Advertisement

The Islets of Infants of Diabetic Mothers

  • Klaus F. Wellmann
  • Bruno W. Volk

Abstract

Ever since Dubreuil and Anderodias1 observed, in 1920, the occurrence of pancreatic islet hypertrophy in a newborn infant and attributed this change to the hyperglycemic state of its diabetic mother, the relationship between a disturbed maternal carbohydrate metabolism and various pathologic alterations in the pancreas and in other tissues of the fetus or neonate has been the subject of a large number of reports in the medical literature. These include review articles concerned with the clinical2–17 or with the morphologic aspects4–7,11,18–30 of this relationship as well as pertinent reports of single1,16–18,31–47 or multiple cases. 6,17,19,20,30,48–73.In the present chapter, the literature on quantitative, qualitative, and functional islet cell changes in neonates of diabetic mothers will be reviewed. To be discussed also are findings pertaining to the pancreas as a whole, some experimental data, questions related to the pathogenesis of the described alterations, and the problem of the development of permanent diabetes in infants born to diabetic mothers.

Keywords

Diabetic Woman Diabetic Mother Maternal Diabetes Islet Tissue Eosinophilic Infiltrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dubreuil, G., and Anderodias: C. R. Soc. Biol., 83: 1490, 1920.Google Scholar
  2. 2.
    Anonymous: Lancet, 1: 669, 1975.Google Scholar
  3. 3.
    Grenet, P., de Paillerets, F., Badoual, J., Galiet, J. P., Babinet, J. M., and Tichet, J.: Arch. Franç. Pédiatr., 29: 925, 1972.Google Scholar
  4. 4.
    Hoet, J. P.: Bull. Acad. Roy. Méd. Belg., Series 7, 7: 85, 1967.Google Scholar
  5. 5.
    Hoet, J. P. and Hoet, J. J., Jr.: In: Handbuch des Diabetes Mellitus. Edited by E. F. Pfeiffer. J. F. Lehmann, Munich, Vol. 2, 1971, p. 537.Google Scholar
  6. 6.
    Klein, H. J., and Fischer, R.: Med. Welt, p. 2621, 1968.Google Scholar
  7. 7.
    Kloos, K., and Vogel, M.: Pathologie der Perinatalperiode. G. Thieme, Stuttgart, 1974, pp. 182 &306.Google Scholar
  8. 8.
    Mayer, J. B., and Camara, J. J. R.: Dtsch. Med. Wochenschr. 89: 974, 1964.PubMedCrossRefGoogle Scholar
  9. 9.
    Morais, T., and Demers, P. P.: Laval Méd., 38: 337, 1967.PubMedGoogle Scholar
  10. 10.
    Pedersen, J.: The Pregnant Diabetic and Her Newborn: Problems and Management. E. Munksgaard, Copenhagen, 1967, p. 71.Google Scholar
  11. 11.
    Pedersen, J.: In: Handbuch des Diabetes Mellitus. Edited by E. F. Pfeiffer. J. F. Lehmann, Munich, Vol. 2, 1971, p. 511.Google Scholar
  12. 12.
    Pildes, R. S.: N. Engl. J. Med., 289: 902, 1973.PubMedCrossRefGoogle Scholar
  13. 13.
    Skipper, E.: Quart J. Med., 2: 353, 1933.Google Scholar
  14. 14.
    Sudan, J. P.: Ré v. Franç. Gynécol. Obstét., 64: 529, 1969.Google Scholar
  15. 15.
    Thalhammer, O.: Pränatale Erkrankungen des Menschen. G. Thieme, Stuttgart, 1967, p. 341.Google Scholar
  16. 16.
    van Beek, C.: Ned. T. Geneesk., 83: 5973, 1939.Google Scholar
  17. 17.
    White, P., and Hunt, H.: J. Clin. Endocrinol., 3: 500, 1943.CrossRefGoogle Scholar
  18. 18.
    Bauer, J. T., and Royster, H. A., Jr.: Bull. Ayer Clin. Lab. Penns. Hosp., 3: 109, 1937.Google Scholar
  19. 19.
    Borchard, F., and Müntefering, H.: Virchows Arch. Path. Anat. A, 346: 178, 1969.CrossRefGoogle Scholar
  20. 20.
    Cardell, B. S.: J. Pathol. Bacteriol., 66: 335, 1953.PubMedCrossRefGoogle Scholar
  21. 21.
    Driscoll, S. G.: Med. Clin. N. Amer., 49: 1053, 1965.Google Scholar
  22. 22.
    Kloos, K.: Klin. Wochenschr., 29: 557, 1951.PubMedCrossRefGoogle Scholar
  23. 23.
    Kloos, K.: Virchows Arch. Pathol. Anat., 321: 177, 1952.CrossRefGoogle Scholar
  24. 24.
    Lazarus, S. S., and Volk, B. W.: The Pancreas in Human and Experimental Diabetes. Grune Sc Stratton, New York, 1962, p. 234.Google Scholar
  25. 25.
    Potter, E. L.: Pathology of the Fetus and Infant. Year Book Medical, Chicago, 1961, p. 334.Google Scholar
  26. 26.
    Potter, E. L., Seckel, H. P. G., and Stryker, W. A.: Arch. Pathol., 31: 467, 1941.Google Scholar
  27. 27.
    Seifert, G.: Verh. Dtsch. Ges. Pathol. 42: 50, 1959.Google Scholar
  28. 28.
    van Assche, F. A.: Thesis: The Fetal Endocrine Pancreas: A Quantitative Morphological Approach. Belgium, Catholic University of Leuven, 1970, p. 62.Google Scholar
  29. 29.
    van Assche, F. A.: In: Carbohydrate Metabolism in Pregnancy and the Newborn. Edited by H. W. Sutherland, and J. M. Stowers. Churchill Livingstone, Edinburgh, 1975, p. 68.Google Scholar
  30. 30.
    Warren, S., LeCompte, P. M., and Legg, M. A.: The Pathology of Diabetes Mellitus. Lea Sc Febiger, Philadelphia, 1966, p. 406.Google Scholar
  31. 31.
    Angyal, F.: Centralbl. Allg. Path. Path. Anat., 66: 209, 1936.Google Scholar
  32. 32.
    Bayer, J.: Virchows Arch. Pathol. Anat., 308: 659, 1942.CrossRefGoogle Scholar
  33. 33.
    Benner, M. C.: Arch. Pathol. 32: 818, 1941.Google Scholar
  34. 34.
    Duncan, G. G., and Fetter, F.: In: Diseases of Metabolism. Edited by G. G. Duncan. W. B. Saunders, Philadelphia, 1947, p. 861.Google Scholar
  35. 35.
    Ehrich, W.: Klin. Wochenschr., 13: 584, 1934.CrossRefGoogle Scholar
  36. 36.
    Feldmann, I.: Centralbl. All. Path. Path. Anat., 42: 435, 1928.Google Scholar
  37. 37.
    Gray, S. H. and Feemster, L. C.: Arch. Path. Lab. Med., 1: 348, 1926.Google Scholar
  38. 38.
    Heiberg, K. A.: Virchows Arch. Path. Anat., 287: 629, 1933.CrossRefGoogle Scholar
  39. 39.
    Jacobsen, N. S.: Ugeskr. Laeger, 96: 347, 1934.Google Scholar
  40. Mellgren, J. A.: Nord. Med.,19:1301, 1943.Google Scholar
  41. 41.
    Nothmann, M., and Hermstein, A.: Arch. Gynlik., 150: 287, 1932.CrossRefGoogle Scholar
  42. 42.
    Poursines, Y., and Cerati, P.: Ann. Anat. Path., 16: 673, 1939.Google Scholar
  43. 43.
    Schretter, G., and Nevinny, H.: Arch. Gynäk., 143: 465, 1930.CrossRefGoogle Scholar
  44. 44.
    Smyth, F. S., and Olney, M. B.: J. Pediatr., 13: 772, 1938.CrossRefGoogle Scholar
  45. 45.
    Von Bakay, L., Jr.: Virchows Arch. Path. Anat., 310: 291, 1943.CrossRefGoogle Scholar
  46. 46.
    Wenig, K.: Frankf. Z. Pathol. 55: 188, 1941.Google Scholar
  47. 47.
    Wiener, H. J.: Amer. J . Obstet. Gynecol., 7: 710, 1924.Google Scholar
  48. 48.
    Cardell, B. S.: J . Obstet. Gynecol. Brit. Emp., 60: 834, 1953.CrossRefGoogle Scholar
  49. 49.
    D’Agostino, A. N., and Bahn, R. C.: Diabetes, 12: 327, 1963.Google Scholar
  50. 50.
    Driscoll, S. G., Benirschke, K., and Curtis, G. W.: Amer. J. Dis. Child., 100: 818, 1960.PubMedGoogle Scholar
  51. 51.
    Geyer, A., and Staeffen, J.: Presse Méd., 65: 1079, 1957.PubMedGoogle Scholar
  52. 52.
    Given, W. P., Douglas, R. G., and Tolstoi, E.: Amer. J. Obstet. Gynecol., 59: 729, 1950.Google Scholar
  53. 53.
    Gordon, W. H.: J . Mich. St. Med. Soc., 34: 167, 1935.Google Scholar
  54. 54.
    Gordon, W. H.: Ohio St. Med. J., 32: 540, 1936.Google Scholar
  55. 55.
    Gryaznova, I. M., Bolkhovotinova, L. M., and Vtorova, V. G.: Vopr. Ohkr. Materin. Det., Vol. 17, No. 11, p. 22, 1972.Google Scholar
  56. 56.
    Helwig, E. B.: Arch. Int. Med., 65: 221, 1940.CrossRefGoogle Scholar
  57. 57.
    Hultquist, G. T., Lindgren, I., and Dalgaard, J. B.: Nord. Med., 31: 1841, 1946.Google Scholar
  58. 58.
    Hultquist, G. T., Olding, L., and Larsson, Y. A. A.: Fifth Congress of the International Diabetes Federation, Excerpta Medica Int. Congr. Series No. 74; Abstract No. 129, 1964, p. 67.Google Scholar
  59. 59.
    Jackson, W. P. U., and Woolf, N.: Diabetes, 7: 446, 1958.PubMedGoogle Scholar
  60. 60.
    Liebegott, G.: Beitr. Path. Anat. Allg. Pathol., 101: 319, 1938.Google Scholar
  61. 61.
    McKay, D. G., Benirschke, K., and Curtis, G. W.: Obstet. Gynecol., 2: 133, 1953.PubMedGoogle Scholar
  62. 62.
    Miller, H. C.: Amer. J. Med. Sci., 209: 447, 1945.CrossRefGoogle Scholar
  63. 63.
    Naeye, R. L.: Pediatrics, 35: 980, 1965.PubMedGoogle Scholar
  64. 64.
    Naeye, R. L., Sims, E. A. H., Welsh, III, G. W., and Gray, M.J.: Arch. Pathol., 81: 552, 1966.PubMedGoogle Scholar
  65. 65.
    Okkels, H., and Brandstrup, E.: Acta Pathol. Microbiol. Scand., 15: 268, 1938.CrossRefGoogle Scholar
  66. 66.
    Rascoff, H., Beilly, J. S., and Jacobi. M.: Amer. J. Dis. Child., 55: 330, 1938.Google Scholar
  67. 67.
    Rose, V.: Canad. Med. Assoc. J., 82: 306, 1960.PubMedGoogle Scholar
  68. 68.
    Rössle, R.: Virchows Arch. Pathol. Anat., 308: 676, 1942.CrossRefGoogle Scholar
  69. 69.
    Silverman, J. L.: Diabetes, 12: 528, 1963.PubMedGoogle Scholar
  70. 70.
    van Beek, C.: Maandschr. Kindergen., 20:84, 129, 141, 1952.Google Scholar
  71. 71.
    van Beek, C.: In: Probleme der fetalen Endokrinologie. Edited by H. Nowakowski. Springer Verlag, Berlin, 1956, p. 124.Google Scholar
  72. 72.
    Woolf, N. and Jackson, W. P. U.: J . Pathol. Bacteriol., 74: 223, 1957.CrossRefGoogle Scholar
  73. 73.
    Sisson, W. R., and White, P.: Trans. Amer. Pediat. Soc., 48: 47, 1936.Google Scholar
  74. 74.
    Miller, H. C., Johnson, R. D., and Durlacher, S. H.: J. Pediatr., 24: 603, 1944.CrossRefGoogle Scholar
  75. 75.
    Miller, H. C., and Wilson, H. M.: J. Pediatr., 23: 251, 1943.CrossRefGoogle Scholar
  76. 76.
    Ringertz, N.: Nord. Med., 19: 1302, 1943.Google Scholar
  77. 77.
    van Assche, F. A.: Bud. Neonat., 12: 331, 1968.CrossRefGoogle Scholar
  78. 78.
    Farquhar, J. W.: Postgrad. Med. J., 38: 612, 1962.PubMedCrossRefGoogle Scholar
  79. 79.
    Hultquist, G. T., and Olding, L. B.: Lancet, 2: 1015, 1975.PubMedCrossRefGoogle Scholar
  80. 80.
    Gepts, W., Gregoire, F., van Assche, A., and de Gasparo, M.: In: The Structure and Metabolism of the Pancreatic Islets. Edited by S. Falkmer, B. Hellman, and I. B. Täljedal. Wenner-Gren International Symposium Series 16, Pergamon Press, Oxford, 1970, p. 283.Google Scholar
  81. 81.
    van Assche, F. A.: Biol. Neonat., 14: 19, 1969.PubMedCrossRefGoogle Scholar
  82. 82.
    de Gasparo, M., van Assche, A., Gepts, W., and Hoet, J. J.: Réo. Franç. Etud. Clin. Biol., 14: 904, 1969.Google Scholar
  83. 83.
    Steinke, J., and Driscoll, S. G.: Diabetes, 14: 573, 1965.PubMedGoogle Scholar
  84. 84.
    Wellmann, K. F., Volk, B. W., and Brancato, P.: Lab. Invest., 25: 97, 1971.PubMedGoogle Scholar
  85. 85.
    Baird, J. D., and Farquhar, J. W.: Lancet, 1: 71, 1962.PubMedCrossRefGoogle Scholar
  86. 86.
    Cole, H. S., Bilder, J. H., Camerini-Davalos, R. A., and Grimaldi, R. D.: Pediatrics, 45: 394, 1970.PubMedGoogle Scholar
  87. 87.
    Isles, T. E., Dickson, M., and Farquhar, J. W.: Pediatr. Res., 2: 198, 1968.PubMedCrossRefGoogle Scholar
  88. 88.
    Klink, D. D., and Estrich, D.: Lancet, 1: 1393, 1964.CrossRefGoogle Scholar
  89. 89.
    Stimmler, L., Brazie, J. W., and O’Brien, D.: Lancet, 1: 137, 1964.PubMedCrossRefGoogle Scholar
  90. 90.
    Thomas, K., de Gasparo, M., and Hoet, J. J.: Diabetologia, 3: 299, 1967.PubMedCrossRefGoogle Scholar
  91. 91.
    Jorgensen, K. R., Deckert, T., Molsted-Pedersen, L., and Pedersen, J. Acta Endocrinol., 52: 154, 1966.PubMedGoogle Scholar
  92. 92.
    Crawford, J. S.: Biol. Neonat., 8: 222, 1965.PubMedCrossRefGoogle Scholar
  93. 93.
    Pedersen, J., Bojsen-Moller, B., and Poulsen, H.: Acta Endocrinol., 15: 33, 1954.PubMedGoogle Scholar
  94. 94.
    Persson, B.: In: Carbohydrate Metabolism in Pregnancy and the Newborn. Edited by H. W. Sutherland and J. M. Stowers. Churchill Livingstone, Edinburgh, 1975, p. 106.Google Scholar
  95. 95.
    Spellacy, W., and Goetz, F. C.: Lancet, 2: 222, 1963.PubMedCrossRefGoogle Scholar
  96. 96.
    Gibb, G.: Zbl. Allg. Path. Path. Anat., 104: 322, 1962.Google Scholar
  97. 97.
    Bartelheimer, H., and Kloos, K.: Z. Ges. Exp. Med., 119: 246, 1952.PubMedCrossRefGoogle Scholar
  98. 98.
    Kim, J. W., Runge, W., Wells, L. J., and Lazarow, A.: Diabetes, 9: 396, 1960.PubMedGoogle Scholar
  99. 99.
    Foglia, V. G.: In: Early Diabetes. Edited by R. A. Camerini-Davalos, and H. S. Cole. Academic Press, New York, 1970, p. 221.Google Scholar
  100. 100.
    Hultquist, G. T.: Acta Pathol. Microbiol. Scand., 27: 695, 1950.CrossRefGoogle Scholar
  101. 101.
    Angervall, L.: Acta Endocrinol. Suppl., 44: 1, 1959.Google Scholar
  102. 102.
    Baranov, V. G., Nikitin, A. I., and Sokoloverova, I. M.: Probl. Endokrinol., Vol. 17, No. 6, p. 96, 1971Google Scholar
  103. 103.
    Frye, B. E.: J. Morphol., 101: 325, 1957.CrossRefGoogle Scholar
  104. 104.
    Tejning, S.: Acta Med. Scand., Suppl., 198: 1, 1947.Google Scholar
  105. 105.
    Kim, J. N.: Diabetes, 14: 137, 1965.PubMedGoogle Scholar
  106. 106.
    Kozma-de Bokay, S., Jacquot, R., and Jost, A.: J. Physiol., 53: 733, 1961.Google Scholar
  107. 107.
    Lazarow, A., and Heggestad, C. B.: In: Early Diabetes. Edited by R. A. Camerini-Davalos and H. S. Cole. Academic Press, New York, 1970, p. 229.Google Scholar
  108. 108.
    Nerenberg, S. T.: Arch. Pathol., 58: 236, 1954.Google Scholar
  109. 109.
    Nikitin, A. I.: Probl. Endocrinol. Vol. 19, No. 4, p. 73, 1973.Google Scholar
  110. 110.
    Carpenter, A. M., Gerritsen, G. G., Dulin, W. E., and Lazarow, A.: Diabetologia, 6: 168, 1970.PubMedCrossRefGoogle Scholar
  111. 111.
    Wellmann, K. F., Volk, B. W., Lazarus, S. S., and Brancato, P.: Diabetes, 18: 138, 1969.PubMedGoogle Scholar
  112. 112.
    Dixit, P. K., Lowe, I. P., Heggestad, C. B., and Lazarow, A.: Diabetes, 13: 71, 1964.PubMedGoogle Scholar
  113. 113.
    Golob, E.: Z. Geburtsh. Gynäk., 171: 18, 1969.Google Scholar
  114. 114.
    Goodner, C. J., and Freinkel, N.: Diabetes, 10: 383, 1961.PubMedGoogle Scholar
  115. 115.
    Asplund, K.: J. Endocrinol., 59: 285, 1973.PubMedCrossRefGoogle Scholar
  116. 116.
    Kaung, H. L. C., Hegre, O. D., and Lazarow, A.: Proc. Soc. Exp. Biol. Med., 148: 75, 1975.PubMedGoogle Scholar
  117. 117.
    Mintz, D. H., Chez, R. A., and Hutchinson, D. L.: Clin. Res., 19: 68, 1971.Google Scholar
  118. 118.
    Lacy, P. E., and Wright, P. H.: Diabetes, 14: 634, 1965.PubMedGoogle Scholar
  119. 119.
    Iacy, P. E., Wright, P. H., and Silverman, J. L.: Fed. Proc., 22: 604, 1963.Google Scholar
  120. 120.
    Pedersen, J., and Osler, M.: Dan. Med. Bull., 8: 78, 1961.PubMedGoogle Scholar
  121. 121.
    Harding, P. G. R., Kinch, R. A. H., and Stevenson, J. A. F.: Diabetes, 11: 321, 1962.PubMedGoogle Scholar
  122. 122.
    Horii, K. I., Watanabe, G. I., and Ingalls, T. H.: Diabetes, 15: 194, 1966.PubMedGoogle Scholar
  123. 123.
    Miller, H. C.: J . Pediatr., 29: 455, 1946.PubMedCrossRefGoogle Scholar
  124. 124.
    Kriss, J. P., and Futcher, P. H.: J. Clin. Endocrinol., 8: 380, 1948.CrossRefGoogle Scholar
  125. 125.
    Scheibenreiter, S., and Thalhammer, O.: Dtsch. Med. Wochenschr. 91: 216, 1966.PubMedCrossRefGoogle Scholar
  126. 126.
    Vallance-Owen, J.: Adv. Metab. Dis., 1: 191, 1964.Google Scholar
  127. 127.
    Vallance-Owen, J., and Lilley, M. D.: Lancet, 1:806, 1961.PubMedCrossRefGoogle Scholar
  128. 128.
    Farquhar, J. W.: Arch. Dis. Child., 44: 36, 1969.PubMedCrossRefGoogle Scholar
  129. 129.
    Yamamoto, H.: Endocrinol. Jap., 18: 375, 1971.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Klaus F. Wellmann
    • 1
  • Bruno W. Volk
    • 1
  1. 1.Isaac Albert Research Institute of the Kingsbrook Jewish Medical Center, and Downstate Medical CenterState University of New YorkBrooklynUSA

Personalised recommendations