Arthritis and Paget’s Disease of Bone

  • Stephen M. Krane
  • Susan F. Kroop


Although Paget’s disease may be asymptomatic and recognized by physicians in the course of radiologic examinations for unrelated clinical problems or the finding of elevated serum alkaline phosphatase activity on routine chemical screening, symptomatic musculoskeletal manifestations are common. These clinical problems result from neural compression, pain over pagetic lesions near joints or referred to joints, joint disease secondary to pagetic involvement of subchondral bone or more distal bone deformities, or occurrence of other rheumatologic disorders on the background of Paget’s disease. It is the purpose of this review to consider these rheumatologic manifestations and illustrate some of the clinical problems with examples from our own experience.


Joint Space Narrowing Serum Uric Acid Level Gold Sodium Thiomalate Nonsteroidal Antiinflammatory Medication Heterotopic Bone Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Elsevier Science Publishing Co., Inc. 1991

Authors and Affiliations

  • Stephen M. Krane
  • Susan F. Kroop

There are no affiliations available

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