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Steroid Hormone Formation and Metabolism

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Perinatal Physiology

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Abstract

The decade of the 1960s saw the development of knowledge on the steroid synthetic capabilities of the fetal adrenals and the placenta in vitro and in situ. The important concept of the fetoplacental unit emerged in the second half of that decade from the extensive research effort of Diczfalusy, Solomon, and others; it emphasized that both organs have extensive but incomplete steroidogenic capabilities : the adrenal, being poor in 3β-hydroxysteroid dehydrogenase, can carry out extensive steroid hydroxylation, but must use exogenous progesterone to synthesize Cortisol; the placenta produces large amounts of this precursor, but not from the basic building block—acetate. It depends on blood cholesterol as a precursor to form progesterone. The concept of fetoplacental unit is also central to the understanding of estrogen formation in pregnancy.

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Authors and Affiliations

  1. Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York, 11203, USA

    Eduardo Orti

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  1. Eduardo Orti
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  1. Mailman Center for Child Development, University of Miami Medical School, USA

    Uwe Stave

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© 1978 Plenum Publishing Corporation

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Orti, E. (1978). Steroid Hormone Formation and Metabolism. In: Stave, U. (eds) Perinatal Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2316-7_37

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  • DOI: https://doi.org/10.1007/978-1-4684-2316-7_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2318-1

  • Online ISBN: 978-1-4684-2316-7

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