. Invest. 56:1652, 1975.CrossRefGoogle Scholar
  45. 45.
    Saito, H., O. D. Ratnoff, R. Waldmann and J. P. Abraham, J. Clin. Invest. 55:1082, 1975.CrossRefGoogle Scholar
  46. 46.
    Donaldson, V. H., H. I. Glueck, M. A. Miller, H. Z. Movat and F. Habal, J. Lab. Clin. Med. 87:327, 1976.Google Scholar
  47. 47.
    Hathaway, W. E., L. P. Belhansen and H. S. Hathaway, Brit. J. Haematol. 26:521, 1965.Google Scholar
  48. 48.
    Wuepper, K. D., J. Exp. Med. 138:1345, 1973.CrossRefGoogle Scholar
  49. 49.
    Weiss, A. S., J. I. Gallin and A. P. Kaplan, J. Clin. Invest. 53:622, 1974.CrossRefGoogle Scholar
  50. 50.
    Saito, H., O. D. Ratnoff and V. H. Donaldson, Circ. Res. 34: 641, 1974.CrossRefGoogle Scholar
  51. 51.
    Meier, H. L., M. Webster, C. Y. Liu, R. W. Colman and A. P. Kaplan, Fed. Proc. 35:692, 1976 (Abst.).Google Scholar
  52. 52.
    Griffin, J., and C. G. Cochrane, Proc. Nat. Acad. Sci. 73: 2559, 1976.CrossRefGoogle Scholar
  53. 53.
    Liu, C. Y., A. Bagdasarian, H. L. Meier, C. F. Scott, J. V. Pierce, A. P. Kaplan and R. W. Colman, Fed. Proc. 35:692, 1976 (Abst.).Google Scholar
  54. 54.
    Mandle, R. J., R. W. Colman and A. P. Kaplan, Proc. Nat. Acad. Sci. 73:4179, 1976.CrossRefGoogle Scholar
  55. 55.
    Morrison, D. C., and C. G. Cochrane, J. Exp. Med. 140:787, 1974.CrossRefGoogle Scholar
  56. 56.
    Cochrane, C. G., S. D. Revak, B. S. Aiken and K. D. Wuepper. In: Inflammation: Mechanisms and Control, P. Ward and I. Lepow (eds.), Academic Press, New York, 119, 1972.Google Scholar

Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Allen P. Kaplan
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

Personalised recommendations