Bilirubin Metabolism

  • Thomas R. C. Sisson


It was pointed out by With(122) in his exhaustive monograph on bile pigments that we are indebted to the work of Hans Fischer and his colleagues for much of our knowledge of the bile pigments. Their metabolism, principally that of bilirubin IXa, is of importance to the pediatrician because hyperbilirubinemia is singular among the common symptoms appearing in the newborn in that it in itself, regardless of cause, can produce severe and irrevocable damage to the developing CNS.


Serum Bilirubin Serum Bilirubin Level Bile Pigment Neonatal Jaundice Unconjugated Bilirubin 
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  1. 1.
    Arias, I. M., 1962, Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults, J. Clin. Invest. 41:2233.PubMedCrossRefGoogle Scholar
  2. 2.
    Arias, I.M., 1970, The pathogenesis of” physiologic” jaundice of the newborn: A re-evaluation, in: “Bilirubin Metabolism in the Newborn,” Birth Defects: Orig. Artic. Ser. 6:55.Google Scholar
  3. 3.
    Arias, I. M., 1972, Transfer of bilirubin from blood to bile, Semin. Hematol. 9:55.PubMedGoogle Scholar
  4. 4.
    Arias, I. M., and Gartner, L. M., 1964, Production of unconjugated hyperbilirubinemia in full-term new-born infants following administration of preg-nane-3(α),20(β)-diol, Nature (London) 203:1292.CrossRefGoogle Scholar
  5. 5.
    Arias, I. M., Gartner, L. M., Seifter, S., and Furman, M., 1964, Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3(alpha),20(beta)-diol, in maternal milk that inhibits glucuronide formation in vitro,J. Clin. Invest. 43:2037.PubMedCrossRefGoogle Scholar
  6. 6.
    Arias, I. M, Johnson, L., and Wolfson, S., 1961, Biliary excretion of injected conjugated and unconjugated bilirubin by normal and Gunn rats, Amer. J. Physiol. 200:1091.PubMedGoogle Scholar
  7. 7.
    Arias, I. M., Wolfson, S., Lucey, J. F., and McKay, R. J., 1965, Transient familial neonatal hyperbilirubinemia, J. Clin. Invest. 44:1442PubMedCrossRefGoogle Scholar
  8. 8.
    Bakken, A. F., Thaler, M. M., and Schmid, R., 1972, Metabolic regulation of heme catabolism and bilirubin production: I. Hormonal control of hepatic heme oxygenase activity, J. Clin. Invest. 51:530.PubMedCrossRefGoogle Scholar
  9. 9.
    Ballowitz, L., and Hanefeld, F., 1976, Effect of drugs on infant Gunn rats under phototherapy, in: “Bilirubin Metabolism in the Newborn (II),” (D. Bergsma and S. H. Blondheim, eds.), Birth Defects: Orig. Artic. Ser. 12:61.Google Scholar
  10. 10.
    Bergsma, D., and Blondheim, S. H. (eds.), 1976, “Bilirubin Metabolism of the Newborn (II),” Birth Defects: Orig. Artic. Ser. 12, American Elsevier, New York.Google Scholar
  11. 11.
    Bernstein, L. H., Ben Ezzer, J., Gartner, L. M., and Arias, I. M., 1966, Hepatic intracellular distribution of tritium-labeled unconjugated and conjugated bilirubin in normal and Gunn rats, J. Clin. Invest. 45:1194.PubMedCrossRefGoogle Scholar
  12. 12.
    Bevan, B.R., Holton, J.B., and Lathe, G.H., 1965, The effect of pregnanediol and pregnanediol glucuronide on bilirubin conjugation by rat liver slices, Clin. Sci. 29:353.PubMedGoogle Scholar
  13. 13.
    Billing, B. H., Cole, P. G., and Lathe, G. H., 1957, The excretion of bilirubin as a diglucuronide giving the direct van den Bergh reaction, Biochem.J. 65:774.PubMedGoogle Scholar
  14. 14.
    Blackburn, M. G., Orzalesi, M. M., and Pigram, P., 1972, Effect of light on fetal red cells in vivo, J. Pediatr. 80:641.Google Scholar
  15. 15.
    Blondheim, S. H., Kapitulnik, J., Valaes, T., and Kaufman, N. A., 1972, Use of a sephadex column to evaluate the bilirubin-binding capacity of the serum of infants with neonatal jaundice, Isr. J. Med. Sci. 8:22.PubMedGoogle Scholar
  16. 16.
    Brown, A. K., 1976, Bilirubin metabolism in the fetus and newborn, in: The Physiology of the Newborn Infant (C. A. Smith and N. M. Nelson, eds.), p. 338, Charles C. Thomas, Springfield, Illinois.Google Scholar
  17. 17.
    Brown, A. K., and Zuelzer, W. W., 1958, Studies on neonatal development of glucuronide conjugating system, J. Clin. Invest. 37:332.PubMedCrossRefGoogle Scholar
  18. 18.
    Catz, C., and Yaffe, S. J., 1962, Pharmacological modification of bilirubin conjugation in the newborn, Amer. J. Dis. Child. 104:516.Google Scholar
  19. 19.
    Cooke, J. R., and Roberts, L. B., 1969, The binding of bilirubin to serum proteins, Clin. Chim. Acta 26:425.PubMedCrossRefGoogle Scholar
  20. 20.
    Cremer, R. J., Perryman, P. W., and Richards, D. H., 1958, Influence of light on the hyperbili-rubinaemia of infants, Lancet 1:1094.PubMedCrossRefGoogle Scholar
  21. 21.
    Crigler, J. F., Jr., and Gold, N. I., 1967, Effect of sodium phenobarbital on the metabolism of bilirubin 3H and 14C in an infant with congenital non-hemolytic jaundice and kernicterus, J. Clin. Invest. 46:1047.Google Scholar
  22. 22.
    Crigler, J. F., Jr., and Najjar, V. A., 1952, Congenital familial nonhemolytic jaundice with kernicterus, Pediatrics 10:169.PubMedGoogle Scholar
  23. 23.
    Davidson, L. T., Merritt, K. K., and Weech, A. A., 1941, Hyperbilirubinemia in the newborn, Amer. J. Dis. Child. 61:958.Google Scholar
  24. 24.
    Dawber, N. H., Bakken, A., and Schmid, R., 1974, Stimulation of bilirubin production by epinephrine and glucagon, Gastroenterology 66:881.Google Scholar
  25. 25.
    Diamond, I., and Schmid, R., 1966, Experimental bilirubin encephalopathy. The mode of entry of bilirubin-14C into the central nervous system, J. Clin. Invest. 45:678.PubMedCrossRefGoogle Scholar
  26. 26.
    Diamond, I., and Schmid, R., 1968, Neonatal hyperbilirubinemia and kernicterus, experimental support for treatment by exposure to visible light, Arch Neurol. 18:699.PubMedCrossRefGoogle Scholar
  27. 27.
    Doxiades, S. A., Fessas, P., and Valaes, T., 1960, Erythrocyte enzyme deficiency in unexplained kernicterus, Lancet 2:44.CrossRefGoogle Scholar
  28. 28.
    Dutton, G. J., 1959, Glucuronide synthesis in foetal liver and other tissue, Biochem. J. 71:141.PubMedGoogle Scholar
  29. 29.
    Dutton, G. J., 1963, Foetal and infant liver function and structure: IV. Bilirubin and related compounds. Comparison of glucuronide synthesis in developing and mammalian and avian liver, Ann. N. Y. Acad. Sci. 111:259.PubMedCrossRefGoogle Scholar
  30. 30.
    Dutton, G. J., Langelaan, D. E., and Ross, P. E., 1964, High glucuronide synthesis in newborn liver: Choice of species and substrate, Biochem. J. 93:4P.Google Scholar
  31. 31.
    Fashena, G. J., 1948, Mechanism of hyperbilirubinemia in the newborn infant, Amer. J. Dis. Child. 76:196.Google Scholar
  32. 31a.
    Fleischner, G. M., and Arias, I. M., 1976, Structure and function of ligandin (Y protein, GSH transferase B) and Z protein in the liver: A progress report, in: Progress in Liver Disease, Vol. 5 (H. Popper and F. Schaffner, eds.), pp. 172–182, Grune and Stratton, New York.Google Scholar
  33. 32.
    Flodgaard, H. J., and Broderson, R., 1967, Bilirubin glucuronide formation in developing guinea pig liver, Scand. J. Clin. Lab. Invest. 19:149.CrossRefGoogle Scholar
  34. 33.
    Gartner, L. M., and Arias, I. M., 1963, Developmental pattern of glucuronide formation in rat and guinea pig liver, Amer. J. Physiol. 20:633.Google Scholar
  35. 34.
    Gartner, L. M., and Arias, I. M., 1966, Studies of prolonged neonatal jaundice in the breast-fed infant, J. Pediatr. 68:54.PubMedCrossRefGoogle Scholar
  36. 35.
    Gartner, L. M., and Arias, I. M., 1969, The transfer of bilirubin from blood to bile in the neonatal guinea pig, Pediatr. Res. 3:171.PubMedCrossRefGoogle Scholar
  37. 36.
    Gartner, L. M., and Lane, D., 1971, Hepatic metabolism and transport of bilirubin during physiologic jaundice in the newborn rhesus monkey, Pediatr. Res. 70:166.Google Scholar
  38. 37.
    Gartner, L. M., Snyder, R. N., Chabon, R. S., and Bernstein, J., 1970, Kernicterus. High incidence in premature infants with low serum bilirubin concentrations, Pediatrics 45:906.PubMedGoogle Scholar
  39. 38.
    Giblett, E. R., 1964, Blood group antibodies causing hemolytic disease of the newborn, Clin. Obstet. Gynecol. 7:1044.CrossRefGoogle Scholar
  40. 39.
    Goldstein, G. W., and Lester, R., 1964, Reduction of biliverdin-C14 in vivo, Proc. Soc. Exp. Biol. Med. 117:681.PubMedGoogle Scholar
  41. 40.
    Gray, C. H., Nicholson, D. C., and Nicolaus, R. A., 1958, The IXa structure of the common bile pigments, Nature (London) 181:183.CrossRefGoogle Scholar
  42. 41.
    Gray, C. H., Neuberger, A., and Sneath, P. H. A., 1950, Studies in congenital porphyria: II. Incorporation of 15N in the normal and in the porphyric, Biochem. J. 47:87.PubMedGoogle Scholar
  43. 41a.
    Habig, W., Pabst, M., Fleischner, B., Gatmaitan, Z., Arias, I. M., and Jakoby, W., 1974, The identity of glutathione transferase B with ligandin, a major binding protein of liver, Proc. Natl. Acad. Sci. U.S.A. 71:3879.PubMedCrossRefGoogle Scholar
  44. 42.
    Halac, E., Jr., and Reff, A., 1967, Studies on bilirubin UDP-glucuronyltransferase, Biochim. Biophys. Acta 139:328.PubMedGoogle Scholar
  45. 43.
    Hargreaves, T., and Holton, J. B., 1962, Jaundice of the new-born due to novobiocin, Lancet 1:839.PubMedCrossRefGoogle Scholar
  46. 44.
    Harris, R. C., Lucey, J. F., and MacLean, J. R., 1958, Kernicterus in premature infants associated with low concentrations of bilirubin in plasma, Pediatrics 21:875.PubMedGoogle Scholar
  47. 45.
    Hart, G., Adamson, R. H., Dixon, R. L., and Fouts, J. R., 1962, Stimulation of hepatic microsomal drug metabolism in the newborn and fetal rabbit, J. Pharmacol. Exp. Ther. 137:103.PubMedGoogle Scholar
  48. 46.
    Hsia, D. Y.-Y., 1966, Inborn Errors of Metabolism. I. Clinical Aspects, 2nd Ed., Year Book Medical Publishers, Chicago.Google Scholar
  49. 47.
    Hsia, D. Y.-Y., Allen, F. H., Diamond, L. K., and Gellis, S. S., 1953, Serum bilirubin in the newborn infant, J. Pediatr. 42:277.PubMedCrossRefGoogle Scholar
  50. 48.
    Hsia, D. Y.-Y., Dowben, R. M., Shaw, R., and Grossman, A., 1960, Inhibition of glucuronosyl transferase by progestational agents from serum of pregnant women, Nature (London) 187:693.CrossRefGoogle Scholar
  51. 49.
    Hsia, D. Y.-Y., Riabov, S., and Dowben, R. M., 1963, Inhibition of glucuronosyl transferase by steroid hormones, Arch. Biochem. 103:181.PubMedCrossRefGoogle Scholar
  52. 50.
    Hubbel, J. P., Jr., Drorbaugh, J. E., Rudolph, A. J., Auld, P. A. M., Cherry, R. B., and Smith, C. A., 1961, “Early” versus “late” feeding of infants of diabetic mothers, N. Engl. J. Med. 265:835.CrossRefGoogle Scholar
  53. 51.
    Inscoe, J. K., and Axelrod, J., 1960, Some factors affecting glucuronide formation in vitro, J. Pharmacol. Exp. Ther. 129:128.PubMedGoogle Scholar
  54. 52.
    Isselbacher, K.J., 1968, Evidence for the multiplicity of glucuronyl transferases, in: Ikterus (K. Beck, ed.), Schattauer, Stuttgart and New York.Google Scholar
  55. 53.
    Jacobsen, J., 1969, Binding of bilirubin to human serum albumin, determination of the dissociation constants, FEBS Lett. 5:112.PubMedCrossRefGoogle Scholar
  56. 54.
    Johnson, L., and Boggs, T. R., Jr., 1974, Bilirubin dependent brain damage: Incidence and indications for treatment, in: Phototherapy: An Overview (G. B. Odell, R. Shaffer, and A. Simopoulos, eds.), pp. 121–149, National Academy of Science, Washington, D.C.Google Scholar
  57. 55.
    Johnson, L., Sarmiento, F., Blanc, W. A., and Day, R. L., 1959, Kernicterus in rats with an inherited deficiency in glucuronyl transferase, Amer. J. Dis. Child. 97:591.Google Scholar
  58. 56.
    Jones, B., 1964, Glucuronyl transferase inhibition by steroids, J. Pediatr. 64:815.PubMedCrossRefGoogle Scholar
  59. 57.
    Kapitulnik, J., Valaes, T., Kaufman, N. A., and Blondheim, S. H., 1974, Clinical evaluation of Sephadex gel filtration in the estimation of bilirubin binding in serum in neonatal jaundice, Arch. Dis. Child. 97:591.Google Scholar
  60. 58.
    Lathe, G. H., and Walker, M., 1958, Inhibition of bilirubin conjugation in rat liver slices by human pregnancy and neonatal serum and steroids, Q. J. Physiol. 43:257.Google Scholar
  61. 59.
    Lathe, G. H., and Walker, M., 1958, The synthesis of bilirubin glucuronide in animal and human liver, Biochem. J. 70:705.PubMedGoogle Scholar
  62. 60.
    Lester, R., and Schmid, R., 1963, Intestinal absorption of bile pigments. I. The enterohepatic circulation in the rat, J. Clin. Invest. 42:736.PubMedCrossRefGoogle Scholar
  63. 61.
    Lester, R., and Schmid, R., 1963, Intestinal absorption of bile pigments. II. Bilirubin absorption in man. N. Engl. J. Med. 269:178.PubMedCrossRefGoogle Scholar
  64. 62.
    Lester, R., and Troxler, R., 1969, Recent advances in bile pigment metabolism, Gastroenterology 56:143.PubMedGoogle Scholar
  65. 63.
    Lester, R., Behrman, R. E., and Lucey, J. F., 1963, Transfer of bilirubin C14 across monkey placenta, Pediatrics 32:416.PubMedGoogle Scholar
  66. 64.
    Lester, R., Hammaker, L., and Schmid, R., 1962, A new therapeutic approach to unconjugated hyperbilirubinemia, Lancet 2:1257.PubMedCrossRefGoogle Scholar
  67. 65.
    Levin, S. E., Charlton, R. W., and Freiman, I., 1964, Glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in South African Bantu infants, J. Pediatr. 65:757.PubMedCrossRefGoogle Scholar
  68. 66.
    Litwak, G., Ketterer, B., and Arias, I. M., 1971, Ligandin: A hepatic protein which binds steroids, bilirubin, carcinogens, and a number of exogenous organic anions, Nature (London) 234:466.CrossRefGoogle Scholar
  69. 67.
    Lokietz, H., Dowben, R. M., and Hsia, D. Y.-Y., 1963, Studies on the effect of novobiocin on glucuronosyl transferase, Pediatrics 32:47.Google Scholar
  70. 68.
    London, I., West, R., Shemin, D., and Rittenberg, D., 1950, On the origin of bile pigment in normal man, J. Biol. Chem. 184:359.PubMedGoogle Scholar
  71. 69.
    Lu, T. C., Wei, H. Y., and Blackwell, R. W., 1966, Increased incidence of severe hyperbilirubinemia among newborn Chinese infants with G-6-PD deficiency, Pediatrics 37:994.PubMedGoogle Scholar
  72. 70.
    Lucey, J. F., Hewitt, J. R., Emery, E. S., Goldstein, S., and Collins, S., 1973, Controlled follow-up study of low birth weight infants at 4–6 years of age treated with phototherapy, Pediatr. Res. 7:313.Google Scholar
  73. 71.
    Lund, H. T., and Jacobsen, J., 1972, Influence of phototherapy on unconjugated bilirubin in duodenal bile of newborn infants with hyperbilirubinemia, Acta Paediatr. Scand. 61:693.PubMedCrossRefGoogle Scholar
  74. 72.
    Lund, H. T., and Jacobsen, J., 1974, Influence of phototherapy on the bilirubin excretion pattern in newborn infants with hyperbilirubinemia, J. Pediatr. 85:262.PubMedCrossRefGoogle Scholar
  75. 73.
    Lundh, B., Johansson, B., and Mercke, C., 1972, Enhancement of heme catabolism by caloric restriction in man, Scand, J. Lab. Clin. Med. 30:421.CrossRefGoogle Scholar
  76. 74.
    McDonagh, A. F., 1971, The role of singlet O2 in bilirubin photooxidation, Biochim. Biophys. Res. Commun. 44:1306.CrossRefGoogle Scholar
  77. 75.
    Meyer, T. C., and Angus, J., 1956, The effect of large doses of “Synkavite” in the newborn, Arch. Dis. Child. 31:212.PubMedCrossRefGoogle Scholar
  78. 76.
    Mims, L. C., Estrada, M., Gooden, D. S., Caldwell, W. R., and Kotas, R. V., 1973, Phototherapy for neonatal hyperbilirubinemia—a dose: response relationship, J. Pediatr. 83:658.PubMedCrossRefGoogle Scholar
  79. 77.
    Mowat, A. P., and Arias, I. M., 1970, Observations of the effect of diethylnitrosamine on glucuronide formation, Biochim. Biophys. Acta 212:65.PubMedGoogle Scholar
  80. 78.
    Newman, A. J., and Gross, S., 1966, Hyperbilirubinemia in breast-fed infants, Pediatrics 32:995.Google Scholar
  81. 79.
    Odell, G. B., 1959, Dissociation of bilirubin from albumin and its clinical implications, J. Pediatr. 55:286.Google Scholar
  82. 80.
    Odell, G. B., 1959, Studies in kernicterus. I. The protein binding of bilirubin, J. Clin. Invest. 38:823.PubMedCrossRefGoogle Scholar
  83. 81.
    Odell, G.B., 1966, The distribution between albumin and mitochondria, J. Pediatr. 68:164.CrossRefGoogle Scholar
  84. 82.
    Odell, G. B., Cohen, S. N., and Gordes, E. H., 1962, Administration of albumin in the management of hyperbilirubinemia by exchange transfusion, Pediatrics 30:613.PubMedGoogle Scholar
  85. 83.
    Odell, G. B., Cohen, S. N., and Keely, P. C., 1969, Studies in kernicterus. II. The determination of the saturation of serum albumin with bilirubin, J. Pediatr. 74:214.PubMedCrossRefGoogle Scholar
  86. 84.
    O’Flynn, M. E. D., and Hsia, D. Y.-Y., 1963, Serum bilirubin levels and glucose-6-phosphate dehydrogenase deficiency in newborn American negroes, J. Pediatr. 63:160.CrossRefGoogle Scholar
  87. 85.
    Ostrow, J. D., and Schmid, R., 1963, The protein binding of C14-bilirubin in human and murine serum, J. Clin. Invest. 42:1286.PubMedCrossRefGoogle Scholar
  88. 86.
    Ostrow, J. D., Hammaker, L., and Schmid, R., 1961, The preparation of crystalline bilirubin-C14, J. Clin. Invest. 40:1442.PubMedCrossRefGoogle Scholar
  89. 87.
    Ostrow, J. D., Jandl, J. H., and Schmid, R., 1962, The formation of bilirubin from hemoglobin in vivo, J. Clin. Invest. 41:1628.CrossRefGoogle Scholar
  90. 88.
    Pearson, H. A., 1967, Life-span of the fetal red blood cell. J. Pediatr. 70:166.PubMedCrossRefGoogle Scholar
  91. 89.
    Poland, R. L., and Odell, G. B., 1971, Physiologic jaundice: The enterohepatic circulation of bilirubin, N. Engl. J. Med. 284:1.PubMedCrossRefGoogle Scholar
  92. 90.
    Ramos, A., Silverberg, M, and Stern, L., 1966, Pregnanediols and neonatal hyperbilirubinemia, Amer. J. Dis. Child. 111:353.PubMedGoogle Scholar
  93. 91.
    Robinson, S. H., Lester, R., Crigler, J. J., and Tsong, M., 1967, Early-labeled peak of bile pigment in man, N Engl. J. Med. 277:1323.PubMedCrossRefGoogle Scholar
  94. 92.
    Rubaltelli, F. F., and Largajolli, G., 1973, Effect of light exposure on gut transit time in jaundiced newborn infants, Acta Paediatr. Scand. 62:146.PubMedCrossRefGoogle Scholar
  95. 93.
    Schacter, B. A., 1975, Induction mechanisms for bile pigment formation, in: Hepatology—Research and Clinical Issues, Vol. 2, Jaundice (C. A. Goresky and M. M. Fisher, eds.), pp. 85–102, Plenum Press, New York.Google Scholar
  96. 94.
    Schenker, S., and Schmid, 1964, Excretion of C14 bilirubin in newborn guinea pigs, Proc. Soc. Exp. Biol. Med. 115:466.Google Scholar
  97. 95.
    Schenker, S., Dawber, N. H., and Schmid, R., 1964, Bilirubin metabolism in the fetus, J. Clin. Invest. 43:32.PubMedCrossRefGoogle Scholar
  98. 96.
    Schmid, R., 1956, Direct-reacting bilirubin, bilirubin glucuronide in serum, bile, and urine, Science 124:76.PubMedCrossRefGoogle Scholar
  99. 97.
    Schmid, R., and Hammaker, L., 1963, Metabolism and disposition of C14-bilirubin in congenital nonhemolytic jaundice, J. Clin. Invest. 42:1720.PubMedCrossRefGoogle Scholar
  100. 98.
    Schmid, R., Axelrod, J., Hammaker, L., and Swarm, R. L., 1958, Congenital jaundice in rats due to a defect in glucuronide formation, J. Clin. Invest. 37:1123.PubMedCrossRefGoogle Scholar
  101. 99.
    Schmid, R., Buckingham, S., Mendilla, G. A., and Hammaker, L., 1959, Bilirubin metabolism in the fetus, Nature (London) 183:1823.CrossRefGoogle Scholar
  102. 100.
    Schmid, R., Marver, H.S., and Hammaker, L., 1966, Enhanced formation of rapidly labeled bilirubin by phenobarbital: Hepatic microsomal cytochromes as a possible source, Biochem. Biophys. Res. Commun. 24:319.PubMedCrossRefGoogle Scholar
  103. 101.
    Sereni, F., Perletti, L., and Marini, A., 1967, Influence of diethylnicotinamide on the concentration of serum bilirubin of newborn infants, Pediatrics 39:446.Google Scholar
  104. 102.
    Silverman, W. A., Andersen, D. H., Blanc, W. A., and Crozier, D. N., 1956, A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens, Pediatrics 18:614.PubMedGoogle Scholar
  105. 103.
    Singleton, J., and Laster, L., 1965, Biliverdin reductase of guinea pig liver, J. Biol. Chem. 244:6388.Google Scholar
  106. 104.
    Sisson, T. R. C., 1977, Phototherapy of neonatal jaundice: Effect on blood biorhythm, in: Research in Photobiology (A. Castellani, ed.), p. 431, Plenum Press, London.CrossRefGoogle Scholar
  107. 105.
    Sisson, T. R. C., Goldberg, S., and Slaven, B., 1974, The effect of visible light on the Gunn rat: Convulsive threshold, bilirubin concentration, and brain color, Pediatr. Res. 8:647.PubMedCrossRefGoogle Scholar
  108. 106.
    Sisson, T. R. C., Kendall, N., Shaw, E., and Kechavaraz-Oliai, L., 1972, Phototherapy of jaundice in the newborn. II. Effect of various light intensities, J. Pediatr. 81:35.PubMedCrossRefGoogle Scholar
  109. 107.
    Sisson, T. R. C., Slaven, B., and Hamilton, P. B., 1976, Effect of broad and narrow spectrum fluorescent light on blood constituents, in: Bilirubin Metabolism in the Newborn (II) (D. Bergsma and S. H. Blodehim, eds.), Birth Defects: Orig. Artic. Ser. 12:122–133, American Elsevier, New York.Google Scholar
  110. 108.
    Smith, K. C. (ed.), 1976, Photochemical and PhotobiologicalReviews, Vol. 1, Plenum Press, New York.Google Scholar
  111. 109.
    Stern, L., and Denton, R. L., 1965, Kernicterus in small premature infants, Pediatrics 35:483.PubMedGoogle Scholar
  112. 110.
    Stiehm, E. R., and Ryan, J., 1965, Breast-milk jaundice, Amer. J. Dis. Child. 109:212.PubMedGoogle Scholar
  113. 111.
    Sutherland, J. M, and Keller, W. H., 1961, Novobiocin and neonatal hyperbilirubinemia, Amer. J. Dis. Child. 101:447.Google Scholar
  114. 112.
    Szeinberg, A., Oliver, M., Schmidt, R., Adam, A., and Sheba, C., 1963, Glucose-6-phosphate dehydrogenase deficiency and hemolytic disease of the newborn in Israel, Arch. Dis. Child. 38:23.PubMedCrossRefGoogle Scholar
  115. 113.
    Taylor, P. M., Bright, N. H., Birchard, E. L., Derinoz, M. N., and Watson, D. W., 1963, The effect of race, weight loss, and the time of clamping of the umbilical cord on neonatal bilirubinemia, Biol. Neonate 5:299.CrossRefGoogle Scholar
  116. 114.
    Tenhunen, R., 1972, The enzymatic degradation of heme, Semin. Hematol. 9:19.PubMedGoogle Scholar
  117. 115.
    Tenhunen, R., Marver, H. S., and Schmid, R., 1968, The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase, Proc. Natl. Acad. Sci. U.S.A. 61:748.PubMedCrossRefGoogle Scholar
  118. 116.
    Thaler, M. M., Gemes, D. L., and Schmid, R., 1972, Enzymatic conversion of heme to bilirubin in normal and starved fetuses and newborn rats, Pediatr. Res. 6:197.PubMedCrossRefGoogle Scholar
  119. 117.
    Tomlinson, G. A., and Yaffe, S. J., 1966, The formation of bilirubin and p-nitrophenyl glucuronides by rabbit liver, Biochem. J. 99:507.PubMedGoogle Scholar
  120. 118.
    Trolle, D., 1968, Phenobarbitone and neonatal icterus, Lancet 1:251.CrossRefGoogle Scholar
  121. 119.
    Ulstrom, R. A., and Eisenklam, E., 1964, The enterohepatic shunting of bilirubin in the newborn infant, J. Pediatr. 65:27.PubMedCrossRefGoogle Scholar
  122. 120.
    Weiss, J., and Arias, I. M., 1967, Hepatic glucuronyl transferase: Submicrosomal distribution and role in intracellular transport of bilirubin, J. Clin. Invest. 46:1130.Google Scholar
  123. 121.
    Wennberg, R. P., Schwartz, R., and Sweet, A. Y., 1966, Early versus delayed feeding of low birth weight infants: Effects on physiologic jaundice, J. Pediatr. 68:860.PubMedCrossRefGoogle Scholar
  124. 122.
    With, T. K., 1968, Bile Pigments, Chemical, Biologicaland Clinical Aspects, p. 1, Academic Press, New York.Google Scholar
  125. 123.
    Wolff, J. A., Grossman, B. H., and Paya, K., 1967, Neonatal serum bilirubin and glucose-6-phosphate dehydrogenase, Amer. J. Dis. Child. 113:251.PubMedGoogle Scholar
  126. 124.
    Wu, P. Y. K., and Hodgman, J., 1967, “Early” versus “late” feeding of low birth weight neonates: Effect on serum bilirubin, blood sugar, and responses to glucagon and epinephrine tolerance tests, Pediatrics 39:733.PubMedGoogle Scholar
  127. 125.
    Yaffe, S. J., Levy, G., Matsuzawa, T., and Baliah, T., 1966, Enhancement of glucuronide-conjugating capacity in a hyperbilirubinemic infant due to apparent enzyme induction by phenobarbital, N. Engl. J. Med. 275:1461.PubMedCrossRefGoogle Scholar
  128. 126.
    Zenone, E. A., Stoll, M. S., and Ostrow, J. D., 1977, Mechanism of unconjugated bilirubin during phototherapy, Gastroenterology 72:1180 (abstr).Google Scholar
  129. 127.
    Zinkham, W. H., 1967, The selective hemolytic action of drugs: Clinical and mechanistic considerations, J. Pediatr. 70:200.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Thomas R. C. Sisson
    • 1
  1. 1.Department of Pediatrics, Obstetrics, and Gynecology (Perinatology), Neonatal Research LaboratoryTemple University School of MedicinePhiladelphiaUSA

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