Maturation of Cellular and Humoral Immunity

  • Gaspard de Muralt


In mammals, immunologic responses can be divided into those mediated by humoral antibodies (antibody-mediated immunity) and by cells (cell-mediated immunity). Both depend on the activity of small lymphocytes that are themselves ultimately derived from bone marrow precursors.(226) The stem cells, which originate in the early embryonic stage in the yolk sac and in later stages of development in the liver, and in adults in the bone marrow, differentiate to form two distinct lymphocyte populations, one thymus-derived (T lymphocytes), the other bone-marrow-derived (B lymphocytes)(77,167) The life span of lymphocytes is not uniform. One can distinguish two populations of lymphocytes: a short-lived population of small, medium, and large lymphocytes with a life span of 1–10 days, and a long-lived population of small lymphocytes with a life span of some 100 days(275); some of these small lymphocytes have a life span of 10 years and more.(192)


Cord Blood Newborn Infant Humoral Immunity Placental Transfer Maternal Antibody 
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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Gaspard de Muralt
    • 1
  1. 1.Department of PerinatologyUniversity Women’s HospitalBernSwitzerland

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