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Indications for Medical Treatment of Paget’s Disease of Bone

  • Ethel S. Siris

Abstract

Paget’s disease of bone was first described in 1876,1 but efficacious and safe medical treatments did not become widely available until nearly 100 years later. To some degree, this delay reflected ignorance of the intrinsic abnormality that produces the characteristic changes in bone. With the emergence of a better understanding of the pathophysiology of Paget’s disease, logical approaches to therapy have become possible. Today, after nearly 20 years of experience with specific antipagetic medications, we have acquired some knowledge of what medical treatments can accomplish, but we are still developing guidelines regarding when, whom, and why to treat.

Keywords

Bone Turnover Giant Cell Tumor Serum Alkaline Phosphatase Serum Alkaline Phosphatase Level Pagetic Bone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Paget J: On a form of chronic inflammation of bones. Med Chir Trans 1877: 60: 37–63.PubMedGoogle Scholar
  2. 2.
    Siris E, Kelsey J, Flaster E, et al: Paget’s disease in the United States: A survey of 700 patients. J Bone Mineral Res 1988; 3 (suppl 1): S93.Google Scholar
  3. 3.
    Schmidek HH: Neurologic and neurosurgical sequelae of Paget’s disease of bone. Clin Orthop 1977; 127: 70–77.PubMedGoogle Scholar
  4. 4.
    Nager GT: Paget’s disease of the temporal bone. Ann Otol Rhinol Laryngol 1975; 84 (suppl 22): 1–32.PubMedGoogle Scholar
  5. 5.
    Herzberg L, Bayliss E: Spinal-cord syndrome due to noncompressive Paget’s disease of bone: A spinal-artery steal phenomenon reversible with calcitonin. Lancet 1980; 2: 13–15.PubMedCrossRefGoogle Scholar
  6. 6.
    Howarth S: Cardiac output in osteitis deformans. Clin Sci 1953; 12: 271–275.PubMedGoogle Scholar
  7. 7.
    Poretta CA, Dahlin DC, Janes JM: Sarcoma in Paget’s disease of bone. J Bone Joint Surg [Am] 1957; 39: 1313–1329.Google Scholar
  8. 8.
    Jacobs TP, Michelsen J, Polay J, et al: Giant cell tumor in Paget’s disease of bone. Cancer 1979; 44: 742–747.PubMedCrossRefGoogle Scholar
  9. 9.
    Singer FR: Paget’s Disease of Bone. New York, Plenum, Medical Book 1977, pp 113–114.Google Scholar
  10. 10.
    Franck WA, Bress NM, Singer FR, Krane SM: Rheumatic manifestations of Paget’s disease of bone. Am J Med 1974; 56: 592–603.PubMedCrossRefGoogle Scholar
  11. 11.
    Siris E, Kelsey J, Flaster E, et al: Environmental exposures and medical histories in Paget’s disease. J Bone Mineral Res 1988; 3 (suppl 1): S93.Google Scholar
  12. 12.
    Posen S, Bligh PC, Wilkinson M: Paget’s disease of bone and hyperparathyroidism: Coincidence or causal relationship? Calcif Tissue Res 1978; 26: 107–109.PubMedCrossRefGoogle Scholar
  13. 13.
    Matkovic V, Apseloff G, Sheppard DR, Gerber N: Use of gallium to treat Paget’s disease of bone: A pilot study. Lancet 1990; 1: 72–75.CrossRefGoogle Scholar
  14. 14.
    ElSammaa M, Linthicum FH Jr, House HP, House JW: Calcitonin as a treatment for hearing loss in Paget’s disease. Am J Otol 1986; 7: 241–243.Google Scholar
  15. 15.
    Meunier PJ, Chapuy MC, Delmas P, et al: Intravenous disodium etidronate therapy in Paget’s disease of bone and hypercalcemia of malignancy: Effects on biochemical parameters and bone histomorphometry. Am J Med 1987; 82 (suppl 2A): 71–78.PubMedCrossRefGoogle Scholar

Copyright information

© Elsevier Science Publishing Co., Inc. 1991

Authors and Affiliations

  • Ethel S. Siris

There are no affiliations available

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