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Spontaneous Diabetes in Animals

  • Arthur A. Like

Abstract

Although a large body of information has been gathered by physicians and scientists during the first half century of the insulin era, human diabetes mellitus is still a poorly understood disease. Most informed individuals agree that although the tendency to develop diabetes may be inherited, environmental factors are also involved in the etiology and the progression of the syndrome’s symptom complex, of which hyperglycemia is the unifying phenomenon. The importance of heredity stems from the well-known familial incidence of diabetes. The importance of environmental factors rests upon evidence suggesting a viral etiology of juvenile-onset diabetes, and upon evidence linking the frequency of maturity-onset diabetes with the degree of nutritional (i.e., caloric) prosperity.

Keywords

Pancreatic Islet Acinar Cell Spiny Mouse Pancreatic Glucagon Spontaneous Diabetes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ingalls, A. M., Dickie, M. M., and Snell, G. D.: J. Hered., 41: 317, 1950.PubMedGoogle Scholar
  2. 2.
    Renold, A. E.: Adv. Metab. Dis., 3: 49, 1968.Google Scholar
  3. 3.
    Stauffacher, W., Orci, L., Cameron, D. P., Burr, I. M., and Renold, A. E.: Rec. Progr. Harm. Res., 27: 41, 1971.Google Scholar
  4. 4.
    Cameron, D. P., Stauffacher, W., and Renold, A. E.: In: Handbook of Physiology. Sec. 7, Endocrinology. Vol. 1, Endocrine Pancreas. Edited by R. O. Greep, E. B. Astwood, D. F. Steiner, N. Freinkel, and S. R. Geiger. Amer. Physiol. Soc., Washington, Chap. 39, 1972, p. 611.Google Scholar
  5. 5.
    First Brook Lodge Workshop on Spontaneous Diabetes in Laboratory Animals. Diabetologia, 3: 63, 1967.CrossRefGoogle Scholar
  6. 6.
    Second Brook Lodge Workshop on Spontaneous Diabetes in Laboratory Animals. Diabetologia, 6: 12, 1970.Google Scholar
  7. 7.
    Third Brook Lodge Workshop on Spontaneous Diabetes in Laboratory Animals. Diabetologia, 10: 491, 1974.CrossRefGoogle Scholar
  8. 8.
    Bleisch, V. R., Mayer, J., and Dickie, M. M.: Amer. J. Pathol., 28: 369, 1952.Google Scholar
  9. 9.
    Wrenshall, G. A., Andrus, S. B., and Mayer, J.: Endocrinology, 56: 335, 1955.CrossRefPubMedGoogle Scholar
  10. 10.
    Christophe, J., Dagenais, Y., and Mayer, J.: Nature (London) 184: 61, 1959.Google Scholar
  11. 11.
    Gepts, W., Christophe, J., and Mayer, J.: Diabetes, 9: 63, 1960.PubMedGoogle Scholar
  12. 12.
    Hellman, B., Brolin, S. E., Hellerström, C., and Hellman, K.: Acta Endocrinol., 36: 609, 1961.PubMedGoogle Scholar
  13. 13.
    Solomon, J., and Mayer, J.: Nature (London) 193: 135, 1962.CrossRefGoogle Scholar
  14. 14.
    Björkman, N., Hellerström, C., and Hellman, B.: Z. Zellforsch., 58: 803, 1963.CrossRefPubMedGoogle Scholar
  15. 15.
    Stauffacher, W., Crofford, O.B., Jeanrenaud, B. and Renold, A. E.: Ann. N.Y. Acad. Sci., 131: 528, 1965.CrossRefPubMedGoogle Scholar
  16. 16.
    Stauffacher, W., Lambert, A. E., Vecchio, D., and Renold, A. E.: Diabetologia, 3: 230, 1967.CrossRefPubMedGoogle Scholar
  17. 17.
    Westman, S.: Acta Soc. Med. Upsal., 73: 81, 1968.PubMedGoogle Scholar
  18. 18.
    Mahler, R. J., Szabo, O., Adler, K., and Levine, R.: Fed. Proc., 29: 380, 1970.Google Scholar
  19. 19.
    Mahler, R. J., and Szabo, O.: Amer. J. Physiol., 221: 980, 1971.PubMedGoogle Scholar
  20. 20.
    Nakamura, M.: Proc. Jap. Acad., 38: 348, 1962.Google Scholar
  21. 21.
    Nakamura, M., and Yamada, K.: Diabetologia, 3: 212, 1967.CrossRefPubMedGoogle Scholar
  22. 22.
    Dulin, W. E., and Wyse, B. M.: Diabetologia, 6: 317, 1970.CrossRefPubMedGoogle Scholar
  23. 23.
    Appel, M. C., Chang, A. Y., and Dulin, W. E.: Diabetologia, 10: 625, 1974.CrossRefPubMedGoogle Scholar
  24. 24.
    Jones, E. E.: In: Structure and Metabolism of the Pancreatic Islets. Edited by S. E. Brolin, B. Hellman, and H. Knutson. Pergamon Press, Oxford, 1964, p. 189.Google Scholar
  25. 25.
    Like, A. A., Steinke, J., Jones, E. E., and Cahill, Jr., G. F.: Amer. J. Pathol. 46: 621, 1965.Google Scholar
  26. 26.
    Cahill, Jr., G. F., Jones, E. E., Lauris, V., Steinke, J., and Soeldner, J. S.: Diabetologia, 3: 171, 1967.CrossRefPubMedGoogle Scholar
  27. 27.
    Gleason, R. E., Lauris, V., and Soeldner, J. S.: Diabetologia, 3: 175, 1967.CrossRefPubMedGoogle Scholar
  28. 28.
    Meier, H., and Yerganian, G. A.: Proc. Soc. Exp. Biol. Med., 100: 810, 1959.PubMedGoogle Scholar
  29. 29.
    Gerritsen, G. C., and Dulin, W. E.: Diabetologia, 3: 74, 1967.CrossRefPubMedGoogle Scholar
  30. 30.
    Carpenter, A. M., Gerritsen, G. C., Dulin, W. E., and Lazarow, A.: Diabetologia, 3: 92, 1967.CrossRefPubMedGoogle Scholar
  31. 31.
    Luse, S. A., Caramia, F., Gerritsen, G. C., and Dulin, W. E.: Diabetologia, 3: 97, 1967.CrossRefPubMedGoogle Scholar
  32. 32.
    Butler, L.: Diabetologia, 3: 124, 1967.CrossRefPubMedGoogle Scholar
  33. 33.
    Boquist, L.: Acta Pathol. Microbiol. Scand., 75: 399, 1969.PubMedGoogle Scholar
  34. 34.
    Gerritsen, G. C., and Blanks, M. C.: Diabetologia, 6: 177, 1970.CrossRefPubMedGoogle Scholar
  35. 35.
    Gerritsen, G. C., and Dulin, W. E.: Acta Diabetol. Lat. (Suppl. I), 9: 597, 1972.Google Scholar
  36. 36.
    Like, A. A., Gerritsen, G. C., Dulin, W. E., and Gaudreau, P.: Diabetologia, 10: 501, 1974.CrossRefPubMedGoogle Scholar
  37. 37.
    Like, A. A., Gerritsen, G. C., Dulin, W. E., and Gaudreau, P.: Diabetologia, 10: 509, 1974.CrossRefPubMedGoogle Scholar
  38. 38.
    Schmidt-Nielson, K., Haines, H. B., and Hackel, D. B.: Science, 143: 689, 1964.CrossRefGoogle Scholar
  39. 39.
    Haines, H. B., Hackel, D. B., and Schmidt-Nielsen, K.: Amer. J. Physiol., 208: 297, 1965.PubMedGoogle Scholar
  40. 40.
    Hackel, D. B., Schmidt-Nielsen, K., Haines, H. B., and Mikat, E.: Lab. Invest., 14: 200, 1965.PubMedGoogle Scholar
  41. 41.
    Hackel, D. B., Frohman, L., Mikat, E., Lebovitz, H. E., Schmidt-Nielson, K., and Kinney, T. D.: Diabetes, 15: 105, 1966.PubMedGoogle Scholar
  42. 42.
    Miki, E., Like, A. A., Steinke, J., and Soeldner, J. S.: Diabetologia, 3: 135, 1967.CrossRefPubMedGoogle Scholar
  43. 43.
    Like, A. A., and Miki, E.: Diabetologia, 3: 143, 1967.CrossRefPubMedGoogle Scholar
  44. 44.
    Malaisse, W. J., Like, A. A., Malaisse-Lagae, F., Gleason, R. E., and Soeldner, J. S.: Diabetes, 17: 752, 1967.Google Scholar
  45. 45.
    Miki, E., Like, A. A., Soeldner, J. S., Steinke, J., and Cahill, Jr., G. F.: Metabolism, 15: 749, 1966.CrossRefPubMedGoogle Scholar
  46. 46.
    Gonet, A. E., Stauffacher, W., Pictet, R., and Renold, A. E.: Diabetologia, 1: 162, 1965.CrossRefGoogle Scholar
  47. 47.
    Stauffacher, W., Orci, I.., Amherdt, M., Burr, I. M., Balant, L., Froesch, E. R., and Renold, A. E.: Diabetologia, 6: 330, 1970.CrossRefPubMedGoogle Scholar
  48. 48.
    Cameron, D. P., Stauffacher, W., Orci, L., Amherdt, M., and Renold, A. E.: Diabetes, 21: 1060, 1972.PubMedGoogle Scholar
  49. 49.
    Malaisse-Lagae, F., Ravazzola, M., Amherdt, M., Gutzeit, A., Malaisse, W. J., and Orci, L.: Diabetologia, 11: 71, 1975.CrossRefPubMedGoogle Scholar
  50. 50.
    Hummel, K. P., Dickie, M. M., and Coleman, D. L.: Science, 153: 1127, 1966.CrossRefPubMedGoogle Scholar
  51. 51.
    Coleman, D. L., and Hummel, K. P.: Diabetologia, 3: 238, 1967.CrossRefPubMedGoogle Scholar
  52. 52.
    Chick, W. L., and Like, A. A.: Diabetologia, 6: 243, 1970.CrossRefPubMedGoogle Scholar
  53. 53.
    Coleman, D. L., and Hummel, K. P.: Diabetologia, 10: 607, 1974.CrossRefPubMedGoogle Scholar
  54. 54.
    Like, A. A., and Chick, W. L.: Science, 163: 941, 1969.CrossRefPubMedGoogle Scholar
  55. 55.
    Like, A. A., and Chick, W. L.: Diabetologia, 6: 207, 1970.CrossRefPubMedGoogle Scholar
  56. 56.
    Like, A. A., and Chick, W. L.: Diabetologia, 6: 216, 1970.CrossRefPubMedGoogle Scholar
  57. 57.
    Coleman, D. L., and Hummel, K. P.: Amer. J. Physiol., 217: 1298, 1969.PubMedGoogle Scholar
  58. 58.
    Coleman, D. L.: Diabetologia, 9: 294, 1973.CrossRefPubMedGoogle Scholar
  59. 59.
    Chick, W. L., and Like, A. A.: Diabetologia, 6: 252, 1970.CrossRefPubMedGoogle Scholar
  60. 60.
    Hummel, K. P., Coleman, D. L., and Lane, P. W.: Biochem. Genet., 7: 1, 1972.CrossRefPubMedGoogle Scholar
  61. 61.
    Coleman, D. L., and Hummel, K. P.: Diabetologia, 9: 287, 1973.CrossRefPubMedGoogle Scholar
  62. 62.
    Nakhooda, A. F., Like, A. A., Chappel, C. I., and Marliss, E. B.: Clin. Res., 23: 638A, 1975.Google Scholar
  63. 63.
    Nakhooda, A. F., Like, A. A., Chappel, C. I., and Marliss, E. B.: Diabetes (Suppl. 1) 25: 378, 1976.Google Scholar
  64. 64.
    Nakhooda, A. F., Like, A. A., Chappel, C. I., Murray, F. T., and Marliss, E. B.: Diabetes, 26: 100, 1977.CrossRefPubMedGoogle Scholar
  65. 65.
    Baetens, D., Coleman, D. L., and Orci, L.: Diabetes (Suppl. 1), 25: 344, 1976.Google Scholar
  66. 66.
    Kahn, C. R., Neville, Jr., D. M., Gorden, P., Freychet, P. and Roth, J.: Biochem. Biophys. Res. Commun., 48: 135, 1972.CrossRefPubMedGoogle Scholar
  67. 67.
    DeMeyts, P., Roth, J., Neville, D. M., Jr., Gavin, J. R., III, and Lesniak, M.A.: Biochem. Biophys. Commun., 55: 154, 1973.CrossRefGoogle Scholar
  68. 68.
    Freychet, P., Laudat, M. H., Laudat, P., Rosselin, G., Kahn, C. R., Gorden, P., and Roth, J.: FEBS Lett., 25: 339, 1972.CrossRefPubMedGoogle Scholar
  69. 69.
    Staats, J.: Diabetologia, 11: 325, 1975.CrossRefPubMedGoogle Scholar
  70. 70.
    Orci, L., Stauffacher, W., Dulin, W. E., Renold, A. E., and Rouiller, C.: Diabetologia, 6: 199, 1970.CrossRefPubMedGoogle Scholar
  71. 71.
    Gepts, W.: Diabetes, 14: 619, 1965.PubMedGoogle Scholar
  72. 72.
    Craighead, J. E., and McLane, M. F.: Science, 162: 913, 1968.CrossRefPubMedGoogle Scholar
  73. 73.
    Klöppel, G., Altenähr, E., and Freychet, P.: Virchows Arch. Path. Anat., 356: 15, 1972.Google Scholar
  74. 74.
    Like, A. A., and Rossini, A. A.: Science, 193: 415, 1976.CrossRefPubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Arthur A. Like
    • 1
  1. 1.University of MassachusettsWorcesterUSA

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