• David P. Houchens
  • Enzo Bonmassar


Virology has played and continues to play an important role in the field of oncology. Although the first indication that a cell-free filtrate could transmit leukemia in chickens was seen early in this century (Ellerman and Bang, 1908), it was not until 3 years later that a virus was definitely found to be the etiologic agent of an animal tumor (Rous, 1911). Since that time animal tumors of viral origin have been found in many species of animals, but to date there has been no definite proof that viruses serve as etiologic agents in human malignancies. Although virus particles have been isolated from several types of human tumors, the establishment of proof that viruses induce human tumors has been limited only to association.


Oncogenic Virus Rous Sarcoma Virus Human Adenovirus Polyoma Virus Mouse Mouse 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • David P. Houchens
    • 1
  • Enzo Bonmassar
    • 1
  1. 1.Immunochemotherapy Section, Laboratory of Experimental Chemotherapy, Drug Research and Development Division of Cancer TreatmentNational Cancer InstituteBethesdaUSA

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