Endocrine Tumors of the Pancreas

  • Werner Creutzfeldt


The endocrine tumors of the pancreas are usually called islet cell tumors (adenomas or carcinomas of islets of Langerhans). This name implies their origin from the pancreatic islets. However, this assumption is not justified. The histologic structure of the endocrine pancreatic tumors is not markedly different from other endocrine tumors, and not all hormones produced by these tumors are normal products of the islets of Langerhans. The still controversial question of the origin of the pancreatic tumors will be discussed later. Any nomenclature anticipating this undecided problem should be avoided. This applies also to the term “nesidioblastoma,” introduced in 1938 by Laidlaw.1 Laidlaw named the cells that differentiate from the duct epithelium to form islets “nesidioblasts,” their proliferation “nesidioblastosis,” and their tumors “nesidioblastomas.”


Secretory Granule Pancreatic Tumor Endocrine Tumor Insulinoma Cell Islet Hyperplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Plenum Press, New York 1977

Authors and Affiliations

  • Werner Creutzfeldt
    • 1
  1. 1.Medizinische Klinik und PoliklinikUniversität GöttingenWest Germany

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