Alterations in Intermediary Metabolism

  • Douglas W. Wilmore
Part of the Reviewing Surgical Topics book series (RST)


Man is a meal-eater. During periods of food intake, energy consumption usually exceeds energy expenditure and the additional fuel is stored to be mobilized and utilized during the postabsorptive period. With the consumption of a mixed diet containing fat, carbohydrate, and protein, carbohydrate serves as the primary fuel and triglycerides are primarily stored as adipose tissue. The substance which mediates this response is insulin, although glucagon suppression may also contribute to substrate storage. Excess dietary carbohydrate may also be converted to depot fat if glycogen stores are full. Dietary protein contributes to the maintenance of body structure; the excess amino acids are oxidized in the liver and converted to urea. Protein is not primarily stored as a body fuel, but dietary nitrogen is utilized to rebuild deficits of body protein if they exist.


Cold Exposure Nitrogen Loss Hepatic Glucose Production Intermediary Metabolism Hepatic Gluconeogenesis 
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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Douglas W. Wilmore
    • 1
  1. 1.U. S. Army Institute of Surgical ResearchBrooke Army Medical CenterFort Sam HoustonUSA

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