Advertisement

Histochemistry and Electron Microscopy of Islets

  • Lennart Boquist

Abstract

The islets of highly different species are composed of parenchymal cells, blood vessels, nervous elements, and connective tissue. The parenchymal cells are either diffusely intermingled with each other, or, more often, the B (β) cells are localized to the central portion of the islets, and the A (α 2) and D (α 1) cells* are localized to the periphery, sometimes with a tendency toward interposition of the D cells between the central B cells and the peripheral A cells (Fig. 1). The differentiation of the parenchymal cell types is based mainly upon the structural appearance of their secretory granules. In most species B, A, and D cells are found, which usually can be easily distinguished by ultrastructural techniques.

Keywords

Islet Cell Pancreatic Islet Parenchymal Cell Secretory Granule Golgi Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Caramia, F.: Amer. J. Anat., 112: 53, 1963.PubMedCrossRefGoogle Scholar
  2. 2.
    Caramia, F., Munger, B. L., and Lacy, P. E.: Z. Zellforsch., 66: 533, 1965.CrossRefGoogle Scholar
  3. 3.
    Hoyos-Guevara, E., de: Z. Zellforsch., 101: 28, 1969.PubMedCrossRefGoogle Scholar
  4. 4.
    Greider, M. H., Bencosme, S. A., and Lechago, J.: Lab. Invest., 22: 344, 1970.PubMedGoogle Scholar
  5. 5.
    Bencosme, S. A., and Lechago, J.: Lab. Invest., 18: 715, 1968.PubMedGoogle Scholar
  6. 6.
    Faller, A.: Z. Zellforsch., 97: 226, 1969.PubMedCrossRefGoogle Scholar
  7. 7.
    Like, A. A.: Lab. Invest., 16: 937, 1967.PubMedGoogle Scholar
  8. 8.
    Sato, T., Herman, L., and Fitzgerald, P. J.: Gen. Comp. Endocrinol., 7: 132, 1966.CrossRefGoogle Scholar
  9. 9.
    Fujita, T.: Arch. Histol. Jap., 29: 1, 1968.PubMedCrossRefGoogle Scholar
  10. 10.
    Shino, A., Matsuo, T., Iwatsuka, H., and Suzuoki, Z.: Diabetologia, 9: 413, 1973.CrossRefGoogle Scholar
  11. 11.
    Melmed, R. N., Benitez, C. J., and Holt, S. J.: J. Cell Sci., 11: 449, 1972.PubMedGoogle Scholar
  12. 12.
    Lacy, P. E.: Anat. Rec., 128: 255, 1957.PubMedCrossRefGoogle Scholar
  13. 13.
    Lacy, P. E.: Diabetes, 6: 498, 1957.PubMedGoogle Scholar
  14. 14.
    Falkmer, S., Hellman, B., and Voigt, G. E.: Acta Pathol. Microbiol. Scand., 60: 47, 1964.PubMedGoogle Scholar
  15. 15.
    Björkman, N., Hellerström, C., Hellman, B., and Petersson, B.: Z. Zellforsch., 72: 425, 1966.PubMedCrossRefGoogle Scholar
  16. 16.
    Boquist, L., and Falkmer, S.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 25.Google Scholar
  17. 17.
    Boquist, L.: Acta Soc. Med. Upsal., 72: 345, 1967.PubMedGoogle Scholar
  18. 18.
    Boquist, L.: Virchows Arch. Abt. Zellpath., 1: 169, 1968.Google Scholar
  19. 19.
    Boquist, L.: Acta Pathol. Microbiol. Scand., 75: 399, 1969.PubMedGoogle Scholar
  20. 20.
    Luse, S. A., Caramia, G., Gerritsen, G., and Dulin, W. E.: Diabetologia, 3: 97, 1967.PubMedCrossRefGoogle Scholar
  21. 21.
    Lazarus, S. S., Shapiro, S. H., and Volk, B. W.: Lab. Invest., 16: 330, 1967.PubMedGoogle Scholar
  22. 22.
    Munger, B. L., Caramia, F., and Lacy, P. E.: Z. Zellforsch., 67: 776, 1965.PubMedCrossRefGoogle Scholar
  23. 23.
    Forssmann, A.: Cell Tiss. Res., 167: 179, 1976.CrossRefGoogle Scholar
  24. 24.
    Parrilla, R., Gomez-Acebo, J., and R-Candela, J. L.: J. Ultrastruc. Res., 26: 1, 1969.CrossRefGoogle Scholar
  25. 25.
    Kobayashi, K.: Arch. Histol. Jap., 26: 439, 1966.PubMedCrossRefGoogle Scholar
  26. 26.
    Munger, B. L.: Amer. J. Anat., 103: 275, 1958.PubMedCrossRefGoogle Scholar
  27. 27.
    Wessels, N. K., and Evans, J.: Develop. Biol., 17: 413, 1968.CrossRefGoogle Scholar
  28. 28.
    Orci, L., Lambert, A. E., Rouiller, C., Renold, A. E., and Samols, E.: Horm. Metab. Res., 1: 108, 1969.PubMedCrossRefGoogle Scholar
  29. 29.
    Perrier, H., and Billat, C.: Diabetologia, 6: 605, 1970.PubMedCrossRefGoogle Scholar
  30. 30.
    Pictet, R., Clark, W. R., Renold, A. E., Williams, R. H., and Rutter, W. J.: J. Cell Biol., 39: 105A, 1968.Google Scholar
  31. 31.
    Deconinck, J. F., Van Assche, F. A., Potvliege, P. R., and Gepts, W.: Diabetologia, 8: 326, 1972.PubMedCrossRefGoogle Scholar
  32. 32.
    Wellmann, K. F., Volk, B. W., and Brancato, P.: Lab. Invest., 25: 97, 1971.PubMedGoogle Scholar
  33. 33.
    Pictet, R., and Rutter, W. J.: In: Handbook of Physiology, Sect. 7, Endocrinology, Vol. 1, Endocrine Pancreas. Edited by R. O. Greep and E. B. Astwood. Amer. Physiol. Soc., Washington, 1972, p. 25.Google Scholar
  34. 34.
    Like, A. A.: Amer. J. Pathol., 59: 225, 1970.Google Scholar
  35. 35.
    Woods, S. C., and Porte, Jr., D.: Physiol. Rev., 54: 596, 1974.PubMedGoogle Scholar
  36. 36.
    Smith, P. H.: Amer. J. Anat., 144: 513, 1975.PubMedCrossRefGoogle Scholar
  37. 37.
    Lever, J. D.: In: Subcellular Organization and Function in Endocrine Tissues. Edited by H. Heller and K. Lederis. Cambridge University Press, Cambridge, 1971, p. 839.Google Scholar
  38. 38.
    Esterhuizen, A. C., and Howell, S. L.: J. Cell Biol., 46: 593, 1970.PubMedCrossRefGoogle Scholar
  39. 39.
    Malaisse, W., Malaisse-Lagae, F., Wright, P. H., and Ashmore, J.: Endocrinology, 80: 975, 1967.PubMedCrossRefGoogle Scholar
  40. 40.
    Shorr, S. S., and Bloom, F. E.: J. Biol. Med., 43: 47, 1970.Google Scholar
  41. 41.
    Orci, L., Lambert, A. E., Amherdt, M. L., Dameron, D., Kanazawa, Y., and Stauffacher, W.: Acta Diab. Lat., 7, Suppl. 1: 184, 1970.Google Scholar
  42. 42.
    Kern, H. F.: Cell Tiss. Res., 164: 261, 1975.CrossRefGoogle Scholar
  43. 43.
    Orci, L., Gabbay, K. H., and Malaisse, W. J.: Science, 175: 1128, 1972.PubMedCrossRefGoogle Scholar
  44. 44.
    Gabbiani, G., Malaisse-Lagae, F., Blondel, B., and Orci, L.: Endocrinology, 95: 1630, 1974.PubMedCrossRefGoogle Scholar
  45. 45.
    Sharp, G. W. G., Wollheim, C., Müller, W. A., Gutzeit, A., Trueheart, P. A., Blondel, B., Orci, L., and Renold, A. E.: Fed. Proc., 34: 1537, 1975.PubMedGoogle Scholar
  46. 46.
    Orci, L.: Diabetologia, 10: 163, 1974.PubMedCrossRefGoogle Scholar
  47. 47.
    Orci, L., Amherdt, M., Henquin, J. C., Lambert, A. E., Unger, R. H., and Renold, A. E.: Science, 180: 647, 1973.PubMedCrossRefGoogle Scholar
  48. 48.
    Orci, L., Unger, R. H., and Renold, A. E.: Experientia, 29: 1015, 1973.PubMedCrossRefGoogle Scholar
  49. 49.
    Wellmann, K. F., Brancato, P., Lazarus, S. S., and Volk, B. W.: Arch. Pathol., 84: 251, 1967.PubMedGoogle Scholar
  50. 50.
    Wellmann, K. F., Volk, B. W., Lazarus, S. S., and Brancato, P.: Diabetes, 18: 138, 1969.PubMedGoogle Scholar
  51. 51.
    Bencosme, S. A., and Martinez-Palamo, A.: Lab. Invest., 18: 746, 1968.PubMedGoogle Scholar
  52. 52.
    Lazarus, S. S., and Volk, B. W.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 159.Google Scholar
  53. 53.
    Aerts, L., and Van Assche, F. A.: Diabetologia, 11: 285, 1975.PubMedCrossRefGoogle Scholar
  54. 54.
    Shino, A., and Iwatsuka, H.: Acta Histochem. Cytochem., 6: 273, 1973.CrossRefGoogle Scholar
  55. 55.
    Boquist, L.: Harm. Metab. Res., 2: 166, 1970.CrossRefGoogle Scholar
  56. 56.
    Greider, M. H., Howell, S. L., and Lacy, P. E.: J. Cell Biol., 41: 162, 1969.PubMedCrossRefGoogle Scholar
  57. 57.
    Bencosme, S. A., Wilson, M. D., Aleyassine, H., de Bold, A. J., and de Bold, M. L.: Diabetologia, 6: 399, 1970.CrossRefGoogle Scholar
  58. 58.
    Grossner, D.: Z. Zellforsch., 83: 82, 1967.CrossRefGoogle Scholar
  59. 59.
    Boquist, L., and Patent, G.: Z. Zellforsch., 115: 416, 1971.PubMedCrossRefGoogle Scholar
  60. 60.
    Kawanishi, H.: Endocrinol. Jap., 13: 384, 1966.CrossRefGoogle Scholar
  61. 61.
    Benzo, C. A.: Amer. J. Anat., 140: 139, 1974.PubMedCrossRefGoogle Scholar
  62. 62.
    Boquist, L., and Ostberg, Y.: Cell Tiss. Res., 158: 78, 1975.CrossRefGoogle Scholar
  63. 63.
    Wasserman, D.: Cell Tiss. Res., 160: 539, 1975.CrossRefGoogle Scholar
  64. 64.
    Martinez-Palomo, A., and Bencosme, S. A.: J. Micros. (Paris), 5: 259, 1966.Google Scholar
  65. 65.
    Boquist, L.: Acta Diab. Lat., 7: 590, 1970.CrossRefGoogle Scholar
  66. 66.
    Boquist, L.: Z. Zellforsch., 106: 69, 1970.PubMedCrossRefGoogle Scholar
  67. 67.
    Ericson, L. E., and Lundquist, I.: Diabetologia, 11: 467, 1975.PubMedCrossRefGoogle Scholar
  68. 68.
    Boquist, L.: J. Cell Biol., 43: 377, 1969.PubMedCrossRefGoogle Scholar
  69. 69.
    Donev, A., and Petkov, P.: Arch. Histol. Jap., 33:351, 1971.PubMedCrossRefGoogle Scholar
  70. 70.
    Petkov, P. E., and Ogneva, V.: Acta Anat., 88: 348, 1974.PubMedCrossRefGoogle Scholar
  71. 71.
    Boquist, L.: Diabetes, 21: 1051, 1972.PubMedGoogle Scholar
  72. 72.
    Boquist, L.: J. Cell Biol., 45: 532, 1970.PubMedCrossRefGoogle Scholar
  73. 73.
    Bangle, Jr., R.: Amer. J. Pathol., 32: 349, 1956.Google Scholar
  74. 74.
    Gabe, M.: Bull. Micr. App., 3: 153, 1953.Google Scholar
  75. 75.
    Gomori, G.: Amer. J. Clin. Pathol., 20: 665, 1950.Google Scholar
  76. 76.
    Scott, H. R., and Clayton, B. P.: J. Histochem. Cytochem., 1: 336, 1953.PubMedCrossRefGoogle Scholar
  77. 77.
    Lever, J. D., and Findlay, J. A.: J. Anat., 98: 55, 1964.PubMedGoogle Scholar
  78. 78.
    Schiebler, T. H., and Schiessler, S.: Z. Zellforsch, 1: 445, 1969.Google Scholar
  79. 79.
    lazarus, S. S., and Volk, B. W.: The Pancreas in Human and Experimental Diabetes. Grune & Stratton, New York, 1962, p. 21.Google Scholar
  80. 80.
    Lange, R. H.: In: Handbuch der Histochemie. Edited by W. Graumann and K. Neumann. Gustav Fischer Verlag, Stuttgart, Vol. VIII/1, 1973, p. 1.Google Scholar
  81. 81.
    Denffer, v., H.: Histochemie, 36: 97, 1973.CrossRefGoogle Scholar
  82. 82.
    Fujita, T., Nasegawa, N., Koga, Y., Kameda, Y., and Takaya, K.: Arch. Histol. pip., 29: 313, 1968.Google Scholar
  83. 83.
    Lazarus, S. S., and Barden, H.: J. Histochem. Cytochem., 9: 628, 1961.Google Scholar
  84. 84.
    lazarus, S. S., Shapiro, S., and Volk, B. W.: J. Histochem. Cytochem., 17: 191, 1969.Google Scholar
  85. 85.
    Kvistberg, D. R., Lester, G., and Lazarow, A.: J. Histochem. Cytochem., 14: 609, 1966.PubMedCrossRefGoogle Scholar
  86. 86.
    Schirner, H.: Z. Naturfarsch., 14b: 690, 1959.Google Scholar
  87. 87.
    Rosenbloom, A. L., and Rennert, O. W.: Stain. Technol., 45: 25, 1970.PubMedGoogle Scholar
  88. 88.
    Fujita, T., and Takaya, K.: Stain. Technol., 43: 329, 1968.PubMedGoogle Scholar
  89. 89.
    Klessen, C.: Histochemistry, 45: 203, 1975.PubMedCrossRefGoogle Scholar
  90. 90.
    Barnett, R. J., and Seligman, M.: J. Histochem. Cytochem., 2: 462, 1954.Google Scholar
  91. 91.
    Denffer, v., H., and Mertz, M.: Histochemie, 29: 54, 1972.CrossRefGoogle Scholar
  92. 92.
    Ivic, M.: Anat. Anz., 107: 347, 1959.PubMedGoogle Scholar
  93. 93.
    Bock, R., and Ockenfels, H.: Histochemie, 21: 181, 1970.PubMedCrossRefGoogle Scholar
  94. 94.
    Mansini, A. M., Frizzera, G., and Vecchi, A.: Histochemie, 6: 301, 1966.CrossRefGoogle Scholar
  95. 95.
    Lacy, P. E.: Exp. Cell. Res., 7: 296, 1959.CrossRefGoogle Scholar
  96. 96.
    Logothetopoulos, J., Yip, C. C., and Coburn, M. E.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 381.Google Scholar
  97. 97.
    Grillo, T. A. I.: J. Endocrinol., 31: 67, 1964.PubMedCrossRefGoogle Scholar
  98. 98.
    Han v. Dorsche, H., Harfelt, E., Pehrmann, P., and Sulzmann, R.: Acta Histochem., 43: 342, 1972.Google Scholar
  99. 99.
    Orci, L., Lambert, A. E., Kanazawa, Y., Amherdt, M., Rouiller, C., and Renold, A. E.: J. Cell Biol., 50: 565, 1971.PubMedCrossRefGoogle Scholar
  100. 100.
    Grillo, T. A. I., and Shima, K.: J. Endocrinol. 36:151, 1966.PubMedCrossRefGoogle Scholar
  101. 101.
    Grant, P. T., and Coombs, T. L.: Biochemistry, 6: 69, 1970.Google Scholar
  102. 102.
    Kemmler, W., and Steiner, D. F.: Biochem. Biophys. Res. Commun., 41: 1223, 1970.PubMedCrossRefGoogle Scholar
  103. 103.
    Lacy, P. E.: Diabetes, 11: 509, 1962.PubMedGoogle Scholar
  104. 104.
    Volk, B. W., and Lazarus, S. S.: Diabetes, 13: 60, 1964.PubMedGoogle Scholar
  105. 105.
    Howell, S. L., Kostianovsky, M., and Lacy, P. E.: J. Cell Biol., 42: 695, 1969.PubMedCrossRefGoogle Scholar
  106. 106.
    Hartroft, W. S., and Wrenshall, G. A.: Diabetes, 4: 1, 1955.PubMedGoogle Scholar
  107. 107.
    Misugi, K., Howell, S. L., Greider, M. H., Lacy, P. E., and Sorenson, G. D.: Arch. Pathol., 89: 97, 1970.PubMedGoogle Scholar
  108. 108.
    Blundell, T. G., Dodson, G., Hodgkin, D., and Mercola, D.: Adv. Protein Chem., 26: 279, 1972.CrossRefGoogle Scholar
  109. 109.
    Jaim-Etcheverry, G., and Zieher, L. M.: Endocrinology, 83: 917, 1968.PubMedCrossRefGoogle Scholar
  110. 110.
    Lazarus, S. S., Barden, H., and Bradshaw, M.: Arch. Pathol., 73: 210, 1962.PubMedGoogle Scholar
  111. 111.
    Berger, W., Dahl, G., and Meissner, H.-P.: Cytobiologie, 12: 119, 1975.Google Scholar
  112. 112.
    Rhoten, W. B.: Amer. J. Anat., 138: 481, 1973.PubMedCrossRefGoogle Scholar
  113. 113.
    Lacy, P. E.: Diabetes, 19: 895, 1970.PubMedGoogle Scholar
  114. 114.
    Zimny, M. L., and Blackard, W. G.: Cell Tiss. Res., 164: 467, 1975.CrossRefGoogle Scholar
  115. 115.
    Creutzfeldt, W., Creutzfeldt, C., and Frerichs, H.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 181.Google Scholar
  116. 116.
    Like, A. A., and Miki, E.: Diabetologia, 3: 143, 1967.PubMedCrossRefGoogle Scholar
  117. 117.
    Lever, J. D., and Findlay, J. A.: Z. Zellforsch., 74:317, 1966.PubMedCrossRefGoogle Scholar
  118. 118.
    Findlay, J. A., Gill, J. R., Irvine, G., Lever, J. D., and Randle, P. J.: Diabetologia, 4: 150, 1968.PubMedCrossRefGoogle Scholar
  119. 119.
    Haist, R. E.: In: On the Nature and Treatment of Diabetes. Edited by B. S. Leibel, and G. A. Wrenshall. Excerpta Medica, Amsterdam, 1965, p. 12.Google Scholar
  120. 120.
    Creutzfeldt, W., Creutzfeldt, C., Frerichs, H., Perings, E., and Sickinger, K.: Horm. Metab. Res., 1: 53, 1969.PubMedCrossRefGoogle Scholar
  121. 121.
    Howell, S. L., Young, D. A., and Lacy, P. E.: J. Cell Biol., 41: 167, 1969.PubMedCrossRefGoogle Scholar
  122. 122.
    Lacy, P. E., Howell, S. L., Young, D. A., and Fink, C. J.: Nature (London) 219: 1177, 1968.CrossRefGoogle Scholar
  123. 123.
    Lacy, P. E., and Malaisse, W. J.: Rec. Progr. Harm. Res., 29: 199, 1973.Google Scholar
  124. 124.
    Lacy, P. E.: Amer. J. Pathol., 70:170, 1975.Google Scholar
  125. 125.
    Lacy, P. E., Walker, M. M., and Fink, C. J.: Diabetes, 21: 987, 1972.PubMedGoogle Scholar
  126. 126.
    Somers, G., Van Obberghen, E., Devis, G., Ravazzola, M., Malaisse-Lagae, F., and Malaisse, W. J.: Europ. J. Clin. Invest., 4: 299, 1974.PubMedGoogle Scholar
  127. 127.
    Lacy, P. E., and Greider, M. H.: In: Handbook of Physiology, Sect. 7, Endocrinology, Vol. 1, Endocrine Pancreas. Edited by R. O. Greep and E. B. Astwood. Amer. Physiol. Soc., Washington, 1972, p. 77.Google Scholar
  128. 128.
    Van Obberghen, E., Devis, G., Somers, G., Ravazzola, M., Malaisse-Lagae, F., and Malaisse, W. J.: Eur. J. Clin. Invest., 4: 307, 1974.PubMedGoogle Scholar
  129. 129.
    Wessels, N. K., Spooner, B. S., Ash, J. F., Bradley, M. O., Luduena, M. A., Taylor, E. L., Wrenn, J. T., and Yamada, K. M.: Science, 17: 135, 1971.CrossRefGoogle Scholar
  130. 130.
    Lacy, P. E., Klein, N. J., and Fink, C. J.: Endocrinology, 92: 1458, 1973.PubMedCrossRefGoogle Scholar
  131. 131.
    Van Obberghen, E., Somers, G., Devis, G., Ravazzola, M., Malaisse-Lagae, F., Orci, L., and Malaisse, W. J.: Diabetes, 24: 892, 1975.PubMedCrossRefGoogle Scholar
  132. 132.
    Orci, L., Malaisse-Lagae, F., Ravazoola, M., Amherdt, M., and Renold, A. E.: Science, 181: 561, 1973.PubMedCrossRefGoogle Scholar
  133. 133.
    Orci, L., Stauffacher, W., Dulin, W. E., Renold, A. E., and Rouiller, C.: Diabetologia, 6: 199, 1970.PubMedCrossRefGoogle Scholar
  134. 134.
    Orci, L., Junod, A., Pictet, R., Renold, A. E., and Rouiller, C.: J. Cell Biol., 38: 462, 1968.PubMedCrossRefGoogle Scholar
  135. 135.
    Wilander, E., and Boquist, L.: Harm. Metab. Res., 4: 426, 1972.CrossRefGoogle Scholar
  136. 136.
    Orci, L., Amherdt, M., Stauffacher, W., Like, A. A., Rouiller, C., and Renold, A. E.: Diabetes, (Suppl. 1 ) 21: 326, 1972.Google Scholar
  137. 137.
    Lazarus, S. S., and Volk, B. W.: Diabetes, 13: 54, 1964.PubMedGoogle Scholar
  138. 138.
    Lazarus, S. S., and Bencosme, S. A.: Amer. J. Clin. Pathol., 26: 1145, 1956.Google Scholar
  139. 139.
    Campbell, J., Rastogi, K. S., and Hausler, H. K.: Endocrinology, 79: 749, 1966.PubMedCrossRefGoogle Scholar
  140. 140.
    Frenkel, J. K.: Progr. Exp. Tumor Res., 16: 300, 1972.PubMedGoogle Scholar
  141. 141.
    Gepts, W., Gregoire, F., Van Assche, A., and de-Gasparo, M.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 283.Google Scholar
  142. 142.
    Boquist, L., Hellman, B., Lernmark, A., and Täljedal, I.-B.: J. Cell Biol., 62: 77, 1974.PubMedCrossRefGoogle Scholar
  143. 143.
    Coleman, D. L., and Hummel, K. P.: Diabetologia, 3: 238, 1967.PubMedCrossRefGoogle Scholar
  144. 144.
    Coleman, D. L., and Hummel, K. P.: In: Diabetes, Proc. VI Congr. Int. Diab. Fed., Exc. Med. Int. Congr. Ser. No. 172. Edited by J. Östman. 1967, p. 813.Google Scholar
  145. 145.
    Hummel, K. P., Coleman, D. L., and Lane, P. W.: Biochem. Genet., 7: 1, 1972.PubMedCrossRefGoogle Scholar
  146. 146.
    Like, A. A., and Chick, W. L.: Diabetologia, 6: 207, 1970.PubMedCrossRefGoogle Scholar
  147. 147.
    Like, A. A., and Chick, W. L.: Diabetologia, 6: 216, 1970.PubMedCrossRefGoogle Scholar
  148. 148.
    Orci, L., Amherdt, M., Malaisse-Lagae, F., Perrelet, A., Dulin, W. E., Gerritsen, G. C., Malaisse, W. J., and Renold, A. E.: Diabetologia, 10: 529, 1974.PubMedCrossRefGoogle Scholar
  149. 149.
    Like, A. A., and Jones, E. E.: Diabetologia, 3: 179, 1967.PubMedCrossRefGoogle Scholar
  150. 150.
    Like, A. A., Steinke, J., Jones, E. E., and Cahill, Jr., G. F.: Amer. J. Pathol., 46: 621, 1965.Google Scholar
  151. 151.
    Borg, L. A. H., Andersson, A., Berne, C., and Westman, J.: Cell Tiss. Res., 162: 313, 1975.CrossRefGoogle Scholar
  152. 152.
    Westman, S.: Acta Soc. Med. Upsal., 73: 81, 1968.PubMedGoogle Scholar
  153. 153.
    Appel, M. C., Chang, A. Y., and Dulin, W. E.: Diabetologia, 10: 625, 1974.PubMedCrossRefGoogle Scholar
  154. 154.
    Östberg, Y., and Boquist, L.: Acta Zool., 57:41, 1976.CrossRefGoogle Scholar
  155. 155.
    Like, A. A., and Chick, W. L.: Science, 163: 941, 1969.PubMedCrossRefGoogle Scholar
  156. 156.
    Boquist, L.: Diabetologia, 8: 274, 1972.PubMedCrossRefGoogle Scholar
  157. 157.
    Cavallero, C., and Mosca, L.: J. Pathol., 66: 147, 1953.CrossRefGoogle Scholar
  158. 158.
    LeCompte, P. M., and Merriam, Jr., J. C.: Diabetes, 11: 35, 1962.PubMedGoogle Scholar
  159. 159.
    Potvliege, P., Gepts, W., and Carpent, G.: Beitr. Path. Anat., 128: 335, 1963.Google Scholar
  160. 160.
    Nakamura, H.: Z. Zellforsch., 65: 340, 1965.PubMedCrossRefGoogle Scholar
  161. 161.
    Yanatori, Y., and Fujita, T.: Arch. Histol. Jap., 39: 67, 1976.PubMedCrossRefGoogle Scholar
  162. 162.
    Boquist, L.: Virchows Arch. Abt. B. Zellpath., 1: 157, 1968.Google Scholar
  163. 163.
    Steiner, H., Oelz, O., Zahnd, G., and Froesch, E. R.: Diabetologia, 6: 558, 1970.PubMedCrossRefGoogle Scholar
  164. 164.
    Gonet, A. E., Stauffacher, W., Pictet, R., and Renold, A. E.: Diabetologia, 1: 162, 1965.CrossRefGoogle Scholar
  165. 165.
    Boquist, L.: The Endocrine pancreas in the Chinese hamster. Studies on non-diabetic, alloxantreated, zinc-deficient, and spontaneously diabetic animals. Thesis, University of Umeâ, Umeâ, Sweden, 1969.Google Scholar
  166. 166.
    Like, A. A., Gerritsen, G. C., Dulin, W. E., and Gaudreau, P.: Diabetologia, 10: 501, 1974.PubMedCrossRefGoogle Scholar
  167. 167.
    Marx, M., Schmidt, W., and Goberna, R.: Z. Zellforsch., 110: 569, 1970.PubMedCrossRefGoogle Scholar
  168. 168.
    Björkman, N., Hellerström, C., Hellman, B., and Rothman, U.: Z. Zellforsch., 59: 535, 1963.PubMedCrossRefGoogle Scholar
  169. 169.
    Björkman, N., and Hellman, B.: Acta Anat., 56: 348, 1964.CrossRefGoogle Scholar
  170. 170.
    Hellerström, C.: Z. Zellforsch., 60: 688, 1963.CrossRefGoogle Scholar
  171. 171.
    Gomez-Acebo, J., Parilla, R., and R-Candela, J. L.: J. Cell Biol., 36: 33, 1968.PubMedCrossRefGoogle Scholar
  172. 172.
    Unger, R. H.: Diabetes, 25: 136, 1976.PubMedGoogle Scholar
  173. 173.
    Munger, B. L.: Lab. Invest., 2: 855, 1962.Google Scholar
  174. 174.
    Leclercq-Meyer, V., Marchand, J., and Malaisse, W. J.: Diabetologia, 10: 215, 1974.PubMedCrossRefGoogle Scholar
  175. 175.
    Baum, J., Simons, Jr., B. E., Unger, R. H., and Madison, L. L.: Diabetes, 11: 371, 1962.PubMedGoogle Scholar
  176. 176.
    Lundquist, G., Brolin, S. E., Unger, R. H., and Eisentraut, A. M.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 115.Google Scholar
  177. 177.
    Hellman, B., Wallgren, A., and Hellerström, C.: Nature (London), 194: 1201, 1962.CrossRefGoogle Scholar
  178. 178.
    Bencosme, S. A., Liepa, E., and Lazarus, S. S.: Proc. Soc. Exp. Biol. Med., 90: 387, 1955.PubMedGoogle Scholar
  179. 179.
    Petersson, B., and Hellman, B.: Acta Endocrinol., 44: 139, 1963.PubMedGoogle Scholar
  180. 180.
    Hellerström, C., and Hellman, B.: Acta Endocrinol., 41: 116, 1962.PubMedGoogle Scholar
  181. 181.
    Petersson, B., Hellerström, C., and Hellman, B.: Z. Zellforsch., 57: 559, 1962.PubMedCrossRefGoogle Scholar
  182. 182.
    Bromer, W. W., Sinn, L. G., Staub, A., and Behrens, O. K.: J. Amer. Chem. Soc., 78: 3858, 1956.CrossRefGoogle Scholar
  183. 183.
    Levine, H. J., and Glenner, G. G.: J. Natl. Cancer Inst., 20: 63, 1958.PubMedGoogle Scholar
  184. 184.
    Boquist, L.: Acta Soc. Med. Upsal., 72: 331, 1967.PubMedGoogle Scholar
  185. 185.
    Bussolati, G., Capella, C., Vassalo, C., and Solcia, E.: Diabetologia, 7: 181, 1971.PubMedCrossRefGoogle Scholar
  186. 186.
    Grimelius, L.: Acta Soc. Med. Upsal., 73: 243, 1968.PubMedGoogle Scholar
  187. 187.
    Grimelius, L.: Acta Soc. Med. Upsal., 74: 28, 1969.PubMedGoogle Scholar
  188. 188.
    Suzuki, H.: J. Electr. Microsc., 23: 33, 1974.Google Scholar
  189. 189.
    Vassalo, G., Capella, C., and Solcia, E.: Stain Technol., 46: 7, 1971.Google Scholar
  190. 190.
    Hellman, B., and Petersson, B.: Endocrinology, 72: 238, 1963.PubMedCrossRefGoogle Scholar
  191. 191.
    Petersson, B., Hellerström, C., and Gunnarsson, R.: Harm. Metab. Res., 2: 313, 1970.CrossRefGoogle Scholar
  192. 192.
    Hellerström, C.: Acta Soc. Med. Upsal., 68: 1, 1963.Google Scholar
  193. 193.
    Petersson, B.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 123.Google Scholar
  194. 194.
    Lehy, T., and Zeitoun, P.: Stain Technol., 45: 63, 1970.PubMedGoogle Scholar
  195. 195.
    Manocchio, I.: Zbl. Allg. Pathol., 101:1, 1960.Google Scholar
  196. 196.
    Solcia, E., and Sampietro, R.: Z. Zellforsch., 65:131, 1965.CrossRefGoogle Scholar
  197. 197.
    Hellerström, C., and Hellman, B.: Acta Endocrinol., 35: 518, 1960.Google Scholar
  198. 198.
    Grimelius, L., and Strand, A.: Virchows Arch. Abt. A Pathol. Anat., 364: 129, 1974.Google Scholar
  199. 199.
    Greider, M. H., and McGulgan, J. E.: Amer. J. Pathol., 59: 76, 1970.Google Scholar
  200. 200.
    Lomsky, R., Langr, F., and Vortel, V.: Nature (London) 223: 618, 1969.CrossRefGoogle Scholar
  201. 201.
    Greider, M. H., and McGuigan, J. E.: Diabetes, 20: 389, 1971.Google Scholar
  202. 202.
    Petersson, B.: Acta Pathol. Microbiol. Scand., 72: 553, 1968.PubMedCrossRefGoogle Scholar
  203. 203.
    Greider, M. H., Rosai, J., and McGuigan, J. E.: Cancer, 33: 1423, 1974.PubMedCrossRefGoogle Scholar
  204. 204.
    Dubois, M. P.: Proc. Nat. Acad. Sci., 72: 1340, 1975.PubMedCrossRefGoogle Scholar
  205. 205.
    Hökfelt, T., Efendie, S., Hellerström, C., Johansson, O., Luft, R., and Rimura, A.: Acta Endocrinol. Suppl. 200: 1, 1975.Google Scholar
  206. 206.
    Luft, R., Efendié, S., Hökfelt, T., Johansson, O., and Arimura, A.: Med. Biol., 52:428, 1974.PubMedGoogle Scholar
  207. 207.
    Orci, L., Baetens, D., Dubois, M. P., and Rufener, C.: Harm. Metab. Res., 7: 400, 1975.CrossRefGoogle Scholar
  208. 208.
    Polak, J. M., Pearse, A. G. E., Grimelius, L., Bloom, S. R., and Arimura, A.: Lancet, 1: 1220, 1975.PubMedCrossRefGoogle Scholar
  209. 209.
    Goldsmith, P. C., Rose, J. C., Arimura, A., and Ganong, W. F.: Endocrinology, 97: 1061, 1975.PubMedCrossRefGoogle Scholar
  210. 210.
    Curry, D. L., Bennett, L. L., and Li, C. H.: Biochem. Biophys. Res. Commun., 58: 885, 1974.CrossRefGoogle Scholar
  211. 211.
    Efendié, S., Luft, R., and Grill, V.: FEBS Lett., 42: 169, 1974.CrossRefGoogle Scholar
  212. 212.
    Gerich, J. E., Lorenzi, M., Schneider, V., Kwan, C. W., Karam, J. H., Guillemin, R., and Forsham. P. H.: Diabetes, 23: 876, 1975.Google Scholar
  213. 213.
    Weir, G. C., Knowlton, S. D., and Martin, D. B.: Endocrinology, 95: 1744, 1974.PubMedCrossRefGoogle Scholar
  214. 214.
    Alberti, K. G. M. M., Christensen, N. J., Christensen, S. E., Hansen, A. P., Iversen, J., Lundbaek, K., Seyer-Hansen, K., and Orskov, H.: Lancet, 2: 1299, 1973.PubMedCrossRefGoogle Scholar
  215. 215.
    Iversen, J.: Scand. J. Clin. Lab. Invest., 33: 125, 1974.CrossRefGoogle Scholar
  216. 216.
    Koerker, D., Ruch, W., Chideckel, E., Palmer, J., Goodner, C., Ensinck, J., and Gale, C.: Science, 184: 482, 1974.Google Scholar
  217. 217.
    Arvy, L. (Ed.): Histo-enzymologie des glandes endocrines. Gauthier-Villars Éditeur, Paris, 1963, p. 105.Google Scholar
  218. 218.
    Arvy, L.: In: Modern Trends in Physiological Sciences. Edited by P. Alexander and Z. M. Bacq. Pergamon Press, Oxford, 1971, p. 249.Google Scholar
  219. 219.
    Gepts, W., and Gregoire, F.: In: Recent Advances in Quantitative Histo-and Cytochemistry. Edited by V. C. Dubach and V. Schmidt. Hans Huber, Bern, 1971, p. 284.Google Scholar
  220. 220.
    Gössner, W.: In: Fortschritte der Diabetesforschung. Edited by K. Oberdisse and K. Jahnke. Georg Thieme Verlag, Stuttgart, 1963, p. 140.Google Scholar
  221. 221.
    Gössner, W.: In: Handbuch des Diabetes Mellitus, Band 1. Edited by E. F. Pfeiffer. J. F. Lehmanns Verlag, München, 1969, p. 63.Google Scholar
  222. 222.
    Hellman, B., and Täljedal, I.-B.: In: Handbook of Physiology, Sect. 7, Endocrinology, Vol. 1, Endocrine Pancreas. Edited by R. O. Greep, and E. B. Astwood. Amer. Physiol. Soc., Washington, 1972, p. 91.Google Scholar
  223. 223.
    Schätzle, W.: Acta Histochem., 6: 93, 1958.PubMedGoogle Scholar
  224. 224.
    Okamoto, K.: Trans. Soc. Pathol. Jap., 32: 99, 1942.Google Scholar
  225. 225.
    McNary, Jr., W. F.: J . Histochem. Cytochem., 2: 185, 1954.PubMedCrossRefGoogle Scholar
  226. 226.
    Voigt, G. E.: Arch. Pathol. Anat. Physiol., 332: 295, 1959.CrossRefGoogle Scholar
  227. 227.
    Schmidt, R., Drosner, H.-P., and Schultka, R.: Morphol. Jb., 115: 344, 1970.Google Scholar
  228. 228.
    Okamoto, K., and Kawanishi, H.: Endocrinol. Jap., 13: 305, 1966.CrossRefGoogle Scholar
  229. 229.
    Pihl, E.: Histochemie, 10: 126, 1967.PubMedCrossRefGoogle Scholar
  230. 230.
    Hahn v. Dorsche, H., and Fiedler, H.: Acta Histochem., 38: 359, 1970.Google Scholar
  231. 231.
    Petkov, P. E., and Galabova, R.: Acta Histochem., 32: 93, 1969.PubMedGoogle Scholar
  232. 232.
    Petkov, P. E., Galabova, R., and Gospodinov, C.: Histochemie, 15: 318, 1968.PubMedGoogle Scholar
  233. 233.
    Stampfl, B.: Verh. Dtsch. Ges. Pathol., 42: 137, 1959.Google Scholar
  234. 234.
    Wolff, H., and Ringleb, D.: Z. Ges. Exp. Med., 124: 326, 1954.CrossRefGoogle Scholar
  235. 235.
    Yokoh, S., Aoji, O., Matsuno, Z., and Yoshida, H.: Diabetologia, 5: 137, 1969.PubMedCrossRefGoogle Scholar
  236. 236.
    Pihl, E.: Acta Pathol. Microbiol. Scand., 74: 145, 1968.PubMedCrossRefGoogle Scholar
  237. 237.
    Falkmer, S., and Pihl, E.: Diabetologia, 4: 239, 1968.PubMedCrossRefGoogle Scholar
  238. 238.
    Boquist, L., and Lernmark, A.: Acta Pathol. Microbiol. Scand., 76: 215, 1969.PubMedCrossRefGoogle Scholar
  239. 239.
    Logothetopoulos, J., Kaneko, M., Wrenshall, G. A., and Best, C. H.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. E. Brolin, B. Hellman, and H. Knutson. Pergamon Press, Oxford, 1964, p. 333.Google Scholar
  240. 240.
    Maske, H.: Diabetes, 6: 335, 1957.PubMedGoogle Scholar
  241. 241.
    Scott, D. A., and Fisher, A. M.: Biochem. J., 29: 1048, 1935.PubMedGoogle Scholar
  242. 242.
    Adams, M. J., Blundell, T. L., Dodson, E. J., Dodson, G. G., Vijayan, M., Baker, E. N., Harding, M. M., Hodgkin, D. C., Rimmer, B., and Sheat, S.: Nature (London), 224: 491, 1969.CrossRefGoogle Scholar
  243. 243.
    Maske, H.: Z. Naturforsch., 8b: 96, 1953.Google Scholar
  244. 244.
    Schmidt, R., Schultka, R., Wiemann, B., and Straub, E.: Acta Histochem., 50: 200, 1974.PubMedGoogle Scholar
  245. 245.
    Kadota, I.: J. Lab. Clin. Med., 35: 568, 1950.PubMedGoogle Scholar
  246. 246.
    Schmidt, R.: In: Handbuch der Allgemeinen Pathologie, Vol. VI/4. Springer Verlag, Berlin/ Heidelberg/New York, 1972, p. 582.Google Scholar
  247. 247.
    Herman, L., Sato, T., and Hales, C. N.: J . Ultrastruct. Res., 42: 298, 1973.PubMedCrossRefGoogle Scholar
  248. 248.
    Schäfter, H.J., and Klöppel, G.: Virchows Arch. Abt. A Pathol. Anat., 362: 231, 1974.Google Scholar
  249. 249.
    Howell, S. L., Montague, W., and Tyhurst, M.: J . Cell Sci., 19: 395, 1975.PubMedGoogle Scholar
  250. 250.
    Dahl, G., and Gratzl, M.: Cytobiologie, 12: 344, 1976.Google Scholar
  251. 251.
    Hellman, B., and Idahl, L.-A.: Endocrinology, 84: 1, 1969.PubMedCrossRefGoogle Scholar
  252. 252.
    Hellman, B., and Idahl, L.-A.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford. 1970, p. 253.Google Scholar
  253. 253.
    Matschinsky, F. M., Ellerman, J. E., Landgraf, R., Krzanowski, J., Kotler-Brajtburg, J., and Fertel, R.: In: Recent Advances in Quantitative Histo-and Cytochemistry. Methods and Applications. Edited by U. C. Dubach and U. Schmidt. Hans Huber, Bern, 1971, p. 143.Google Scholar
  254. 254.
    Brolin, S. E., and Berne, C.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford. 1970, p. 245.Google Scholar
  255. 255.
    Pagundes, L. A., and Cohen, R. B.: Lab. Invest., 15: 312, 1966.Google Scholar
  256. 256.
    Williamson, J. R., and Lacy, P. E.: Arch. Pathol., 72: 637, 1961.PubMedGoogle Scholar
  257. 257.
    Duff, G. L., and Toreson, W. E.: Endocrinology, 48: 298, 1951.PubMedCrossRefGoogle Scholar
  258. 258.
    Matschinsky, F. M., and Ellerman, J. E.: J. Biol. Chem., 243: 2730, 1968.PubMedGoogle Scholar
  259. 259.
    Volk, B. W., and Lazarus, S. S.: Diabetes, 12: 162, 1963.Google Scholar
  260. 260.
    Toreson, W. E.: Amer. J. Anat., 62: 31, 1951.Google Scholar
  261. 261.
    Pictet, R., Orci, L., Gonet, A. E., Rouiller, C., and Renold, A. E.: Diabetologia, 3: 188, 1967.PubMedCrossRefGoogle Scholar
  262. 262.
    Volk, B. W., Lazarus, S. S., and Wellmann, K. F.: Diabetes, 14: 792, 1965.PubMedGoogle Scholar
  263. 263.
    Carpenter, A. M., Gerritsen, G. C., Dulin, W. E., and Lazarow, A.: 3: 92, 1967.Google Scholar
  264. 264.
    Carpenter, A. M., Gerritsen, G. C., Dulin, W. E., and Lazarow, A.: Diabetologia, 6: 168, 1970.PubMedCrossRefGoogle Scholar
  265. 265.
    Soret, M. G., Dulin, W. E., Mathews, J., and Gerritsen, G. C.: Diabetologia, 10: 567, 1974.PubMedCrossRefGoogle Scholar
  266. 266.
    Lazarus, S. S., and Volk, B. W.: Arch. Pathol., 66: 59, 1958.Google Scholar
  267. 267.
    Theodossiou, A.: Klin. Wochenschr., 34: 1161, 1956.PubMedCrossRefGoogle Scholar
  268. 268.
    Gepts, W.: In: Handbuch des Diabetes Mellitus. Edited by E. F. Pfeiffer. J. F. Lehmanns Verlag, München, 1971, p. 3.Google Scholar
  269. 269.
    Warren, S.: Diabetes, 2: 257, 1953.PubMedGoogle Scholar
  270. 270.
    Falck, B., and Hellman, B.: Acta Endocrinol., 45: 133, 1964.PubMedGoogle Scholar
  271. 271.
    Cegrell, L.: Acta Physiol. Scand., Suppl., 314, 1968.Google Scholar
  272. 272.
    Gershon, M. D., and Ross, L. L.: J. Physiol., 186: 477, 1966.PubMedGoogle Scholar
  273. 273.
    Ritzén, M., Hammarström, L., and Ullberg, S.: Biochem. Pharmacol., 14: 313, 1965.PubMedCrossRefGoogle Scholar
  274. 274.
    Petkov, P. E.: Ann. Histochim., 10: 17, 1965.PubMedGoogle Scholar
  275. 275.
    Lundquist, I., Sundler, F., Häkanson, R., Larsson, L.-I., and Heding, L. G.: Endocrinology, 97: 937, 1975.PubMedCrossRefGoogle Scholar
  276. 276.
    Ekholm, R., Ericson, L. E., and Lundquist, I.: Diabetologia, 7: 339, 1971.PubMedCrossRefGoogle Scholar
  277. 277.
    Feldman, J. M., and Lebovitz, H. E.: Endocrinology, 86: 66, 1970.PubMedCrossRefGoogle Scholar
  278. 278.
    Owman, C., Häkanson, R., and Sundler, F.: Fed. Proc., 32: 1785, 1973.PubMedGoogle Scholar
  279. 279.
    Wong, K. K., Symchowicz, S., Staub, M. S., and Tabachnick, J. J. A.: Life Sci., 6: 2285, 1967.PubMedCrossRefGoogle Scholar
  280. 280.
    Feldman, J. M., and Chapman, B.: Diabetologia, 11: 487, 1975.PubMedCrossRefGoogle Scholar
  281. 281.
    Brolin, S. E., Borglund, E., and Ohlsson, A.: Acta Soc. Med. Upsal., 71: 334, 1966.PubMedGoogle Scholar
  282. 282.
    Ashcroft, S. J. H., and Randle, P. J.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 225.Google Scholar
  283. 283.
    Andersson, A., Grill, V., Asplund, K., Berne, C., Agren, A., and Hellerström, C.: In: Early Diabetes in Early Life. Edited by R. A. Camerini-Davelos and H. S. Cole. Academic Press, New York, 1975, p. 49.Google Scholar
  284. 284.
    Gepts, W., and Toussaint, D.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. E. Brolin and B. Hellman. Pergamon Press, Oxford, 1964, p. 357.Google Scholar
  285. 285.
    Hellman, B., and Hellerström, C.: Acta Endocrinol., 39: 474, 1962.PubMedGoogle Scholar
  286. 286.
    Lazarus, S. S.: Proc. Soc. Exp. Biol. Med., 101: 819, 1959.PubMedGoogle Scholar
  287. 287.
    Lazarus, S. S., and Bradshaw, M.: Proc. Soc. Exp. Biol. Med., 102: 463, 1959.PubMedGoogle Scholar
  288. 288.
    Petersson, B.: Histochemie, 7: 116, 1966.PubMedCrossRefGoogle Scholar
  289. 289.
    Brolin, S. E., Berne, C., Petersson, B., and Larsson, A.: J. Histochem. Gytochem., 16: 654, 1968.CrossRefGoogle Scholar
  290. 290.
    Kissane, J. M., Lacy, P. E., Brolin, S. E., and Smith, C. H.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. E. Brolin, B. Hellman, and H. Knutson. Pergamon Press, Oxford, 1974, p. 281.Google Scholar
  291. 291.
    Lacy, P. E.: Diabetes, 11: 96, 1962.PubMedGoogle Scholar
  292. 292.
    Lazarow, A., Dixit, P. K., Lindall, A., Moran, J., Hostetler, K., and Cooperstein, S. J.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. E. Brolin, B. Hellman, and H. Knutson. Pergamon Press, Oxford, 1964, p. 249.Google Scholar
  293. 293.
    Täljedal, I.-B.: Biochem. J., 114: 387, 1969.Google Scholar
  294. 294.
    Dixit, P. K., and Lazarow, A.: Metabolism, 13: 285, 1964.PubMedCrossRefGoogle Scholar
  295. 295.
    Dixit, P. K., and Lazarow, A.: Diabetologia, 18: 589, 1969.Google Scholar
  296. 296.
    Täljedal, I.-B.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 233.Google Scholar
  297. 297.
    Hellerström, C., and Brolin, S. E.: In: Handbook of Experimental Pharmacology. Edited by G. V. R. Born, O. Eichler, A. Farah, H. Herken, and A. D. Welch. Vol. 32/2 Insulin II. Edited by A. Hasselblatt and F. v. Bruchhausen. Springer Verlag, Berlin/Heidelberg, 1975, p. 57.Google Scholar
  298. 298.
    Hellerström, C., and Hellman, B.: Acta Pathol. Microbiol. Scand., 55: 385, 1962.PubMedCrossRefGoogle Scholar
  299. 299.
    Hellman, B., and Hellerström, C.: Z. Zellforsch., 56: 97, 1962.PubMedCrossRefGoogle Scholar
  300. 300.
    Petkov, P. E.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 213.Google Scholar
  301. 301.
    Matschinsky, F. M., Kauffman, F. C., and Ellerman, J. E.: Diabetes, 17: 475, 1968.PubMedGoogle Scholar
  302. 302.
    Täljedal, I.-B.: Histochemie, 21: 307, 1970.PubMedCrossRefGoogle Scholar
  303. 303.
    Randle, P. J., and Aschcroft, S. J. H.: Acta Diab. Lat. 7, Suppl., 1: 159, 1970.Google Scholar
  304. 304.
    Yoshikawa, O.: Endocrinol. Jap., 16: 609, 1969.CrossRefGoogle Scholar
  305. 305.
    Petkov, P. E., Verne, J., and Wegmann, R.: Ann. Histochim., 10: 257, 1965.PubMedGoogle Scholar
  306. 306.
    Montague, W., and Taylor, K. W.: Biochem. J., 115: 257, 1969.PubMedGoogle Scholar
  307. 307.
    Täljedal, I.-B.: Histochemie, 19: 355, 1969.PubMedGoogle Scholar
  308. 308.
    Lazarus, S. S., and Barden, H.: Diabetes, 14: 146, 1965.PubMedGoogle Scholar
  309. 309.
    Nakamura, M., and Yamada, K.: Z. Zellforsch., 66: 396, 1965.PubMedCrossRefGoogle Scholar
  310. 310.
    Hellerström, C. and Hellman, B.: Acta Endocrinol., 42: 615, 1963.Google Scholar
  311. 311.
    Idahl, L.-A., and Täljedal, I.-B.: Biochem. J., 106: 161, 1968.PubMedGoogle Scholar
  312. 312.
    Hellerström, C., Hellman, B., Täljedal, I.-B.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. E. Brolin, B. Hellman, and H. Knutson. Pergamon Press, Oxford, 1964, p. 311.Google Scholar
  313. 313.
    Täljedal, I.-B., Hellman, B., and Hellerström, C.: J. Histochem. Cytochem., 12: 491, 1964.CrossRefGoogle Scholar
  314. 314.
    Hellerström, C., Täljedal, I.-B., and Hellman, B.: Endocrinology, 76: 315, 1965.CrossRefGoogle Scholar
  315. 315.
    Lazarus, S. S., and Barden, H.: J. Histochem. Cytochem., 10: 368, 1962.CrossRefGoogle Scholar
  316. 316.
    Täljedal, I.-B.: Acta Endocrinol., 55:153, 1967.PubMedGoogle Scholar
  317. 317.
    Berne, C.: J. Histochem. Cytochem., 23: 660, 1975.CrossRefGoogle Scholar
  318. 318.
    Petkov, P. E., Gospodinov, C. Izmirov, I., and Donev, S.: Acta Histochem., 39:185, 1971.PubMedGoogle Scholar
  319. 319.
    Gössner, W.: Verh. Dtsch. Ges. Pathol., 42: 125, 1959.Google Scholar
  320. 320.
    Hammar, H., and Berne, C.: Diabetologia, 6: 526, 1970.PubMedCrossRefGoogle Scholar
  321. 321.
    Berne, C.: Diabetologia, 8: 364, 1972.Google Scholar
  322. 322.
    Wegmann, R., and Petkov, P.: Ann. Histochim., 10:93, 1965.PubMedGoogle Scholar
  323. 323.
    Hellman, B.: Diabetologia, 3:222, 1966.CrossRefGoogle Scholar
  324. 324.
    Danielsson, A., Hellman, B., and Idahl, L.-A.: Harm. Metab. Res., 2: 28, 1970.CrossRefGoogle Scholar
  325. 325.
    Hellerström, C., Westman, S., Marsden, N., and Turner, D. S.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I.-B. Täljedal. Pergamon Press, Oxford, 1970, p. 315.Google Scholar
  326. 326.
    Hellerström, C., Brolin, S. E., Larsson, S., and Hellman, B.: Acta Endocrinol., 40: 604, 1962.PubMedGoogle Scholar
  327. 327.
    Verne, J., and Petkov, P.: Ann. Endocrinol., 22: 500, 1961.Google Scholar
  328. 328.
    Weiss, I., and Hildebrandt, H.-J.: Anat. Anz., 125: 541, 1969.Google Scholar
  329. 329.
    Täljedal, I.-B., Hellman, B., Peterson, B., and Hellerström, C.: Nature (London), 209: 409, 1966.CrossRefGoogle Scholar
  330. 330.
    Hellman, B., Hellerström, C., Larsson, S., and Brolin, S.: Z. Zellforsch., 55: 235, 1961.PubMedCrossRefGoogle Scholar
  331. 331.
    Jirâsek, J. E.: Acta Histochem., 22: 62, 1965.PubMedGoogle Scholar
  332. 332.
    Hellerström, C., Täljedal, I.-B., and Hellman, B.: Acta Endocrinol., 45: 476, 1964.Google Scholar
  333. 333.
    Lazarus, S. S., Volk, B. W., and Barden, H.: J. Histochem. Cytochem., 14: 233, 1966.PubMedCrossRefGoogle Scholar
  334. 334.
    Orci, L., Stauffacher, W., Rufener, C., Lambert, A. E., Rouiller, C., and Renold, A. E.: Diabetes, 20: 385, 1971.PubMedGoogle Scholar
  335. 335.
    Klöppel, G., Freytag, G., and Bommer, G.: Diabetologia, 8: 19, 1972.PubMedCrossRefGoogle Scholar
  336. 336.
    Ihara, N.: Endocrinol. Jap., 12: 215, 1965.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Lennart Boquist
    • 1
  1. 1.University of UmeaUmeaSweden

Personalised recommendations