Vitamin B12 and Folic Acid in Chronic Alcoholics

  • E. Heilmann


The adverse effects of alcohol on haemopoiesis have been well documented. The most important manifestation of alcohol toxicity is anaemia, but abnormalities in platelets and white blood cell production are also observed. One of the earliest indications of the ability of ethanol to interfere in cellular metabolism was the observation by Gram (1884) of macrocytosis in association with cirrhosis. The nutritional deficit associated with alcoholism was suspected by Bianco and Jolliffe (1938); they regarded the macrocytosis of the alcohol addict not as a manifestation of inability on the part of the liver to store a haemopoietic principle, but as an extrinsic deficiency of some necessary haemopoietic substance required to prevent macrocytosis.


Folic Acid Chronic Alcoholic Folate Deficiency Folic Acid Level Serum Folic Acid 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • E. Heilmann
    • 1
  1. 1.Medizinische Poliklinik der WestfalischenWilhelms-UniversitatMunsterGermany

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