The Pathology of Paget’s Disease

  • Steven L. Teitelbaum


Paget’s disease is a common affliction in Western society, being pathologically manifest in approximately 4% of older whites.1 Although rarely fatal, the disorder may be extremely disabling and painful and lead to marked skeletal distortion.


Measle Virus Cement Line Marrow Fibrosis Osteitis Fibrosa Respiratory Syncytial Viral Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Schmorl G: Ueber osteitis deformans Paget. Virchows Arch (Pathol Anat) 1932; 283: 694.CrossRefGoogle Scholar
  2. 2.
    Meunier PJ, Coindre JM, Edouard CM, et al: Bone histomorphometry in Paget’s disease: Quantitative and dynamic analysis of pagetic and nonpagetic bone tissue. Arthritis Rheum 1980; 23: 1095.PubMedCrossRefGoogle Scholar
  3. 3.
    Williams CP, Meachim G, Taylor WH: Effect of calcitonin treatment on osteoclast counts in Paget’s disease of bone. J Clin Pathol 1978; 31: 1212.PubMedCrossRefGoogle Scholar
  4. 4.
    Matthews JL, Martin JH: Intracellular transport of calcium and its relationship to homeostasis and mineralization. Am J Med 1971; 50: 589.PubMedCrossRefGoogle Scholar
  5. 5.
    Talmage RV, Grubb SA: A laboratory model demonstrating osteocyte-osteoblast control of calcium concentrations. Clin Orthop 1977, 22: 299.Google Scholar
  6. 6.
    Fallon MD, Teitelbaum SL: The interpretation of fluorescent tetracycline markers in the diagnosis of metabolic bone diseases. Hum Pathol 1982; 13: 416.PubMedCrossRefGoogle Scholar
  7. 7.
    Coccia PF, Krivit W, Cervenka J, et al: Successful bone marrow transplantation for infantile malignant osteopetrosis. N Engl J Med 1980; 302: 701.PubMedCrossRefGoogle Scholar
  8. 8.
    Alvarez JI, Teitelbaum SL, Menton D, Blair HC: Osteoclast generation from avian marrow monocytic precursors in vitro: Characterization by isoenzymes, ultrastructure, and bone resorption showing identity with freshly isolated osteoclasts. J Bone Mineral Res 1989; 4: S265.Google Scholar
  9. 9.
    Blair HC, Kahn AJ, Crouch EC, et al: Isolated osteoclasts resorb the organic and inorganic components of bone. J Cell Biol 1986; 102: 1164.PubMedCrossRefGoogle Scholar
  10. 10.
    Blair HC, Teitelbaum SL, Ghiselli R, Gluck S: Osteoclasts bone resorption by a polarized vacuolar proton pump. Science 1989; 245: 855.PubMedCrossRefGoogle Scholar
  11. 11.
    Frost HM: Tetracycline-based histological analysis of bone remodeling. Calcif Tissue Res 1969; 3: 211.PubMedCrossRefGoogle Scholar
  12. 12.
    Parfitt AM: The coupling of bone formation to bone resorption: A critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. Metab Bone Dis 1982; 4: 1.CrossRefGoogle Scholar
  13. 13.
    Rebel A, Malkani K, Basle M, Bregeon C: Osteoclast ultrastructure in Paget’s disease. Clin Orthop 1987; 217: 4.Google Scholar
  14. 14.
    Mills BG, Singer FR, Weiner LP, et al: Evidence for both respiratory syncytial virus and measles virus antigens in the osteoclasts of patients with Paget’s disease of bone. Clin Orthop 1984; 183: 303.PubMedGoogle Scholar
  15. 15.
    Mills BG, Singer FR: Critical evaluation of viral antigen data in Paget’s disease of bone. Clin Orthop 1987; 217: 16.PubMedGoogle Scholar
  16. 16.
    Basle MF, Fournier JG, Rosenblatt S, et al: Measles virus RNA detected in Paget’s disease of bone tissue by in situ hybridization. J Gen Virol 1986; 67: 907.PubMedCrossRefGoogle Scholar
  17. 17.
    Lai MC, Wang Y-J, Mills B, and Singer F: Molecular cloning and characterization of a paramyxovirus RNA: Sequences in Paget’s disease of bone. J Bone Mineral Res 1989; 4: 198.Google Scholar
  18. 18.
    Friedenstein AJ: Precursor cells of mechanocytes. Int Rev Cytol 1976; 47: 327.PubMedCrossRefGoogle Scholar
  19. 19.
    Fallon MD, Schwamm HA: Paget’s disease of bone: An update on the pathogenesis, pathophysiology, and treatment of osteitis deformans. Pathol Annu 1989; 24: 115.PubMedGoogle Scholar
  20. 20.
    Altman RD, Johnston CC, Khairi MR, et al: Influence of disodium etidronate on clinical and laboratory manifestations of Paget’s disease of bone (osteitis deformans). N Engl J Med 1973; 289: 1379.PubMedCrossRefGoogle Scholar
  21. 21.
    Chambers TJ, Moore A: The sensitivity of isolated osteoclasts to morphological transformation by calcitonin. J Clin Endocrinol Metab 1983; 57: 819.PubMedCrossRefGoogle Scholar
  22. 22.
    Carano A, Teitelbaum SL, Konsek JD, et al: Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro. J Clin Invest 1990; 85: 456.PubMedCrossRefGoogle Scholar
  23. 23.
    Murphy WA, Whyte MP, Haddad JG Jr: Paget bone disease: Radiologic documentation of healing with human calcium therapy. Radiology 1980; 136: 1.PubMedGoogle Scholar
  24. 24.
    Huvos AG, Butler A, Bretsky SS: Osteogenic sarcoma associated with Paget’s disease of bone: A clinicopathologic study of 65 patients. Cancer 1983; 52: 1489.PubMedCrossRefGoogle Scholar
  25. 25.
    Haibach H, Farrell C, Dittrich FJ: Neoplasms arising in Paget’s disease of bone: A study of 82 cases. Am J Clin Pathol 1985; 83: 594.PubMedGoogle Scholar

Copyright information

© Elsevier Science Publishing Co., Inc. 1991

Authors and Affiliations

  • Steven L. Teitelbaum

There are no affiliations available

Personalised recommendations